29th National Congress of the Italian Society for the Study of Hemostasis and Thrombosis, 2025

• PO31 | Comparative analysis of anticoagulant therapy in patients over 90 years old: vitamin K antagonists versus direct oral anticoagulants G. Sottilotta¹, P. Arrigo², S. Cuzzocrea¹, D. Megalizzi¹, F. Luise³ | ¹UOSD Microcitemie, Emostasi e Trombosi, Grande Ospedale Metropolitano di Reggio Calabria; ²Associazione Italiana Pazienti Anticoagulati, Sezione di Reggio Calabria; ³Laboratorio Analisi. Grande Ospedale Metropolitano di Reggio Calabria, Italy

  https://doi.org/10.4081/btvb.2025.292

  0

• PO32 | Effect of the sodium-glucose co-transporter-2 (SGLT2) inhibitors on platelet activation and lipid peroxidation: results of a pilot study P. Simeone¹, R. Liani¹, M. Alfonsetti¹, B. Cancelli¹, M. Frezza¹, G. Raggiunti¹, S. Zeeba², F. Cipollone¹, G. Renda², F. Santilli¹ | ¹Department of Medicine and Aging Sciences, Center for Advanced Studies and Technology, University of Chieti; ²Department of Neuroscience, Imaging and Clinical Sciences, G. D’Annunzio University of Chieti-Pescara; ³University Cardiology Division, Heart Department, Policlinico SS Annunziata, Chieti, Italy

  https://doi.org/10.4081/btvb.2025.293

  0

• PO33 | Whole blood hypercoagulable profiles in patients with rheumatoid arthritis L. Spiezia¹, A. Giollo², C. Samà¹, A. Benetti¹, L. Di Luozzo², M. Salvato², A. Doria², P. Simioni¹ | ¹First Chair of Internal Medicine, Thrombotic and Hemorrhagic Diseases Unit, Department of Medicine, University Hospital of Padova; ²Rheumatology Unit, Department of Medicine, University Hospital of Padova, Italy

  https://doi.org/10.4081/btvb.2025.296

  0

• PO34 | A negative oncologic follow up doesn’t always really mean no cancer: two case report of cancer-associated thrombotic microangiopathy E. Cosi, A. Bertomoro, G. Bogoni, I. Bertozzi, I. Cortella, P. Simioni | Clinica Medica ORI, Azienda Ospedale-Università Padova, DIDAS, Italy

  https://doi.org/10.4081/btvb.2025.297

  0

• CS01 | Elucidating the evil relationship of metabolic dysfunction–associated fatty liver disease with cardiovascular comorbidities: the complex interplay among hypercoagulability, inflammation and liver fibrosis G. Gagliardi, E. Campello, A. Napolitano, B. Stocco, C. Di Gesù, G. Gobbo, I. Condonato, M. Allegra, G. Camporese, P. Scarinzi, R Pesavento, F. Bilora, C. Bulato, A. Benetti, C. Samà, C. Portinari, G. Antonello, C. Goffi, L. Di Daniel, A. Zambon, L. Fabris, P. Simioni | First Chair of Internal Medicine, Department of Medicine, University-Hospital of Padua Medical School, Padua, Italy

  https://doi.org/10.4081/btvb.2025.196

  7

• CS02 | Functional and structural impairments of the cerebral microcirculation in a mouse model of hemophilia A G. Venturin¹, C. Olgasi², C. Borsotti¹, P.E. Di Simone¹, E. Spicuglia¹ A. Cucci¹, C. Sgromo¹, A. Follenzi^2,3 | ¹Department of Health Science, Università del Piemonte Orientale, Novara; ²Department of Translational Medicine, Università del Piemonte Orientale, Novara; ³Department of Attività Integrate Ricerca Innovazione, Azienda Ospedaliero-Universitaria SS. Antonio e Biagio e C. Arrigo, Alessandria, Italy

  https://doi.org/10.4081/btvb.2025.197

  4

• CS03 | Khorana risk score and genomic profiling for prediction of venous thromboembolism in ovarian cancer P. Santini, F. Mancinetti, S.M.P. D’Ambrosio, M. Bigossi, A. D’Errico, E. Fondi, G. Fracassa, E. Ianuà, L. Mastrantoni, G. Anderson, F. Camarda, I. Marino, J. Preziosi, M. Buttarelli, M. Manfredelli, A. Minucci, F. Persiani, L. Giacò, T. Pasciuto, I. Conti, I. Mozzetta, C. Marchetti, V. Salutari, G. Scambia, C. Nero, R. Pola | Agostino Gemelli University Polyclinic Foundation IRCCS, Roma, Italy

  https://doi.org/10.4081/btvb.2025.200

  0

• CS04 | Association between elevated plasma levels of tissue plasminogen activator (tPA) and occult cancer risk: a nested case-cohort analysis in 10,294 healthy subjects S. Bolognini^1,2, C. Ticozzi¹, P. Gomez-Rosas^1,3, L. Russo^1,2, Cj. Tartari^1,2, F. Schieppati^1,2, G. Sampietro⁴, L. Barcella¹, M. Marchetti^1,2, A. Falanga^1,2 | ¹Immunohematology and Transfusion Medicine, Hospital Papa Giovanni XXIII, Bergamo, Italy; ²School of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy; ³Maastricht University Medical Center, Cardiovascular Research Institute Maastricht, The Netherlands; ⁴Unit of Epidemiology and Statistics, ATS Bergamo, Italy

  https://doi.org/10.4081/btvb.2025.201

  0

• CS05 | Joint ultrasound follow-up in pediatric patients with haemophilia: a 12-year prospective single-center experience B. Borsellino^1,2, B. Pollio¹, C. Martinoli³, T. Martini¹, R. Albiani¹, I. Ricca¹ | ¹Haemophilia Centre, Immune-Haematology and Transfusion Medicine, University Hospital “Città della Salute e della Scienza”, Turin; ²Department of Biomedicine and Prevention, PhD in Immunology, Molecular Medicine and Applied Biotechnology, University of Roma Tor Vergata, Roma; ³Department of Health Science DISSAL, University of Genoa, Unit of Radiology and IRCCS San Martino Hospital, Genoa, Italy

  https://doi.org/10.4081/btvb.2025.202

  0

• CS06 | Patient specific iPSCs-derived sinusoidal endothelial cells for phenotypic correction of haemophilia A A. Benetti¹, C.M. Radu¹, C. Samà¹, M. Trevisan², C. Simion¹, E. Campello¹, P. Simioni¹ | ¹Department of Medicine - DIMED, Padua University Hospital; ²Department of Molecular Medicine, University of Padua, Italy

  https://doi.org/10.4081/btvb.2025.203

  0

• CS07 | Endothelial dysfunction and impaired angiogenesis in Hermansky-Pudlak syndrome (HPS) type 1: studies with endothelial colony forming cells F. Tondi¹, G. Purgatorio¹, C. Sgromo², E. Giglio¹, E. Petito¹, E. Falcinelli¹, G. Guglielmini¹, A. Follenzi², P. Gresele¹, L. Bury^1*, C. Olgasi^3* | ^*Shared senior authorship; ¹Department of Medicine and Surgery, Section of Internal and Cardiovascular Medicine, University of Perugia; ²Department of Health Sciences, School of Medicine, University of Piemonte Orientale, Novara; ³Department of Translational Medicine, School of Medicine, University of Piemonte Orientale, Novara, Italy

  https://doi.org/10.4081/btvb.2025.204

  0

• CS08 | A combination of two rapid immunoassays improves HIT diagnosis G. Ciarrocca Taranta¹, A. Rogolino², A. Bertelli¹, A. Sorrentino¹, M. Di Gioia², F. Cesari², B. Giusti^1,2, E. Sticchi^1,2, M. Berteotti^1,2, A.M. Gori^1,2, R. Marcucci^1,2 | ¹Department of Experimental and Clinical Medicine, University of Firenze; ²Atherothrombotic Disease Unit, Careggi University Hospital, Firenze, Italy

  https://doi.org/10.4081/btvb.2025.205

  0

• CO01 | Statin therapy for the prevention of venous thromboembolism in cancer patients: a systematic review and meta-analysis F. Catalani, R. Del Giorno, R. Canevascini, W. Ageno, L. Gabutti, G. Prouse, L. Giovannacci | Ospedale Regionale di Bellinzona, Switzerland.

  https://doi.org/10.4081/btvb.2025.199

  1

• CO02 | Hepatic fibrosis as predictor of cancer-associated thrombosis in patients with intrahepatic cholangiocarcinoma Y. Frion-Herrera^1,2, C. Venturin^1,3, M. Cadamuro⁴, J. Gasparello⁵, C.M. Radu¹, M. Fassan⁵, C. Mescoli⁶, U. Cillo⁷, E. Gringeri⁷, G. Zanus⁸, L. Fabris^1,3, P. Simioni¹ | ¹Clinical Medicine and Thrombotic and Haemorrhagic Disease Unit, and Haemophilia Center, Padua University-Hospital, Department of Medicine [DIMED], University of Padua, Italy; ²Department of Biology [DiBio], University of Padua, Italy; ³Department of Internal Medicine, Digestive Disease Section, Liver Center, Yale University, New Haven, CT, USA; ⁴School of Medicine and Surgery, University of Milan-Bicocca, Milan, Italy; ⁵Department of Pathology Ca’ Foncello Hospital, ULSS2 Marca Trevigiana, Italy; ⁶Pathology Unit, Padua University-Hospital, Padua, Italy; ⁷Hepatobiliary Surgery and Liver Transplantation Unit, Padua University-Hospital, Department of Surgery, Oncology and Gastroenterology [DISCOG], University of Padua, Italy; ⁸General Surgery Unit, Ca’ Foncello Hospital, ULSS2 Marca Trevigiana, Department of Surgery, Oncology and Gastroenterology [DISCOG], University of Padua, Italy

  https://doi.org/10.4081/btvb.2025.207

  0

• CO03 | Early discharge and home treatment of low-risk pulmonary embolism: a cohort study E. Ruggeri¹, L. Vulcano¹, W. Ageno², F. Cortellaro³, M.P. Donadini^3,4 | ¹Scuola di Medicina, Università degli Studi dell’Insubria, Varese; ²Dipartimento di Medicina, Università degli Studi di Padova; ³Pronto Soccorso e Medicina d’Urgenza, Ospedale di Circolo, ASST Sette Laghi, Varese; ⁴Dipartimento di Medicina e Chirurgia, Università degli Studi dell’Insubria, Varese, Italy

  https://doi.org/10.4081/btvb.2025.208

  0

• CO04 | Direct oral anticoagulants in antiphospholipid syndrome: a single center real-life experience A. Hoxha¹, E. Campello¹, F. Ahmad², L. Spiezia¹, P. Scarinzi¹, G. Gobbo¹, S. Gavasso¹, F. Sartorelli¹, C. Simion¹, E. Zanon¹, P. Simioni¹ | ¹Internal Medicine Unit, Thrombotic and Haemorrhagic Centre, Department of Medicine - DIMED; ²Department of Statistical Sciences) University of Padova, Italy

  https://doi.org/10.4081/btvb.2025.209

  0

• CO06 | Recurrences of catheter associated upper extremity deep vein thrombosis in cancer: a two year prospective study with enoxaparin M. Sartori, A. Trentini, S. Cavara, L. Borgese, M. Soldati, B. Cosmi | Angiology and Blood Coagulation Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Italy

  https://doi.org/10.4081/btvb.2025.210

  0

• CO07 | Real word management of anticoagulant therapy in brain metastasis: moving toward a multidisciplinary approach in complex cases E. Lotti¹, C. Manneschi², S. Fancelli², F. Scolari¹, F. Crudele¹, D. Poli¹, M. Berteotti¹, D. Rossini³, S. Pillozzi², L. Antonuzzo^2,3, R. Marcucci^1,3 | ¹Disease Unit, Careggi University Hospital, Firenze; ²Oncology Unit, Careggi University Hospital, Firenze; ³Department of Experimental and Clinical Biomedical Sciences, University of Firenze, Italy

  https://doi.org/10.4081/btvb.2025.211

  0

• CO08 | The utility of urine qualitative assessment for direct oral anticoagulants in routine clinical practice F. Schieppati^1,2, P. Gomez-Rosas^1,3, C. Ambaglio¹, V. Brusegan¹, Oc. Cretu^1,2, E. Galimberti¹, F. Zunino¹, L. Barcella¹, J. Harenberg^4,5, A. Falanga^1,2, M. Marchetti^1,2 | ¹Immunohematology and Transfusion Medicine, Hospital Papa Giovanni XXIII, Bergamo, Italy; ²School of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy; ³Maastricht University Medical Center, Cardiovascular Research Institute Maastricht, Maastricht, The Netherlands; ⁴Ruprecht Karls University of Heidelberg, Germany; ⁵Germany DOASENSE GmbH, Heidelberg, Germany

  https://doi.org/10.4081/btvb.2025.212

  0

• CO09 | Long term effectiveness and safety of direct oral anticoagulants in patients with factor V Leiden and/or prothrombin gene mutation and venous thromboembolism: a single centre, retrospective cohort study I.M. Palumbo¹, E. Valeriani^1,2, A. Pannunzio¹, S. Marucci³, D. Menichelli¹, D. Pastori^3,4, P. Pignatelli³ | ¹Department of General Surgery and Surgical Specialty, Sapienza University of Roma; ²Department of Infectious Disease, Azienda Ospedaliero-Universitaria Policlinico Umberto I, Roma; ³Department of Clinical Internal, Anaesthesiologic and Cardiovascular Sciences, Sapienza University of Roma; ⁴IRCCS Neuromed, Pozzilli, Italy

  https://doi.org/10.4081/btvb.2025.213

  0

• CO10 | Multidimensional risk assessment of venous thromboembolism (risk): an observational study comparing the Padua prediction score, Barthel index, and quality of life in hospitalized patients A. Mameli, S. Cornacchini, P. Schirru, F. Marongiu, D. Barcellona | Hemostasis and Thrombosis Unit, University of Cagliari, Italy

  https://doi.org/10.4081/btvb.2025.214

  1

• CO11 | Oral anticoagulation with vitamin K antagonists in early childhood: a single centre-experience B. Borsellino^1,2, B. Pollio¹, I. Ricca¹, R. Albiani¹, T. Martini¹ | ¹Haemophilia Centre, Immune-Haematology and Transfusion Medicine, University Hospital “Città della Salute e della Scienza”, Torino; ²Department of Biomedicine and Prevention, PhD in Immunology, Molecular Medicine and Applied Biotechnology, University of Roma Tor Vergata, Roma, Italy

  https://doi.org/10.4081/btvb.2025.215

  4

• CO12 | Left internal carotid artery thrombosis in a patient with antiphospholipid antibody syndrome successfully treated with eculizumab A. Hoxha¹, L. Nico², F. Viaro³, L. Fabris¹, Y.F. Herrera¹, M. Munari⁴, C. Baracchini³, F. Causin², P. Simioni¹ | ¹Internal Medicine Unit, Thrombotic and Haemorrhagic Centre, Department of Medicine - DIMED, University of Padua; ²Neuradiology Unit, University Hospital of Padua; ³Stroke Unit, Neurology Department, University of Padua; ⁴Intensive Care Unit, University Hospital of Padua, Italy

  https://doi.org/10.4081/btvb.2025.216

  1

• CO13 | Genetic background in hypercholesterolemic patients framing cardiovascular risk A. Kura¹, E. Sticchi², G. Barbieri¹, R. Orsi¹, S. Suraci¹, G.M. Scaturro³, E. Lotti⁴, F. Crudele⁴, M. Berteotti², A.M. Gori², R. Marcucci², B. Giusti² | ¹Department of Experimental and Clinical Medicine, Firenze; ²Department of Experimental and Clinical Medicine, Atherothrombotic Diseases Center, Careggi Hospital, Firenze; ³Meyer Children’s Hospital IRCCS, Firenze; ⁴Atherothrombotic Diseases Center, Careggi Hospital, Firenze, Italy

  https://doi.org/10.4081/btvb.2025.217

  1

• CO14 | Inflammation and fibrinolysis biomarkers as predictors of cancer risk in healthy subjects: results from the hypercan study C. Ticozzi¹, S. Bolognini^1,2, P. Gomez-Rosas^1,3, L. Russo^1,2, Cj. Tartari^1,2, F. Schieppati^1,2, G. Sampietro⁴, L. Barcella¹, M. Marchetti^1,2, A. Falanga^1,2 | ¹Immunohematology and Transfusion Medicine, Hospital Papa Giovanni XXIII, Bergamo, Italy; ²School of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy; ³Maastricht University Medical Center, Cardiovascular Research Institute Maastricht, Maastricht, The Netherlands; ⁴Unit of Epidemiology and Statistics, ATS Bergamo, Italy

  https://doi.org/10.4081/btvb.2025.218

  2

• CO15 | Longitudinal coagulation profiling of individuals undergoing gender-affirming hormone therapy: the hyper-gender study A. Napolitano, E. Campello, A. Scala, C. Simion, C. Bulato, S. Gavasso, C. Samà, A. Benetti, S. Toffanin, G. Faggian, R. Scafa, A. Garolla, P. Simioni | First Chair of Internal Medicine, Department of Medicine, University Hospital of Padua; Unit of Andrology and Reproductive Medicine, Department of Medicine, University Hospital of Padua, Italy

  https://doi.org/10.4081/btvb.2025.219

  3

• CO16 | The predictive value of high-sensitivity C-reactive protein for assessing thrombosis risk in non-small cell lung cancer P. Gomez-Rosas^1,2, M. Marchetti^1,3, L. Russo¹, C.J. Tartari¹, S. Bolognini¹, C. Ticozzi¹, F. Schieppati¹, A. D’Alessio⁴, R. Labianca⁵, A. Falanga^1,3 All on behalf of the Hypercan Investigators | ¹Hospital Papa Giovanni XXIII, Bergamo, Italy; ²Cardiovascular Research Institute Maastricht, CARIM, Maastricht University, Maastricht, the Netherlands; ³School of Medicine and Surgery, University of Milan Bicocca, Italy; ⁴University Vita-Salute San Raffaele, Milan, Italy; ⁵Fondazione ARTET Onlus, Bergamo, Italy

  https://doi.org/10.4081/btvb.2025.220

  3

• CO17 | Clinical relevance of isolated anti-phosphatidylserine/ prothrombin antibody positivity A. Hoxha¹, P. Žigon^2,3, L. Katja^2,3, S. Čučnik^2,4, Ž. Rotar^2,5, S. Gavasso¹, P. Zerbinati¹, G. Gobbo¹, P. Simioni¹ | ¹University of Padua, Internal Medicine Unit, Thrombotic and Hemorrhagic Centre, Department of Medicine-DIMED, Padua, Italy; ²University Medical Centre Ljubljana, Department of Rheumatology, Ljubljana, Slovenia; ³University of Primorska, Faculty of Mathematics, Natural Sciences and Information Technologies, Koper, Slovenia; ⁴University of Ljubljana, Faculty of Pharmacy, Ljubljana, Slovenia; ⁵University of Ljubljana, Faculty of Medicine, Ljubljana, Slovenia

  https://doi.org/10.4081/btvb.2025.221

  3

• CO18 | Relationship between gut permeability and PCSK9 in heterozygous familial hypercholesterolemia V. Castellani¹, V. Cammisotto², F. Baratta², S. Bartimoccia³, C. Nocella², L. D’erasmo¹, N. Cocomello², C. Barale⁴, R. Scicali⁵, I. Russo⁴, F. Purrello⁵, R. Carnevale³, F. Violi², M. Arca¹, P. Pignatelli² | ¹Department of Translational and Precision Medicine, Sapienza University of Roma; ²Department of Clinical, Internal Medicine, Anesthesiology and Cardiovascular Sciences, Sapienza University of Roma; ³Department of Medical-Surgical Sciences and Biotechnologies, Sapienza University of Roma; ⁴Department of Clinical and Biological Sciences, University of Turin; ⁵Department of Clinical and Experimental Medicine, Internal Medicine, University of Catania, Italy

  https://doi.org/10.4081/btvb.2025.222

  3

• CO19 | Hypercoagulability in wild-type transthyretin amyloidosis: evidence from whole blood thromboelastometry A. Napolitano¹, L. Spiezia¹, C. Samà¹, A. Benetti¹, G. Sinigiani², L. De Michieli², A. Cipriani², P. Simioni¹ | ¹First Chair of Internal Medicine, Department of Medicine, University Hospital of Padua; ²Department of Cardiothoracic and Vascular Sciences & Public Health, University Hospital of Padua, Italy

  https://doi.org/10.4081/btvb.2025.223

  0

• CO20 | Coagulation alterations as prognostic indicators in septic patients L. Baratti¹, S. N. Pasturenzi¹, P. Onorato², W. Ageno³, F. Cortellaro², M.P. Donadini^2,4 | ¹Scuola di Medicina, Università degli Studi dell’Insubria, Varese; ²Pronto Soccorso e Medicina d’Urgenza, Ospedale di Circolo, Varese; ³Dipartimento di Medicina, Università degli Studi di Padova; ⁴Dipartimento di Medicina e Chirurgia, Università degli Studi dell’Insubria, Varese, Italy

  https://doi.org/10.4081/btvb.2025.226

  0

• CO21 | Viscoelastic testing in inherited bleeding disorders: a cross-sectional comparison between viscoelastic coagulation monitoring (VCM) and rotational thromboelastometry (ROTEM) C. Simion, C. Samà, C. Bulato, G. Gottardi, D. Regazzo, E. Campello, P. Simioni | Department of Medicine – DIMED, University of Padua, Italy

  https://doi.org/10.4081/btvb.2025.227

  0

• CO22 | Assessment of coagulation profiles in septic patients using viscoelastic coagulation monitoring and rotational thromboelastometry in an internal medicine setting G. Gottardi, C. Simion, D. Regazzo, C. Samà, G.P. Arcidiacono, L. Gianesello, E. Campello, P. Simioni | Department of Medicine – DIMED, University of Padua, Italy

  https://doi.org/10.4081/btvb.2025.228

  0

• CO23 | Markers of inflammation and hypofibrinolysis are associated with cognitive dysfunction and motor performances in atrial fibrillation patients on oral anticoagulant therapy: insights from the Strat-AF study F. Alfano^1,2, F. Cesari^1,2, A.M. Gori^1,2, M. Berteotti^1,2, E. Salvadori³, B. Giusti^1,2, A. Bertelli^1,2, F. Fratini⁴, A. Rogolino^1,2, B. Formelli^4,5, F. Pescini^4,5, E. Fainardi⁶, E. Barucci⁴, G. Salti⁵, A. Cavaliere⁴, A. Ginestroni⁶, A. Poggesi^4,5, R. Marcucci^1,2 | ¹Department of Experimental and Clinical Medicine, University of Firenze; ²Center for Atherothrombotic Diseases, Careggi University Hospital, Firenze; ³Department of Biomedical and Clinical Sciences, University of Milan; ⁴NEUROFARBA Department, Neuroscience Section, University of Firenze; ⁵Stroke Unit, Careggi University Hospital, Firenze; ⁶Neuroradiology Unit, Careggi University Hospital, Department of Experimental and Clinical Biomedical Sciences, University of Firenze, Italy

  https://doi.org/10.4081/btvb.2025.229

  0

• CO24 | Extracellular vesicles profiles in patients with wild-type transthyretin amyloidosis S. Toffanin¹, L. Spiezia¹, C.M. Radu¹, A. Napolitano¹, A. Benetti¹, C. Samà¹, E. Campello¹, L. De Michieli², G. Sinigiani², A. Cipriani², P. Simioni¹ | ¹First Chair of Internal Medicine, Department of Medicine, University-Hospital of Padua Medical School, Padua; ²Department of Cardiac, Thoracic and Vascular Sciences and Public Health, University of Padua, Italy

  https://doi.org/10.4081/btvb.2025.230

  0

• CO25 | Thromboinflammation and ros accumulation in individuals with high lipoprotein(a) levels M. Frezza¹, P. Simeone¹, M. Alfonsetti¹, R. Liani¹, M. Cellini¹, P. Del Boccio², M.C. Cufaro³, O. Iuliani⁴, A. Quaglietta⁴, F. Cipollone¹, F. Santilli¹ | ¹Department of Medicine and Ageing Sciences, Center for Advanced Studies and Technology “CAST”, University of Chieti; ²Department of Pharmacy, Center for Advanced Studies and Technology “CAST”, Chieti; ³Department of Innovative Technologies in Medicine and Dentistry, Center for Advanced Studies and Technology “CAST”, Chieti; ⁴Department of Haematolgy and Oncology, Center of Transfusion Medicine, Pescara General Hospital, Pescara. Italy

  https://doi.org/10.4081/btvb.2025.231

  3

• CO26 | Relationship between SMAD3 variants and non-aortic cardiovascular features L. Squillantini, E. Sticchi, P. Cantini, S. Suraci, A. Rogolino, F. Gensini, S. Nistri, G. Pepe, A.M. Gori, M. Berteotti, R. Marcucci, B. Giusti | Università degli Studi di Firenze, Dipartimento di Medicina Sperimentale e Clinica, Firenze, Italy

  https://doi.org/10.4081/btvb.2025.232

  2

• CO27 | Intracerebral hemorrhage in hemophilia A and B: a 10-year prospective multicenter study in Italy (2012–2022) E. Zanon¹, A. Napolitano¹, A. Porreca², F. Demartis³, A. Coppola⁴, C. Santoro⁵, I. Cantori⁶, A. C. Molinari⁷, C. Biasioli⁸, M. Luciani⁹, G. Sottilotta¹⁰, B. Pollio¹¹, A. Borchiellini¹², A. Tosetto¹³, P. Flora¹⁴, P. Simioni¹ | ¹Haemophilia Center, First Chair of Internal Medicine, Department of Medicine, University-Hospital of Padua Medical School, Padua; ²Department of Human Sciences and Promotion of the Quality of Life, Unit of Clinical and Molecular Epidemiology IRCCS San Raffaele Roma Open University, Roma; Unit of Clinical and Molecular Epidemiology IRCCS San Raffaele, Roma; ³Centre for Bleeding Disorders, Careggi University Hospital of Firenze; ⁴Azienda Ospedaliero Universitaria di Parma; ⁵Hematology Division, Umberto I University Hospital of Roma; ⁶Haemophilia Center, Department of Transfusion Medicine, Hospital of Macerata; ⁷IRCCS Istituto Giannina Gaslini, Genova; ⁸Haemophilia and Transfusion Centre, Bufalini Hospital, Cesena; ⁹Children’s Hospital Bambino Gesù, Roma; ¹⁰Haemophilia Center, Department of Onco-Hematology and Radioterapy, Hospital of Reggio Calabria; ¹¹Haemophilia Pediatric Center, Transfusion Medicine, City of Health and Science of Turin; ¹²City of Health and Science of Turin; ¹³Hemorrhagic and Thrombotic Diseases Unit, S. Bortolo Hospital of Vicenza; ¹⁴RCCS Foundation Ca’ Granda Maggiore Policlinico Hospital, Milan, Italy

  https://doi.org/10.4081/btvb.2025.233

  3

• CO28 | Cognitive, adaptive abilities and behavioral symptoms in children and adolescents with hemophilia: a pilot study R. Vallone¹, M. Luciani², A. Smigliani², M. F. Mansueto³, S. Vicari^1,4, D. Menghini¹ | ¹Child and Adolescent Neuropsychiatry Unit, Bambino Gesù Children’s Hospital, IRCCS, Roma; ²OncoHematology Unit, Bambino Gesù Children’s Hospital, IRCCS, Roma; ³Department of Oncology U.O. Hematology AUO Policlinico, Paolo Giaccone, Palermo; ⁴Department of Life Science and Public Health, Università Cattolica del Sacro Cuore, Roma, Italy

  https://doi.org/10.4081/btvb.2025.234

  3

• CO29 | Emergency room physicians and oral anticoagulants related bleeding D. Barcellona^1,2, G. Melis¹, A. Bussu¹, M. Orrù¹, Ml. Caddeo¹, E. Antonucci², A. Mameli¹, F. Marongiu^1,2 | ¹SSD Emostasi e Trombosi, AOU Cagliari; ²Fondazione Arianna, Bologna, Italy

  https://doi.org/10.4081/btvb.2025.235

  3

• CO30 | Joint prosthetic surgery in patients with hemophilia A: clinical-functional outcomes and quality of life E. Zanon¹, A. Napolitano¹, A. Berizzi², P. Simioni¹ | ¹Haemophilia Center, First Chair of Internal Medicine, Department of Medicine, University-Hospital of Padua Medical School, Padua; ²Orthopedics and Traumatology Unit, University-Hospital of Padua Medical School, Padua, Italy

  https://doi.org/10.4081/btvb.2025.236

  3

• CO31 | Immune system profiling in FVIII-treated and emicizumab-treated pediatric HA patients A. Cottonaro¹, S. Akula¹, B. Pollio², I. Ricca², T. Martini², J. Agnelli Giacchello³, P. Sciancalepore³, R. Santi³, A. Follenzi^1,3, S. Merlin¹ | ¹Università del Piemonte Orientale, Health Sciences, Novara; ²A.O. Città della Salute e della Scienza, SIMT Immunohematology and Transfusion Medicine Service, Diagnostic Department, Torino; ³Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo, Alessandria, Italy

  https://doi.org/10.4081/btvb.2025.238

  3

• CO32 | Major surgery in patients with severe hemophilia A without inhibitors receiving prophylaxis with fitusiran E. Zanon, C. Simion, A. Napolitano, L. Spiezia, P. Simioni | Haemophilia Center, First Chair of Internal Medicine, Department of Medicine, University-Hospital of Padua Medical School, Padua, Italy

  https://doi.org/10.4081/btvb.2025.239

  0

• CO33 | Acquired hemophilia A in Liguria, Italy: what six years of data reveal C. Vernarecci¹, A. C. Molinari¹, P. Ballarino², M. Caiti², E. Cenni², P. Moscatelli², L. Banov¹ | ¹IRCCS Istituto Giannina Gaslini, Genova; ²IRCCS Policlinico San Martino, Genova, Italy

  https://doi.org/10.4081/btvb.2025.240

  2

• CO34 | Evaluation of emicizumab concentration and thrombin generation in a cohort of severe hemophilia A patients with and without inhibitor A. Taglietti¹, S. Ligia¹, F. Paoletti¹, R. Mormile¹, E. Baldacci², A. Chistolini¹, C. Santoro^1,2 | ¹Hematology, Department of Translational and Precision Medicine, Sapienza University of Roma; ²Hematology, Azienda Ospedaliera Universitaria Policlinico Umberto I, Roma, Italy

  https://doi.org/10.4081/btvb.2025.241

  0

• CO35 | Bleeding phenotype characterization in patients with congenital bleeding disorders: a multigenic approach using next generation sequencing to identify coagulation-modulating variants C. Simion, L. Gianesello, C. Bulato, A. Benetti, E. Campello, A. Giannella, G. Ceolotto, E. Zanon, L. Spiezia, P. Simioni | Department of Medicine – DIMED, University of Padua, Italy

  https://doi.org/10.4081/btvb.2025.242

  0

• CO36 | Inhibitor titer at diagnosis and clinical course in acquired hemophilia A: a single-center experience C. Simion, B. Stocco, E. Dalla Porta, E. Campello, G. Furlan, L. Spiezia, G. Saggiorato, F. Sartorello, E. Zanon, P. Simioni | Department of Medicine – DIMED, University of Padua, Italy

  https://doi.org/10.4081/btvb.2025.243

  0

• CO37 | Assessment of clotting factor activity and sterility in thawed fresh frozen plasma supplied to helicopter emergency medical services for prehospital transfusion D. Romeo¹, M. Marchetti^1,2, M. Testa¹, A. Motta¹, P. Gomez-Rosas¹, G. Ravasio¹, F. Daminelli³, L. Barcella¹, A. Falanga^1,2 | ¹Immunohematology and Transfusion Medicine Department, Hospital Papa Giovanni XXIII, Bergamo; ²School of Medicine and Surgery, University Milano Bicocca, Milan; ³Anesthesia and Resuscitation Department, Hospital Papa Giovanni XXIII, Bergamo, Italy

  https://doi.org/10.4081/btvb.2025.244

  0

• CO38 | Management of pregnancy, delivery, and postpartum in Italian carriers and women with hemophilia A and B S. Linari¹, B. Pollio², A. Ferretti³, M. Napolitano⁴, E. Grandone⁵, S. Siboni⁶, Ab. Aru⁷, E. Bertoni⁸, C. Biasoli⁹, I. Cantori¹⁰, P. Di Gregorio¹¹, G. Lassandro¹², G. Sottilotta¹³, A. Strangio¹⁴, Mr. Villa¹⁵, A. Rocino¹⁶, G. Castaman¹ | ¹Center for Bleeding Disorders and Coagulation, Careggi University Hospital, Firenze; ²Regional Reference Center for Inherited Bleeding and Thrombotic Disorders, Transfusion Medicine, Regina Margherita Children Hospital, Turin; ³Center for Hemorrhagic and Thrombotic Diseases, IRCCS A. Gemelli University Hospital Foundation, Roma; ⁴Department of Health Promotion, Maternal-Childhood, Internal Medicine of Excellence G. D’Alessandro, University of Palermo; ⁵Thrombosis and Hemostasis Unit, Fondazione IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo; ⁶Angelo Bianchi Bonomi Hemophilia and Thrombosis Center and Fondazione Luigi Villa, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan; ⁷Pediatric Onco-Hematology Center, Microcitemico Hospital Cagliari; ⁸Pediatric Oncohematology and Bone Marrow Transplant “BMT” Unit, Children’s Hospital, Spedali Civili, Brescia; ⁹Hemophilia and Transfusion Center, Bufalini Hospital, Cesena; ¹⁰Hemophilia Center, Department of Transfusion Medicine, Hospital of Macerata; ¹¹Transfusion Medicine Department, SS. Annunziata Hospital, Chieti; ¹²B. Trambusti General and Specialised Pediatrics Unit, Giovanni XXIII Hospital, University of Bari; ¹³Hemophilia Center, Grande Ospedale Metropolitano, Reggio Calabria; ¹⁴Center for Hemorrhagic and Thrombotic Disorders, Pugliese Ciaccio Hospital, Catanzaro; ¹⁵Hemophilia and Thrombosis Center, Haematology Unit, Ospedale del Mare Hospital, Naples; ¹⁶Past President of the Italian Association of Hemophilia Centers, Italy

  https://doi.org/10.4081/btvb.2025.245

  0

• CO39 | Artificial intelligence in hemophilia management: challenging the need for experts G. Sottilotta¹, D. Megalizzi¹, F. Luise² | ¹UOSD Microcitemie - Emostasi e Trombosi. Grande Ospedale Metropolitano Bianchi-Melacrino-Morelli, Reggio Calabria; ²Laboratorio Analisi, Grande Ospedale Metropolitano Bianchi-Melacrino-Morelli, Reggio Calabria, Italy

  https://doi.org/10.4081/btvb.2025.246

  0

• CO40 | The co-inheritance of two ITGB3 variants exerting additive detrimental effects on platelets leads to variant Glanzmann thrombasthenia N. Arndt¹, E. Falcinelli¹, A. Zamora-Canovas², A. Sánchez Fuentes², A. Marín-Quilez², I. Tano¹, M.D.M. Nieto-Hernández³, J.M. Bastida⁴, J. Rivera², P. Gresele¹, L. Bury¹ | ¹Department of Medicine and Surgery, Section of Internal and Cardiovascular Medicine, University of Perugia, Italy; ²Servicio de Hematología y Oncología Médica, Hospital Universitario Morales Meseguer, Centro Regional de Hemodonación, Universidad de Murcia, IMIB-Pascual Parrilla, ISCIII-CIBERER, Murcia, Spain; ³Servicio de Hematología, Hospital Universitario de Jaen, Spain; ⁴Departamento de Hematología, Complejo Asistencial Universitario de Salamanca “CAUSA”, Instituto de Investigación Biomédica de Salamanca “IBSAL”, Centro de Investigación del Cáncer, IBMCC-CSIC, Universidad de Salamanca “USAL”, Salamanca, Spain

  https://doi.org/10.4081/btvb.2025.247

  0

• CO42 | Oxidative stress may contribute to enhanced thrombopoiesis through miR-150: implications for aspirin response R. Liani¹, P.G. Simeone¹, M. Alfonsetti¹, M. Frezza¹, R. Tripaldi¹, S. Ciotti¹, M. Luongo², F. Cipollone¹, L. Vanella³, F. Santilli¹ | ¹Department of Medicine and Aging, and Center for Advanced Studies and Technology “CAST”, G. d’Annunzio University of Chieti-Pescara, Chieti; ²Immunotransfusion Service, Clinical Haematology of Chieti University Hospital, Chieti; ³Department of Drug Sciences, University of Catania, Italy

  https://doi.org/10.4081/btvb.2025.248

  0

• CO43 | Early platelet dysfunction in sepsis: an ICU pilot study S. Sorrentino¹, C. Gori², L. D’Innocenzo¹, M. De Siati¹, Mg. Bocci³, E. De Candia¹ | ¹Unit of Haemostasis and Thrombosis Diseases, Fondazione Policlinico Universitario A. Gemelli, IRCCS, Roma; ²UOC Shock & Trauma, Azienda Ospedaliera San Camillo Forlanini, Roma; ³National Institute for Infectious Diseases, Lazzaro Spallanzani, IRCCS, Roma, Italy

  https://doi.org/10.4081/btvb.2025.249

  0

• CO44 | First interlaboratory validation workshop of immunofluorescence microscopy on the peripheral blood smear for recognizing patients with inherited platelet disorders C. Zaninetti¹, L. Bury², V. Bozzi³, A. Zamora-Cánovas⁴, K. Althaus⁵, G. Uzun⁵, S. Brown⁶, A. Norman⁶, D. Faille⁷, A. Stepanian⁸, C. Freyer¹, L. Kager⁹, T. Bakchoul⁵, A. Pecci³, P. Gresele², T. Thiele¹, J. Rivera⁴, A. Greinacher¹ | ¹Institut für Immunologie und Transfusionsmedizin, Universitätsmedizin Greifswald, Germany; ²Department of Medicine, Section of Internal and Cardiovascular Medicine, University of Perugia, Italy; ³Department of Internal Medicine, University of Pavia, Italy; General Medicine 1, IRCCS Policlinico San Matteo Foundation, Pavia, Italy; ⁴Servicio de Hematología, Hospital Universitario Morales Meseguer, Centro Regional de Hemodonacio´n, Universidad de Murcia, Spain; ⁵Institute for Clinical and Experimental Transfusion Medicine, University Hospital of Tuebingen, Germany; Center for Clinical Transfusion Medicine, Tuebingen, Germany; ⁶Centre for Children’s Health and Research CCHR, South Brisbane, Australia; ⁷Laboratoire d’Hématologie, Assistance Publique Hôpitaux de Paris, Hôpital Bichat-Claude-Bernard, Paris, France; ⁸AP-HP, Service d’Hématologie Biologique, Hôpital Lariboisière, Paris Cité University, Paris, France; ⁹St. Anna Kinderspital, Universitätsklinik für Kinder- und Jugendheilkunde der Medizinischen Universität Wien, Austria

  https://doi.org/10.4081/btvb.2025.250

  0

• CO45 | Role of urinary 11-dehydro-thromboxane B2 as a predictor of preeclampsia in pregnant high-risk women on low-dose aspirin treatment P. Simeone¹, R. Liani¹, M. Alfonsetti¹, A. Ricci¹, V. Cianci¹, S. Zeeba², M. Molino³, S. Palma², R. Malizia⁴, M. Luongo⁴, A. Di Castelnuovo⁵, F. Cipollone¹, F. D’antonio⁶, F. Ricci², G. Renda², F. Santilli¹ | ¹Department of Medicine and Aging Sciences, Center for Advanced Studies and Technology, University of Chieti; ²Department of Neuroscience, Imaging and Clinical Sciences, G D’Annunzio University of Chieti-Pescara, Chieti; University Cardiology Division, Heart Department, Policlinico SS Annunziata, Chieti; ³Clinical Pathology of Chieti University Hospital; ⁴Immunotransfusion Service, Clinical Haematology of Chieti University Hospital, Chieti; ⁵Mediterranea Cardiocentro, Napoli; ⁶Centre for Fetal Care and High-Risk Pregnancy, Department of Obstetrics and Gynecology, University of Chieti, Italy

  https://doi.org/10.4081/btvb.2025.251

  2

• CO46 | Comparison of reticulated platelet procoagulant role in liver cirrhosis vs. fibrosis S. Toffanin¹, E. Campello¹, A. Zanetto², G. Gagliardi¹, A. Napolitano¹, E. Stocco¹, G. Gobbo¹, E. Pinto², M.C. Radu¹, M. Senzolo², L. Fabris¹, P. Simioni¹ | ¹First Chair of Internal Medicine, Department of Medicine, University-Hospital of Padua Medical School, Padova; ²Department of Surgery Oncology and Gastroenterology, Gastroenterology and Multivisceral Transplant Unit, Padova University Hospital, Padova, Italy

  https://doi.org/10.4081/btvb.2025.256

  0

• CO47 | Genetic characterization of the KIV2 LPA polymorphism in subjects with bicuspid aortic valve with different clinical complications R. Orsi¹, G. Barbieri¹, E. Sticchi^1,2, A. Kura¹, L. Squillantini¹, P. Cantini¹, A. Rogolino², M. Berteotti^1,2, S. Nistri³, P. Stefàno⁴, R. Marcucci^1,2, B. Giusti^1,2 | ¹Department of Experimental and Clinical Medicine, University of Firenze; ²Centre for Atherothrombotic Diseases, AOU Careggi, Firenze; ³Cardiology, CMSR Veneto Medica, Altavilla Vicentina; ⁴Cardiac Surgery, AOU-Careggi, Firenze, Italy

  https://doi.org/10.4081/btvb.2025.257

  0

• CO48 | Gynecological involvement in females with congenital plasminogen deficiency type 1 C. Dalla Porta^1,2, M.T. Sartori¹, G. Saggiorato¹, I. Cortella¹, S.A. Malerba^1,3, P. Simioni¹ | ¹First Medical Clinic, Department of Medicine - DIMED, Università degli Studi di Padova; ²Department of Medicine, Casa di Cura Villa Maria, Padova; ³Medicina Generale, Ospedale dell’Angelo, Mestre, Italy

  https://doi.org/10.4081/btvb.2025.258

  0

• CO49 | The burden of cerebral small vessel disease in ITTP patients from acute phase to remission A. Truma^1,2, F. M. Lo Russo¹, G. Conte^1,2, I. Mancini¹, M. Abbattista¹, J. Giannotta¹, A. Artoni¹, B. Ferrari¹, P. Agosti^1,2, F. M. Triulzi^1,2, F. Peyvandi^1,2 | ¹Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Milan; ²Università degli Studi di Milano, Department of Pathophysiology and Transplantation, Milan, Italy

  https://doi.org/10.4081/btvb.2025.259

  0

• CO50 | Diagnostic accuracy of the heparin-induced multiple electrode aggregometry (HIMEA) functional test for heparin-induced thrombocytopenia M. Bovara¹, M. Sebastiani², Am. Gori^3,4, A. Rogolino^3,4, A. Bertelli^3,4, G. Ciarrocca Taranta^3,4, R. Marcucci^3,4, M. Sartori⁵, B. Cosmi⁵, M. Silingardi⁶, A. Pizzini⁶, A. Marrocchi¹, R. Mancini¹ | ¹Laboratorio Unico Metropolitano Ospedale Maggiore, AUSL Bologna; ²IRCCS Istituto delle Scienze Neurologiche, Bologna; ³Centro Malattie Aterotrombotiche Azienda Ospedaliera Universitaria Careggi, Firenze; ⁴Dipartimento di Medicina Sperimentale e Clinica, Università di Firenze; ⁵U.O. di Angiologia e Malattie della Coagulazione dell’Azienda Ospedaliero Universitaria Policlinico S. Orsola-Malpighi, Bologna; ⁶Medicina Interna Ospedale Maggiore, Bologna, Italy

  https://doi.org/10.4081/btvb.2025.260

  0

• CO51 | Novel biomarkers of neurological damage in acute immune-mediated thrombotic thrombocytopenic purpura A. Truma^1,2, I. Mancini¹, F. Verde^2,3, J. A. Giannotta¹, A. Artoni¹, B. Ferrari¹, P. Agosti^1,2, M. Gagliardi¹, A. Ratti^3,4, N. Ticozzi^2,3, F. Peyvandi^1,2 | ¹Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Milan; ²Università degli Studi di Milano, Department of Pathophysiology and Transplantation, Milan; ³Department of Neurology and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, Milan; ⁴Università degli Studi di Milano, Department of Medical Biotechnology and Translational Medicine, Milan, Italy

  https://doi.org/10.4081/btvb.2025.261

  0

• CO52 | The impact of KRAS mutations on the risk of recurrent venous thromboembolism in patients with cancer-associated thrombosis and gastrointestinal neoplasms B. Cosmi^1,2, S. Cavara², M. Soldati², L. Borgese², M. Sartori² | ¹Angiology and Blood Coagulation Unit, Department of Medical and Surgical Sciences, University of Bologna; ²Angiology and Blood Coagulation Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Italy

  https://doi.org/10.4081/btvb.2025.262

  0

• PO03 | Enlarged platelets with reduced GP IB/IX can indicate disorders other than Bernard-Soulier syndrome C. Zaninetti¹, A. Marín-Quílez², S. Semenowitsch¹, A. Sánchez-Fuentes², A. Zamora- Cánovas², P. Gómez-González², E. Birgitte Leinøe³, N. Fernández-Mosteirin⁴, T. Murciano^5,6, C. Freyer¹, T. Thiele¹, J. Rivera^2,7, A. Greinacher¹ | ¹Universitätsmedizin Greifswald, Institut Für Transfusionsmedizin, Greifswald, Germany; ²Universidad De Murcia, Servicio De Hematología, Hospital Universitario Morales Meseguer, Centro Regional De Hemodonacion, Imib-Pascual Parrilla, Ciberer-U765, Murcia, Spain; ³Rigshospitalet University Hospital, Department of Haematology and Department of Genomic Medicine, Copenhagen, Denmark; ⁴Hospital Universitario Miguel Servet, Servicio De Hematología, Zaragoza, Spain; ⁵Hospital Universitario Vall D’Hebron, Servicio De Oncología y Hematología Pediatricas; ⁶Vall D’Hebron Institut De Recerca, Barcelona, Spain; ⁷Grupo Español De Alteraciones Plaquetarias Congénitas, Murcia, Spain

  https://doi.org/10.4081/btvb.2025.265

  0

• PO04 | Classification criteria for antiphospholipid syndrome: ACR/EULAR 2023 versus Sydney 2006 – A monocentric and retrospective study S. Suardi*, A. Marino*, J. Croce, F. Maiolini, E. Tinazzi, S. Moruzzi, L. Delfino, F. Pizzolo, E. Bassanello, G. Marcassa, C. Spillere, S. Friso, N. Martinelli | *the two authors equally contributed to the work and share the first authorship; Department of Medicine, Section of Internal Medicine, University of Verona, Italy

  https://doi.org/10.4081/btvb.2025.266

  0

• PO05 | Intensive FVIII replacement in haemophilia patients with hypertrophic synovium: a randomized study I.L. Calcaterra¹, E. Baldacci², R. Marino³, F. Valeri⁴, R.C. Santoro⁵, G. Pasta⁶, C. Martinoli⁷, M. Di Minno¹ | ¹Department of Clinical Medicine and Surgery, Federico II University, Naples; ²Haematology, University Hospital Policlinico Umberto I, Roma; ³Haemophilia Center and thrombosis, Policlinico, Bari; ⁴Regional Centre for Haemorrhagic and Thrombotic Diseases, AOU Città Della Salute e Della Scienza; Turin; ⁵Centre for Hemorrhagic and Thrombotic Disorders, Pugliese Ciaccio Hospital, Catanzaro; ⁶Fondazione IRCCS San Matteo Hospital, Pavia; ⁷Department of Health Science DISSAL, University of Genoa, Unit of Radiology and IRCCS San Martino Hospital, Genoa, Italy

  https://doi.org/10.4081/btvb.2025.267

  0

• PO06 | Extracellular vesicles profiles in patients with porto-sinusoidal vascular disease S. Toffanin¹, E. Campello¹, A. Zanetto², M.C. Radu¹, E. Pinto², K. Fernande², C. Bulato¹, B. Serena¹, L. Spiezia¹, P. Burra², M. Senzolo², P. Simioni¹ | ¹First Chair of Internal Medicine, Department of Medicine, University Hospital of Padua Medical School, Padua; ²Department of Surgery Oncology and Gastroenterology, Gastroenterology and Multivisceral Transplant Unit, University Hospital of Padua, Italy

  https://doi.org/10.4081/btvb.2025.268

  0

• PO07 | Liver transplant in a case of congenital afibrinogenemia G. Murante^1,2,3, S. Bergonzi^1,2,3, C. Sella^1,2,3, F. Valeri^1,2, C. Dainese^1,2, A. Valpreda⁴, R. Pastorino^1,3, R. Romagnoli⁵, D. Patrono⁵, D. Cussa⁵, S. Martini⁶, B. Bruno^2,3, A. Borchiellini^1,2 | ¹Regional Centre for Hemorrhagic and Thrombotic Diseases, AOU Città della Salute e della Scienza, Torino; ²Division of Hematology, AOU Città della Salute e della Scienza, University of Turin; ³Department of Molecular Biotechnology and Health Sciences, University of Turin; ⁴Central Laboratory Baldi and Riberi, AOU Città della Salute e della Scienza, Torino; ⁵General Surgery 2U - Liver Transplant Center, Molinette Hospital, AOU Città della Salute e della Scienza, Torino; ⁶SSD Hepatic insufficiency and Liver Transplant, AOU Città della Salute e della Scienza, Torino, Italy

  https://doi.org/10.4081/btvb.2025.269

  0

• PO08 | Efficacy and safety of thromboprophylaxis in hospitalized hematological patients: a monocenter retrospective study S. Cordella^1,2, V. Coluccio³, M. Luppi¹, M. Marietta¹ |  ¹Department of Medical and Surgical Sciences, Section of Hematology. University of Modena and Reggio Emilia, Azienda Ospedaliero-Universitaria di Modena; ²Clinical and Experimental Medicine PhD Programme, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena; ³Department of Hematology, Unità Sanitaria Locale di Modena, Italy 

  https://doi.org/10.4081/btvb.2025.270

  0

• PO09 | Comparison of different aggregometry methods for evaluation of platelet function in patients with myeloproliferative neoplasms C. Fortino, I. Bertozzi, D. Regazzo, L. Gianesello, G. Nuozzi, F. Sartorello, V. Azzaro, G. Saggiorato, A. Bertomoro, P. Simioni | First Medical Clinic, Department of Medicine – DIMED, Università degli Studi di Padova, Italy

  https://doi.org/10.4081/btvb.2025.271

  0

• PO10 | Clinical and laboratory features of long-Covid syndrome: a cross-sectional study of 1,337 Covid-19 survivors C. Ambaglio¹, S. V. Benatti², C. J. Tartari^1,3, L. Russo^1,3, S. Bolognini^1,3, C. Ticozzi¹, F. Schieppati¹, V. Brusegan¹, S. Venturelli², L. Barcella¹, M. Rizzi², M. Marchetti^1,3, A. Falanga^1,3 | ¹Department of Immunohematology and Transfusion Medicine, Papa Giovanni XXIII Hospital, Bergamo; ²Division of Infectious Diseases, Papa Giovanni XXIII Hospital, Bergamo; ³Department of Medicine and Surgery, University of Milan Bicocca, Monza, Italy

  https://doi.org/10.4081/btvb.2025.272

  0

• PO11 | Neutrophil cathepsin G and risk of cardiovascular events in patients with diabetes mellitus V. Cammisotto¹, F. Baratta², S. Bartimoccia³, D. Pastori¹, N. Cocomello⁴, V. Castellani⁵, C. Nocella¹, R. Carnevale³, G. Desideri¹, F. Violi¹, P. Pignatelli¹ | ¹Department of Clinical, Internal Medicine, Anesthesiological and Cardiovascular Sciences, Sapienza University of Roma; ²Geriatric Unit, Department of Internal Medicine and Medical Specialties, AOU Policlinico Umberto I, Roma; ³Department of Medical-Surgical Sciences and Biotechnologies, Sapienza University of Roma; ⁴Department of Anatomical Sciences, Histological, Legal Medical and Locomotor, Sapienza University of Roma; ⁵Department of Experimental Medicine, Sapienza University of Roma, Italy

  https://doi.org/10.4081/btvb.2025.273

  0

• PO12 | Characterisation and real word clinical data of HEM006, a newly formulated intranasal spray desmopressin (DDAVP) to address a global treatment gap G. De Giorgi¹, A. Gringeri², R. Franceschini¹, A. Koganti³ | ¹Hemorare Srl, Italy; ²Fondazione Charta, Milan, Italy; ³Quenya LLC, USA

  https://doi.org/10.4081/btvb.2025.274

  0

• PO14 | Searching for safer rescue immunosuppressive therapy protocols in acquired hemophilia A: two case reports G. Quintavalle¹, I.M. Tassoni¹, B.M. Roccon¹, G. Lucchini², F. Magalini², M. Zardo², R. Rossi³, C. Cattabiani³, A. Tagliaferri¹, A. Coppola¹ | ¹SSD Centro HUB Emofilia e MEC; ²UOS Medicina Interna e Reumatologia; ³UO Diagnostica Ematochimica, Azienda Ospedaliero Universitaria, Parma, Italy

  https://doi.org/10.4081/btvb.2025.275

  0

• PO15 | Venous thromboembolism risk associated with midline catheters and peripherally inserted central catheters: a systematic review and meta-analysis D. Santagata¹, F. Subri¹, F. Dentali^1,2, M.P. Donadini¹, I. Giarretta² | ¹Department of Medicine and Surgery, Research Center on Thromboembolic Disorders and Antithrombotic Therapies, University of Insubria, Varese and Como; ²Department of Internal Medicine, Ospedale di Circolo and Fondazione Macchi, Varese, Italy

  https://doi.org/10.4081/btvb.2025.276

  0

• PO16 | Antithrombotic treatment and outcomes in retinal vein occlusion: a retrospective cohort study and comparison with historical group S.A. Malerba^1,2, M.T. Sartori¹, G. Libralon¹, C. Dalla Porta¹, P. Simioni¹ | ¹First Medical Clinic, Department of medicine- DIMED, Università degli Studi di Padova; ²Medicina Generale, Ospedale dell’Angelo, Mestre, Italy

  https://doi.org/10.4081/btvb.2025.277

  0

• PO18 | Does muscle mass matter? Appendicular lean mass as a determinant of anti-XA activity in elderly patientes B.M. Zanforlini¹, V. Bernardi¹, E. Campello², E.M. Bicego¹, C. Curreri¹, A. Vaticano¹, C. Sartori¹, L. Manfron¹, A. Perencin¹, P. Rollo¹, A. Baruffol¹, L. Ruoso¹, C. Simion², C. Bulato², P. Berto², P. Simioni², G. Sergi¹ | ¹Department of Medicine, Geriatrics Section, University of Padova; ²Haemorrhagic and Thrombotic Diseases Unit, Department of Medicine DIMED, Padova University Hospital, Padova, Italy

  https://doi.org/10.4081/btvb.2025.278

  0

• PO19 | Joint health status in patients with moderate hemophilia A: a cross-sectional multi-center study I.L. Calcaterra¹, F. Picasso², F. Valeri³, E. Baldacci⁴, M. Napolitano⁵, C. Guerrino¹, E. Zanon⁶, C. Santoro⁴, S. Siragusa⁷, C. Martinoli², M. Di Minno¹ | ¹Department of Clinical Medicine and Surgery, Regional Reference Centre for Coagulation Disorders, Federico II University, Naples; ²Department of Health Sciences “DISSAL”, Università di Genova; ³Regional Centre for Hemorrhagic and Thrombotic Diseases, AOU Città della Salute e della Scienza, Turin; ⁴Haematology, Department of Translational and Precision Medicine, Sapienza University, Roma; ⁵Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, University of Palermo and Haematology Unit and Rare Disorders Hospital “V. Cervello”, Palermo; ⁶Haemophilia Centre, General Medicine, Padua University Hospital, Padua; ⁷Department PROMISE, University of Palermo, Italy

  https://doi.org/10.4081/btvb.2025.279

  0

• PO20 | Impact of endovascular treatment on functional outcome in ischemic stroke: a real-world retrospective study M.G. Mosconi¹, G. Maraziti¹, M. Paciaroni², J. Fagotti³, V. Caso¹ | ¹Azienda Ospedaliera di Perugia; ²Università degli Studi di Ferrara; ³Ospedale San Giovanni Battista, Foligno (PG), Italy

  https://doi.org/10.4081/btvb.2025.280

  0

• PO21 | Exploring endothelial damage: the interplay between coagulopathy, capillary leak and vasoplegia in sepsis M. Facci¹, G. Turcato¹, A. Zaboli², L. Filippi¹, P. Ferretto¹, M. Maggi¹, F. Lucente¹, D. Milazzo¹, A. Bresolin¹, M. Marchetti¹ | ¹UOC Medicina Generale, Ospedale Alto Vicentino, Santorso, (VI); ²Innovation, Research and Teaching Service “SABES-ASDAA” of Azienda Sanitaria dell’Alto Adige, Italy

  https://doi.org/10.4081/btvb.2025.281

  0

• PO22 | Early detection and management of PICC-related thrombosis in oncohematologic patients through serial ultrasound monitoring: a prospective observational study S. Laurenti, M. Schneeberger, G. Rosati, A. Pozzi, M. Padrini, R. Vacchelli, A. Morotti | University of Turin, AUO San Luigi Gonzaga, Orbassano (TO), Italy

  https://doi.org/10.4081/btvb.2025.282

  0

• PO23 | Plasmic score applicability for the diagnosis of thrombotic microangiopathy associated with acquired ADAMTS13 deficiency in emergency settings at the hub laboratory of AUSL Romagna: state of the art and future prospects M. Olivieri¹, M. Rosetti¹, A. Clementoni¹, V. Marinucci¹, M. Monterosso¹, E. Massari¹, V. Polli¹, M. Zauli¹, V. Sambri² | ¹Clinical Pathology Unit; ²Unit of Microbiology, Area Hub Laboratory, Cesena, Italy

  https://doi.org/10.4081/btvb.2025.284

  0

• PO24 | Emicizumab prophylaxis and bleeding outcomes: a single center clinical experience A. Taglietti¹, S. Ligia¹, F. Paoletti¹, R. Mormile¹, E. Baldacci², A. Chistolini¹, C. Santoro^1,2 | ¹Hematology, Department of Translational and Precision Medicine, Sapienza University of Roma; ²Hematology, Azienda Ospedaliera Universitaria Policlinico Umberto I, Roma, Italy

  https://doi.org/10.4081/btvb.2025.285

  0

• PO25 | Baseline thrombin generation test does not predict thrombotic events in acute leukemia: a monocentric prospective study M. Biglietto, R. Mormile, M.L. Bisegna, A. Laganà, A. Faccini, A. Papa, E. Baldacci, C. Santoro, M.S. De Propris, A. Chistolini | Hematology, Department of Translational and Precision Medicine Sapienza University of Roma, Italy

  https://doi.org/10.4081/btvb.2025.286

  0

• PO26 | Non-canonical coagulation platelets function: monocyte-platelet interaction a bridge between inflammation and coagulation A. Benetti¹, A. Galbiati¹, M. Cola², L. Calandrino², C. Samà¹, D. Regazzo¹, S. Ferrari¹, C.M. Radu¹, A. Cattelan², P. Simioni¹ | ¹Department of Medicine - DIMED; ²Infectious and Tropical Diseases Unit, Padua University Hospital, Padua, Italy

  https://doi.org/10.4081/btvb.2025.287

  0

• PO27 | B-cell lymphoproliferative disorder and acquired coagulopathy: an insidious link C. Caputo, P. Conca, I.L. Calcaterra, E. Cimino, M. Romeo, M. Aversano, E. Franco, C. De Luca, R. Russo, C. Fierarossa, M. Di Minno, A. Tufano | Department of Clinical Medicine and Surgery, Federico II University, Naples, Italy

  https://doi.org/10.4081/btvb.2025.288

  0

• PO28 | Long term effectiveness and safety of venous thromboembolism with fondaparinux: data from the start registry I.M. Palumbo¹, E. Valeriani^1,2, A. Pannunzio¹, S. Marucci³, D. Menichelli¹, D. Pastori^3,4, P. Pignatelli³ | ¹Department of General Surgery and Surgical Specialty, Sapienza University of Roma; ²Department of Infectious Disease, Azienda Ospedaliero-Universitaria Policlinico Umberto I, Roma; ³Department of Clinical Internal, Anaesthesiologic and Cardiovascular Sciences, Sapienza University of Roma, Roma; ⁴IRCCS NeuRomad, Pozzilli, Italy

  https://doi.org/10.4081/btvb.2025.289

  0

• PO29 | Quality of anticoagulation as a predictor of early left ventricular thrombosis resolution: a retrospective cohort study A. Pannunzio¹, I.M. Palumbo¹, M.P. Donadini², D. Santagata², W. Ageno², F. Dragoni³, A. Chistolini³, C. Becattini⁴, K. Satula⁴, D. Menichelli¹, D. Pastori¹, P. Pignatelli⁵, E. Valeriani¹ | ¹Department of General Surgery and Surgical Specialty Paride Stefanini, Sapienza University of Roma; ²Department of Medicine and Surgery, University of Insubria, Varese; ³Hematology, Department of Translational and Precision Medicine, Sapienza University of Roma; ⁴Internal Vascular and Emergency Medicine - Stroke Unit, University of Perugia; ⁵Department of Clinical Internal, Anesthesiological and Cardiovascular Sciences, Sapienza University of Roma, Italy

  https://doi.org/10.4081/btvb.2025.290

  0

• PO30 | Acquired angioedema associated with B-non Hodgkin lymphoma: a case report A. Pozzi, G. Rosati, S. Pizzimenti, M. Padrini, S. Laurenti, G. Ferrari, R. M. Medici, C. Barale, I. Russo, A. Morotti | Univeristy of Turin, AUO San Luigi Gonzaga, Orbassano (TO), Italy

  https://doi.org/10.4081/btvb.2025.291

  0