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PO62 | CLINICAL AND MOLECULAR DIAGNOSTIC CHALLENGES IN MYELOPROLIFERATIVE NEOPLASMS WITH LOW JAK2V617F ALLELIC BURDEN E. Morsia, D. Lame, M. Pianelli, G. Gramazio, R. Ceccarelli, I. Battilà, S. Rupoli, A. Poloni | Department of Clinical and Molecular Science, Università Politecnica delle Marche, Ancona, Italy
424PDF: 102 -
When a feminist platelet went to the convention of prostaglandins and thromboxanes
1208PDF: 155HTML: 177Italian version: 99 -
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PO55 | HISTORY OF CANCER IN PATIENTS WITH SEVERE HEREDITARY THROMBOPHILIA VERSUS NO THROMBOPHILIA: A SINGLE-CENTER COHORT OF PATIENTS WITH VENOUS THROMBOSIS A. Napolitano, E. Campello, C. Simion, G. Furlan, S. Gavasso, C. Bulato, C. Samà, S. Toffanin, B. Serena, L. Spiezia, P. Simioni | Internal Medicine 1 and Thrombotic and Hemorrhagic Diseases Unit, Department of Medicine, University of Padova, Italy
430PDF: 103 -
Diagnostic and management practices for inherited fibrinogen disorders: a nationwide survey of Italian Hemophilia Treatment Centers
834PDF: 106HTML: 112Supplementary: 70Appendix: 72 -
The key to fibrinolysis and thrombolysis
1641PDF: 500HTML: 247 -
PO51 | MECHANISTIC POPULATION PHARMACOKINETIC/PHARMACODYNAMIC MODELING OF FACTOR XI-TARGETING MONOCLONAL ANTIBODIES SUPPORTS DURABLE ANTICOAGULANT COVERAGE AND TRANSLATIONAL DOSE AND REGIMEN SELECTION O. Milberg1, H. Abdallah1, R.K. Lokken2, R. Dingman1, K.A. Meagher1, M.E. Burczynski1, E. Marin1, A.P. Kithcart1, D. E. Gutstein1 | 1Regeneron Pharmaceuticals, Inc., Tarrytown, NY, USA; 2Allucent, Cary, NC, USA
403PDF: 108 -
OC05 | TIME TO START OF ANTICOAGULANT THERAPY AND SURVIVAL OUTCOMES IN CANCER PATIENTS WITH PULMONARY EMBOLISM K. Bria, B. Gage, M. Bealsey, K. Sanfilippo | Washington University in St. Louis School of Medicine, St. Louis, MO, USA
400PDF: 93 -
Welcome to the 12th International Conference on Thrombosis and Hemostasis Issues in Cancer! Oral Communications and Posters
872PDF: 555 -
PO26 | OUTCOMES OF DIRECT ORAL ANTICOAGULANTS IN UNUSUAL-SITE THROMBOSIS: IMPACT OF ACTIVE CANCER S. Guglielmo1, M. Lovisotto1, L. Scarano1, E. De Bon2, S. Barbar2 | 1Internal Medicine, Department of Medicine, Azienda Ulss 6 Euganea, Cittadella (PD), Italy; 2Thrombotic and Hemorrhagic Disorders Unit, Department of Medicine, Azienda Ulss 6 Euganea, Cittadella (PD), Italy
403PDF: 100 -
PO50 | SUB-ANALYSIS OF INTERIM RESULTS FROM A PHASE 2 STUDY INVESTIGATING REGN9933A2 AND REGN7508CAT FOR THE PREVENTION OF CONTACT-MEDIATED VENOUS THROMBOEMBOLISM IN PATIENTS WITH ACTIVE CANCER UNDERGOING PERIPHERALLY INSERTED CENTRAL CATHETER PLACEMENT (ROXI-CATH) J. Zwicker1,2, A.P. Kithcart3, J. Kaplan3, Y-C. Cheng3, J.G. Raya3, J. Xiao3, S. Li3, K. Musgrave4, D.E. Gutstein3, G. Piazza5 | 1Memorial Sloan Kettering Cancer Center, New York, NY, USA; 2Weill Cornell Medical Center, New York, NY, USA; 3Regeneron Pharmaceuticals, Inc. , Tarrytown, NY, USA; 4Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK; 5Brigham and Women’s Hospital, Boston, MA, USA
409PDF: 117 -
OC04 | DIRECT ORAL ANTICOAGULANTS PROVIDE EFFECTIVE THROMBOPROPHYLAXIS IN NEWLY DIAGNOSED MYELOMA: REAL WORLD FINDINGS FROM THE ATOMM STUDY T. Bull1, Heamstar Collaborators2, W. Wilson3, E. Ganendra4, M. Thomas5, R. Alikhan6, M. Karanth1, M. Camilleri7 | 1West Suffolk Hospital NHS Foundation Trust, UK; 2Haematology Specialty Training Audit and Research HaemSTAR Network, UK; 3University College London Clinical Trial Centre, UK; 4North West Anglia NHS Foundation Trust, UK; 5University College London Hospitals, UK; 6Cardiff and Vale University Health Board, Wales, UK; 7Cambridge University Hospitals NHS Foundation Trust, UK
520PDF: 117 -
PO57 | A NOVEL RISK ASSESSMENT MODEL FOR CANCER DETECTION WITHIN ONE YEAR AFTER INCIDENT VENOUS THROMBOEMBOLISM C. Antoun1, J. Hansen1|3, S. Brækkan1|3, C. Langholm1, N. Eide1, V. Morelli1|3, K. Hveem2 | 1Department of Clinical Medicine, UiT The Arctic University of Norway, Tromsø; 2HUNT Center for Molecular and Clinical Epidemiology, Norwegian University of Science and Technology, Trondheim; 3Thrombosis Research Center, Division of Internal Medicine, University Hospital of North Norway, Tromsø, Norway
411PDF: 93 -
PO18 | THE THROMBO-INFLAMMATION AXIS AS PREDICTOR OF TOXICITY IN PATIENTS TREATED WITH CAR-T CELLS C. Fernández-Arias1, M. Marcos-Jubilar1, M. Panizo1, C. Vázquez-Puerta2, J.R. González-Porras2, M. Ibáñez1, A. Queralt1, M. Carrasco1, M.B. Villacrés1, C. Conde1, P. Elizalde1, S. Huerga1, A. Alfonso1, P. Rodríguez-Otero1, S. Villar1, M.A. Canales1, J. Rifón1, F. Prósper1, J.A. Páramo1, J. Orbe1, R. Lecumberri1 | 1Clínica Universidad de Navarra, Pamplona; 2Hospital Clínico Universitario de Salamanca, Salamanca, Spain
434PDF: 78 -
PO45 | KHORANA RISK SCORE AND GENOMIC PROFILING FOR PREDICTION OF VENOUS THROMBOEMBOLISM IN OVARIAN CANCER P. Santini, L. Mastrantoni, G. Anderson, F. Camarda, I. Marino, J. Preziosi, M. Buttarelli, M. Manfredelli, A. Minucci, F. Persiani, L. Giacò, T. Pasciuto, I. Conti, I. Mozzetta, F. Mancinetti, S. M. P. D’Ambrosio, M. Bigossi, C. Marchetti, V. Salutari, G. Scambia, C. Nero, R. Pola | Agostino Gemelli University Hospital Foundation IRCCS, Rome, Italy
374PDF: 104 -
PO12 | IMPACT OF INHERITED THROMBOPHILIA ON CANCER-ASSOCIATED THROMBOSIS: A SYSTEMATIC REVIEW AND META-ANALYSIS E. Campello1, G. Furlan1, A. Boccatonda2, A. Napolitano1, C. Simion1, P. Simioni1 | 1Internal Medicine 1 and Thrombotic and Hemorrhagic Diseases Unit, Department of Medicine, University of Padova, Italy; 2Diagnostic and Therapeutic Interventional Ultrasound Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlinico Sant'Orsola-Malpighi, Bologna, Italy
381PDF: 93 -
PO37 | CLINICAL SIGNIFICANCE OF SYMPTOMATIC AND INCIDENTAL VENOUS THROMBOEMBOLISM IN CANCER PATIENTS TREATED WITH APIXABAN P. Hussaini1, T.L. Larsen2, W. Ghanima1|3, A.E.A. Dahm1|2 | 1Institute of Clinical Medicine, University of Oslo, Oslo, Norway; 2Department of Hematology, Akershus University Hospital; Lørenskog, Norway; 3Clinic of Internal Medicine, Østfold Hospital, Grålum, Norway
352PDF: 100 -
PO54 | Resolvin response in bronchial asthma patients: endotype and clinical severity R. Liani1, I. Altomare2, P.G.M. Simeone1, M. Alfonsetti1, M. Mucci3, D. Madonna1, S. Lattanzio1, A. Ricci4, A.M. Draicchio2, A. De Sanctis2, P. Di Mattia2, F. Papa2, E. Cavallucci2, F. Cipollone1, A. Recchiuti3, F. Santilli1 | 1Department of Medicine and Aging, and Center for Advanced Studies and Technology “CAST”, G. d’Annunzio University of Chieti-Pescara, Chieti; 2Allergy and Immunology Section, Department Internal Medicine, G. d’Annunzio University, School of Medicine, Chieti; 3Department of Medical, Oral and Biotechnological Sciences, and Center for Advanced Studies and Technology “CAST”, G. d’Annunzio University, Chieti-Pescara; 4Department of Pharmacy, University G. d’Annunzio of Chieti Pescara, Chieti, Italy
547PDF: 4 -
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PO10 | RISK OF VENOUS THROMBOEMBOLISM IN CANCER PATIENTS WITH CENTRAL VENOUS CATHETERS: RESULTS FROM THE VIENNA CAT-BLED STUDY B. Sunder-Plassmann 1, N, Vladic1, C. Englisch1, F. Moik1|3, V. Sunder-Plassmann2, A. Berghoff2, M. Preusser2, I. Pabinger1, C. Ay1 | 1Division of Hematology and Haemostaseology, Department of Medicine I, Medical University of Vienna; Vienna, Austria; 2Division of Oncology, Department of Medicine I, Medical University of Vienna; Vienna, Austria; 3Division of Oncology, Department of Internal Medicine, Medical University of Graz; Graz, Austria
379PDF: 95 -
PO36 | EXTENDED DURATION REDUCED DOSE ANTICOAGULATION IN CANCER-ASSOCIATED THROMBOSIS: A REAL-WORLD COHORT WITH LONG TERM FOLLOW UP A. Bhide1, I. Welding1, O. Ogunbiyi1, S. Hawkins2, E. Greenlay1, N. Prasannan1, J. Westwood1, M. Thomas1 | 1Department of Clinical Haematology, University College London Hospital, London; 2Data Clinic, University College London, UK; A. Bhide and I. Welding joint First Authors
398PDF: 104 -
Anticoagulation in obese patients: challenges and strategies
1983PDF: 502HTML: 291XML: 173 -
PO53 | PHASE 3 TRIAL EVALUATING THE EFFICACY AND SAFETY OF REGN7508CAT FOR PRIMARY PROPHYLAXIS OF CANCER-ASSOCIATED THROMBOSIS FOR PARTICIPANTS WITH SOLID TUMORS UNDERGOING CANCER TREATMENT (ROXI-CAT-I) J. Zwicker1, M. P. O’Brien2, M. Carrier3, J. Connors4, A. Falanga5, A. Manzano6, R. Mcbane7, Y.Y. Janjigian1, G. O’Kane8, M. Onisko2, J. Kaplan2, A.P. Kithcart2, D.E. Gutstein2, A. Khorana9, M. F. Walsh2 | 1Memorial Sloan Kettering Cancer Center, New York, USA; 2Regeneron Pharmaceuticals, Inc. , Tarrytown, NY, USA; 3University of Ottawa, Ottawa, ON, Canada; 4Harvard Medical School, Boston, MA, USA; 5Hospital Papa Giovanni XXIII, Bergamo, Italy; 6Hospital Universitario 12 de Octubre, Madrid, Spain; 7Mayo Clinic, Rochester, MN, USA; 8St. Vincent's University Hospital and School of Medicine, University College Dublin, Dublin, Ireland; 9James P. Wilmot Cancer Center and the Department of Medicine, University of Rochester, Rochester, NY, USA
416PDF: 108 -
PO09 | CANCER MORTALITY AFTER INCIDENT VENOUS THROMBOEMBOLISM C. Langholm1, N.H. Eide1, K. Hveem2|3|4, N. Van Es5|6, V.M. Morelli1|7, S.K. Braekkan1|7, J.B. Hansen1|7 | 1Thrombosis Research Group, Department of Clinical Medicine, UiT – The Arctic University of Norway, Tromsø, Norway; 2HUNT Research Centre, Department of Public Health and General Practice, Norwegian University of Science and Technology, Levanger, Norway; 3HUNT Center for Molecular and Clinical Epidemiology, Department of Public Health and Nursing, Norwegian University of Science and Technology, Trondheim, Norway; 4Department of Research, St. Olav University Hospital, Trondheim, Norway; 5Department of Vascular Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands; 6Amsterdam Cardiovascular Sciences Pulmonary Hypertension and Thrombosis Amsterdam, the Netherlands; 7Thrombosis Research Center, Department of Internal Medicine, University Hospital of North Norway, Tromsø, Norway
388PDF: 72 -
PO32 | ANTICOAGULANT THROMBOPROPHYLAXIS IN AGGRESSIVE LYMPHOMAS PATIENTS: PREDICTIVE THROMBOTIC RISK SCORES AND RISK FACTORS L. Gurgoglione1, G. Gini1, S. Rupoli1, A. Poloni1|2 | 1Hematology, AOU delle Marche, Ancona; 2Università Politecnica delle Marche, Ancona, Italy
420PDF: 86 -
PO52 | MECHANISTIC POPULATION PHARMACOKINETIC/PHARMACODYNAMIC AND TIME-TO-EVENT MODELING SUPPORT SUSTAINED FACTOR XI INHIBITION AND SUPERIOR POST-OPERATIVE VENOUS THROMBOEMBOLISM PREVENTION WITH REGN7508CAT O. Milberg1, H. Abdallah1, R.K. Lokken2, R. Dingman1, K.A. Meagher1, P. Banerjee1, M.E. Burczynski1, E. Marin1, A.P. Kithcart1, D.E. Gutstein1 | 1Regeneron Pharmaceuticals, Inc., Tarrytown, NY, USA; 2Allucent, Cary, NC, USA
427PDF: 107 -
OC09 | BLEEDING RISK ASSOCIATED WITH FACTOR XI MONOCLONAL ANTIBODIES IN COMBINATION WITH ASPIRIN IN HEALTHY VOLUNTEERS AND ORTHOPEDIC SURGERY PATIENTS: ANALYSIS FROM RECENT PHASE 1 AND PHASE 2 STUDIES A.P. Kithcart1, M.E. Burczynski1, P. Banerjee1, M. Onisko1, Y. Wang1, K. Mohammadi1, D. Li1, S. Li1, J. Ackroyd2, B.A. Olenchock1, D.E. Gutstein1, J. I. Weitz3 | 1Regeneron Pharmaceuticals, Inc., Tarrytown, NY, USA; 2Clinical Research, Fortrea Clinical Research Unit Ltd, Leeds, UK; 3McMaster University, Hamilton, ON, Canada
381PDF: 98 -
PO68 | RISK OF VENOUS THROMBOEMBOLISM IN PATIENTS WITH CANCER AND MIGRAINE: A COHORT ANALYSIS AMONG DANISH NATIONAL HEALTH SURVEY PARTICIPANTS O. Rosenkrantz1, P. Szentkúti1, L. Amdisen1, E. Horváth-Puhó1, A.L. Pedersen1, H.E. Bøtker2, H. Elser1|3, J.P. Vandenbroucke1|4|5, H.T. Sørensen1 | 1Department of Clinical Epidemiology and Center for Population Medicine, Aarhus University Hospital and Aarhus University, Denmark; 2Department of Cardiology, Aarhus University Hospital, Department of Clinical Medicine, University of Aarhus, Denmark; 3Department of Neurology, Hospital of the University of Pennsylvania, Philadelphia, PA, USA; 4Department of Clinical Epidemiology, Leiden University Medical School Leiden, The Netherlands; 5School of Hygiene and Tropical Medicine, London, UK
426PDF: 100 -
PO25 | Baseline thrombin generation test does not predict thrombotic events in acute leukemia: a monocentric prospective study M. Biglietto, R. Mormile, M.L. Bisegna, A. Laganà, A. L. Faccini, A. Papa, E. Baldacci, C. Santoro, M.S. De Propris, A. Chistolini | Hematology, Department of Translational and Precision Medicine Sapienza University of Roma, Italy
618PDF: 5 -
CO15 | Longitudinal coagulation profiling of individuals undergoing gender-affirming hormone therapy: the hyper-gender study A. Napolitano, E. Campello, A. Scala, C. Simion, C. Bulato, S. Gavasso, C. Samà, A. Benetti, S. Toffanin, G. Faggian, R. Scafa, A. Garolla, P. Simioni | First Chair of Internal Medicine, Department of Medicine, University Hospital of Padua; Unit of Andrology and Reproductive Medicine, Department of Medicine, University Hospital of Padua, Italy
626PDF: 7 -
PO65 | Utilization of emicizumab in acquired hemophilia A: a case report C. Caputo, P. Conca, I.L. Calcaterra, E. Cimino, M. Romeo, M. Aversano, E. Franco, C. De Luca, G. D’errico, L. Jr Valletta, M. Di Minno, A. Tufano | Department of Clinical Medicine and Surgery, Federico II University, Naples, Italy
584PDF: 12 -
CO47 | Genetic characterization of the KIV2 LPA polymorphism in subjects with bicuspid aortic valve with different clinical complications R. Orsi1, G. Barbieri1, E. Sticchi1,2, A. Kura1, L. Squillantini1, P. Cantini1, A. Rogolino2, M. Berteotti1,2, S. Nistri3, P. Stefàno4, R. Marcucci1,2, B. Giusti1,2 | 1Department of Experimental and Clinical Medicine, University of Firenze; 2Centre for Atherothrombotic Diseases, AOU Careggi, Firenze; 3Cardiology, CMSR Veneto Medica, Altavilla Vicentina; 4Cardiac Surgery, AOU-Careggi, Firenze, Italy
576PDF: 7 -
PO37 | Single centre experience on anticoagulation in carriers of non-mild inherited thrombophilia: direct oral anticoagulants (DOAC) efficacy and safety M. D’uva1,2, G. La Barba1, G. Montanaro1, M. Di Ianni1,2, P. Ranalli1,2 | 1Hematology Unit, S. Spirito Hospital, Pescara; 2Department of Medicine and Aging Sciences, D’Annunzio University, Chieti, Italy
622PDF: 8 -
CO24 | Extracellular vesicles profiles in patients with wild-type transthyretin amyloidosis S. Toffanin1, L. Spiezia1, C.M. Radu1, A. Napolitano1, A. Benetti1, C. Samà1, E. Campello1, L. De Michieli2, G. Sinigiani2, A. Cipriani2, P. Simioni1 | 1First Chair of Internal Medicine, Department of Medicine, University-Hospital of Padua Medical School, Padua; 2Department of Cardiac, Thoracic and Vascular Sciences and Public Health, University of Padua, Italy
630PDF: 4 -
PO80 | Heparin-induced thrombocytopenia: a monocentric experience with danaparoid L. D’Innocenzo, S. Sorrentino, M. De Siati, A. Ferretti, E. De Candia | Unit of Haemostasis and Thrombosis Diseases, Fondazione Policlinico Universitario A. Gemelli, IRCCS, Roma, Italy
669PDF: 5 -
PO09 | Comparison of different aggregometry methods for evaluation of platelet function in patients with myeloproliferative neoplasms C. Fortino, I. Bertozzi, D. Regazzo, L. Gianesello, G. Nuozzi, F. Sartorello, V. Azzaro, G. Saggiorato, A. Bertomoro, P. Simioni | First Medical Clinic, Department of Medicine – DIMED, Università degli Studi di Padova, Italy
528PDF: 6 -
PO02 | Pregnancy and delivery in women with hemophilia and carriers are still challenging: a ten years analysis from The Italian Association of Hemophilia Centers (AICE) M. Napolitano1, M. Mattana2, C. Cammarata1, M. Leotta3, S. Linari4, M.E. Mancuso5, G. F. Rivolta6, C. Santoro7, L. Valdrè8, R.C. Santoro3, S. Siragusa1 | 1Department of Health Promotion, Mother and Child Care, Internal Medicine and Med, Palermo; University of Palermo, Italy; 2Department of Precision Medicine in Medical, Surgical and Critical Care “Me. Pre. Cc”, University of Palermo; 3Hemostasis and Thrombosis Unit, Azienda Ospedaliera Universitaria Dulbecco, Catanzaro; 4Center for Bleeding Disorders, Careggi University Hospital, Firenze; 5Center for Thrombosis and Hemorrhagic Diseases, IRCCS Humanitas Research Hospital, Rozzano, Milan; 6Regional Reference Center for the Treatment of Congenital Hemorrhagic Diseases, Parma University Hospital, Parma; 7Hematology, University Hospital Policlinico Umberto I, Roma; 8Inherited Bleeding Disorders Unit, IRCCS AOUBO, Bologna, Italy
650PDF: 7 -
CO35 | Bleeding phenotype characterization in patients with congenital bleeding disorders: a multigenic approach using next generation sequencing to identify coagulation-modulating variants C. Simion, L. Gianesello, C. Bulato, A. Benetti, E. Campello, A. Giannella, G. Ceolotto, E. Zanon, L. Spiezia, P. Simioni | Department of Medicine – DIMED, University of Padua, Italy
510PDF: 11 -
PO89 | Apixaban for secondary prevention of venous thromboembolism in hemodialysis patients: pharmacokinetic profile and safety outcomes S. Guglielmo1, E. De Bon2, L. Scarano1, R. Fabris1, E. Pierobon3, S. Barbar2 | 1Internal Medicine, Department of Medicine; 2Thrombotic and Hemorrhagic Disorders Unit, Department of Medicine; 3Nephrology and Dialysis Unit, Azienda ULSS 6 Euganea, Cittadella and Camposampiero, Padua, Italy
807PDF: 6 -
PO24 | Emicizumab prophylaxis and bleeding outcomes: a single center clinical experience A. Taglietti1, S. Ligia1, F. Paoletti1, R. Mormile1, E. Baldacci2, A. Chistolini1, C. Santoro1,2 | 1Hematology, Department of Translational and Precision Medicine, Sapienza University of Roma; 2Hematology, Azienda Ospedaliera Universitaria Policlinico Umberto I, Roma, Italy
591PDF: 10 -
CO12 | Left internal carotid artery thrombosis in a patient with antiphospholipid antibody syndrome successfully treated with eculizumab A. Hoxha1, L. Nico2, F. Viaro3, L. Fabris1, Y.F. Herrera1, M. Munari4, C. Baracchini3, F. Causin2, P. Simioni1 | 1Internal Medicine Unit, Thrombotic and Haemorrhagic Centre, Department of Medicine - DIMED, University of Padua; 2Neuradiology Unit, University Hospital of Padua; 3Stroke Unit, Neurology Department, University of Padua; 4Intensive Care Unit, University Hospital of Padua, Italy
647PDF: 9 -
PO64 | A silent hemorrhage in the immuno-thrombotic chaos of antiphospholipid syndrome G. Autiero, S.A. Malerba, A. Malaguti, M. Dalla Vestra, F. Presotto | Medicina Generale, Ospedale dell’Angelo, Mestre-Venezia, Italy
625PDF: 9 -
CO46 | Comparison of reticulated platelet procoagulant role in liver cirrhosis vs. fibrosis S. Toffanin1, E. Campello1, A. Zanetto2, G. Gagliardi1, A. Napolitano1, E. Stocco1, G. Gobbo1, E. Pinto2, C. M. Radu1, M. Senzolo2, L. Fabris1, P. Simioni1 | 1First Chair of Internal Medicine, Department of Medicine, University-Hospital of Padua Medical School, Padova; 2Department of Surgery Oncology and Gastroenterology, Gastroenterology and Multivisceral Transplant Unit, Padova University Hospital, Padova, Italy
565PDF: 10 -
PO35 | Cerebral veins thrombosis in patients with and without myeloproliferative neoplasm: a real life retrospective monocentric study I. Bertozzi, M.T. Sartori, M. Zerbinati, G. Libralon, A. Galbiati, P. Simioni | First Medical Clinic, Department of Medicine - DIMED, Università degli Studi di Padova, Italy
567PDF: 10 -
CO23 | Markers of inflammation and hypofibrinolysis are associated with cognitive dysfunction and motor performances in atrial fibrillation patients on oral anticoagulant therapy: insights from the Strat-AF study F. Alfano1,2, F. Cesari1,2, A.M. Gori1,2, M. Berteotti1,2, E. Salvadori3, B. Giusti1,2, A. Bertelli1,2, F. Fratini4, A. Rogolino1,2, B. Formelli4,5, F. Pescini4,5, E. Fainardi6, E. Barucci4, G. Salti5, A. Cavaliere4, A. Ginestroni6, A. Poggesi4,5, R. Marcucci1,2 | 1Department of Experimental and Clinical Medicine, University of Firenze; 2Center for Atherothrombotic Diseases, Careggi University Hospital, Firenze; 3Department of Biomedical and Clinical Sciences, University of Milan; 4NEUROFARBA Department, Neuroscience Section, University of Firenze; 5Stroke Unit, Careggi University Hospital, Firenze; 6Neuroradiology Unit, Careggi University Hospital, Department of Experimental and Clinical Biomedical Sciences, University of Firenze, Italy
680PDF: 10 -
PO79 | Trying to hit the hit in the shadow of renal failure: a complex case managed with danaparoid S. Chessa1,2, M. Anedda2, M.V. Cherchi2, M. Vacca1,2, M. Caboni2, J. Pilia2, A.M. Bussu2, M. Mantega2, G. Costanzo1, D. Firinu1, S. Del Giacco1, A. Mameli3, D. Barcellona3 | 1Department of Medical Science and Public Health, University of Cagliari; 2Internal Medicine, ASL Sulcis, PO Sirai, Carbonia; 3Department of Medical Sciences and Public Health, Hemostasis and Thrombosis Unit, University of Cagliari and AOU of Cagliari, Italy
629PDF: 3 -
PO06 | Extracellular vesicles profiles in patients with porto-sinusoidal vascular disease S. Toffanin1, E. Campello1, A. Zanetto2, C. M. Radu1, E. Pinto2, K. Fernande2, C. Bulato1, B. Serena1, L. Spiezia1, P. Burra2, M. Senzolo2, P. Simioni1 | 1First Chair of Internal Medicine, Department of Medicine, University Hospital of Padua Medical School, Padua; 2Department of Surgery Oncology and Gastroenterology, Gastroenterology and Multivisceral Transplant Unit, University Hospital of Padua, Italy
591PDF: 3 -
PO01 | Diagnosis of inherited platelet function disorders by platelet aggregometry using a fully automated coagulation analyzer E. Falcinelli1, A.M. Mezzasoma1, L. Bury1, R. Martini1, I. Tano1, A. Rechner2, P. Gresele1 | 1Department of Medicine, Section of Internal and Cardiovascular Medicine, University of Perugia, Italy; 2Sysmex Europe, Germany
619PDF: 5 -
CO34 | Evaluation of emicizumab concentration and thrombin generation in a cohort of severe hemophilia A patients with and without inhibitor A. Taglietti1, S. Ligia1, F. Paoletti1, R. Mormile1, E. Baldacci2, A. Chistolini1, C. Santoro1,2 | 1Hematology, Department of Translational and Precision Medicine, Sapienza University of Roma; 2Hematology, Azienda Ospedaliera Universitaria Policlinico Umberto I, Roma, Italy
632PDF: 5 -
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PO88 | Bacterial lysate “lantigen B” induces proliferation of B and NK cells and the release of related cytokines M. Alfonsetti1, R. Liani1, P. Di Mattia3, M. Tredicine4, F. Papa3, Q. Niu5, M. Di Gioacchino2, F. Santilli1,3 | 1Department of Medicine and Aging, Center for Advanced Studies and Technology, University of Chieti, Italy; 2Institute for Clinical Immunotherapy and Advanced Biological Treatments, Pescara, Italy; 3Specialization School of Allergy and Clinical Immunology, G. d’Annunzio University, Chieti, Italy; 4Department of Medical, Oral, and Biotechnology Science, University G. d’Annunzio, Chieti-Pescara, Chieti, Italy; 5Department of Occupational Health, School of Public Health, Shanxi Medical University, Taiyuan, Shanxi, China
702PDF: 7 -
PO21 | Exploring endothelial damage: the interplay between coagulopathy, capillary leak and vasoplegia in sepsis M. Facci1, G. Turcato1, A. Zaboli2, L. Filippi1, P. Ferretto1, M. Maggi1, F. Lucente1, D. Milazzo1, A. Bresolin1, M. Marchetti1 | 1UOC Medicina Generale, Ospedale Alto Vicentino, Santorso, (VI); 2Innovation, Research and Teaching Service “SABES-ASDAA” of Azienda Sanitaria dell’Alto Adige, Italy
520PDF: 7 -
CO03 | Early discharge and home treatment of low-risk pulmonary embolism: a cohort study E. Ruggeri1, L. Vulcano1, W. Ageno2, F. Cortellaro3, M.P. Donadini3,4 | 1Scuola di Medicina, Università degli Studi dell’Insubria, Varese; 2Dipartimento di Medicina, Università degli Studi di Padova; 3Pronto Soccorso e Medicina d’Urgenza, Ospedale di Circolo, ASST Sette Laghi, Varese; 4Dipartimento di Medicina e Chirurgia, Università degli Studi dell’Insubria, Varese, Italy
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PO56 | Safety of anticoagulant treatment in patients with splanchnic vein thrombosis and history of portal hypertension-related bleeding R. Talerico1, S. Pellegrino1, A. Plessier2, F.R. Ponziani3, A. Porfidia1, F. Landi1, A. Gasbarrini3, R. Pola1, F. Santopaolo3 | 1Department of Geriatric, Orthopedic, and Rheumatologic Sciences, Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica del Sacro Cuore, Roma, Italy; 2Université de Paris, AP-HP, C, DMU DIGEST, Centre de Référence des Maladies Vasculaires du Foie, FILFOIE, ERN RARE-LIVE. Centre de recherche sur l’inflammation, Inserm, Paris, France; 3Department of Medical and Surgical Sciences, Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica del Sacro Cuore, Roma, Italy
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CO45 | Role of urinary 11-dehydro-thromboxane B2 as a predictor of preeclampsia in pregnant high-risk women on low-dose aspirin treatment P.G.M. Simeone1, R. Liani1, M. Alfonsetti1, A. Ricci1, V. Cianci1, S. Zeeba2, M. Molino3, S. Palma2, R. Malizia4, M. Luongo4, A. Di Castelnuovo5, F. Cipollone1, F. D’antonio6, F. Ricci2, G. Renda2, F. Santilli1 | 1Department of Medicine and Aging Sciences, Center for Advanced Studies and Technology, University of Chieti; 2Department of Neuroscience, Imaging and Clinical Sciences, G D’Annunzio University of Chieti-Pescara, Chieti; University Cardiology Division, Heart Department, Policlinico SS Annunziata, Chieti; 3Clinical Pathology of Chieti University Hospital; 4Immunotransfusion Service, Clinical Haematology of Chieti University Hospital, Chieti; 5Mediterranea Cardiocentro, Napoli; 6Centre for Fetal Care and High-Risk Pregnancy, Department of Obstetrics and Gynecology, University of Chieti, Italy
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The landscape of rare coagulation factor deficiency management in Italy: a national hemophilia center survey
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PO34 | A negative oncologic follow up doesn’t always really mean no cancer: two case report of cancer-associated thrombotic microangiopathy E. Cosi, A. Bertomoro, G. Bogoni, I. Bertozzi, I. Cortella, P. Simioni | Clinica Medica ORI, Azienda Ospedale-Università Padova, DIDAS, Italy
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CO22 | Assessment of coagulation profiles in septic patients using viscoelastic coagulation monitoring and rotational thromboelastometry in an internal medicine setting G. Gottardi, C. Simion, D. Regazzo, C. Samà, G.P. Arcidiacono, L. Gianesello, E. Campello, P. Simioni | Department of Medicine – DIMED, University of Padua, Italy
529PDF: 9 -
PO56 | EXTERNAL VALIDATION OF THE SAVED SCORE IN A CANADIAN REGIONAL CANCER CENTER COHORT: A REAL-WORLD ANALYSIS A. Naassan, R. Fatima, M. Naassan, C. Chisholm | Lakeridge Health, R.S. McLaughlin Durham Regional Cancer Centre, Department of Oncology, Oshawa, ON, Canada
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PO70 | Clinical safety and monitoring of apixaban combined with tacrolimus and everolimus in kidney transplant patients: a prospective study S. Guglielmo1, E. De Bon2, L. Scarano1, R. Fabris1, E. Pierobon3, S. Barbar2 | 1Internal Medicine, Department of Medicine, Azienda ULSS 6 Euganea, Cittadella; 2Thrombotic and Hemorrhagic Disorders Unit, Department of Medicine, Azienda ULSS 6 Euganea, Cittadella; 3Nephrology and Dialysis Unit, Azienda ULSS 6 Euganea, Cittadella and Camposampiero, Padova, Italy
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PO05 | Intensive FVIII replacement in haemophilia patients with hypertrophic synovium: a randomized study I.L. Calcaterra1, E. Baldacci2, R. Marino3, F. Valeri4, R.C. Santoro5, G. Pasta6, C. Martinoli7, M. Di Minno1 | 1Department of Clinical Medicine and Surgery, Federico II University, Naples; 2Haematology, University Hospital Policlinico Umberto I, Roma; 3Haemophilia Center and thrombosis, Policlinico, Bari; 4Regional Centre for Haemorrhagic and Thrombotic Diseases, AOU Città Della Salute e Della Scienza; Turin; 5Centre for Hemorrhagic and Thrombotic Disorders, Pugliese Ciaccio Hospital, Catanzaro; 6Fondazione IRCCS San Matteo Hospital, Pavia; 7Department of Health Science DISSAL, University of Genoa, Unit of Radiology and IRCCS San Martino Hospital, Genoa, Italy
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CO41 | Failure in assisted reproductive techniques: insights from the first registry E. Grandone1,3,4, C. Lodigiani2, D. Colaizzo3, M. Passaretti2, J. Khizroeva4, A. De Laurenzo3, P. Totaro5, E. Bucherini6, D. Baldini7, V. Bitsadze4, A. Makatsarya4, M. Mastroianno3, G. Piazza8, M. Othman9, M. Margaglione1 | 1University of Foggia, Italy; 2Humanitas University, Rozzano, Italy; 3IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy; 4First Sechenov University, Russia; 5Santa Maria Hospital, Bari, Italy; 6Angiologia, Faenza, Italy; 7Momo Fertilife, Bisceglie, Italy; 8Brigham Women Hospital, USA; 9Queen’s University, Kingston, Canada
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CO33 | Acquired hemophilia A in Liguria, Italy: what six years of data reveal C. Vernarecci1, A. C. Molinari1, P. Ballarino2, M. Caiti2, E. Cenni2, P. Moscatelli2, L. Banov1 | 1IRCCS Istituto Giannina Gaslini, Genova; 2IRCCS Policlinico San Martino, Genova, Italy
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PO86 | Emicizumab in patients with moderate hemophilia A and severe bleeding phenotype: single-center real-world experience A.L. Faccini, M. Biglietto, S. Sorella, E. Crisanti, M. Antonacci, R. Mormile, R. Ciciani, E. Baldacci, C. Santoro, S. Ligia | Hematology, Department of Translational and Precision Medicine Sapienza University of Roma, Italy
718PDF: 11 -
PO19 | Joint health status in patients with moderate hemophilia A: a cross-sectional multi-center study I.L. Calcaterra1, F. Picasso2, F. Valeri3, E. Baldacci4, M. Napolitano5, C. Guerrino1, E. Zanon6, C. Santoro4, S. Siragusa7, C. Martinoli2, M. Di Minno1 | 1Department of Clinical Medicine and Surgery, Regional Reference Centre for Coagulation Disorders, Federico II University, Naples; 2Department of Health Sciences “DISSAL”, Università di Genova; 3Regional Centre for Hemorrhagic and Thrombotic Diseases, AOU Città della Salute e della Scienza, Turin; 4Haematology, Department of Translational and Precision Medicine, Sapienza University, Roma; 5Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, University of Palermo and Haematology Unit and Rare Disorders Hospital “V. Cervello”, Palermo; 6Haemophilia Centre, General Medicine, Padua University Hospital, Padua; 7Department PROMISE, University of Palermo, Italy
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CS03 | Khorana risk score and genomic profiling for prediction of venous thromboembolism in ovarian cancer P. Santini, F. Mancinetti, S.M.P. D’Ambrosio, M. Bigossi, A. D’Errico, E. Fondi, G. Fracassa, E. Ianuà, L. Mastrantoni, G. Anderson, F. Camarda, I. Marino, J. Preziosi, M. Buttarelli, M. Manfredelli, A. Minucci, F. Persiani, L. Giacò, T. Pasciuto, I. Conti, I. Mozzetta, C. Marchetti, V. Salutari, G. Scambia, C. Nero, R. Pola | Agostino Gemelli University Polyclinic Foundation IRCCS, Roma, Italy
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CO43 | Early platelet dysfunction in sepsis: an ICU pilot study S. Sorrentino1, C. Gori2, L. D’Innocenzo1, M. De Siati1, Mg. Bocci3, E. De Candia1 | 1Unit of Haemostasis and Thrombosis Diseases, Fondazione Policlinico Universitario A. Gemelli, IRCCS, Roma; 2UOC Shock & Trauma, Azienda Ospedaliera San Camillo Forlanini, Roma; 3National Institute for Infectious Diseases, Lazzaro Spallanzani, IRCCS, Roma, Italy
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Still unmet problems with low molecular weight heparin prophylaxis of venous thromboembolism. An Italian survey
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PO33 | Whole blood hypercoagulable profiles in patients with rheumatoid arthritis L. Spiezia1, A. Giollo2, C. Samà1, A. Benetti1, L. Di Luozzo2, M. Salvato2, A. Doria2, P. Simioni1 | 1First Chair of Internal Medicine, Thrombotic and Hemorrhagic Diseases Unit, Department of Medicine, University Hospital of Padova; 2Rheumatology Unit, Department of Medicine, University Hospital of Padova, Italy
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CO21 | Viscoelastic testing in inherited bleeding disorders: a cross-sectional comparison between viscoelastic coagulation monitoring and rotational thromboelastometry C. Simion, C. Samà, C. Bulato, G. Gottardi, D. Regazzo, E. Campello, P. Simioni | Department of Medicine – DIMED, University of Padua, Italy
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PO69 | Whole blood thrombin generation hypercoagulable profile in a patient with hemolytic crisis due to paroxysmal nocturnal hemoglobinuria: a case report A. Napolitano, L. Spiezia, C. Bulato, E. Campello, P. Simioni | First Chair of Internal Medicine, Department of Medicine, University-Hospital of Padua Medical School, Padua, Italy
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CO51 | Novel biomarkers of neurological damage in acute immune-mediated thrombotic thrombocytopenic purpura A. Truma1,2, I. Mancini1, F. Verde2,3, J. A. Giannotta1, A. Artoni1, B. Ferrari1, P. Agosti1,2, M. Gagliardi1, A. Ratti3,4, N. Ticozzi2,3, F. Peyvandi1,2 | 1Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Milan; 2Università degli Studi di Milano, Department of Pathophysiology and Transplantation, Milan; 3Department of Neurology and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, Milan; 4Università degli Studi di Milano, Department of Medical Biotechnology and Translational Medicine, Milan, Italy
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PO41 | Comparison of the haemorrhagic phenotype between female and male patients affected by autosomal inherited bleeding disorders in a single-centre cohort B. Borsellino1,3, C. Zuccotti2, L. Guarnera3,4, C. Biasoli5, P. Pedrazzi5, T. Martini1 | 1Haemophilia Centre, Immune-Haematology and Transfusion Medicine, University Hospital “Città della Salute e della Scienza”, Turin, Italy; 2Department of Clinical Pathology, Bufalini Hospital, Cesena, Italy; 3Department of Biomedicine and Prevention, PhD in Immunology, Molecular Medicine and Applied Biotechnology, University of Roma Tor Vergata, Roma, Italy; 4Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, USA; 5Haemophilia and Transfusion Centre, Bufalini Hospital, Cesena, Italy
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CO32 | Major surgery in patients with severe hemophilia A without inhibitors receiving prophylaxis with fitusiran E. Zanon, C. Simion, A. Napolitano, L. Spiezia, P. Simioni | Haemophilia Center, First Chair of Internal Medicine, Department of Medicine, University-Hospital of Padua Medical School, Padua, Italy
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PO84 | Beyond the scores: unmasking a silent pulmonary embolism in essential thrombocythemia N. Battino | ASL Sulcis Iglesiente PO CTO, Italy
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PO18 | Does muscle mass matter? Appendicular lean mass as a determinant of anti-XA activity in elderly patientes B.M. Zanforlini1, V. Bernardi1, E. Campello2, E.M. Bicego1, C. Curreri1, A. Vaticano1, C. Sartori1, L. Manfron1, A. Perencin1, P. Rollo1, A. Baruffol1, L. Ruoso1, C. Simion2, C. Bulato2, P. Berto2, P. Simioni2, G. Sergi1 | 1Department of Medicine, Geriatrics Section, University of Padova; 2Haemorrhagic and Thrombotic Diseases Unit, Department of Medicine DIMED, Padova University Hospital, Padova, Italy
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CO01 | Statin therapy for the prevention of venous thromboembolism in cancer patients: a systematic review and meta-analysis F. Catalani, R. Del Giorno, R. Canevascini, W. Ageno, L. Gabutti, G. Prouse, L. Giovannacci | Ospedale Regionale di Bellinzona, Switzerland.
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PO49 | Use of emicizumab in two patients with acquired hemophilia A: a new therapeutic approach S. Sorella, J. Micozzi, E. Baldacci, M. Biglietto, R. Mormile, A. Chistolini, R. Ciciani, L. Torrieri, N. Zhdanovskaya, M. Lorenzon, A. Delli Paoli, S. Ligia, C. Santoro | Hematology, Department of Translational and Precision Medicine, Policlinico Umberto I, Sapienza University of Roma, Italy
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CO42 | Oxidative stress may contribute to enhanced thrombopoiesis through miR-150: implications for aspirin response R. Liani1, P.G.M. Simeone1, M. Alfonsetti1, M. Frezza1, R. Tripaldi1, S. Ciotti1, M. Luongo2, F. Cipollone1, L. Vanella3, F. Santilli1 | 1Department of Medicine and Aging, and Center for Advanced Studies and Technology “CAST”, G. d’Annunzio University of Chieti-Pescara, Chieti; 2Immunotransfusion Service, Clinical Haematology of Chieti University Hospital, Chieti; 3Department of Drug Sciences, University of Catania, Italy
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PO32 | Effect of the sodium-glucose co-transporter-2 (SGLT2) inhibitors on platelet activation and lipid peroxidation: results of a pilot study P.G.M. Simeone1, R. Liani1, M. Alfonsetti1, B. Cancelli1, M. Frezza1, G. Raggiunti1, S. Zeeba2, F. Cipollone1, G. Renda2, F. Santilli1 | 1Department of Medicine and Aging Sciences, Center for Advanced Studies and Technology, University of Chieti; 2Department of Neuroscience, Imaging and Clinical Sciences, G. D’Annunzio University of Chieti-Pescara; 3University Cardiology Division, Heart Department, Policlinico SS Annunziata, Chieti, Italy
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CO19 | Hypercoagulability in wild-type transthyretin amyloidosis: evidence from whole blood thromboelastometry A. Napolitano1, L. Spiezia1, C. Samà1, A. Benetti1, G. Sinigiani2, L. De Michieli2, A. Cipriani2, P. Simioni1 | 1First Chair of Internal Medicine, Department of Medicine, University Hospital of Padua; 2Department of Cardiothoracic and Vascular Sciences & Public Health, University Hospital of Padua, Italy
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PO68 | Whole blood hypercoagulable profiles in a patient with markedly elevated lipoprotein(A) plasma levels and thrombotic complications: a case report C. Portinari, M. Biolo, A. Napolitano, L. Spiezia, A. Colpo, S. Zambon, A. Zambon, P. Simioni | Department of Medicine, Padova University Hospital, Padova, Italy
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CO50 | Diagnostic accuracy of the heparin-induced multiple electrode aggregometry (HIMEA) functional test for heparin-induced thrombocytopenia M. Bovara1, M. Sebastiani2, Am. Gori3,4, A. Rogolino3,4, A. Bertelli3,4, G. Ciarrocca Taranta3,4, R. Marcucci3,4, M. Sartori5, B. Cosmi5, M. Silingardi6, A. M. Pizzini6, A. Marrocchi1, R. Mancini1 | 1Laboratorio Unico Metropolitano Ospedale Maggiore, AUSL Bologna; 2IRCCS Istituto delle Scienze Neurologiche, Bologna; 3Centro Malattie Aterotrombotiche Azienda Ospedaliera Universitaria Careggi, Firenze; 4Dipartimento di Medicina Sperimentale e Clinica, Università di Firenze; 5U.O. di Angiologia e Malattie della Coagulazione dell’Azienda Ospedaliero Universitaria Policlinico S. Orsola-Malpighi, Bologna; 6Medicina Interna Ospedale Maggiore, Bologna, Italy
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PO40 | Management of paediatric patients affected by mild factor VII deficiency undergoing surgery B. Borsellino1,2, B. Pollio1, I. Ricca1, R. Albiani1, T. Martini1 | 1Haemophilia Centre, Immune-Haematology and Transfusion Medicine, University Hospital “Città della Salute e della Scienza”, Turin; 2Department of Biomedicine and Prevention, PhD in Immunology, Molecular Medicine and Applied Biotechnology, University of Roma Tor Vergata, Roma, Italy
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CO30 | Joint prosthetic surgery in patients with hemophilia A: clinical-functional outcomes and quality of life E. Zanon1, A. Napolitano1, A. Berizzi2, P. Simioni1 | 1Haemophilia Center, First Chair of Internal Medicine, Department of Medicine, University-Hospital of Padua Medical School, Padua; 2Orthopedics and Traumatology Unit, University-Hospital of Padua Medical School, Padua, Italy
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