Commentaries
Vol. 4 No. 3 (2025)
https://doi.org/10.4081/btvb.2025.401

Executive summary of the SISET position paper on the management of antithrombotic therapy in left ventricular thrombus

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Published: 16 December 2025
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acenocumarol, anticoagulants, heparin, venous thromboembolism, warfarin

Authors

Emanuele Valeriani
emanuele.valeriani@uniroma1.it
Department of General Surgery and Surgical Specialty, Sapienza University of Rome; Department of Internal Medicine, Endocrine-Metabolic Sciences and Infectious Diseases, Umberto I Hospital of Rome, Italy.
Arianna Pannunzio
Department of General Surgery and Surgical Specialty, Sapienza University of Rome, Italy.
Danilo Menichelli
Department of General Surgery and Surgical Specialty, Sapienza University of Rome, Italy.
Domenico Prisco
Department of Experimental and Clinical Medicine, University of Florence, Italy.
Walter Ageno
Department of Medicine and Surgery, University of Insubria, Varese, Italy.
Daniele Pastori
Department of Medical and Cardiovascular Sciences, Sapienza University of Rome; IRCCS Neuromed, Pozzilli (IS), Italy.
Pasquale Pignatelli
Department of Medical and Cardiovascular Sciences, Sapienza University of Rome, Italy.

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4. Zhang Z, Si D, Zhang Q, et al. Prophylactic rivaroxaban therapy for left ventricular thrombus after anterior ST-segment elevation myocardial infarction. JACC Cardiovasc Interv 2022;15:861-72. DOI: https://doi.org/10.1016/j.jcin.2022.01.285
5. Maniwa N, Fujino M, Nakai M, et al. Anticoagulation combined with antiplatelet therapy in patients with left ventricular thrombus after first acute myocardial infarction. Eur Heart J 2018;39:201-8. DOI: https://doi.org/10.1093/eurheartj/ehx551
6. Mehrpooya M, Barakzehi MR, Nikoobakhsh M. Evaluation of the safety and efficacy of direct oral anticoagulants compared with vitamin-k antagonists in the treatment of left ventricular thrombosis. A systematic review and meta-analysis. Heart Lung 2024;67:121-36. DOI: https://doi.org/10.1016/j.hrtlng.2024.04.019
7. Kim SE, Lee CJ, Oh J, Kang SM. Factors influencing left ventricular thrombus resolution and its significance on clinical outcomes. ESC Heart Fail 2023;10:1987-95. DOI: https://doi.org/10.1002/ehf2.14369
8. Valeriani E, Astorri G, Pannunzio A, et al. Long-term left ventricular thrombosis resolution in patients receiving vitamin k antagonists: a multicenter observational study. Intern Emerg Med 2025;20:1069-76. DOI: https://doi.org/10.1007/s11739-025-03922-6
9. Gibson CM, Mehran R, Bode C, et al. Prevention of bleeding in patients with atrial fibrillation undergoing PCI. N Engl J Med 2016;375:2423-34. DOI: https://doi.org/10.1056/NEJMoa1611594
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1.
Valeriani E, Pannunzio A, Menichelli D, Prisco D, Ageno W, Pastori D, et al. Executive summary of the SISET position paper on the management of antithrombotic therapy in left ventricular thrombus. Bleeding Thromb Vascul Biol [Internet]. 2025 Dec. 16 [cited 2026 Feb. 2];4(3). Available from: https://www.btvb.org/btvb/article/view/401
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