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PO62 | CLINICAL AND MOLECULAR DIAGNOSTIC CHALLENGES IN MYELOPROLIFERATIVE NEOPLASMS WITH LOW JAK2V617F ALLELIC BURDEN E. Morsia, D. Lame, M. Pianelli, G. Gramazio, R. Ceccarelli, I. Battilà, S. Rupoli, A. Poloni | Department of Clinical and Molecular Science, Università Politecnica delle Marche, Ancona, Italy
537PDF: 112 -
When a feminist platelet went to the convention of prostaglandins and thromboxanes
1277PDF: 165HTML: 195Italian version: 106 -
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PO55 | HISTORY OF CANCER IN PATIENTS WITH SEVERE HEREDITARY THROMBOPHILIA VERSUS NO THROMBOPHILIA: A SINGLE-CENTER COHORT OF PATIENTS WITH VENOUS THROMBOSIS A. Napolitano, E. Campello, C. Simion, G. Furlan, S. Gavasso, C. Bulato, C. Samà, S. Toffanin, B. Serena, L. Spiezia, P. Simioni | Internal Medicine 1 and Thrombotic and Hemorrhagic Diseases Unit, Department of Medicine, University of Padova, Italy
534PDF: 116 -
Diagnostic and management practices for inherited fibrinogen disorders: a nationwide survey of Italian Hemophilia Treatment Centers
948PDF: 123HTML: 139Supplementary: 79Appendix: 81 -
The key to fibrinolysis and thrombolysis
1713PDF: 532HTML: 267 -
CO050 | INTERACTION BETWEEN DIRECT ORAL ANTICOAGULANTS AND ANTIEPILEPTIC DRUGS: A MULTICENTER OBSERVATIONAL STUDY A. Lipari1, S. Sorrentino1, M. De Siati1, L. D'Innocenzo1, A. Ferretti1, D. Menichelli2, V. Cammisotto2, P. Pignatelli2, G. Ragna3, MC. Vedovati3, C. Becattini3, G. Frisullo4, V. Forte5, T. Pirozzi1, L. Di Gennaro1, M. Basso1, E. De Candia1 | 1Unit of Haemostasis and Thrombosis Diseases, Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italy; 2Department of Clinical Internal, Anesthesiological and Cardiovascular Sciences, Sapienza University of Roma, Roma, Italy; 3Department of Internal and Cardiovascular Medicine and Stroke Unit, University of Perugia, Perugia, Italy; 4Dipartimento di Neuroscienze, Organi di Senso e Torace, Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italy; 5Hematology, Department of Biomedicine and Prevention, University of Rome Tor Vergata, Roma, Italy
69PDF: 30 -
CO-80 | EMICIZUMAB PLASMA CONCENTRATIONS AND CLINICAL OUTCOMES IN ACQUIRED HEMOPHILIA A: A REAL-WORLD SINGLE-CENTER EXPERIENCE C. Simion1|2, E. Zanon1|2, C. Bulato1, B. Stocco1|2, F. Righetto1, F. Sartorello1, P. Simioni1|2 | 1First Chair of Internal Medicine and Thrombotic and Haemorrhagic Diseases Unit, Department of Medicine, Padova University Hospital, Italy; 2Hemophilia Center, Padova University Hospital, Italy
62PDF: 23 -
CO-18 | PSYCHOMETRIC ASSESSMENT OF PATIENT REPORTED EXPERIENCES WITH ARTIFICIAL INTELLIGENCE TOOLS IN HEMOPHILIA CARE G. Sottilotta 1|2 , G. Praticò 1 , D. Megalizzi 1 , M. Hart 2 , C. Komar 2 , F. Luise 3 | 1 UOSD Centro Microcitemie - Servizio Emostasi e Trombosi. Grande Ospedale Metropolitano di Reggio Calabria, Italy; 2 Save One Life Inc., USA; 3 Laboratorio Analisi. Grande Ospedale Metropolitano di Reggio Calabria, Italy
61PDF: 17 -
PO09 | CANCER MORTALITY AFTER INCIDENT VENOUS THROMBOEMBOLISM C. Langholm1, N.H. Eide1, K. Hveem2|3|4, N. Van Es5|6, V.M. Morelli1|7, S.K. Braekkan1|7, J.B. Hansen1|7 | 1Thrombosis Research Group, Department of Clinical Medicine, UiT – The Arctic University of Norway, Tromsø, Norway; 2HUNT Research Centre, Department of Public Health and General Practice, Norwegian University of Science and Technology, Levanger, Norway; 3HUNT Center for Molecular and Clinical Epidemiology, Department of Public Health and Nursing, Norwegian University of Science and Technology, Trondheim, Norway; 4Department of Research, St. Olav University Hospital, Trondheim, Norway; 5Department of Vascular Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands; 6Amsterdam Cardiovascular Sciences Pulmonary Hypertension and Thrombosis Amsterdam, the Netherlands; 7Thrombosis Research Center, Department of Internal Medicine, University Hospital of North Norway, Tromsø, Norway
487PDF: 100 -
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CO093 | PROGNOSTIC ROLE OF ANTIPLATELET ANTIBODY TESTING IN IMMUNE THROMBOCYTOPENIA G. Maraziti, C. Schiavone, A. Fiaccadori, A. Mezzasoma, C. Becattini | Internal and Emergency Medicine - Stroke Unit, S. Maria della Misericordia Hospital – University of Perugia, Perugia, Italy
72PDF: 26 -
CO031 | PREEMPTIVE RITUXIMAB IN ADAMTS13 RELAPSE DURING CLINICAL REMISSION OF IMMUNE THROMBOTIC THROMBOCYTOPENIC PURPURA: A MULTICENTER ITALIAN STUDY A. Dedola1|2, G. Carli3, C. Sartor1, B. Scappini4, B. Cambò5, G. Marchesini3, A. Dizdari6, S. Pozzi7, P. Bernuzzi8, A. Merli9, C. Lucarelli4, F. Salvatore1|2, D. Cavallina1|2, N. Severi1|2, F. Branzanti2, F. Lanza6, A. Lucchesi10, F. Palandri1 | 1IRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia “Seràgnoli”, Bologna, Italy; 2Dipartimento di Scienze Mediche e Chirurgiche, Università di Bologna, Bologna, Italy; 3Hematology Unit, Ospedale San Bortolo, ULSS8 Berica, Vicenza, Italy; 4Hematology Department, Azienda Ospedaliero-Universitaria Careggi, Firenze, Italy; 5U.O.C. Ematologia e Centro Trapianti Midollo Osseo, Azienda Ospedaliero-Universitaria di Parma, Parma, Italy; 6AUSL Romagna, Ospedale di Ravenna, Ravenna, Italy; 7Hematology Unit, Azienda USL-IRCSS di Reggio Emilia, Reggio Emilia, Italy; 8Hematology Unit, Department of Onco-Hematology, Guglielmo da Saliceto Hospital, Piacenza, Italy; 9U. O. C. Ematologia Infermi Rimini AUSL Romagna, Rimini, Italy; 10IRCCS Istituto Romagnolo per lo Studio dei Tumori IRST 'Dino Amadori', Meldola, Italy
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CO-52 | CARDIOVASCULAR EVENTS AND SUBCLINICAL ATHEROSCLEROSIS IN HEMOPHILIA A AND B PATIENTS: A MULTICENTER COHORT STUDY A. Napolitano, E. Zanon, L. Spiezia, G. Camporese, P. Scarinzi, F. Ahmad, G. Saggiorato, C. Bulato, S. Toffanin, S. Gavasso, F. Sartorello, C. Simion, E. Campello, P. Simioni | Hemophilia Center, University Hospital of Padua, Italy
59PDF: 23 -
CO062 | REDUCED-DOSE DOACs IN EXTENDED TREATMENT OF CANCER-ASSOCIATED THROMBOSIS (RED-CAT): INTERIM ANALYSIS FROM A MULTICENTER RETROSPECTIVE OBSERVATIONAL STUDY (COORDINATING CENTER DATA) S. Bergonzi1|2|3, A. Ghigo4, L. Carpisassi4, G. Murante1|2|3, M. Capetta1|2|3, F. Valeri1|2, C. Dainese1|2, A. Valpreda3|5, R. Pastorino3|5, F. Bocchi3|5, A. Porreca6|7, B. Bruno2|3, A. Borchiellini1|2 | 1Regional Centre for Hemorrhagic and Thrombotic Diseases, AOU Città della Salute e della Scienza, Turin, Italy; 2Division of Hematology, AOU Città della Salute e della Scienza, Università di Torino, Italy; 3Department of Molecular Biotechnology and Health Sciences, University of Turin, Italy; 4Division of Internal Medicine, AOU Città della Salute e della Scienza, Università di Torino, Italy; 5Central Laboratory Baldi and Riberi, AOU Città della Salute e della Scienza, Università di Torino, Italy; 6Department of Human Sciences and Quality of Life Promotion, San Raffaele University, Roma, Italy; 7Clinical and Molecular Epidemiology, IRCCS San Raffaele, Roma, Italy
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CO002 | RETROSPECTIVE LONGITUDINAL ASSESSMENT OF JOINT HEALTH AND QUALITY OF LIFE IN ADOLESCENT AND ADULT PATIENTS AFFECTED BY MODERATE OR SEVERE HAEMOPHILIA A WITH OR WITHOUT INHIBITOR SWITCHING FROM INTRAVENOUS FVIII TREATMENT TO SUBCUTANEOUS PROPHYLAXIS WITH EMICIZUMAB S. Ceglie1, R. Gualtierotti1|2, S. Arcudi1, A. Ciavarella1, S.M. Siboni1, F. Peyvandi1|2 | 1Centro Emofilia e Trombosi Angelo Bianchi Bonomi, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano, Italy; 2Dipartimento di Fisiopatologia Medico-Chirurgica e dei Trapianti, Università degli Studi di Milano, Milano, Italy
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CO-28 | SYNERGISTIC EFFECT OF RECOMBINANT FACTOR INFUSION ON THROMBIN GENERATION IN HEMOPHILIA PATIENTS UNDER EMICIZUMAB OR CONCIZUMAB PROPHYLAXIS F. Bocchi1|2, R. Pastorino1|2, G. Murante1|2|3, S. Bergonzi1|2|3, M. Capetta1|2|3, F. Valeri2|3, C. Dainese2|3, A. Valpreda4, B. Bruno1|3, A. Borchiellini2|3 | 1Department of Molecular Biotechnology and Health Sciences, University of Turin, Italy; 2Regional Centre for Thrombotic and Hemorrhagic Diseases, AOU Città della salute e della Scienza di Torino, Italy; 3Division of Hematology, AOU Città della Salute e della Scienza, University of Turin, Italy; 4Central Lab Baldi and Riberi, AOU Città della salute e della Scienza di Torino, Italy
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PO32 | ANTICOAGULANT THROMBOPROPHYLAXIS IN AGGRESSIVE LYMPHOMAS PATIENTS: PREDICTIVE THROMBOTIC RISK SCORES AND RISK FACTORS L. Gurgoglione1, G. Gini1, S. Rupoli1, A. Poloni1|2 | 1Hematology, AOU delle Marche, Ancona; 2Università Politecnica delle Marche, Ancona, Italy
522PDF: 99 -
CO108 | MECHANOCHEMICAL REPROGRAMMING OF VWF–GPIB INTERACTIONS UNCOUPLES AFFINITY FROM AVIDITY AND LINKS THROMBOCYTOPENIA TO ANGIODYSPLASIA IN TYPE 2B VON WILLEBRAND DISEASE A. Ferretti1, M. Sacco1, S. Lancellotti1, P. Concolino2, A. Minucci2, R. De Cristofaro1|3 | 1Center for Hemorrhagic and Thrombotic Diseases; 2Molecular and Genomic Diagnostics Unit, Fondazione Policl.nico Univ. Gemelli IRCCS, Roma, Italy; 3Department of Translational Medicine and Surgery, Catholic University of the Sacred Heart, Roma, Italy
52PDF: 24 -
CO038 | PROGNOSTIC PERFORMANCE OF BLEEDING SEVERITY CLASSIFICATIONS IN HOSPITALIZED PATIENTS WITH GASTROINTESTINAL BLEEDING ON DIRECT ORAL ANTICOAGULANTS G. Maraziti, A. Vinci, M. Verso | Internal and Emergency Medicine - Stroke Unit, S. Maria della Misericordia Hospital – University of Perugia, Perugia, Italy
87PDF: 26 -
CO-65 | COVID-19-ASSOCIATED HYPERCOAGULABILITY IN TYPE 2B VON WILLEBRAND DISEASE: INSIGHTS FROM GLOBAL HEMOSTATIC ASSAYS I. Condonato, C. Simion, E. Zanon, P. Simioni | Hemophilia Center, University Hospital of Padua, Italy
63PDF: 26 -
BEST-06 | OPTIMIZING LABORATORY MONITORING OF EFANESOCTOCOG ALFA: IMPACT OF APTT REAGENTS AND CHROMOGENIC ASSAYS ON DIAGNOSTIC ACCURACY A. Strangio, A. Ierardi, M. Leotta, L.C. Elia, M. Falbo, C. Condina, G. Procopio, R.C. Santoro | Hemophilia Hemostasis and Thrombosis Unit, Azienda Ospedaliero Universitaria Renato Dulbecco, Catanzaro, Italy
142PDF: 26 -
CO069 | POLYSTYRENE NANOPLASTICS PRIME PLATELET TO DRIVE PRO-INFLAMMATORY AND PRO-FIBROTIC ACTIVATION OF CARDIAC FIBROBLASTS Z. Saeed1|2, M. Dovizio1|3, C. Milillo1|3, P. Lanuti1|4, S. Porro1|4, F. D’Ascanio1|4, A. Bruno1|3, P. Ballerini1|3, G. Renda1|2 | 1Center for Advanced Studies and Technology (CAST), “G. d’Annunzio” University of Chieti-Pescara, Chieti, Italy; 2Department of Neurosciences, Imaging and Clinical Sciences, "G. d'Annunzio" University of Chieti-Pescara, Chieti, Italy; 3Department of Innovative Technologies in Medicine & Dentistry, “G. d’Annunzio” University of Chieti-Pescara, Chieti, Italy; 4Department of Medicine and Aging Sciences, “G. d’Annunzio” University of Chieti-Pescara, Chieti, Italy
88PDF: 25 -
CO018 | THE MOLI-SANI RISK SCORE, A MEASURE OF MODIFIABLE CARDIOVASCULAR RISK, PREDICTS NON-CARDIOVASCULAR MORTALITY AND SELECTED CANCERS, BUT NOT NEURODEGENERATIVE DISEASES F. Bracone1, S. Costanzo1|2, M. Bonaccio1, T. Panzera1, A. De Curtis1, S. Magnacca1, C. Cerletti1, MB. Donati1, G. de Gaetano1, L. Iacoviello1|3, A. Di Castelnuovo1 | 1Unità di Ricerca di Epidemiologia e Prevenzione, IRCCS Neuromed, Pozzilli, Italy; 2Università della Insubria, Varese, Italy; 3Università LUM Giuseppe Degennaro, Casamassima, Italy
95PDF: 24 -
CO-40 | ONE-STAGE ASSAYS VS. CHROMOGENIC ASSAYS IN rpFVIII: STILL A DISCREPANCY? L. Banov, G. Gazzelli, Y. Azzanelli, C. Vernarecci, F. Marotta, F. Giacopelli, F. Tappino, A.C. Molinari | IRCCS Istituto Giannina Gaslini, Genova, Italy
63PDF: 22 -
PO52 | MECHANISTIC POPULATION PHARMACOKINETIC/PHARMACODYNAMIC AND TIME-TO-EVENT MODELING SUPPORT SUSTAINED FACTOR XI INHIBITION AND SUPERIOR POST-OPERATIVE VENOUS THROMBOEMBOLISM PREVENTION WITH REGN7508CAT O. Milberg1, H. Abdallah1, R.K. Lokken2, R. Dingman1, K.A. Meagher1, P. Banerjee1, M.E. Burczynski1, E. Marin1, A.P. Kithcart1, D.E. Gutstein1 | 1Regeneron Pharmaceuticals, Inc., Tarrytown, NY, USA; 2Allucent, Cary, NC, USA
536PDF: 119 -
CO114 | ANTI-PS/PT IgM IDENTIFIES AN ANTIGEN-DEFINED SUBSET WITHIN LUPUS ANTICOAGULANT POSITIVITY ASSOCIATED WITH THROMBOTIC PHENOTYPE M. Sacco1, S. Lancellotti1, A. Ferretti1, M. Basso1, C. Gavotti2, A. Ortolan2, V.A. Pacucci2, P. Calzoni3, L. Puccetti3, R. De Cristofaro1|4 | 1Center for Hemorrhagic and Thrombotic Diseases; 2Rheumatology and Clinical Immunology Unit, Fondazione Policl. Univ. Gemelli IRCCS, Roma, Italy; 3Azienda Ospedaliera-Universitaria Senese, Unità specialistica Coagulopatie Trombotiche ed Emorragiche, Dipartimento di Scienze Mediche, Chirurgiche e Neuroscienze, Università di Siena, Siena, Italy; 4Department of Translational Medicine and Surgery, Catholic University of the Sacred Heart, Roma, Italy
65PDF: 23 -
CO049 | RANDOMIZED CONTROLLED TRIAL TO IDENTIFY THE OPTIMAL SCHEME OF HEPARIN FOR TREATMENT OF DEEP VEIN THROMBOSIS IN PREGNANCY E. Grandone1|3, E. Antonucci2, A. de Laurenzo1, L. Latino1, M. Mastroianno1, G. Tiscia1, M. Margaglione3, P. Prandoni2 | 1IRCCS Casa Sollievo della Sofferenza, S.Giovanni Rotondo, Italy; 2Fondazione Arianna, Italy; 3Università di Foggia, Italy
71PDF: 33 -
CO-75 | ASSAY DISCREPANCY IN HEMOPHILIA A CARRIERS: CLINICAL AND GENETIC INSIGHTS M. Leotta, A. Strangio, A. Ierardi, R.C. Santoro | Hemophilia Treatment Center AOU Dulbecco, Catanzaro, Italy
60PDF: 28 -
CO-15 | HEMOPHILIA AND PHYSICAL ACTIVITY: A SURVEY ON THE CURRENT STATUS OF SPORTS ACCESSIBILITY IN THE ITALIAN POPULATION L. Laterza1, M. Attanasi1, C. Cassone2, P. Giordano3, G. Lassandro3 | 1University of Bari "Aldo Moro", Interdisciplinary of Medicine, Bari, Italy; 2Fedemo, Milano, Italy; 3Pediatric Haemophilia Center - AOUC Pol. Giovanni XXXIII, University of Bari "Aldo Moro", Italy
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OC09 | BLEEDING RISK ASSOCIATED WITH FACTOR XI MONOCLONAL ANTIBODIES IN COMBINATION WITH ASPIRIN IN HEALTHY VOLUNTEERS AND ORTHOPEDIC SURGERY PATIENTS: ANALYSIS FROM RECENT PHASE 1 AND PHASE 2 STUDIES A.P. Kithcart1, M.E. Burczynski1, P. Banerjee1, M. Onisko1, Y. Wang1, K. Mohammadi1, D. Li1, S. Li1, J. Ackroyd2, B.A. Olenchock1, D.E. Gutstein1, J. I. Weitz3 | 1Regeneron Pharmaceuticals, Inc., Tarrytown, NY, USA; 2Clinical Research, Fortrea Clinical Research Unit Ltd, Leeds, UK; 3McMaster University, Hamilton, ON, Canada
466PDF: 123 -
CO092 | FOSTAMATINIB IN CHRONIC IMMUNE THROMBOCYTOPENIA: A REAL-WORLD MONOCENTRIC EXPERIENCE M. Biglietto, S. Sorella, S. Ligia, S. Santostefano, R. Celia, R. Mormile, E. Baldacci, A. Chistolini, C. Santoro | Sapienza University of Roma, Italy
72PDF: 31 -
CO030 | MILD HEMOPHILIA A AND JOINT HEALTH IN REAL LIFE: IS THAT AN EMERGING ISSUE? A SINGLE CENTER EXPERIENCE G. Murante1|2|3, F. Valeri1|2, S. Bergonzi1|2|3, M. Capetta1|2|3, C. Dainese1|2, A. Valpreda4, R. Pastorino1|3, F. Bocchi1|3, B. Bruno2|3, A. Borchiellini1|2 | 1Regional Centre for Hemorrhagic and Thrombotic Diseases, AOU Città della Salute e della Scienza di Torino, Italy; 2Division of Hematology, AOU Città della Salute e della Scienza, Università di Torino, Italy; 3Dep. of Molecular Biotechnology and Health Sciences, University of Turin, Italy; 4Central Lab. Baldi and Riberi, AOU Città della Salute e della Scienza di Torino, Italy
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PO68 | RISK OF VENOUS THROMBOEMBOLISM IN PATIENTS WITH CANCER AND MIGRAINE: A COHORT ANALYSIS AMONG DANISH NATIONAL HEALTH SURVEY PARTICIPANTS O. Rosenkrantz1, P. Szentkúti1, L. Amdisen1, E. Horváth-Puhó1, A.L. Pedersen1, H.E. Bøtker2, H. Elser1|3, J.P. Vandenbroucke1|4|5, H.T. Sørensen1 | 1Department of Clinical Epidemiology and Center for Population Medicine, Aarhus University Hospital and Aarhus University, Denmark; 2Department of Cardiology, Aarhus University Hospital, Department of Clinical Medicine, University of Aarhus, Denmark; 3Department of Neurology, Hospital of the University of Pennsylvania, Philadelphia, PA, USA; 4Department of Clinical Epidemiology, Leiden University Medical School Leiden, The Netherlands; 5School of Hygiene and Tropical Medicine, London, UK
537PDF: 114 -
CO058 | ELEVATED PLASMA LEVELS OF OMEGA-3 STEARIDONIC ACID ARE ASSOCIATED WITH DECREASED FACTOR VIII COAGULANT ACTIVITY INDEPENDENTLY OF FACTOR VIII ANTIGEN AND VON WILLEBRAND FACTOR LEVELS: PRELIMINARY RESULTS FROM AN ANGIOGRAPHICALLY-CONTROLLED CARDIOVASCULAR COHORT STUDY N. Osti1, G. Musuraca1, A. Castagna2, M. Spizzo2, P. Pattini2, G. Mango2, M. Baroni3, B. Lunghi3, G. Poli4, C. Brocco1, C. Angheben1, M. Grusse5, P. Van Dreden5, A. Anesi1, G. Lippi3, M. Del Greco1, S. Friso2, A. Ferro1, F. Bernardi3, N. Martinelli2 | 1Azienda Sanitaria Universitaria Integrata del Trentino, Trento, Italy; 2Dip. di Medicina, Università di Verona, Verona, Italy; 3Dip. di Scienze della Vita e Biotecnologie, Università di Ferrara, Ferrara, Italy; 4Sez. di Biochimica Clinica, Università di Verona, Verona, Italy; 5Clinical Research, Diagnostica STAGO, Gennevillers, France
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CO001 | DERIVATION AND VALIDATION OF THE BLEEPE SCORE FOR RISK STRATIFICATION OF MAJOR BLEEDING IN PATIENTS WITH ACUTE PULMONARY EMBOLISM M. Vedovati1, L. Cimini1, V. Valeriano2, I. Montenovo1, A. Murgia3, L. Pierpaoli4, G. Tratar5, S. Zaccaroni6, A. Bongarzoni7, A. Vinci1, A. Mavri5, L. Martinelli8, G. Pepe9, S. Cozzio10, C. Becattini1 | 1University of Perugia, Perugia, Italy; 2Sandro Pertini Hospital, Roma, Italy; 3SS. Annunziata Hospital, Sassari, Italy; 4S. Maria delle Croci Hospital, Ravenna, Italy; 5University Medical Centre Ljubljana, Ljubljana, Slovenia; 6Maggiore Hospital, Bologna, Italy; 7ASST Santi Paolo e Carlo-PO San Carlo, Milano, Italy; 8Città di Castello Hospital, Città di Castello, Italy; 9Versilia Hospital, Tuscany North West Health System, Lido di Camaiore (LU), Italy; 10Rovereto Hospital, Rovereto, Italy
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CO-25 | MILD HEMOPHILIA A AND JOINT HEALTH IN REAL LIFE: IS THAT AN EMERGING ISSUE? A SINGLE CENTER EXPERIENCE F. Valeri1, G. Murante1, C. Dainese1, M. Capetta1, S. Bergonzi1, R. Pastorino1, F. Bocchi1, B. Bruno2, A. Borchiellini1 | 1Regional Centre for Haemorrhagic and Thrombotic Disease, Hematology Division, AOU Città della Salute e della Scienza, Torino, Italy; 2Division of Hematology, AOU Città della Salute e della Scienza, Department of Molecular Biotechnology and Health sciences, University of Turin, Italy
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CO106 | ENDOTHELIAL DYSFUNCTION AS A POSSIBLE ADDITIONAL DRIVER OF BLEEDING IN HERMANSKY–PUDLAK SYNDROME F. Tondi1, G. Purgatorio1, E. Giglio1, E. Petito1, E. Falcinelli1, G. Guglielmini1, P. Gresele1, C. Olgasi2, L. Bury1 | 1Dep. of Medicine and Surgery, Section of Internal and Cardiovascular Medicine, University of Perugia, Perugia, Italy; 2Dep. of Translational Medicine, School of Medicine, University of Piemonte Orientale, Novara, Italy
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CO037 | PERFORMANCE OF A QUALITATIVE POINT-OF-CARE TEST IN PATIENTS EXPERIENCING ACUTE THROMBOEMBOLIC OR MAJOR BLEEDING EVENTS TREATED WITH DOACs: THE T-BLEEDOAC MULTICENTER PROSPECTIVE COHORT STUDY M. Vedovati1, G. Pepe2, S. Vanni3, E. Campello4, F. Morello5, S. Beccatini1, D. Giudici1, F. Lucarini2, L. Parmeggiani3, G. Fabiani3, P. Simioni4, M. Santoro5, P. Nazerian6, M. Mosconi1, C. Becattini1 | 1University of Perugia, Perugia, Italy; 2Versilia Hospital, Tuscany North West Health System, Lido di Camaiore (LU), Italy; 3Università di Firenze, Firenze, Italy; 4University of Padua, Padova, Italy; 5A.O.U. Città della Salute e della Scienza, Torino, Italy; 6Careggi University Hospital, Firenze, Italy
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CO-60 | A TURNING POINT IN THE MANAGEMENT OF HEMOPHILIA B WITH INHIBITORS: OUTCOMES OF CONCIZUMAB PROPHYLAXIS IN TWO CHILDREN FROM EXPLORER10 G. Quintavalle1, A. Matichecchia1, M.I. Tassoni1, B.M. Roccon1, F. Riccardi1, R.P. Serra2, A. Tiri2, P. Bertolini2, A. Tagliaferri1, A. Coppola1 | 1Regional Hub Center for Hemophilia and Congenital Bleeding Disorders, University Hospital of Parma, Italy; 2Pediatric Hematology-Oncology Unit, University Hospital of Parma, Italy
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CO068 | FACTORS AFFECTING SPONTANEOUS PLATELET AGGREGATION IN HEALTHY SUBJECTS AND PATIENTS WITH STABLE CORONARY ARTERY DISEASE M. Scavone1, A. Fioretti1, C. Ghali1, B. Clerici1, E. Popov2, G.M. Podda1, M. Cattaneo3 | 1Laboratorio di emostasi e trombosi, Dipartimento di Scienze della Salute, Università degli Studi di Milano, Divisione di Medicina Generale II, ASST Santi Paolo e Carlo, Italy; 2National Medical Research Center of Cardiology, Ministry of Health of the Russian Federation, Moscow, Russia; 3Fondazione Arianna Anticoagulazione, Bologna, Italy
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CO014 | INCIDENCE OF NEW OR RECURRENT MALIGNANCY AFTER SUPERFICIAL VEIN THROMBOSIS: A SYSTEMATIC REVIEW AND META-ANALYSIS D. Santagata1, D. Todorovic1, G. Di Cugno1, G. Bassanese1, L. Girardi1|2, A. Abenante1, O. Cohen3, P. Santini4, M.P. Donadini1, A. Squizzato1 | 1Department of Medicine and Surgery, University of Insubria, Varese and Como, Italy; 2Department of Medicine, the Ottawa Hospital Research Institute, University of Ottawa, Ottawa, Canada; 3Kaplan Medical Center and Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel; 4Thrombosis Unit, Department of Geriatric, Orthopedic, and Rheumatologic Sciences, Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica del Sacro Cuore, Roma, Italy
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CO-39 | MYELOID CELL FUNCTION AND CYTOKINE PROFILES IN PEDIATRIC HEMOPHILIA A: INSIGHTS FROM FACTOR VIII AND EMICIZUMAB PROPHYLAXIS T. Martini1, A. Cottonaro2, S. Akula2, B. Pollio1, I. Ricca3, J. Agnelli Giacchello4, P. Sciancalepore4, R. Santi4, A. Follenzi2|4, S. Merlin2 | 1Haemophilia Centre, Immune-Haematology and Transfusion Medicine, University Hospital “Città della Salute e della Scienza”, Torino, Italy; 2Department of Health Sciences, Università del Piemonte Orientale, Novara, Italy; 3Transfusion Medicine, Ivrea Hospital, Ivrea, Italy; 4Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo, Alessandria, Italy
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PO51 | MECHANISTIC POPULATION PHARMACOKINETIC/PHARMACODYNAMIC MODELING OF FACTOR XI-TARGETING MONOCLONAL ANTIBODIES SUPPORTS DURABLE ANTICOAGULANT COVERAGE AND TRANSLATIONAL DOSE AND REGIMEN SELECTION O. Milberg1, H. Abdallah1, R.K. Lokken2, R. Dingman1, K.A. Meagher1, M.E. Burczynski1, E. Marin1, A.P. Kithcart1, D. E. Gutstein1 | 1Regeneron Pharmaceuticals, Inc., Tarrytown, NY, USA; 2Allucent, Cary, NC, USA
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CO113 | AN OBSERVATIONAL STUDY ON THE EFFECT OF HEMODIALYSIS MEMBRANES ON ENDOGENOUS THROMBIN POTENTIAL IN END-STAGE RENAL DISEASE PATIENTS Z. Saeed1|4, O. Ndrecka2, V. Sirolli2, M. Bonomini2, P. Lanuti1|3, S. Gallina4, G. Rend1|4 | 1Center for Advanced Studies and Technology, G. d’Annunzio University of Chieti-Pescara, Chieti, Italy; 2Nephrology and Dialysis Unit, Department of Medicine, G. d’Annunzio University of Chieti-Pescara, SS. Annunziata Hospital, Chieti, Italy; 3Department of Medicine and Aging Sciences, G. d’Annunzio University of Chieti-Pescara, Chieti, Italy; 4Department of Neuroscience, Imaging and Clinical Sciences, G. d’Annunzio University of Chieti-Pescara, Chieti, Italy
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CO047 | OXIDATIVE STRESS–RELATED PLATELET HO-1 AND MICRO-RNA MODULATION IN PATIENTS WITH TYPE 2 DIABETES MELLITUS UNDER ASPIRIN THERAPY R . Liani1, P.G. Simeone1, M. Alfonsetti1, M. Frezza1, B. Di Marco1, V. Sorrenti2, A. Russo2, C. Di Giacomo2, M. Gulisano2, M. Luongo3, F. Cipollone1, T. Colangelo4, L. Vanella2, F. Santilli1 | 1Dep. of Medicine and Aging Sciences, Center for Advanced Studies and Technology (CAST), University of Chieti, Italy; 2Dep. of Drug and Health Sciences, University of Catania, Italy; 3Immunotransfusion Service, Clinical Haematology of Chieti University Hospital, Italy; 4Dep. of Medical and Surgical Sciences, University of Foggia, Italy
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CO-70 | CONGENITAL AFIBRINOGENEMIA: BLEEDING PHENOTYPE, THROMBOTIC COMPLICATIONS, AND LONG-TERM MANAGEMENT IN A MULTICENTER COHORT M. Biglietto1|2, M. Presti1, R.C. Santoro3, I. Nichele4, M. Napolitano5, S. Pasca6, A. Borchiellini7, B. Pollio8, E. Zanon9, G. Barillari10, A. Poz10, S. Sorella1, S. Ligia1, R. Mormile1, E. Baldacci1, G. Castaman11, F. Peyvandi12|13, C. Santoro1 | 1Hematology, Department of Translational and Precision Medicine, Sapienza University of Rome, Italy; 2Department of Molecular Biology, Sapienza University of Rome, Italy; 3Hemostasis and Thrombosis Unit, Azienda Ospedaliera Pugliese-Ciaccio, Catanzaro, Italy; 4Hematology Unit, Azienda ULSS 8 Berica - San Bortolo Hospital, Vicenza, Italy; 5Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, University of Palermo, Italy; 6Coagulation Diseases Center, Transfusion Medicine Department - Azienda Sanitaria Universitaria Integrata del Trentino, Trento, Italy; 7Centro di Riferimento Regionale Malattie Emorragiche e Trombotiche dell'Adulto, Divisione di Ematologia, Università Città della Salute e della Scienza di Torino, Italy; 8SIMT Immunohematology and Transfusion Medicine Service, Diagnostic Department, A.O. Città della Salute e della Scienza, Torino, Italy; 9Department of Medicine, Haemophilia Centre, University Hospital of Padua, Italy; 10Center for Hemorrhagic and Thrombotic Diseases, General and University Hospital S. Maria della Misericordia, Udine, Italy; 11Centre for Bleeding Disorders and Coagulation, Careggi University Hospital, Firenze, Italy; 12IRCCS Fondazione Ca' Granda Ospedale Maggiore Policlinico, Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Milano, Italy; 13Università degli Studi di Milano, Department of Pathophysiology and Transplantation, Milano, Italy
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CO-13 | USE OF THE MULTIDIMENSIONAL HEMOPHILIA PAIN QUESTIONNAIRE IN PATIENTS WITH SEVERE HEMOPHILIA A TREATED WITH EMICIZUMAB: A PILOT CROSS-SECTIONAL, SINGLE-CENTER STUDY I.L. Calcaterra, S. Donnarumma, G. D’Errico, C. De Luca, C. Caputo, P. Ciciola, E. Cimino, M. Di Minno | Università Federico II di Napoli, Italy
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OC05 | TIME TO START OF ANTICOAGULANT THERAPY AND SURVIVAL OUTCOMES IN CANCER PATIENTS WITH PULMONARY EMBOLISM K. Bria, B. Gage, M. Bealsey, K. Sanfilippo | Washington University in St. Louis School of Medicine, St. Louis, MO, USA
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CO086 | CLINICAL AND GENETIC CHARACTERIZATION OF A NEW FAMILY CARRYING THE “FACTOR VIII PADUA” F8 DUPLICATION E. Campello, C. Simion, F. Sartorello, D. Regazzo, C. Bulato, B. Serena, S. Toffanin, L. Spiezia, P. Simioni | Department of Medicine, University of Padova, Italy
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CO029 | REAL WORLD EVALUATION OF A NOVEL PATIENT CENTERED OUTCOME INDICATOR TO SUPPORT VALUE BASED HEALTHCARE DECISION-MAKING IN HEMOPHILIA A IN ITALY: THE HEMPROVE NON-INTERVENTIONAL STUDY G. Castaman1, C. Santoro2, E. Ferri Grazzi3, S. Bendinelli4, R. Perrone4, C. Lainez Diaz4, P.A. Cortesi5, M.N.D. Di Minno6 | 1Dep. of Oncology, Centre for Bleeding Disorders and Coagulation, Careggi Univ. Hosp., Firenze, Italy; 2Hematology, Dep. of Translational and Precision Medicine, Sapienza University of Roma, Italy; 3FedEmo, Milano, Italy; 4Roche S.p.A. Italy, Monza, Italy; 5CESP, Univ. of Milano-Bicocca, Monza, Italy; 6Dep. of Clinical Medicine and Surgery, Regional Reference Center for Coagulation Disorders, Federico II Univ., Napoli, Italy
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CO057 | THROMBOPOIETIN-PLATELET AXIS IN METABOLIC-ASSOCIATED STEATOTIC LIVER DISEASE M. Alfonsetti1, P. Simeone1, R. Liani1, M. Frezza1, B. Di Marco1, A. Cipollone1, C. Della Penna1, L. Cantagallo1, G. Ciferni1, L. Del Rosso1, M. Caporale1, S. Brandolino2, E. Vitacolonna2, P. Di Carlo3, F. Cipollone1, F. Santilli1 | 1Department of Medicine and Aging Sciences, Center for Advanced Studies and Technology (CAST), University of Chieti, Chieti, Italy, University General Medicine Division, Medical Department, SS. Annunziata Hospital, Chieti, Italy; 2Department of Medicine and Aging, School of Medicine and Health Sciences, G. d'Annunzio University, Chieti, Italy; 3Department of Innovative Technologies in Medicine & Dentistry, "G. d'Annunzio" University of Chieti-Pescara, Chieti, Italy
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CO-89 | FEMORAL FRACTURE SURGERY IN AN ELDERLY, FRAIL PATIENT WITH ACQUIRED HEMOPHILIA A RECEIVING EMICIZUMAB PROPHYLAXIS: A CASE REPORT C. Simion1|2, E. Zanon1|2, B. Stocco1|2, F. Sartorello1, C. Bulato1, G. Saggiorato1, P. Simioni1|2 | 1First Chair of Internal Medicine and Thrombotic and Haemorrhagic Diseases Unit, Department of Medicine, Padova University Hospital, Italy; 2Hemophilia Center, Padova University Hospital, Italy
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CO-24 | BALANCING BLEEDING AND THROMBOSIS: SAFETY OF LOW-MOLECULAR-WEIGHT HEPARIN THROMBOPROPHYLAXIS IN PATIENTS WITH HEMOPHILIA UNDERGOING MAJOR SURGERY S. Bergonzi1|2|3, G. Murante1|2|3, M. Capetta1|2|3, F. Valeri1|2, C. Dainese1|2, A. Valpreda3|4, R. Pastorino3|4, F. Bocchi3|4, B. Bruno2|3, A. Borchiellini1|2 | 1Regional Centre for Hemorrhagic and Thrombotic Diseases, AOU Città della Salute e della Scienza, Torino, Italy; 2Division of Hematology, AOU Città della Salute e della Scienza, University of Turin, Italy; 3Department of Molecular Biotechnology and Health Sciences, University of Turin, Italy; 4Central Laboratory Baldi and Riberi, AOU Città della Salute e della Scienza, University of Turin, Italy
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PO26 | OUTCOMES OF DIRECT ORAL ANTICOAGULANTS IN UNUSUAL-SITE THROMBOSIS: IMPACT OF ACTIVE CANCER S. Guglielmo1, M. Lovisotto1, L. Scarano1, E. De Bon2, S. Barbar2 | 1Internal Medicine, Department of Medicine, Azienda Ulss 6 Euganea, Cittadella (PD), Italy; 2Thrombotic and Hemorrhagic Disorders Unit, Department of Medicine, Azienda Ulss 6 Euganea, Cittadella (PD), Italy
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CO105 | THALIDOMIDE FOR RECURRENT GASTROINTESTINAL BLEEDING IN RARE BLEEDING DISORDERS AND VENOUS MALFORMATIONS: A MONOCENTRIC EXPERIENCE M. De Siati1|2, F.G. Perretta1|2, F. Ricci1|2, A. Ferretti1, M. Comand1|2, S. Sorrentino1, L. D’Innocenzo1|2, D. Feliciani2, B. Funaro2, M.E. Riccioni3, A. Gasbarrini2|4, E. De Candia1|2 | 1UOSD Malattie Emorragiche e Trombotiche, Fondazione Policlinico Agostino Gemelli IRCCS, Roma 00168, Italy; 2Department of Translational Medicine and Surgery, Catholic University of the Sacred Heart, Roma, Italy; 3Digestive Endoscopy Unit, Fondazione Policlinico Universitario Agostino Gemelli, IRCCS, Università Cattolica del Sacro Cuore, Largo Agostino Gemelli, Roma 00168, Italy; 4Department of Medical and Surgical Sciences, Digestive Disease Center, Universitary Policlinic Agostino Gemelli Foundation IRCCS, Roma, Italy
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CO036 | NEUROCOGNITIVE ASSESSMENT OF IMMUNE-MEDIATED THROMBOTIC THROMBOCYTOPENIC PURPURA PATIENTS USING A COMPREHENSIVE TEST BATTERY IN A CROSS-SECTIONAL MRI-INTEGRATED STUDY A. Truma1, T. Difonzo2, F. Lo Russo3, G. Conte3|4, I. Mancini1, E. Cesari1, M. Gagliardi1, J.A. Giannotta1, A. Artoni1, E. Piccin3, P. Agosti4, F. Triulzi3|4, F. Peyvandi1|4 | 1Fondazione IRCCS Ca’ Granda ospedale maggiore policlinico, Angelo Bianchi Bonomi hemophilia and thrombosis center, Milano, Italy; 2Fondazione IRCCS Ca’ Granda ospedale maggiore policlinico, neurology unit, Milano, Italy; 3Fondazione IRCCS Ca’ Granda ospedale maggiore policlinico, neuroradiology unit, Milano, Italy; 4Università degli studi di Milano, Milano, Italy
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CO-57 | NXT007 PROPHYLAXIS IN PEOPLE WITH HEMOPHILIA A WITH OR WITHOUT FACTOR VIII INHIBITORS: COMBINED ANALYSIS OF TWO PHASE I/II MULTIPLE-ASCENDING-DOSE STUDIES M.E. Mancuso1|2, M. Shima3, J.M. Staber4, Y.C. Chen5, F.J. López-Jaime6, M.C. Shen7, G. Ventriglia8, M. Takeyama9, C. Schmitt8, Y.S. Park10, A. Kiialainen8, N. Mizuno11, M. Niggli8, T. Miyake11, D. Matino12, T. Saito11, V. Jiménez-Yuste13, R. Kobayashi11, D. Hart14, K. Nogami15 | 1Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milano, Italy; 2Center for Thrombosis and Hemorrhagic Diseases, IRCCS Humanitas Research Hospital, Rozzano, Milano, Italy; 3Thrombosis and Hemostasis Research Center, Nara Medical University, Kashihara, Nara, Japan; 4Stead Family Department of Pediatrics, Carver College of Medicine, University of Iowa, Iowa City, USA; 5Hemophilia Care and Research Center, Tri-Service General Hospital, National Defense Medical University, Taipei, Taiwan; 6Servicio de Hematología, Hospital Universitario Regional de Málaga / Instituto de Investigación Biomédica de Málaga (IBIMA), Málaga, Spain; 7Department of Internal Medicine, Changhua Christian Hospital, Changhua, Taiwan; 8F. Hoffmann-La Roche Ltd, Basel, Switzerland; 9Division of Hemophilia, National Hospital Organization, Osaka National Hospital, Osaka, Japan; 10Department of Pediatrics, Kyung Hee University Hospital at Gangdong, Seoul, South Korea; 11Chugai Pharmaceutical Co., Ltd, Tokyo, Japan; 12McMaster University, Hamilton, Ontario, Canada; 13La Paz University Hospital-IdiPAZ, Autónoma University, Madrid, Spain; 14Roche Products Ltd, Welwyn Garden City, UK; 15Department of Pediatrics, Nara Medical University, Kashihara, Nara, Japan
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CO067 | ELUCIDATING THE EVIL RELATIONSHIP OF METABOLIC DYSFUNCTION–ASSOCIATED FATTY LIVER DISEASE WITH CARDIOVASCULAR COMORBIDITIES: THE COMPLEX INTERPLAY AMONG HYPERCOAGULABILITY, INFLAMMATION, AND LIVER FIBROSIS G. Gagliardi, E. Campello, A. Napolitano, B. Stocco, C. Di Gesù, G. Gobbo, I. Condonato, M. Allegra, G. Antonello, C. Portinari, C. Goffi, G. Camporese, P. Scarinzi, R. Pesavento, F. Bilora, M. Di Pascoli, C. Bulato, A. Montagna, D. Regazzo, A. Zambon, L. Fabris, P. Simioni | Department of Medicine, University of Padova, Italy
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CO012 | LONG-TERM RISK OF RECURRENT VENOUS THROMBOEMBOLISM IN ADULT PATIENTS WITH ACTIVE CANCER AND FIRST CATHETER-RELATED UPPER EXTREMITY DEEP VEIN THROMBOSIS AFTER DISCONTINUATION OF ANTICOAGULANT TREATMENTS AND LINE REMOVAL: A RETROSPECTIVE MULTI-CENTER COHORT STUDY – CANCER-CRT STUDY L. Girardi1|2, W. Ageno3, L. Bertù1, C. Lodigiani4, L.A. Ciuffini4, M.C. Vedovati5, C. Becattini5, A. Sammarco6, G. Camporese6, G. Cuni1|7, C. Ambaglio7, M.P. Donadini1 | 1Research Center on Thromboembolic Diseases and Antithrombotic Treatment, Department of Medicine and Surgery, University of Insubria, Varese, Italy; 2Department of Medicine, The Ottawa Hospital Research Institute, University of Ottawa, Ontario, Canada; 3Department of Medicine, University of Padua, Padova, Italy; 4Center for Thrombosis and Hemorrhagic Diseases, IRCCS Humanitas Research Hospital, Rozzano, Milano, Italy; 5Internal and Cardiovascular Medicine-Stroke Unit, University of Perugia, Perugia, Italy; 6Clinica Medica 1, Department of Medicine, DIMED, Padova University Hospital, Padova, Italy; 7Immunohematology and Transfusion Medicine, Department of Transfusion Medicine and Hematology, ASST Papa Giovanni XXIII, Bergamo, Italy
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CO-36 | PLATELETS MATTER: THROMBIN GENERATION IN PLATELET‐RICH-PLASMA VS. PLATELET‐POOR‐PLASMA UNDER NON-REPLACEMENT THERAPIES IN HEMOPHILIA F. Bocchi1|2, R. Pastorino1|2, G. Murante1|2|3, S. Bergonzi1|2|3, M. Capetta1|2|3, F. Valeri2|3, C. Dainese2|3, A. Valpreda4, B. Bruno1|3, A. Borchiellini2|3 | 1Department of Molecular Biotechnology and Health Sciences, University of Turin, Italy; 2Regional Centre for Thrombotic and Hemorrhagic Diseases, AOU Città della salute e della Scienza di Torino, Italy; 3Division of Hematology, AOU Città della Salute e della Scienza, University of Turin, Italy; 4Central Lab Baldi and Riberi, AOU Città della salute e della Scienza di Torino, Italy
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PO50 | SUB-ANALYSIS OF INTERIM RESULTS FROM A PHASE 2 STUDY INVESTIGATING REGN9933A2 AND REGN7508CAT FOR THE PREVENTION OF CONTACT-MEDIATED VENOUS THROMBOEMBOLISM IN PATIENTS WITH ACTIVE CANCER UNDERGOING PERIPHERALLY INSERTED CENTRAL CATHETER PLACEMENT (ROXI-CATH) J. Zwicker1,2, A.P. Kithcart3, J. Kaplan3, Y-C. Cheng3, J.G. Raya3, J. Xiao3, S. Li3, K. Musgrave4, D.E. Gutstein3, G. Piazza5 | 1Memorial Sloan Kettering Cancer Center, New York, NY, USA; 2Weill Cornell Medical Center, New York, NY, USA; 3Regeneron Pharmaceuticals, Inc. , Tarrytown, NY, USA; 4Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK; 5Brigham and Women’s Hospital, Boston, MA, USA
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CO112 | LIPOPROTEIN(a) PLASMA LEVELS AND COAGULATION BIOMARKERS: RESULTS FROM A COMPREHENSIVE LABORATORY ASSESSMENT IN AN ANGIOGRAPHICALLY-CONTROLLED CARDIOVASCULAR COHORT N. Osti1, G. Musuraca1, M. Spizzo2, P. Pattini2, G. Poli3, C. Brocco1, C. Cemin1, A. Madaffari1, G. Mango2, F. Presa2, M. Grusse4, P. Van Dreden4, A. Anesi1, G. Lippi3, M. Del Greco1, A. Castagna2, S. Friso2, A. Ferro1, N. Martinelli2 | 1Azienda Sanitaria Universitaria Integrata del Trentino (ASUIT), Trento, Italy; 2U.O. Medicina Interna B, Dip. Medicina, Università di Verona, Italy; 3Sez. Biochimica Clinica, Università di Verona, Italy; 4Dep. Clinical Research, Diagnostica Stago, Gennevilliers, France
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CO046 | BLEEDING RISK FACTOR–BASED PHENOTYPES AND THEIR ASSOCIATION WITH MORTALITY AND HEMORRHAGIC OUTCOMES IN ATRIAL FIBRILLATION T. Bucci1, A.G. Rigutini1, A. Perrotta1, A. Moffa1, C. Seviroli1, M. Giustozzi2, M.C. Vedovati1, C. Becattini1 | 1Internal, Vascular and Emergency Medicine - Stroke Unit, University of Perugia, Perugia, Italy; 2SSD Angiology, San Giovanni Battista Hospital, Foligno, Italy
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CO-69 | IN VITRO CORRECTION OF SEVERE FACTOR V DEFICIENCY USING A NOVEL PLASMA-DERIVED FACTOR V CONCENTRATE: A WHOLE BLOOD THROMBIN GENERATION STUDY C. Bulato1, E. Campello1, L. Spiezia1, B. Serena1, S. Toffanin1, C. Simion1, A. Caricasole2, M. Sotgiu2, A. Salvatore2, F. Pierantoni2, T.M. Hackeng3|4, H.M.H. Spronk3|4, P. Simioni1 | 1First Chair of Internal Medicine, Thrombotic and Haemorrhagic Diseases Unit and Haemophilia Centre, Department of Medicine, Padova University Hospital, Padova, Italy; 2Kedrion SpA, Barga Lucca, Italy; 3Coagulation Profile B.V., Maastricht, Netherland; 4Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, Netherland
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CO-12 | BEYOND CLOTTING FACTORS: NURSING AS A CORNERSTONE OF LIFELONG HEMOPHILIA CARE M.V. Puliga1, C. Manzi2, A. Besagni3, S. Linari1, C. Carulli4, M. Morfini5 | 1SODc Malattie Emorragiche e della Coagulazione, AOU Careggi, Firenze, Italy; 2SSD Malattie Emorragiche Congenite, IRCCS Policlinico Sant'Orsola, Bologna, Italy; 3Indipendente, Italy; 4Clinica Ortopedica, Università di Firenze, SOD Ortopedia, AOU Careggi, Firenze, Italy; 5Associazione Italiana Centri Emofilia, AICE, Milano, Italy
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OC04 | DIRECT ORAL ANTICOAGULANTS PROVIDE EFFECTIVE THROMBOPROPHYLAXIS IN NEWLY DIAGNOSED MYELOMA: REAL WORLD FINDINGS FROM THE ATOMM STUDY T. Bull1, Heamstar Collaborators2, W. Wilson3, E. Ganendra4, M. Thomas5, R. Alikhan6, M. Karanth1, M. Camilleri7 | 1West Suffolk Hospital NHS Foundation Trust, UK; 2Haematology Specialty Training Audit and Research HaemSTAR Network, UK; 3University College London Clinical Trial Centre, UK; 4North West Anglia NHS Foundation Trust, UK; 5University College London Hospitals, UK; 6Cardiff and Vale University Health Board, Wales, UK; 7Cambridge University Hospitals NHS Foundation Trust, UK
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CO083 | IN VITRO CORRECTION OF SEVERE FACTOR V DEFICIENCY USING A NOVEL PLASMA-DERIVED FV CONCENTRATE: A WHOLE BLOOD THROMBIN GENERATION STUDY C. Bulato1, L. Spiezia1, E. Campello1, B. Serena1, S. Toffanin1, C. Simion1, A. Caricasole2, M. Sotgiu2, A. Salvatore2, F. Pierantoni2, T.M. Hackeng3|4, H.M.H. Spronk3|4, P. Simioni1 | 1Thrombotic and Hemorrhagic Diseases Unit, General Internal Medicine, Department of Medicine, Padova University Hospital, Italy; 2Kedrion SpA, Barga Lucca, Italy; 3Coagulation Profile B.V., Maastricht, the Netherlands; 4Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University, the Netherlands
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CO027 | PREIMPLANTATION GENETIC TESTING IN FAMILIES AT RISK OF HEMOPHILIA: RESULTS FROM A SINGLE CENTER M. Mortarino1, I. Garagiola1, V. Nicotra2, A. Riccaboni3, C. Guarneri3, E. Somigliana3, F. Peyvandi1|4 | 1Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Angelo Bianchi Bonomi Hemophilia and Thrombosis Center and Fondazione Luigi Villa, Milano, Italy; 2Medical Genetics Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano, Italy; 3Infertility Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano, Italy; 4Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Milano, Italy
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PO57 | A NOVEL RISK ASSESSMENT MODEL FOR CANCER DETECTION WITHIN ONE YEAR AFTER INCIDENT VENOUS THROMBOEMBOLISM C. Antoun1, J. Hansen1|3, S. Brækkan1|3, C. Langholm1, N. Eide1, V. Morelli1|3, K. Hveem2 | 1Department of Clinical Medicine, UiT The Arctic University of Norway, Tromsø; 2HUNT Center for Molecular and Clinical Epidemiology, Norwegian University of Science and Technology, Trondheim; 3Thrombosis Research Center, Division of Internal Medicine, University Hospital of North Norway, Tromsø, Norway
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CO056 | URINARY MARKERS OF PLATELET ACTIVATION AND OXIDATIVE STRESS IN ATHEROSCLEROTIC CARDIOVASCULAR DISEASE IN TYPE 2 DIABETES M. Alfonsetti1, P. Simeone1, R. Liani1, M. Frezza1, B. Di Marco1, A. Cipollone1, D. D’ Ardes1, T. Taverriti1, C. Della Penna1, L. Cantagallo1, G. Ciferni1, L. Del Rosso1, M. Caporale1, S. Brandolino2, E. Vitacolonna2, P. Di Carlo3, F. Cipollone1, F. Santilli1 | 1Department of Medicine and Aging Sciences, Center for Advanced Studies and Technology (CAST), University of Chieti, Chieti, Italy, University General Medicine Division, Medical Department, SS. Annunziata Hospital, Chieti, Italy; 2Department of Medicine and Aging, School of Medicine and Health Sciences, G. d'Annunzio University, Chieti, Italy; 3Department of Innovative Technologies in Medicine & Dentistry, "G. d'Annunzio" University of Chieti-Pescara, Chieti, Italy
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CO-88 | TRANSIENT IDIOPHATIC ACQUIRED VON WILLEBRAND DISEASE: A RARE, CHALLENGING CONDITION WITH A POSSIBLE RAPID AND FAVORABLE EVOLUTION G. Murante1|2|3, S. Bergonzi1|2|3, M. Capetta1|2|3, F. Valeri1|2, C. Dainese1|2, A. Valpreda4, R. Pastorino1|3, F. Bocchi1|3, B. Bruno2|3, A. Borchiellini1|2 | 1Regional Centre for Hemorrhagic and Thrombotic Diseases, AOU Città della Salute e della Scienza of Turin, Italy; 2Division of Hematology, AOU Città della Salute e della Scienza, University of Turin, Italy; 3Dep. of Molecular Biotechnology and Health Sciences, University of Turin, Italy; 4Central Lab. Baldi and Riberi, AOU Città della Salute e della Scienza of Turin, Italy
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CO-23 | PERIOPERATIVE MANAGEMENT OF MILD-TO-MODERATE HEMOPHILIA: A COMPARATIVE STUDY OF EXTENDED HALF-LIFE VERSUS STANDARD HALF-LIFE CONCENTRATES ON CLINICAL OUTCOMES AND FACTOR CONSUMPTION M. Capetta1|2|3, F. Valeri1|2, C. Dainese1|2, S. Bergonzi1|2|3, G. Murante1|2|3, A. Valpreda4, R. Pastorino1|3, F. Bocchi1|3, B. Bruno2|3, A. Borchiellini1|2 | 1Regional Centre for Hemorrhagic and Thrombotic Diseases, AOU Città della Salute e della Scienza, Torino, Italy; 2Division of Hematology, AOU Città della Salute e della Scienza, University of Turin, Italy; 3Department of Molecular Biotechnology and Health Sciences, University of Turin, Italy; 4Central Laboratory Baldi and Riberi, AOU Città della Salute e della Scienza, University of Turin, Italy
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PO18 | THE THROMBO-INFLAMMATION AXIS AS PREDICTOR OF TOXICITY IN PATIENTS TREATED WITH CAR-T CELLS C. Fernández-Arias1, M. Marcos-Jubilar1, M. Panizo1, C. Vázquez-Puerta2, J.R. González-Porras2, M. Ibáñez1, A. Queralt1, M. Carrasco1, M.B. Villacrés1, C. Conde1, P. Elizalde1, S. Huerga1, A. Alfonso1, P. Rodríguez-Otero1, S. Villar1, M.A. Canales1, J. Rifón1, F. Prósper1, J.A. Páramo1, J. Orbe1, R. Lecumberri1 | 1Clínica Universidad de Navarra, Pamplona; 2Hospital Clínico Universitario de Salamanca, Salamanca, Spain
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Welcome to the 12th International Conference on Thrombosis and Hemostasis Issues in Cancer! Oral Communications and Posters
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CO098 | ANTI-β2GPI AND ANTI-PS/PT ANTIBODIES, AND THEIR COMBINATION, EXERT A DISTINCT PLATELET ACTIVATION PROFILE M. Camera1|2, A. Becchetti2, M.O. Borghi3|4, M. Brambilla2, P.A. Lonati4, C. Bodio4, E. Pontara5, M.G. Cattini5, E. Bison5, M. Tonello6, N. Pozzi7, P. Meroni4, V. Pengo5 | 1Department of Pharmaceutical Sciences, University of Milano, Milano, Italy; 2Unit of Cell and Molecular Biology in Cardiovascular Diseases, Centro Cardiologico Monzino IRCCS, Milano, Italy; 3Dipartimento di Scienze Cliniche e di Comunità, Dipartimento di Eccellenza 2023-2027, University of Milano, Milano, Italy; 4IRCCS Istituto Auxologico Italiano, Milano, Italy; 5Department of Cardiac-Thoracic-Vascular Sciences and Public Health, University of Padua, Padova, Italy; 6Department of Medicine, University of Padua, Padova, Italy; 7Saint Louis University School of Medicine, St. Louis, United States
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CO034 | VALIDATION OF A MICROFLUIDIC PLATFORM FOR HEMOSTASIS EVALUATION UNDER FLOW CONDITIONS: FROM PATHOGENETIC MECHANISMS TO THERAPEUTIC MONITORING F. Boggio1|2, L. Padovan1|2, S. La Marca1, G. Donadoni1, A. Lecchi1|2, A. Artoni1, S. Bozzi3, A. Redaelli3, F. Peyvandi1|2 | 1Centro Emofilia e Trombosi A. Bianchi Bonomi, IRCCS Fondazione Ca’ Granda Ospedale Maggiore Policlinico di Milano, Italy; 2Dipartimento di Fisiopatologia Medico-Chirurgica e dei Trapianti, Università degli Studi di Milano, Italy; 3Dipartimento di Elettronica, Informazione e Bioingegneria, Politecnico di Milano, Italy
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CO-56 | EVALUATING AN AI MODEL’S HEMATOLOGY CONSULTATION PERFORMANCE FOR HOSPITALIZED PATIENTS WITH BLEEDING DISORDERS G. Sottilotta1, F. Misiti2, G. Praticò1, D. Megalizzi1, F. Luise3 | 1UOSD Microcitemie - Emostasi e Trombosi. Grande Ospedale Metropolitano di Reggio Calabria, Italy; 2Associazione Emofilici di Reggio Calabria, Italy; 3Laboratorio Analisi. Grande Ospedale Metropolitano di Reggio Calabria, Italy
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CO066 | COAGULOPATHY IN CAR-T CELL-TREATED PATIENTS WITH LYMPHOPROLIFERATIVE DISORDERS: A RETROSPECTIVE, SINGLE-CENTER OBSERVATIONAL STUDY I. Santo1, R. Morganti2, G. Leoni3, G. Tancredi3, L. Contino4, S. Galimberti3, R.M. Santi4, E. Orciuolo5 | 1Azienda Toscana Nord Ovest, Versilia Hospital, Italy; 2Hematology Division AOUP, Pisa, Italy; 3University of Pisa, Hematology Pisa, Italy; 4Azienda Ospedaliera Universitaria Alessandria, Italy; 5Azienda Ospedaliera Universitaria Pisana, Hematology Pisa, Italy
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CO008 | ALLOSTATIC LOAD AND THE RISK OF ARTERIAL AND VENOUS VASCULAR EVENTS: A PROSPECTIVE ANALYSIS FROM THE MOLI-SANI STUDY T. Panzera1, A. Di Castelnuovo1, M. Bonaccio1, S. Magnacca1, A. De Curtis1, F. Bracone1, W. Ageno2, C. Cerletti1, M.B. Donati1, G. de Gaetano1, L. Iacoviello1|3, S. Costanzo1|4 | 1Research Unit of Epidemiology and Prevention, IRCCS NEUROMED, Pozzilli, Italy; 2Department of Medicine, University of Padua, Padova, Italy; 3Department of Medicine and Surgery LUM University “Giuseppe Degennaro”, Casamassima, Italy; 4Department of Medicine and Surgery, University of Insubria, Varese, Italy
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CO-34 | SIMPLIFIED PERIOPERATIVE MANAGEMENT WITH N8-GP (TUROCTOCOG ALFA PEGOL) IN MAJOR ABDOMINAL SURGERY IN MILD HEMOPHILIA A WITH SEVERE BLEEDING PHENOTYPE: A CASE REPORT J. Di Paolo, R. Malizia, M. Luongo, P. Massaro, M. Di Mascio, S. Verna | Immunohematology Service, ASL 02 Abruzzo, Chieti, Italy
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PO45 | KHORANA RISK SCORE AND GENOMIC PROFILING FOR PREDICTION OF VENOUS THROMBOEMBOLISM IN OVARIAN CANCER P. Santini, L. Mastrantoni, G. Anderson, F. Camarda, I. Marino, J. Preziosi, M. Buttarelli, M. Manfredelli, A. Minucci, F. Persiani, L. Giacò, T. Pasciuto, I. Conti, I. Mozzetta, F. Mancinetti, S. M. P. D’Ambrosio, M. Bigossi, C. Marchetti, V. Salutari, G. Scambia, C. Nero, R. Pola | Agostino Gemelli University Hospital Foundation IRCCS, Rome, Italy
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CO111 | ROLE OF CONSTITUTIVE ENDOTHELIAL DYSFUNCTION IN THE PATHOGENESIS OF UNPROVOKED VENOUS THROMBOEMBOLISM: CHARACTERIZATION OF ENDOTHELIAL COLONY-FORMING CELLS AND ASSOCIATION WITH RISK OF RECURRENCE F. Calcaterra1|2, R. Ciceri1|2, M. Bacci1, A. Cancellara1|2, E. Romualdi3, L. Guerrieri1|2, F. Tumminello1, C. Lodigiani1, W. Ageno4, S. Della Bella1|2, D. Mavilio1|2, M.P. Donadini3|5 | 1IRCCS Humanitas Research Hospital, Italy; 2University of Milano, Italy; 3ASST Sette Laghi, Varese, Italy; 4University of Padua, Padova, Italy; 5University of Insubria, Varese, Italy
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CO045 | BEYOND THE VISIBLE: LIPOPROTEIN(a) AS A SILENT DRIVER OF RETINAL VASCULAR DAMAGE L. Agrelli1, M. Berteotti2, E. Lotti2, F. Crudele2, D. Poli2, A.M. Gori2, A Rogolino2, D. Prisco2, R. Marcucci2 | 1Department of Internal Medicine, University of Salerno, Italy; 2Department of Medical and Surgical Critical Care, Thrombosis Centre, University of Florence, AOU Careggi, Firenze, Italy
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CO-68 | ACQUIRED FACTOR XIII DEFICIENCY ASSOCIATED WITH CROHN’S DISEASE: A CHALLENGING DIAGNOSTIC AND THERAPEUTIC CASE A. Colombo1, A. Dal Buono2|3, I. Quaglia1, C. Novembrino4, M.R. Fasulo1, C. Lodigiani1, M.E. Mancuso1|2 | 1Center for Thrombosis and Hemorrhagic Diseases, IRCCS Humanitas Research Hospital, Rozzano, Milano, Italy; 2Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milano, Italy; 3IBD Center, IRCCS Humanitas Research Hospital, Rozzano, Milano, Italy; 4Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico Angelo Bianchi Bonomi, Hemophilia and Thrombosis Center and Fondazione Luigi Villa, Milano, Italy
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CO-11 | MAPPING THE COMPETENCIES OF NURSES IN ITALIAN HEMOPHILIA CENTERS: CURRENT STATUS AND PERSPECTIVES FOR THE IDENTIFICATION OF NURSE-SENSITIVE OUTCOMES M.V. Puliga1, A.C. Ferrini2, C. Manzi3, D. Meneghini4, E. Tosi4, P. Berto5, M. Amelotti-Botta6, E. Quercio6, M.E. Mancuso7, R.C. Santoro8 | 1SODc Malattie Emorragiche e della Coagulazione, AOU Careggi, Firenze, Italy; 2SSI Malattie Emorragiche e Tromboemboliche, Osp. Bufalini, Cesena, Italy; 3SSD Malattie Emorragiche Congenite, IRCCS Policlinico Sant'Orsola, Bologna, Italy; 4Centro Emofilia e UOC Medicina Trasfusionale, AOU Integrata, Verona, Italy; 5Centro Emofilia Hub, AO di Padova, Italy; 6SSD Emostasi e Coordinamento Malattie Rare, AO SS. Antonio e Biagio, Alessandria, Italy; 7UOC Centro Trombosi e Malattie Emorragiche, IRCCS Humanitas Research Hospital, Rozzano, Milano, Italy; 8UOD Emofilia, Emostasi e Trombosi, AOU Renato Dulbecco, Catanzaro, Italy
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CO076 | ASSOCIATION OF MATRIX METALLOPROTEINASE 2 PLASMA LEVELS WITH CARDIOVASCULAR EVENTS IN PATIENTS WITH ATRIAL FIBRILLATION: A NESTED CASE CONTROL STUDY FROM THE ATHERO-AF COHORT D. Menichelli1, E. Falcinelli2, P. Pignatelli3, R. Carnevale4|5, A. D’Amico4, F. Violi2, P. Gresele2, D. Pastori4|5, F. Paciullo6 | 1Dip. di Chirurgia Generale e Specialità Chirurgiche Paride Stefanini, Università La Sapienza, Roma, Italy; 2Dip. di Medicina e Chirurgia, Sez. di Medicina Interna Cardiovascolare, Università degli Studi di Perugia, Italy; 3Dip. di Scienze Medico-Chirurgiche e Biotecnologie, Università La Sapienza, Latina, Italy; 4IRCCS Neuromed, Pozzilli, Isernia, Italy; 5Dip. di Scienze Mediche e Cardiovascolari, Università La Sapienza, Roma, Italy; 6Fac. di Medicina e Chirurgia , Vita-Salute San Raffaele University, Milano, Italy
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CO026 | LIVER FIBROSIS, STEATOSIS, AND SUBCLINICAL ATHEROSCLEROSIS IN PATIENTS WITH HEMOPHILIA: A CROSS-SECTIONAL STUDY C. Simion, B. Stocco, I. Condonato, E. Dalla Porta, A. Napolitano, E. Zanon, L. Fabris, L. Spiezia, P. Simioni | Department of Medicine, University of Padova, Italy
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CO-43 | VALIDATION OF THROMBIN GENERATION MEASUREMENT IN PLATELET-RICH PLASMA: EVOLUTION IN THE ST GENESIA® SYSTEM F. Bocchi1|2, R. Pastorino1|2, G. Murante1|2|3, S. Bergonzi1|2|3, M. Capetta1|2|3, F. Valeri2|3, C. Dainese2|3, A. Valpreda4, B. Bruno1|3, A. Borchiellini2|3 | 1Department of Molecular Biotechnology and Health Sciences, University of Turin, Italy; 2Regional Centre for Thrombotic and Hemorrhagic Diseases, AOU Città della salute e della Scienza di Torino, Italy; 3Division of Hematology, AOU Città della Salute e della Scienza, University of Turin, Italy; 4Central Lab Baldi and Riberi, AOU Città della salute e della Scienza di Torino, Italy
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CO055 | COMPARISON OF VISCOELASTIC COAGULATION MONITOR AND ROTATIONAL THROMBOELASTOMETRY FOR HEMOSTATIC PHENOTYPING AND OUTCOME PREDICTION IN SEPSIS G. Gottardi, E. Campello, C. Simion, C. Samà, A. Benetti, C. Bulato, D. Regazzo, G.P. Arcidiacono, P. Simioni | Department of Medicine, University of Padua, Italy
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CO-85 | ACQUIRED HEMOPHILIA A IN LIVER CIRRHOSIS: BALANCING HEMOSTASIS BETWEEN HIGH HEMORRHAGIC AND THROMBOTIC RISKS N. Portesi, G. Martini | ASST Spedali Civili di Brescia, Italy
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CO-20 | REAL-WORLD EXPERIENCE ON THE MANAGEMENT OF MILD HEAD INJURY IN A COHORT OF CHILDREN WITH HEMOPHILIA A WITH AND WITHOUT INHIBITORS TREATED WITH EMICIZUMAB B. Pollio1, B. Borsellino1|2, T. Martini1 | 1Haemophilia Centre, Immune-Haematology and Transfusion Medicine, University Hospital “Città della Salute e della Scienza”, Torino, Italy; 2Department of Biomedicine and Prevention, PhD in Immunology, Molecular Medicine and Applied Biotechnology, University of Rome Tor Vergata, Roma, Italy
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PO12 | IMPACT OF INHERITED THROMBOPHILIA ON CANCER-ASSOCIATED THROMBOSIS: A SYSTEMATIC REVIEW AND META-ANALYSIS E. Campello1, G. Furlan1, A. Boccatonda2, A. Napolitano1, C. Simion1, P. Simioni1 | 1Internal Medicine 1 and Thrombotic and Hemorrhagic Diseases Unit, Department of Medicine, University of Padova, Italy; 2Diagnostic and Therapeutic Interventional Ultrasound Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlinico Sant'Orsola-Malpighi, Bologna, Italy
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CO096 | WHEN THE BODY SAYS ‘NO’: CHRONIC RELATIONAL STRESS AND IMMUNE THROMBOCYTOPENIA—TOWARD AN INTEGRATED PSYCHONEUROIMMUNOLOGICAL MODEL G. Auteri1, L. Ricci2, B. Lovrencic3, A. Cuneo4, V. De Stefano5 | 1Azienda Ospedaliero-Universitaria di Ferrara, Italy; 2Presidente dell’Associazione DOCEAT; 3Presidente dell’Associazione AIPIT; 4Università di Ferrara, Italy; 5Ospedale Policlinico Gemelli di Roma, Italy
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