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CO51 | Novel biomarkers of neurological damage in acute immune-mediated thrombotic thrombocytopenic purpura A. Truma1,2, I. Mancini1, F. Verde2,3, J. A. Giannotta1, A. Artoni1, B. Ferrari1, P. Agosti1,2, M. Gagliardi1, A. Ratti3,4, N. Ticozzi2,3, F. Peyvandi1,2 | 1Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Milan; 2Università degli Studi di Milano, Department of Pathophysiology and Transplantation, Milan; 3Department of Neurology and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, Milan; 4Università degli Studi di Milano, Department of Medical Biotechnology and Translational Medicine, Milan, Italy
584PDF: 14 -
PO008 | HISTORY OF CANCER IN VTE PATIENTS WITH AND WITHOUT HEREDITARY THROMBOPHILIA: A SINGLE CENTER COHORT STUDY A. Napolitano, E. Campello, C. Simion, G. Furlan, S. Gavasso, C. Bulato, C. Samà, S. Toffanin, B. Serena, L. Spiezia, P. Simioni | Department of Medicine, University of Padova, Italy
7PDF: 1 -
CO045 | BEYOND THE VISIBLE: LIPOPROTEIN(a) AS A SILENT DRIVER OF RETINAL VASCULAR DAMAGE L. Agrelli1, M. Berteotti2, E. Lotti2, F. Crudele2, D. Poli2, A.M. Gori2, A Rogolino2, D. Prisco2, R. Marcucci2 | 1Department of Internal Medicine, University of Salerno, Italy; 2Department of Medical and Surgical Critical Care, Thrombosis Centre, University of Florence, AOU Careggi, Firenze, Italy
7PDF: 2 -
CO-56 | EVALUATING AN AI MODEL’S HEMATOLOGY CONSULTATION PERFORMANCE FOR HOSPITALIZED PATIENTS WITH BLEEDING DISORDERS G. Sottilotta1, F. Misiti2, G. Praticò1, D. Megalizzi1, F. Luise3 | 1UOSD Microcitemie - Emostasi e Trombosi. Grande Ospedale Metropolitano di Reggio Calabria, Italy; 2Associazione Emofilici di Reggio Calabria, Italy; 3Laboratorio Analisi. Grande Ospedale Metropolitano di Reggio Calabria, Italy
25PDF: 14 -
PO41 | Comparison of the haemorrhagic phenotype between female and male patients affected by autosomal inherited bleeding disorders in a single-centre cohort B. Borsellino1,3, C. Zuccotti2, L. Guarnera3,4, C. Biasoli5, P. Pedrazzi5, T. Martini1 | 1Haemophilia Centre, Immune-Haematology and Transfusion Medicine, University Hospital “Città della Salute e della Scienza”, Turin, Italy; 2Department of Clinical Pathology, Bufalini Hospital, Cesena, Italy; 3Department of Biomedicine and Prevention, PhD in Immunology, Molecular Medicine and Applied Biotechnology, University of Roma Tor Vergata, Roma, Italy; 4Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, USA; 5Haemophilia and Transfusion Centre, Bufalini Hospital, Cesena, Italy
610PDF: 21 -
CO010 | MAPPING HEMOSTATIC BIOMARKER EXPRESSION ACROSS CANCER TYPES AND STAGES WITHIN THE HYPERCAN COHORT P. Gómez-Rosas1|2, D. Romeo1, S. Bolognini1, C. Ticozzi1, F. Schieppati1|4|5, A. D’Alessio3, R. Labianca3, L. Barcella1|4|5, A. Falanga3|5, M. Marchetti1|4|5 | 1Hospital Papa Giovanni XXIII, Bergamo, Italy; 2Hospital de Oncología, Unidad Médica de Alta Especialidad (UMAE), Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social (IMSS), Ciudad de México, México; 3Fondazione ARTET Onlus, Bergamo, Italy; 4ERN EuroBloodNet; 5School of Medicine and Surgery, University of Milan Bicocca, Italy. On behalf of the HYPERCAN Investigators
7PDF: 2 -
BEST-07 | ULTRASOUND EVALUATION AND JOINT SCORING IN MILD HEMOPHILIA A: A SINGLE-CENTER CASE SERIES FOR THE IDENTIFICATION OF SUBCLINICAL ARTHROPATHY M. Leotta, A. Strangio, R.C. Santoro | Hemophilia Hemostasis and Thrombosis Unit, Azienda Ospedaliero Universitaria Renato Dulbecco, Catanzaro, Italy
68PDF: 14 -
PO41 | VENOUS THROMBOEMBOLISM IN PERIPHERAL BLOOD STEM CELL COLLECTION. A SINGLE CENTER EXPERIENCE P. Holly1, J. Hudecek1, J. Chudej1, L. Valekova1, I. Plamenova1, E. Flochova1, R. Simonova1, J. Sokol1, J. Stasko1, M. Pietrzykova1|2, E. Vescecikova2 | 1Department of Hematology and Transfusion Medicine, University Hospital in Martin, Martin, Slovakia; 2National Transfusion Service, Martin, Slovakia
508PDF: 103 -
PO68 | Whole blood hypercoagulable profiles in a patient with markedly elevated lipoprotein(A) plasma levels and thrombotic complications: a case report C. Portinari, M. Biolo, A. Napolitano, L. Spiezia, A. Colpo, S. Zambon, A. Zambon, P. Simioni | Department of Medicine, Padova University Hospital, Padova, Italy
640PDF: 26 -
PO11 | Neutrophil cathepsin G and risk of cardiovascular events in patients with diabetes mellitus V. Cammisotto1, F. Baratta2, S. Bartimoccia3, D. Pastori1, N. Cocomello4, V. Castellani5, C. Nocella1, R. Carnevale3, G. Desideri1, F. Violi1, P. Pignatelli1 | 1Department of Clinical, Internal Medicine, Anesthesiological and Cardiovascular Sciences, Sapienza University of Roma; 2Geriatric Unit, Department of Internal Medicine and Medical Specialties, AOU Policlinico Umberto I, Roma; 3Department of Medical-Surgical Sciences and Biotechnologies, Sapienza University of Roma; 4Department of Anatomical Sciences, Histological, Legal Medical and Locomotor, Sapienza University of Roma; 5Department of Experimental Medicine, Sapienza University of Roma, Italy
591PDF: 22 -
CO062 | REDUCED-DOSE DOACs IN EXTENDED TREATMENT OF CANCER-ASSOCIATED THROMBOSIS (RED-CAT): INTERIM ANALYSIS FROM A MULTICENTER RETROSPECTIVE OBSERVATIONAL STUDY (COORDINATING CENTER DATA) S. Bergonzi1|2|3, A. Ghigo4, L. Carpisassi4, G. Murante1|2|3, M. Capetta1|2|3, F. Valeri1|2, C. Dainese1|2, A. Valpreda3|5, R. Pastorino3|5, F. Bocchi3|5, A. Porreca6|7, B. Bruno2|3, A. Borchiellini1|2 | 1Regional Centre for Hemorrhagic and Thrombotic Diseases, AOU Città della Salute e della Scienza, Turin, Italy; 2Division of Hematology, AOU Città della Salute e della Scienza, Università di Torino, Italy; 3Department of Molecular Biotechnology and Health Sciences, University of Turin, Italy; 4Division of Internal Medicine, AOU Città della Salute e della Scienza, Università di Torino, Italy; 5Central Laboratory Baldi and Riberi, AOU Città della Salute e della Scienza, Università di Torino, Italy; 6Department of Human Sciences and Quality of Life Promotion, San Raffaele University, Roma, Italy; 7Clinical and Molecular Epidemiology, IRCCS San Raffaele, Roma, Italy
6PDF: 2 -
CO-71 | ACQUIRED FACTOR XIII DEFICIENCY IN A PATIENT POST-CAR-T THERAPY FOR NON-HODGKIN LYMPHOMA: A CASE REPORT A. Strangio, M. Leotta, A. Ierardi, R.C. Santoro | Hemophilia, Hemostasis and Thrombosis Unit, Azienda Ospedaliero Universitaria Renato Dulbecco, Catanzaro, Italy
26PDF: 17 -
PO27 | URINE QUALITATIVE ASSESSMENT OF DIRECT ORAL ANTICOAGULANTS IN ROUTINE CLINICAL PRACTICE F. Schieppati1|2, P. Gomez-Rosas1|3, C. Ambaglio1, V. Brusegan1, O.C. Cretu1, E. Galimberti1, F. Zunino1, L. Barcella1, J. Harenberg4|5, A. Falanga1|2, M. Marchetti1|2 | 1Immunohematology and Transfusion Medicine, Hospital Papa Giovanni XXIII, Bergamo, Italy; 2School of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy; 3Maastricht University Medical Center, Cardiovascular Research Institute Maastricht, Maastricht, The Netherlands; 4Ruprecht Karls University of Heidelberg, Heidelberg, Germany; 5DOASENSE GmbH, Heidelberg, Germany
440PDF: 96 -
CO16 | The predictive value of high-sensitivity C-reactive protein for assessing thrombosis risk in non-small cell lung cancer P. Gomez-Rosas1,2, M. Marchetti1,3, L. Russo1, C.J. Tartari1, S. Bolognini1, C. Ticozzi1, F. Schieppati1, A. D’Alessio4, R. Labianca5, A. Falanga1,3 All on behalf of the Hypercan Investigators | 1Hospital Papa Giovanni XXIII, Bergamo, Italy; 2Cardiovascular Research Institute Maastricht, CARIM, Maastricht University, Maastricht, the Netherlands; 3School of Medicine and Surgery, University of Milan Bicocca, Italy; 4University Vita-Salute San Raffaele, Milan, Italy; 5Fondazione ARTET Onlus, Bergamo, Italy
631PDF: 16 -
CO113 | AN OBSERVATIONAL STUDY ON THE EFFECT OF HEMODIALYSIS MEMBRANES ON ENDOGENOUS THROMBIN POTENTIAL IN END-STAGE RENAL DISEASE PATIENTS Z. Saeed1|4, O. Ndrecka2, V. Sirolli2, M. Bonomini2, P. Lanuti1|3, S. Gallina4, G. Rend1|4 | 1Center for Advanced Studies and Technology, G. d’Annunzio University of Chieti-Pescara, Chieti, Italy; 2Nephrology and Dialysis Unit, Department of Medicine, G. d’Annunzio University of Chieti-Pescara, SS. Annunziata Hospital, Chieti, Italy; 3Department of Medicine and Aging Sciences, G. d’Annunzio University of Chieti-Pescara, Chieti, Italy; 4Department of Neuroscience, Imaging and Clinical Sciences, G. d’Annunzio University of Chieti-Pescara, Chieti, Italy
7PDF: 2 -
CO025 | HEPHAESTUS: A DIGITAL ATLAS FOR TRAINING AND STANDARDIZATION OF JOINT POINT-OF-CARE ULTRASOUND IN HEMOPHILIC ARTHROPATHY R. Gualtierotti1|2, N. D'Amico3, S. Mascetti3, M. Fassi1, A. Giachi1, C. Bettini3, F. Peyvandi1|2 | 1Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Milano, Italy; 2Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Milano, Italy; 3Department of Computer Science, Università degli Studi di Milano, Milano, Italy
7PDF: 2 -
PO77 | The clinical awareness of mixing test interpretation in the era of complex reporting algorithm: do we forget the origins? A. Fassina, L. De Valentin, S. Luzi, R. Turrini, A. Antico, L. Zardo | Laboratorio Analisi Castelfranco Veneto, ULSS Marca Trevigiana, Italy
627PDF: 16 -
PO063 | EVALUATION OF PLATELET ACTIVATION MARKERS IN PATIENTS WITH THROMBOTIC THROMBOCYTOPENIC PURPURA M. Di Fuorti1, M.R. Cozzi2, A. Steffan3, I. Quaglia1, C. Sacco1, C. Lodigiani1, M. Bacci1 | 1Center for Thrombosis and Hemorrhagic Diseases, IRCCS Humanitas Research Hospital, Rozzano, Italy; 2Immunopathology and Cancer Biomarkers Unit, Centro di Riferimento Oncologico di Aviano IRCCS, Aviano, Italy; 3Clinical Pathology Unit, ASFO General Hospital, Pordenone, Italy
2PDF: 2 -
CO080 | INVESTIGATING MECHANISMS OF ACQUIRED VON WILLEBRAND SYNDROME ACROSS HEMATOLOGICAL DISEASES: THE CONTRIBUTION OF INTRAPLATELET VWF A. Ciavarella1, L. Baronciani1, O. Seidizadeh1, P. Colpani1, F. Boggio1, D. Cattaneo2|3, S. Ceglie1, M.T. Pagliari1, A. Iurlo2, S.M. Siboni1, F. Peyvandi1|4 | 1Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Milano, Italy; 2Hematology Division, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano, Italy; 3Department of Oncology and Hemato-Oncology, University of Milano, Milano, Italy; 4Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Milano, Italy
9PDF: 2 -
CO-83 | ACQUIRED FACTOR V DEFICIENCY IN A HIGH-THROMBOTIC-RISK PATIENT: DIAGNOSTIC DILEMMA AND SUCCESSFUL MANAGEMENT G. Gazzelli1, L. Banov1, Y. Azzanelli1, C. Vernarecci1, F. Marotta1, F. Giacopelli1, E. Cenni2, V. Agostini2, A.C. Molinari1 | 1IRCCS Istituto Giannina Gaslini, Italy; 2IRCSS AOM S. Martino, Genova, Italy
36PDF: 20 -
PO34 | INVESTIGATORS’ DECISIONS ON ANTICOAGULATION AFTER EXTENDED API-CAT TREATMENT FOR CANCER VENOUS THROMBOEMBOLISM I. Mahé1|4, F. Happe2, M. Monreal5|7, H. Robert-Ebadi8, P. Debourdeau9, J. R. Fabreguettes10, S. Accassat11, P. Mismetti4|11|12, P. Girard13, S. Laporte4|12|14, C. Chapelle14 | 1Paris Cité University; 2Assistance Publique - Hôpitaux de Paris, Louis Mourier Hospital, Department of Internal Medicine; 3Inserm UMR-S970, Paris Cardiovascular Research Center, Team « Endotheliopathy and Hemostasis Disorders », Paris, France; 4F-CRIN INNOVTE Network, France; 5Department of Internal Medicine, Institut de Recerca Germans Trias i Pujol, Hospital Universitari Germans Trias i Pujol, Badalona, Spain; 6Department of Medicine, Universitat Autonoma de Barcelona, Barcelona; 7Universidad Catolica San Antonio de Murcia, Murcia, Spain; 8Division of Angiology and Hemostasis, Faculty of Medicine, Geneva University Hospitals, Geneva, Switzerland; 9Arles Hospital, Oncology unit, Arles, France; 10Assistance Publique - Hôpitaux de Paris, AGEPS, France; 11Service de Médecine Vasculaire et Therapeutique, CHU de Saint-Etienne, Saint-Etienne, France; 12Université Jean Monnet, Mines Saint-Étienne, INSERM Unité 1059, Santé Ingénierie Biologie Saint-Étienne SAINBIOSE, Saint-Étienne, France; 13Département de Pneumologie, Institut Mutualiste Montsouris, Paris; 14Service de Pharmacologie Clinique, CHU de Saint-Etienne, Saint-Etienne, France
423PDF: 90 -
CO49 | The burden of cerebral small vessel disease in ITTP patients from acute phase to remission A. Truma1,2, F. M. Lo Russo1, G. Conte1,2, I. Mancini1, M. Abbattista1, J. A. Giannotta1, A. Artoni1, B. Ferrari1, P. Agosti1,2, F. M. Triulzi1,2, F. Peyvandi1,2 | 1Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Milan; 2Università degli Studi di Milano, Department of Pathophysiology and Transplantation, Milan, Italy
623PDF: 15 -
PO007 | OUTCOMES OF PATIENTS WITH JAK2V617F VAF ≤2% EVALUATED FOR SUSPECTED MYELOPROLIFERATIVE NEOPLASMS E. Morsia, F. Saladino, R. Ceccarelli, L. Gurgoglione, A. Poloni | Università Politecnica delle Marche, Italy
6PDF: 2 -
CO038 | PROGNOSTIC PERFORMANCE OF BLEEDING SEVERITY CLASSIFICATIONS IN HOSPITALIZED PATIENTS WITH GASTROINTESTINAL BLEEDING ON DIRECT ORAL ANTICOAGULANTS G. Maraziti, A. Vinci, M. Verso | Internal and Emergency Medicine - Stroke Unit, S. Maria della Misericordia Hospital – University of Perugia, Perugia, Italy
8PDF: 2 -
CO-54 | DECREASED BONE MINERAL DENSITY IN HEMOPHILIA IS NOT CORRELATED WITH INCREASED RISK OF FRACTURES M.R. Fasulo1, F. Carrone2, G. Mazziotti3|4, A. Colombo1, C. Lodigiani1, M.E. Mancuso1|4 | 1Center for Thrombosis and Hemorrhagic Diseases, IRCCS Humanitas Research Hospital, Rozzano, Milano, Italy; 2Endocrinology and Diabetology Unit, Humanitas Mater Domini, Castellanza, Varese, Italy; 3Endocrinology, Diabetology and Medical Andrology Unit, Metabolic Bone Diseases and Osteoporosis Section, IRCCS Humanitas Research Hospital, Rozzano, Milano, Italy; 4Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milano, Italy
24PDF: 15 -
PO19 | THE INTER-RELATIONSHIP BETWEEN NETOSIS, THE ADAMTS-13/VWF AXIS, AND HEMOSTATIC ACTIVATION IN PATIENTS WITH GYNECOLOGICAL MALIGNANCIES: PROGNOSTIC SIGNIFICANCE AND IMPACT OF CHEMOTHERAPY A. Makatsariya1, E. Beloborodova2,V. Bitsadze1, J. Khizroeva1, A. Vorobev1, A. Solopova1, M. Tretyakova1, N. Gashimova1, K. Grigoreva1, A. Oskolkova1, J. Christophe Gris1|3, I. Elalamy1|4|5, G. Gerotziafas1|4|5 | 1Department of Obstetrics, Gynecology and Perinatal Medicine, N. F. Filatov Clinical Institute of Children’s Health, I. M. Sechenov First Moscow State Medical University Sechenov University, Moscow, Russia; 2MEDSI Network of Medical Centers, Moscow, Russia; 3Faculty of Pharmaceutical and Biological Sciences, Montpellier University, France; 4Department Hematology and Thrombosis Center, Medicine Sorbonne University, Paris, France; 5Hospital Tenon, Paris, France
464PDF: 94 -
PO84 | Beyond the scores: unmasking a silent pulmonary embolism in essential thrombocythemia N. Battino | ASL Sulcis Iglesiente PO CTO, Italy
639PDF: 13 -
PO39 | Bleeding events in Von Willebrand disease type 1 yearly treatable with desmopressin A. Gringeri1,2, P.M. Mannucci3, M. Gringeri4, G. Castaman5, F. Peyvandi3,6 | 1Fondazione Charta, Milan; 2Centro di Sanità Solidale, Lucca; 3Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Angelo Bianchi Bonomi Hemophilia and Thrombosis Center and Fondazione Luigi Villa, Milan; 4Department of Medical Biotechnologies and Translational Medicine, Postgraduate School of Clinical Pharmacology and Toxicology, University of Milan; 5Centre for Bleeding Disorders and Coagulation, Careggi University Hospital, Firenze; 6Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Italy
636PDF: 23 -
CO092 | FOSTAMATINIB IN CHRONIC IMMUNE THROMBOCYTOPENIA: A REAL-WORLD MONOCENTRIC EXPERIENCE M. Biglietto, S. Sorella, S. Ligia, S. Santostefano, R. Celia, R. Mormile, E. Baldacci, A. Chistolini, C. Santoro | Sapienza University of Roma, Italy
9PDF: 2 -
BEST-06 | OPTIMIZING LABORATORY MONITORING OF EFANESOCTOCOG ALFA: IMPACT OF APTT REAGENTS AND CHROMOGENIC ASSAYS ON DIAGNOSTIC ACCURACY A. Strangio, A. Ierardi, M. Leotta, L.C. Elia, M. Falbo, C. Condina, G. Procopio, R.C. Santoro | Hemophilia Hemostasis and Thrombosis Unit, Azienda Ospedaliero Universitaria Renato Dulbecco, Catanzaro, Italy
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PO122 | SUCCESSFUL MANAGEMENT OF THERAPEUTIC ANTICOAGULATION FOR PROVOKED VENOUS THROMBOEMBOLISM IN A PATIENT WITH FACTOR VII DEFICIENCY AND SEPTIC SHOCK S. Birocchi1, F.M. Monda1, B. Clerici1|2, M. Scavone2, R. Cabiddu1, E. Pontisso1, C. Ortelli1, M.L.G. Perego1, E. Fiorini1, L. Catarini1, A. Bortoli1, M. Manzoni1, F.M. Casanova1, A. Tripodi2|3, F. Peyvandi2|3, G.M. Podda1|2 | 1S.C. Medicina Generale 2, Ospedale San Paolo, ASST Santi Paolo e Carlo, Milano, Italy; 2Dipartimento di Scienze della Salute, Università degli Studi di Milano, Italy; 3Centro di riferimento emofilia e trombosi "Emilio Bianchi"; 4S. Birocchi and F.M. Monda contributed equally as co-first authors
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PO022 | ARTIFICIAL INTELLIGENCE–ASSISTED PREDICTION OF THROMBOTIC AND HEMORRHAGIC COMPLICATIONS IN PATIENTS TREATED WITH VITAMIN K ANTAGONISTS: A RETROSPECTIVE EXPLORATORY STUDY G. Sottilotta1, F. Misiti2, G. Praticò1, D. Megalizzi1, F. Luise3 | 1UOSD Microcitemie - Emostasi e Trombosi; 3Laboratorio Analisi Grande Ospedale Metropolitano di Reggio Calabria, Italy; 2Associazione Emofilici di Reggio Calabria, Italy
6PDF: 2 -
CO061 | IMMUNOFLUORESCENCE MICROSCOPY REVEALS PLATELET- AND RED BLOOD CELL ALTERATIONS AS MORPHOLOGICAL BIOMARKERS IN MYELOPROLIFERATIVE NEOPLASMS C. Zaninetti1, L. Kaderali2, L. Vater1, S. Semenowitsch1, L. Porges1, T.M. Schnöder3|4, C.C. Crodel5, J. Fuhrmann1, J. Wesche1, C. Freyer1, T. Thiele1, F.H. Heidel3|6, A. Greinacher1 | 1Institut für Transfusionsmedizin Universitätsmedizin Greifswald, Greifswald, Germany; 2Institut für Bioinformatik, Universitätsmedizin Greifswald, Greifswald, Germany; 3Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany; 4Innere Medizin C, Universitätsmedizin Greifswald, Greifswald, Germany; 5Innere Medizin II, Abt. Hämatologie und Onkologie, Universitätsklinikum Jena, Jena, Germany; 6Leibniz Institute on Aging, Fritz-Lipmann Institute, Jena, Germany
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PO96 | Patient management with arteriovenous thrombotic manifestation and hemorrhagic complications M. Aversano, E. Cimino, L. Jr Valletta, C. Caputo, M. Romeo, M.D. Di Minno, A. Tufano, I.L. Calcaterra, C. De Luca, R. Russo, G. D’errico, P. Conca | Università degli Studi Federico II, Napoli, Italy
586PDF: 14 -
CO109 | THE ROLE OF SELECTED LDLR AND LRP1 VARIANTS IN MODULATING LDL AND FVIII LEVELS IN METABOLIC SYNDROME P. Agosti1|2, A. Cairo2, S. Spena2, S. Pelusi3, F. Malvestiti1, D. Prati3, M. Clerici2, E. Scalambrino2, A. Tripodi1|2, V. La Mura1|2, L. Valenti1|3, F. Peyvandi1|2 | 1Università degli Studi di Milano, Department of Pathophysiology and Transplantation, Milano, Italy; 2Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, and Fondazione Luigi Villa, Milano, Italy; 3Biological Resource Center and Department of Transfusion Medicine, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano, Italy
2PDF: 2 -
CO-19 | A CASE OF LOSS OF EFFICACY OF EMICIZUMAB AFTER 6 YEARS OF REGULAR USE M.R. Fasulo1, I. Quaglia1, A. Colombo1, C. Lodigiani1, M.E. Mancuso1|2 | 1Center for Thrombosis and Hemorrhagic Diseases, IRCCS Humanitas Research Hospital, Rozzano, Milano, Italy; 2Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milano, Italy
24PDF: 14 -
PO06 | ACTIVATED PLATELETS INDUCE THE FORMATION OF NEUTROPHIL EXTRACELLULAR TRAPS VIA TOLL-LIKE RECEPTOR-4 AND P-SELECTIN GLYCOPROTEIN LIGAND-1 I.C. Moschonas, A.D. Tselepis | Atherothrombosis Research Centre, University of Ioannina, Greece
471PDF: 97 -
PO136 | PHENOTYPE CHARACTERIZATION OF PATIENTS HOSPITALIZED FOR ACUTE SARS-COV2 INFECTION WITH AND WITHOUT ACUTE CEREBRAL ISCHEMIA P. Agosti1|2, R. Gualtierotti1|2, C. Suffritti1, L. Valenti2|3, M. Morena2, M. Tettamanti4, A. Nobili4, A. Bandera2|5, F. Peyvandi1|2 | 1Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Milano, Italy; 2Università degli Studi di Milano, Department of Pathophysiology and Transplantation, Milano, Italy; 3Department of Transfusion Medicine and Biological Resource Center, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano, Italy; 4Department of Health Policy, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milano, Italy; 5Department of Infectious Diseases, Fondazione IRCCS Ca’ Granda, Ospedale Maggiore Policlinico, Milano, Italy
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PO061 | LONG-TERM HEADACHE IMPROVEMENT WITH VITAMIN K ANTAGONISTS IN PRIMARY AND SECONDARY ANTIPHOSPHOLIPID SYNDROME: 2-YEAR OBSERVATIONAL COHORT A. Hoxha1|2, C. Belizna3, E. Esteve-Valverde4, A. Prundean5, A. Godon6, G. Gobbo1|2, A. Anunciación-Llunell7|8|9, R. Ferrer-Oliveras10, J.O. Latino11, S. Udry11, J. Alijotas-Reig7|8|9 | 1Department of Medicine, University of Padua, Padova, Italy; 2Internal Medicine Unit, Thrombosis and Bleeding Disorder Center, University Hospital of Padua, Padova, Italy; 3Vascular and Coagulation Department, University Hospital Angers, Angers, France; 4Systemic Autoimmune Diseases Unit, Department of Internal Medicine, Hospital Sant Camil, Consorci Sanitari del Garraf, Barcelona, Spain; 5University of Angers, Inserm, CNRS, MITOVASC, SFR ICAT, Angers, France; 6Centre Hospitalier Universitaire Angers, Institut National de la Santé et de la Recherche Médicale, Centre National de la Recherche Scientifique, Centre de Recherche en Cancérologie et Immunologie Intégrée Nantes Angers, Laboratoire d'Hématologie, Université d'Angers, Nantes Université, Angers, France; 7Department of Medicine, Universitat Autònoma de Barcelona, Spain; 8Systemic Autoimmune Disease Unit, Department of Internal Medicine, Vall d'Hebron University Hospital, Spain; 9Systemic Autoimmune Diseases Research Unit, Vall d'Hebron Institut de Recerca, Barcelona, Spain; 10Obstetrics Department, High-Risk Unit, Hospital Universitario Quirónsalud, Barcelona, Spain; 11Autoimmune, Thrombophilic Diseases and Pregnancy Division, Dr. Carlos G. Durand Hospital, Buenos Aires, Argentina
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CO076 | ASSOCIATION OF MATRIX METALLOPROTEINASE 2 PLASMA LEVELS WITH CARDIOVASCULAR EVENTS IN PATIENTS WITH ATRIAL FIBRILLATION: A NESTED CASE CONTROL STUDY FROM THE ATHERO-AF COHORT D. Menichelli1, E. Falcinelli2, P. Pignatelli3, R. Carnevale4|5, A. D’Amico4, F. Violi2, P. Gresele2, D. Pastori4|5, F. Paciullo6 | 1Dip. di Chirurgia Generale e Specialità Chirurgiche Paride Stefanini, Università La Sapienza, Roma, Italy; 2Dip. di Medicina e Chirurgia, Sez. di Medicina Interna Cardiovascolare, Università degli Studi di Perugia, Italy; 3Dip. di Scienze Medico-Chirurgiche e Biotecnologie, Università La Sapienza, Latina, Italy; 4IRCCS Neuromed, Pozzilli, Isernia, Italy; 5Dip. di Scienze Mediche e Cardiovascolari, Università La Sapienza, Roma, Italy; 6Fac. di Medicina e Chirurgia , Vita-Salute San Raffaele University, Milano, Italy
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CO-80 | EMICIZUMAB PLASMA CONCENTRATIONS AND CLINICAL OUTCOMES IN ACQUIRED HEMOPHILIA A: A REAL-WORLD SINGLE-CENTER EXPERIENCE C. Simion1|2, E. Zanon1|2, C. Bulato1, B. Stocco1|2, F. Righetto1, F. Sartorello1, P. Simioni1|2 | 1First Chair of Internal Medicine and Thrombotic and Haemorrhagic Diseases Unit, Department of Medicine, Padova University Hospital, Italy; 2Hemophilia Center, Padova University Hospital, Italy
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PO58 | Gender differences in primary haemostasis A. Becchetti2, M. Brambilla2, M. Conti2, D. Trabattoni2, E. Tremoli3, M. Camera1,2 | 1Department of Pharmaceutical Sciences, Università degli Studi di Milano; 2Centro Cardiologico Monzino IRCCS, Milan; 3Maria Cecilia Hospital, Cotignola (RA), Italy
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CO036 | NEUROCOGNITIVE ASSESSMENT OF IMMUNE-MEDIATED THROMBOTIC THROMBOCYTOPENIC PURPURA PATIENTS USING A COMPREHENSIVE TEST BATTERY IN A CROSS-SECTIONAL MRI-INTEGRATED STUDY A. Truma1, T. Difonzo2, F. Lo Russo3, G. Conte3|4, I. Mancini1, E. Cesari1, M. Gagliardi1, J.A. Giannotta1, A. Artoni1, E. Piccin3, P. Agosti4, F. Triulzi3|4, F. Peyvandi1|4 | 1Fondazione IRCCS Ca’ Granda ospedale maggiore policlinico, Angelo Bianchi Bonomi hemophilia and thrombosis center, Milano, Italy; 2Fondazione IRCCS Ca’ Granda ospedale maggiore policlinico, neurology unit, Milano, Italy; 3Fondazione IRCCS Ca’ Granda ospedale maggiore policlinico, neuroradiology unit, Milano, Italy; 4Università degli studi di Milano, Milano, Italy
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PO14 | SYMPTOM BURDEN IN PATIENTS WITH CANCER AND THROMBOEMBOLISM: A POPULATION-BASED MATCHED COHORT STUDY D. Siegal1|2, Z. O’Neill1|2, L. Nguyen3, N. Liu3, M. Carrier1|2, R. Sutradhar3|4 | 1Ottawa Hospital Research Institute, Ottawa; 2Department of Medicine, University of Ottawa, Ottawa; 3ICES, Toronto, Canada; 4Dalla Lana School of Public Health, University of Toronto, Toronto, Canada
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PO072 | DIAGNOSTIC CHALLENGES IN THROMBOTIC MICROANGIOPATHY: A CASE OF ATYPICAL HEMOLYTIC UREMIC SYNDROME M. Moretti1, R. Gervasi2, E. Rossini2, G.F. Romiti1, P. Carfagna2, S. Basili1, P. Battisti2 | 1Azienda Ospedaliero-Universitaria Policlinico Umberto I, Roma, Italy; 2Azienda Ospedaliera San Giovanni Addolorata, Roma, Italy
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BEST-05 | LONG-TERM EMICIZUMAB PROPHYLAXIS IN PEOPLE WITH HEMOPHILIA A: REAL-WORLD EXPERIENCE ACROSS ALL AGES A. Colombo1, I. Quaglia1, M.R. Fasulo1, C. Lodigiani1, M.E. Mancuso1|2 | 1Center for Thrombosis and Hemorrhagic Diseases, IRCCS Humanitas Research Hospital, Rozzano, Milano, Italy; 2Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milano, Italy
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OC05 | TIME TO START OF ANTICOAGULANT THERAPY AND SURVIVAL OUTCOMES IN CANCER PATIENTS WITH PULMONARY EMBOLISM K. Bria, B. Gage, M. Bealsey, K. Sanfilippo | Washington University in St. Louis School of Medicine, St. Louis, MO, USA
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PO64 | A silent hemorrhage in the immuno-thrombotic chaos of antiphospholipid syndrome G. Autiero, S.A. Malerba, A. Malaguti, M. Dalla Vestra, F. Presotto | Medicina Generale, Ospedale dell’Angelo, Mestre-Venezia, Italy
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PO08 | Efficacy and safety of thromboprophylaxis in hospitalized hematological patients: a monocenter retrospective study S. Cordella1,2, V. Coluccio3, M. Luppi1, M. Marietta1 | 1Department of Medical and Surgical Sciences, Section of Hematology. University of Modena and Reggio Emilia, Azienda Ospedaliero-Universitaria di Modena; 2Clinical and Experimental Medicine PhD Programme, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena; 3Department of Hematology, Unità Sanitaria Locale di Modena, Italy
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CO054 | ULTRA-PROCESSED FOOD CONSUMPTION IS ASSOCIATED WITH AN INCREASED RISK OF UNPROVOKED VENOUS THROMBOEMBOLISM IN THE MOLI-SANI STUDY M. Bonaccio1, A. Di Castelnuovo1, S. Costanzo1|2, T. Panzera1, C. Cerletti1, MB. Donati1, G. de Gaetano1, W. Ageno3, L. Iacoviello1|4 | 1Research Unit of Epidemiology and Prevention, IRCCS NEUROMED, Pozzilli (IS), Italy; 2Dep. of Medicine and Surgery, University of Insubria, Varese, Italy; 3Dep. of Medicine, Università degli Studi di Padova, Padova, Italy; 4Dep. of Medicine and Surgery LUM University, Casamassima (BA), Italy
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Development of a shared decision-making tool for gene therapy in hemophilia A in Italy
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The evolving landscape of gene therapy for congenital severe hemophilia: a 2024 state of the art
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CO102 | VARIABILITY IN ANTIPHOSPHOLIPID ANTIBODY TESTING AND TREATMENT STRATEGIES IN OBSTETRIC ANTIPHOSPHOLIPID SYNDROME: RESULTS FROM THE OAPS-CARE SURVEY, ON BEHALF OF THE EUROPEAN FORUM ON ANTIPHOSPHOLIPID ANTIBODIES A. Hoxha1|2, E. Esteve-Valverde3|4, G. Gobbo1|2, F. Miró-Mur4, M. Radin5, S. De Carolis6, C. Trilla7|8|9|10, A. Tincani11|12, R. Cervera13|14, J. Alijotas-Reig3|15|16 | 1Department of Medicine - DIMED, University of Padua, Padova, Italy; 2Internal Medicine Unit, Thrombosis and Bleeding Disorder, University Hospital of Padua, Padova, Italy; 3Systemic Autoimmune Diseases Unit. Department of Internal Medicine, Hospital Sant Camil, Consorci Sanitari Alt-Penedes-Garraf, Sant Pere de Ribas, Barcelona, Spain; 4Systemic Autoimmune Disease Research Unit. Vall d'Hebron Institut de Recerca (VHIR), Barcelona, Spain; 5Center of Research of Immunopathology and Rare Diseases - Coordinating Center of Piemonte and Valle d'Aosta Network for Rare Diseases, SCDU Nephrology and Dialysis, School of Specialization of Clinical Pathology, Department of Clinical and Biological Sciences, S. Giovanni Bosco Hospital, University of Turin, Torino, Italy; 6Fondazione Policlinico Universitario A. Gemelli IRCCS, Dipartimento di Scienze per la salute della Donna e del Bambino e di Sanità Pubblica, Roma, Italy; 7Hospital de la Santa Creu i Sant Pau, Barcelona, Spain; 8Universitat Autònoma de Barcelona, Barcelona, Spain; 9Spanish Network in Maternal, Neonatal, Child and Developmental Health Research (RICORS-SAMID, RD24/0013/0001), Instituto de Salud Carlos III, 28040 Madrid, Spain; 10Women and Perinatal Health Research Group, Institut de Recerca (IR SANT PAU), Sant Quintí 77-79, 08041 Barcelona, Spain; 11Rheumatology and Clinical Immunology Unit - ERN ReCONNET, ASST Spedali Civili, Brescia, Italy; 12Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy; 13Department of Autoimmune Diseases, Hospital Clínic, University of Barcelona, Barcelona, Catalonia, Spain; 14August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Catalonia, Spain; 15Department of Medicine. Universitat Autonoma de Barcelona, Barcelona, Spain; 16Systemic Autoimmune Disease Unit, Department of Internal Medicine, Vall d’Hebron University Hospital, Barcelona, Spain
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CO-10 | APPLICATIONS OF ARTIFICIAL INTELLIGENCE IN HEMOPHILIA MANAGEMENT: INNOVATIONS AND FUTURE PERSPECTIVES A. Ierardi, M. Leotta, A. Strangio, S. Prejanò, R.C. Santoro | UO Hemophilia, Hemostasis and Thrombosis. Azienda Ospedaliero Universitaria Renato Dulbecco, Catanzaro, Italy
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PO05 | DESIGN, SYNTHESIS, AND BIOLOGICAL EVALUATION OF NOVEL IMATINIB AND NILOTINIB ANALOGUES EXPRESSING ENHANCED ANTIPLATELET AND ANTICANCER ACTIVITIES D. Pantazi1, L. Pechlivani1, A. Kosma1, K. Lalechou1, M.G. Siskos2, D. Alivertis3, A.D. Tselepis1 | 1Atherothrombosis Research Centre, Laboratory of Biochemistry, Department of Chemistry, University of Ioannina, Greece; 2Laboratory of Organic Chemistry, Department of Chemistry, University of Ioannina, Greece; 3Department of Biological Applications and Technology, University of Ioannina, Greece
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PO26 | Non-canonical coagulation platelets function: monocyte-platelet interaction a bridge between inflammation and coagulation A. Benetti1, A. Galbiati1, M. Cola2, L. Calandrino2, C. Samà1, D. Regazzo1, S. Ferrari1, C.M. Radu1, A. Cattelan2, P. Simioni1 | 1Department of Medicine - DIMED; 2Infectious and Tropical Diseases Unit, Padua University Hospital, Padua, Italy
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PO135 | CHRONIC ERYTHROCYTE REMODELING AND IMPAIRED RHEOLOGICAL FUNCTION IN PATIENTS WITH PATENT FORAMEN OVALE M. Conti1, D. Trabattoni1, T. Congiu2, A. Becchetti1, P. Della Valle1, M. Brambilla1, K. Nallio1, L.V. Renna3, R. Cardani3, M. Chessa3, V. Fanos4, M. Camera1|5 | 1Centro Cardiologico Monzino IRCCS, Milano, Italy; 2Università degli Studi di Cagliari, Cagliari, Italy; 3IRCCS Policlinico San Donato, San Donato, Milano, Italy; 4University Hospital of Cagliari, Monserrato, Cagliari, Italy; 5Università degli Studi di Milano, Department of Pharmaceutical Sciences, Milano, Italy
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PO055 | THROMBIN GENERATION PROFILES IN PATIENTS WITH WILD-TYPE TRANSTHYRETIN AMYLOIDOSIS L. Spiezia1, A. Napolitano1, C. Bulato1, S. Toffanin1, A. Benetti1, C. Samà1, L. De Michieli2, G. Sinigiani2, A. Cipriani2, P. Simioni1 | 1Dipartimento di Medicina, Azienda Osp. Università di Padova, Italy; 2Dipartimento di Scienze cardio toraco vascolari, Azienda Osp. Università di Padova, Italy
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CO075 | PLATELET ACTIVATION PROFILE IN RELAPSING-REMITTING MULTIPLE SCLEROSIS AND ITS RELATIONSHIP WITH NEURONAL AND ASTROGLIAL BIOMARKERS A. Fioretti1, M. Scavone1, A. Mingione2|3, C. Monzani2|3, M. Miozzo4, F. Martinelli-Boneschi2|3|5, G.M. Podda1 | 1Division of Medicina Generale SP, ASST Santi Paolo e Carlo, Laboratory of Haemostasis and Thrombosis, Dipartimento di Scienze della Salute, Università degli Studi di Milano, Milano, Italy; 2Laboratory of Precision Medicine of Neurological Diseases, Department of Health Science, University of Milano, Milano, Italy; 3CRC “Aldo Ravelli” for Experimental Brain Therapeutics, Department of Health Science, University of Milano, Milano, Italy; 4Department of Health Sciences, Division of Medical Genetics, University of Milano, ASST Santi Paolo e Carlo, Milano, Italy; 5Clinical Neurology Unit, ASST Santi Paolo e Carlo and Department of Health Sciences, University of Milano, Milano, Italy
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CO-78 | REAL-WORLD MANAGEMENT OF ACQUIRED HEMOPHILIA A: FOCUS ON RECOMBINANT PORCINE FVIII AS FIRST-LINE HEMOSTATIC TREATMENT AND LONG-TERM OUTCOMES M. Leotta, A. Strangio, A. Ierardi, R.C. Santoro | Hemophilia, Hemostasis and Thrombosis Centre, Azienda Ospedaliero Universitaria Renato Dulbecco, Catanzaro, Italy
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CO033 | THE BURDEN OF CEREBRAL SMALL VESSEL DISEASE AND GLOBAL CORTICAL ATROPHY IN PATIENTS WITH IMMUNE-MEDIATED THROMBOTIC THROMBOCYTOPENIC PURPURA DURING REMISSION A. Truma1, F. Lo Russo2, G. Conte2|3, I. Mancini1, E. Cesari1, M. Gagliardi1, J.A. Giannotta1, A. Artoni1, E. Piccin2, P. Agosti3, F. Triulzi2|3, F. Peyvandi1|3 | 1Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Milano, Italy; 2Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Neuroradiology Unit, Milano, Italy; 3Università degli Studi di Milano, Milano, Italy
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CO-45 | BRIDGING THE CLINICAL CHASM: GENETIC ANALYSIS AS A CONFIRMATORY TOOL IN MISMATCHED GLANZMANN THROMBASTHENIA R. Pastorino1|3, F. Bocchi1|3, A. Valpreda4, G. Murante1|2|3, S. Bergonzi1|2|3, M. Capetta1|2|3, F. Valeri1|2, C. Dainese1|2, M. Gilestro5, D. Peruccio6, E. De Candia7, P. Concolino8, B. Bruno2|3, A. Borchiellini1|2 | 1Regional Centre for Hemorrhagic and Thrombotic Diseases, AOU Città della Salute e della Scienza, Italy; 2Division of Hematology, AOU Città della Salute e della Scienza and University of Turin, Italy; 3Department of Molecular Biotechnology and Health Sciences, University of Turin, Italy; 4Central Laboratory Baldi and Riberi, AOU Città della Salute e della Scienza di Torino, Italy; 5AOU Citta' della Salute e della Scienza, PO Molinette, Anatomy and Pathological Histology 1 U, Department of Laboratory Medicine - Flow Cytometry Laboratory, Torino, Italy; 6AOU Citta' della Salute e della Scienza di Torino, Maternal-Infant and Trauma Transfusion Medicine, Regina Margherita Hospital, Department of Laboratory Medicine, Torino, Italy; 7Haemostasis and Thrombosis Unit, Fondazione Policlinico Universitario A.Gemelli, IRCCS, Department of Translational Medicine, Università Cattolica del Sacro Cuore, Roma, Italy; 8Fondazione Policlinico Universitario A. Gemelli, IRCCS, Department of Laboratory and Hematological Sciences, Unit of Clinical Chemistry, Biochemistry and Molecular Biology, UOSD of Molecular and Genomic Diagnostics, Roma, Italy
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PO070 | INFECTIVE ENDOCARDITIS AND ISCHEMIC CEREBRAL EVENTS IN A PATIENT WITH SYSTEMIC LUPUS ERYTHEMATOSUS AND TRIPLE ANTIPHOSPHOLIPID POSITIVITY: THE ROLE OF ANTICOAGULATION IN PRIMARY PREVENTION T. Marrazzo1, M.P. Ursi2, R. Andini1, R. Albisinni3 | 1UOC Med Interna e dei Trapianti; 2UOC Mecau; 3UOC CCH generale, Osp. Monaldi AORN dei Colli, Napoli, Italy
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CO004 | A NOVEL GENETIC CLASSIFICATION OF INHIBITOR RISK FOR F8 NONSENSE MUTATIONS BASED ON IMMUNOGENIC PROFILING OF RIBOSOMAL READTHROUGH M.F. Testa1, M. Pinotti1, A. Branchini1, M.E. Mancuso2, F. Bernardi1, D. Balestra2 | 1Department of Life Sciences and Biotechnology and LTTA Center, University of Ferrara, Ferrara, Italy; 2IRCCS, Humanitas Research Hospital, Center for Thrombosis and Hemorrhagic diseases, Milano, Italy
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BEST-02 | PERIOPERATIVE BLEEDING IN CHILDREN WITH LOW VON WILLEBRAND FACTOR UNDERGOING ADENOID AND TONSIL SURGERY: A 15-YEAR SINGLE-CENTER EXPERIENCE T. Martini1, B. Borsellino1|2, B. Pollio1 | 1Haemophilia Centre, Immune-Haematology and Transfusion Medicine, University Hospital “Città della Salute e della Scienza”, Torino, Italy; 2Department of Biomedicine and Prevention, PhD in Immunology, Molecular Medicine and Applied Biotechnology, University of Rome Tor Vergata, Roma, Italy
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CO050 | INTERACTION BETWEEN DIRECT ORAL ANTICOAGULANTS AND ANTIEPILEPTIC DRUGS: A MULTICENTER OBSERVATIONAL STUDY A. Lipari1, S. Sorrentino1, M. De Siati1, L. D'Innocenzo1, A. Ferretti1, D. Menichelli2, V. Cammisotto2, P. Pignatelli2, G. Ragna3, MC. Vedovati3, C. Becattini3, G. Frisullo4, V. Forte5, T. Pirozzi1, L. Di Gennaro1, M. Basso1, E. De Candia1 | 1Unit of Haemostasis and Thrombosis Diseases, Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italy; 2Department of Clinical Internal, Anesthesiological and Cardiovascular Sciences, Sapienza University of Roma, Roma, Italy; 3Department of Internal and Cardiovascular Medicine and Stroke Unit, University of Perugia, Perugia, Italy; 4Dipartimento di Neuroscienze, Organi di Senso e Torace, Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italy; 5Hematology, Department of Biomedicine and Prevention, University of Rome Tor Vergata, Roma, Italy
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PO24 | WE ARE JUGGLING MANY POSSIBILITIES: HEALTHCARE PROFESSIONALS’ EXPERIENCES AND PERSPECTIVES ON INTERPRETATION OF PULMONARY EMBOLISM SIGNS AND SYMPTOMS IN PATIENTS WITH LUNG CANCER A.A. Højen1, M. Søgaard1, A.G. Ording1, M.R. Saugbjerg2, T.D. Christensen2|3, H.R. Jacobsen4, L. Jørgensen5, H. Enggaard5 | 1Danish Center for Health Services Research, Aalborg University Hospital; 2Department of Cardiothoracic Surgery, Aarhus University Hospital; 3Department of Clinical Medicine, Aarhus University Hospital; 4Department of Oncology, Aalborg University Hospital; 5Clinical Nursing Research Unit, Aalborg University Hospital, Denmark
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PO44 | Emicizumab in acquired haemophilia A M. Leotta, A. Strangio, A. Ierardi, S. Prejanò, R C. Santoro | Hemostasis and Thrombosis Unit, Department Hemato-Oncology, Azienda Ospedaliero-Universitaria Renato; Dulbecco, Catanzaro, Italy
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PO088 | INVESTIGATING THE MEAN PLATELET VOLUME OF PATIENTS WITH LIVER CIRRHOSIS AND CHRONIC LIVER DISEASE: A CASE-CONTROL STUDY B. Clerici1|2, C. Pisetta1, C. Urtis1|2, C. Brizio1, G. Vismara3, S. Vavassori4, A.L. Crosignani4, M. Scavone2, S. Birocchi1, S. De Matteis2|5, P.M. Battezzati2|4, M.N. Cattaneo6, G.M. Podda1|2 | 1S.C. Medicina Generale SP, Ospedale San Paolo, ASST Santi Paolo e Carlo, Milano, Italy; 2Dipartimento di Scienze della Salute (DISS), Università degli Studi di Milano, Milano, Italy; 3Servizio di Immunoematologia e Medicina Trasfusionale (SIMT), Ospedale San Paolo, ASST Santi Paolo e Carlo, Milano, Italy; 4S.C. Medicina ad indirizzo Epatologico e Gastroenterologia, Ospedale San Paolo, ASST Santi Paolo e Carlo, Università degli Studi di Milano, Milano, Italy; 5S.S. Medicina del Lavoro, Ospedale San Paolo, ASST Santi Paolo e Carlo, Università degli Studi di Milano, Milano, Italy; 6Fondazione Arianna Anticoagulazione, Bologna, Italy. B. Clerici contributed equally as co-first authors
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CO-01 | BLEEDING EVENTS IN MILD HEMOPHILIA A AND VON WILLEBRAND DISEASE TYPE 1 YEARLY TREATABLE WITH DESMOPRESSIN IN ITALY A. Gringeri1|2, P.M. Mannucci3, G.C. Castaman4, F. Peyvandi3|5 | 1Fondazione Charta, Milano, Italy; 2Centro di Sanità Solidale, Lucca, Italy; 3Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Angelo Bianchi Bonomi Hemophilia and Thrombosis Center and Fondazione Luigi Villa, Milano, Italy; 4Centre for Bleeding Disorders and Coagulation, Careggi University Hospital, Firenze, Italy; 5Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Italy
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PO25 | Baseline thrombin generation test does not predict thrombotic events in acute leukemia: a monocentric prospective study M. Biglietto, R. Mormile, M.L. Bisegna, A. Laganà, A. L. Faccini, A. Papa, E. Baldacci, C. Santoro, M.S. De Propris, A. Chistolini | Hematology, Department of Translational and Precision Medicine Sapienza University of Roma, Italy
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PO038 | GLOBAL IMPLEMENTATION AND CLINICAL USE OF POINT-OF-CARE JOINT ULTRASOUND IN HEMOPHILIA: RESULTS FROM AN INTERNATIONAL SURVEY R. Gualtierotti1|2, C. Tedesco1, S. Acharya3, N. Bakeer4, M.N.D. Di Minno5, M. Fassi1, A. von Drygalski6, K. Fijnvandraat7, A. Boban8, C. Martinoli9|10, N. O'connell11, M. Sigl-Kraetzig12, A. Srivastava13, F. Peyvandi1|2 | 1Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Milano, Italy; 2Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Milano, Italy; 3Division of Pediatric Hematology, Oncology and Stem Cell Transplant, Cohen Children's Medical Center, Northwell Health, New York, United States; 4Division of Hematology, Children's Hospital of Philadelphia, Philadelphia, United States; 5Department of Clinical Medicine and Surgery, Federico II University, Napoli, Italy; 6Division of Hematology/Oncology, Department of Medicine, University of California San Diego, La Jolla, United States; 7Emma Children's Hospital, Pediatric Hematology, University of Amsterdam, Amsterdam, The Netherlands; 8Haemophilia Centre, Department of Haematology, University Hospital Centre Zagreb, Zagreb, Croatia; 9Department of Health Science, University of Genoa, Genova, Italy; 10istituto di Ricovero e Cura a Carattere Scientifico San Martino Hospital, Unit of Radiology, Genova, Italy; 11National Coagulation Centre, St. James's Hospital, Dublin, Ireland; 12Institute for Paediatric Research and Further Education, Blaubeuren, Germany; 13Haematology Research Unit, St. John's Research Institute & Department of Clinical Haematology, St. John's Medical College Hospital, Bengaluru, India
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CO066 | COAGULOPATHY IN CAR-T CELL-TREATED PATIENTS WITH LYMPHOPROLIFERATIVE DISORDERS: A RETROSPECTIVE, SINGLE-CENTER OBSERVATIONAL STUDY I. Santo1, R. Morganti2, G. Leoni3, G. Tancredi3, L. Contino4, S. Galimberti3, R.M. Santi4, E. Orciuolo5 | 1Azienda Toscana Nord Ovest, Versilia Hospital, Italy; 2Hematology Division AOUP, Pisa, Italy; 3University of Pisa, Hematology Pisa, Italy; 4Azienda Ospedaliera Universitaria Alessandria, Italy; 5Azienda Ospedaliera Universitaria Pisana, Hematology Pisa, Italy
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CO-77 | PERINATAL MANAGEMENT IN WOMAN WITH MILD HEMOPHILIA B: A TWIN PREGNANCY CASE T. Martini1, B. Borsellino1|2, B. Pollio1 | 1Haemophilia Centre, Immune-Haematology and Transfusion Medicine, University Hospital “Città della Salute e della Scienza”, Torino, Italy; 2Department of Biomedicine and Prevention, PhD in Immunology, Molecular Medicine and Applied Biotechnology, University of Rome Tor Vergata, Roma, Italy
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CO32 | Major surgery in patients with severe hemophilia A without inhibitors receiving prophylaxis with fitusiran E. Zanon, C. Simion, A. Napolitano, L. Spiezia, P. Simioni | Haemophilia Center, First Chair of Internal Medicine, Department of Medicine, University-Hospital of Padua Medical School, Padua, Italy
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