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  The landscape of rare coagulation factor deficiency management in Italy: a national hemophilia center survey

  Silvia Linari, Renato Marino, Marzia Leotta, Antonio Coppola, Patrizia Di Gregorio, Augusto Bramante Federici, Flora Peyvandi, Cristina Santoro, Ezio Zanon, Rita Carlotta Santoro

  05-11-2025

  https://doi.org/10.4081/btvb.2025.369

  1360

  PDF: 220

  HTML: 135

  Appendix: 120
• 

  Bioequivalence of von Willebrand factor-containing concentrates: implications for the choice in patients with von Willebrand disease. A position paper from the Italian Association of Hemophilia Centers

  Ezio Zanon, Giancarlo Castaman, Augusto Bramante Federici, Maria Elisa Mancuso, Gianfranco Pasut, Alberto Tosetto, Angiola Rocino, Rita Carlotta Santoro

  26-01-2026

  https://doi.org/10.4081/btvb.2026.415

  1307

  PDF: 347

  HTML: 165

• PO162 | A RARE CASE OF PLATELET DISORDER MIMICKING HEMOPHILIA A M. Shani, T. Goxhaj | Mother Theresa University Hospital, Università Nostra Signora Dell Buon Consiglio, Tirana, Albania

  Marsela Shani

  26-10-2026

  https://doi.org/10.4081/btvb.2026.978

  22

  PDF: 10

• PO27 | B-cell lymphoproliferative disorder and acquired coagulopathy: an insidious link C. Caputo, P. Conca, I.L. Calcaterra, E. Cimino, M. Romeo, M. Aversano, E. Franco, C. De Luca, R. Russo, C. Fierarossa, M.N.D. Di Minno, A. Tufano | Department of Clinical Medicine and Surgery, Federico II University, Naples, Italy

  22-10-2025

  https://doi.org/10.4081/btvb.2025.288

  623

  PDF: 15

• CO-86 | A RARE CASE OF ACQUIRED HEMOPHILIA A ASSOCIATED WITH MYELOPROLIFERATIVE NEOPLASM A. Ierardi, A. Strangio, M. Leotta, R.C. Santoro | Hemophilia, Hemostasis and Thrombosis Unit, Azienda Ospedaliero Universitaria Renato Dulbecco, Catanzaro, Italy

  Antonella Ierardi

  14-10-2026

  https://doi.org/10.4081/btvb.2026.696

  41

  PDF: 18

• PO78 | Acquired hemophilia A as a paraneoplastic syndrome: two cases report on a rare coexistence M. Gagliardi, L. Capone, A. Ciampa | Centro Emostasi, AORN Moscati, Avellino, Italy

  22-10-2025

  https://doi.org/10.4081/btvb.2025.347

  643

  PDF: 19

• PO056 | SYNERGISTIC EFFECT OF RECOMBINANT FACTOR INFUSION ON THROMBIN GENERATION IN HEMOPHILIA PATIENTS UNDER EMICIZUMAB OR CONCIZUMAB PROPHYLAXIS F. Bocchi^1|2, R. Pastorino^1|2, M. Capetta^1|2|3, S. Bergonzi^1|2|3, G. Murante^1|2|3, F. Valeri^2|3, C. Dainese^2|3, A. Valpreda⁴, B. Bruno^1|3, A. Borchiellini^2|3 | ¹Department of Molecular Biotechnology and Health Sciences, University of Turin, Italy; ²Regional Center for Thrombotic and Hemorrhagic Diseases; ³Division of Hematology; ⁴Central Lab Baldi and Riberi, AOU Città della Salute e della Scienza di Torino, Italy

  Matilde Capetta

  26-10-2026

  https://doi.org/10.4081/btvb.2026.872

  23

  PDF: 8

• PO44 | Emicizumab in acquired haemophilia A M. Leotta, A. Strangio, A. Ierardi, S. Prejanò, R C. Santoro | Hemostasis and Thrombosis Unit, Department Hemato-Oncology, Azienda Ospedaliero-Universitaria Renato; Dulbecco, Catanzaro, Italy

  22-10-2025

  https://doi.org/10.4081/btvb.2025.307

  628

  PDF: 20

• CO086 | CLINICAL AND GENETIC CHARACTERIZATION OF A NEW FAMILY CARRYING THE “FACTOR VIII PADUA” F8 DUPLICATION E. Campello, C. Simion, F. Sartorello, D. Regazzo, C. Bulato, B. Serena, S. Toffanin, L. Spiezia, P. Simioni | Department of Medicine, University of Padova, Italy

  Elena Campello

  26-10-2026

  https://doi.org/10.4081/btvb.2026.788

  28

  PDF: 10

• CO-41 | COMPARISON OF COAGULATION AND CHROMOGENIC METHODS IN PHARMACOKINETICS WITH EXTENDED HALF-LIFE FACTOR VIII R. Pastorino^1|2, F. Bocchi^1|2, G. Murante^1|2|3, S. Bergonzi^1|2|3, M. Capetta^1|2|3, F. Valeri^2|3, C. Dainese^2|3, A. Valpreda⁴, B. Bruno^1|3, A. Borchiellini^2|3 | ¹Department of Molecular Biotechnology and Health Sciences, University of Turin, Italy; ²Regional Centre for Thrombotic and Hemorrhagic Diseases, AOU Città della salute e della Scienza di Torino, Italy; ³Division of Hematology, AOU Città della Salute e della Scienza, University of Turin, Italy; ⁴Central Lab Baldi and Riberi, AOU Città della salute e della Scienza di Torino, Italy

  Rebecca Pastorino

  14-10-2026

  https://doi.org/10.4081/btvb.2026.651

  39

  PDF: 14

• CO058 | ELEVATED PLASMA LEVELS OF OMEGA-3 STEARIDONIC ACID ARE ASSOCIATED WITH DECREASED FACTOR VIII COAGULANT ACTIVITY INDEPENDENTLY OF FACTOR VIII ANTIGEN AND VON WILLEBRAND FACTOR LEVELS: PRELIMINARY RESULTS FROM AN ANGIOGRAPHICALLY-CONTROLLED CARDIOVASCULAR COHORT STUDY N. Osti¹, G. Musuraca¹, A. Castagna², M. Spizzo², P. Pattini², G. Mango², M. Baroni³, B. Lunghi³, G. Poli⁴, C. Brocco¹, C. Angheben¹, M. Grusse⁵, P. Van Dreden⁵, A. Anesi¹, G. Lippi³, M. Del Greco¹, S. Friso², A. Ferro¹, F. Bernardi³, N. Martinelli² | ¹Azienda Sanitaria Universitaria Integrata del Trentino, Trento, Italy; ²Dip. di Medicina, Università di Verona, Verona, Italy; ³Dip. di Scienze della Vita e Biotecnologie, Università di Ferrara, Ferrara, Italy; ⁴Sez. di Biochimica Clinica, Università di Verona, Verona, Italy; ⁵Clinical Research, Diagnostica STAGO, Gennevillers, France

  Nicola Osti

  26-10-2026

  https://doi.org/10.4081/btvb.2026.760

  22

  PDF: 8

• CO-28 | SYNERGISTIC EFFECT OF RECOMBINANT FACTOR INFUSION ON THROMBIN GENERATION IN HEMOPHILIA PATIENTS UNDER EMICIZUMAB OR CONCIZUMAB PROPHYLAXIS F. Bocchi^1|2, R. Pastorino^1|2, G. Murante^1|2|3, S. Bergonzi^1|2|3, M. Capetta^1|2|3, F. Valeri^2|3, C. Dainese^2|3, A. Valpreda⁴, B. Bruno^1|3, A. Borchiellini^2|3 | ¹Department of Molecular Biotechnology and Health Sciences, University of Turin, Italy; ²Regional Centre for Thrombotic and Hemorrhagic Diseases, AOU Città della salute e della Scienza di Torino, Italy; ³Division of Hematology, AOU Città della Salute e della Scienza, University of Turin, Italy; ⁴Central Lab Baldi and Riberi, AOU Città della salute e della Scienza di Torino, Italy

  Francesca Bocchi

  14-10-2026

  https://doi.org/10.4081/btvb.2026.638

  49

  PDF: 21

• PO123 | PERIOPERATIVE MANAGEMENT OF FEMORAL FRACTURE SURGERY IN AN ELDERLY PATIENT WITH ACQUIRED HEMOPHILIA A RECEIVING EMICIZUMAB C. Simion, E. Zanon, B. Stocco, G. Saggiorato, F. Sartorello, C. Bulato, P. Simioni | Department of Medicine, University of Padova, Italy

  Chiara Simion

  26-10-2026

  https://doi.org/10.4081/btvb.2026.939

  20

  PDF: 8

• PO060 | DISCREPANCY IN FACTOR VIII LEVELS AMONG HEMOPHILIA A CARRIERS: ONE-STAGE VS. CHROMOGENIC ASSAY A. Strangio, M. Leotta, A. Ierardi, L. Elia, M. Falbo, C. Condina, G. Procopio, RC Santoro | Centro Emofilia AOU R. Dulbecco Catanzaro, Italy

  Alessandra Strangio

  26-10-2026

  https://doi.org/10.4081/btvb.2026.876

  24

  PDF: 8

• PO146 | COMPARISON OF COAGULATION AND CHROMOGENIC METHODS IN PHARMACOKINETICS WITH EXTENDED HALF-LIFE FACTOR VIII R. Pastorino^1|2, F. Bocchi^1|2, G. Murante^1|2|3, S. Bergonzi^1|2|3, M. Capetta^1|2|3, F. Valeri^2|3, C. Dainese^2|3, A. Valpreda⁴, B. Bruno^1|3, A. Borchiellini^2|3 | ¹Department of Molecular Biotechnology and Health Sciences, University of Turin, Torino, Italy; ²Regional Centre for Thrombotic and Hemorrhagic Diseases; ³Division of Hematology; ⁴Central Lab Baldi and Riberi, AOU Città della salute e della Scienza di Torino, Torino, Italy

  Rebecca Pastorino

  26-10-2026

  https://doi.org/10.4081/btvb.2026.962

  23

  PDF: 9

• CO-58 | SUCCESSFUL TREATMENT WITH EFANESOCTOCOG ALFA OF INTRACRANIAL HEMORRHAGE IN A NEWBORN AFFECTED BY SEVERE HEMOPHILIA A T. Martini¹, B. Borsellino^1|2, B. Pollio¹ | ¹Hemophilia Centre, Immune-Haematology and Transfusion Medicine, University Hospital “Città della Salute e della Scienza”, Torino, Italy; ²Department of Biomedicine and Prevention, PhD in Immunology, Molecular Medicine and Applied Biotechnology, University of Rome Tor Vergata, Roma, Italy

  Tiziano Martini

  14-10-2026

  https://doi.org/10.4081/btvb.2026.668

  48

  PDF: 14

• CO-38 | CALIBRATION OF HUMAN COAGULATION FACTOR VIII IN NOVEL QUALITY CONTROL MATERIALS: A COLLABORATIVE STUDY G. Gullifa¹, A. Carocci¹, C. Albertini^1|2, L. Luchetti¹, M.T. Pasquino¹, M. Simeoni¹, L. Mandarino¹, C. Adriano^1|3, R. Risoluti³, S. Massimi¹ | ¹Centro Nazionale per il Controllo e la Valutazione dei Farmaci, Istituto Superiore di Sanità, Roma, Italy; ²Centro Nazionale Sangue, Istituto Superiore di Sanità, Roma, Italy; ³Sapienza Università di Roma, Italy

  Giuseppina Gullifa

  14-10-2026

  https://doi.org/10.4081/btvb.2026.648

  40

  PDF: 15

• CO-48 | HEMOFISH: A NEW ANIMAL MODEL FOR STUDY THE ROLE OF FACTOR VIII IN BONE DISEASE M. Berni¹, L. Caliogna¹, F. Tonelli², C. Aresi², G. Rizzi¹, A. Forlino², G. Pasta¹ | ¹Orthopedics and Traumatology Clinic, IRCCS Policlinico San Matteo Foundation, Pavia, Italy; ²Dep. of Molecular Medicine, Biochemistry Unit, University of Pavia, Italy

  Micaela Berni

  14-10-2026

  https://doi.org/10.4081/btvb.2026.658

  52

  PDF: 14

• CO-62 | ACCESS TO ULTRA-LONG HALF-LIFE FACTOR VIII AS THE DEFINITIVE MOTIVATION FOR IMMUNE TOLERANCE INDUCTION IN THE ERA OF NON-REPLACEMENT THERAPIES B. Borsellino¹, T. Martini¹, I. Ricca², C. Linari³, B. Pollio¹ | ¹Paediatric Haemophilia Centre, Immune-Haematology and Transfusion Medicine, University Hospital "Città della Salute e della Scienza", Torino, Italy; ²Transfusion Medicine, Ivrea Hospital, Ivrea, Italy; ³Department of Laboratory Medicine, Azienda Ospedaliera Universitaria Città della Salute e della Scienza, Turin, Italy

  Beatrice Borsellino

  14-10-2026

  https://doi.org/10.4081/btvb.2026.672

  39

  PDF: 12

• PO127 | ANAPHYLACTIC REACTION TO RECOMBINANT ACTIVATED FVII IN A MILD HEMOPHILIA A PATIENT WITH INHIBITOR: A CASE REPORT I. Nichele, G. Carli, G. Marchesini, A. Tosetto | Haematology Department, S. Bortolo Hospital, Vicenza, Italy

  Ilaria Nichele

  26-10-2026

  https://doi.org/10.4081/btvb.2026.943

  19

  PDF: 11

• CO-84 | PARAPROTEIN-DRIVEN ACQUIRED VON WILLEBRAND SYNDROME IN A PATIENT WITH MONOCLONAL GAMMOPATHY OF UNDETERMINED SIGNIFICANCE AND UROTHELIAL CARCINOMA A. Ierardi, A. Strangio, M. Leotta, R.C. Santoro | Hemostasis Unit, AOU Dulbecco, Catanzaro, Italy

  Antonella Ierardi

  14-10-2026

  https://doi.org/10.4081/btvb.2026.694

  38

  PDF: 15

• CO19 | Hypercoagulability in wild-type transthyretin amyloidosis: evidence from whole blood thromboelastometry A. Napolitano¹, L. Spiezia¹, C. Samà¹, A. Benetti¹, G. Sinigiani², L. De Michieli², A. Cipriani², P. Simioni¹ | ¹First Chair of Internal Medicine, Department of Medicine, University Hospital of Padua; ²Department of Cardiothoracic and Vascular Sciences & Public Health, University Hospital of Padua, Italy

  22-10-2025

  https://doi.org/10.4081/btvb.2025.223

  599

  PDF: 10

• PO101 | COMPREHENSIVE EVALUATION OF COAGULATION PROFILES IN REFRACTORY MODERATE-TO-SEVERE ULCERATIVE COLITIS L. Spiezia¹, G. Di Lecce², B. Barberio², M. Zanconato², E. Bicego¹, C. Samà¹, B. Serena¹, M. De Bona³, A. Buda³, F. Zingone², E.V. Savarino², P. Simioni¹ | ¹First Chair of Internal Medicine, Department of Medicine (DIMED), Padova University Hospital, Padova, Italy; ²Gastroenterology Unit, Department of Surgery, Oncology and Gastroenterology (DISCOG), University of Padova, Padova, Italy; ³Gastroenterology Unit, Department of Oncological Gastrointestinal Surgery, S. Maria del Prato Hospital, Feltre, Italy

  Luca Spiezia

  26-10-2026

  https://doi.org/10.4081/btvb.2026.917

  25

  PDF: 9

• CO084 | NEW INSIGHTS INTO HEMOPHILIA A: FACTOR VIII–INTEGRIN Β1 PATHWAY AS KEY REGULATOR OF ENDOTHELIAL CELL FUNCTION A. Cucci¹, C. Olgasi², G. Venturin¹, S. Assanelli¹, C. Sgromo¹, S. Reano², M. Manfredi², A. Follenzi^1|3 | ¹Dip. di Scienze della Salute, Università del Piemonte Orientale, Novara, Italy; ²Dip. di Medicina Traslazionale, Università del Piemonte Orientale, Novara, Italy; ³Dip. Attività Integrate Ricerca Innovazione, AOU SS. Antonio e Biagio e C. Arrigo, Alessandria, Italy

  Alessia Cucci

  26-10-2026

  https://doi.org/10.4081/btvb.2026.786

  27

  PDF: 9

• CO-20 | REAL-WORLD EXPERIENCE ON THE MANAGEMENT OF MILD HEAD INJURY IN A COHORT OF CHILDREN WITH HEMOPHILIA A WITH AND WITHOUT INHIBITORS TREATED WITH EMICIZUMAB B. Pollio¹, B. Borsellino^1|2, T. Martini¹ | ¹Haemophilia Centre, Immune-Haematology and Transfusion Medicine, University Hospital “Città della Salute e della Scienza”, Torino, Italy; ²Department of Biomedicine and Prevention, PhD in Immunology, Molecular Medicine and Applied Biotechnology, University of Rome Tor Vergata, Roma, Italy

  Tiziano Martini

  14-10-2026

  https://doi.org/10.4081/btvb.2026.630

  36

  PDF: 15

• CO019 | THE COMPLEX INTERACTION BETWEEN THE SECRETOR AND AB0 BLOOD GROUP GENOTYPES DETERMINES LARGE DIFFERENCES IN FACTOR VIII LEVELS AMONG SEVERE AORTIC STENOSIS PATIENTS B. Lunghi¹, A. Castagna², M. Baroni¹, G. Marchetti³, M. Spizzo², G. Mango², S. Friso², N. Martinelli², F. Bernardi¹ | ¹Dept. of Life Sciences and Biotechnology, University of Ferrara, Italy; ²Dept. of Medicine, University of Verona, Italy; ³Dept. of Neuroscience and Rehabilitation, University of Ferrara, Italy

  Francesco Bernardi

  26-10-2026

  https://doi.org/10.4081/btvb.2026.721

  29

  PDF: 8

• BEST-06 | OPTIMIZING LABORATORY MONITORING OF EFANESOCTOCOG ALFA: IMPACT OF APTT REAGENTS AND CHROMOGENIC ASSAYS ON DIAGNOSTIC ACCURACY A. Strangio, A. Ierardi, M. Leotta, L.C. Elia, M. Falbo, C. Condina, G. Procopio, R.C. Santoro | Hemophilia Hemostasis and Thrombosis Unit, Azienda Ospedaliero Universitaria Renato Dulbecco, Catanzaro, Italy

  Alessandra Strangio

  14-10-2026

  https://doi.org/10.4081/btvb.2026.606

  86

  PDF: 16

• PO083 | WOMEN AND HEMOPHILIA: ASSESSMENT OF THE BLEEDING PHENOTYPE – ANALYSIS OF THE BRESCIA COHORT N. Portesi, S. Pontoglio, G. Carracchia, G. Albrici, E. Bertoni, G. Martini | ASST Spedali Civili di Brescia, Italy

  Nicola Portesi

  26-10-2026

  https://doi.org/10.4081/btvb.2026.899

  29

  PDF: 5

• CO112 | LIPOPROTEIN(a) PLASMA LEVELS AND COAGULATION BIOMARKERS: RESULTS FROM A COMPREHENSIVE LABORATORY ASSESSMENT IN AN ANGIOGRAPHICALLY-CONTROLLED CARDIOVASCULAR COHORT N. Osti¹, G. Musuraca¹, M. Spizzo², P. Pattini², G. Poli³, C. Brocco¹, C. Cemin¹, A. Madaffari¹, G. Mango², F. Presa², M. Grusse⁴, P. Van Dreden⁴, A. Anesi¹, G. Lippi³, M. Del Greco¹, A. Castagna², S. Friso², A. Ferro¹, N. Martinelli² | ¹Azienda Sanitaria Universitaria Integrata del Trentino (ASUIT), Trento, Italy; ²U.O. Medicina Interna B, Dip. Medicina, Università di Verona, Italy; ³Sez. Biochimica Clinica, Università di Verona, Italy; ⁴Dep. Clinical Research, Diagnostica Stago, Gennevilliers, France

  Nicola Osti

  26-10-2026

  https://doi.org/10.4081/btvb.2026.814

  22

  PDF: 7

• CO-07 | ITALIAN RESOURCE USE IN MILD HEMOPHILIA A AND TYPE 1 VON WILLEBRAND DISEASE A. Gringeri^1|2, G.C. Castaman³ | ¹Fondazione Charta, Milano, Italy; ²Centro di Sanità Solidale, Lucca, Italy; ³Centre for Bleeding Disorders and Coagulation, Careggi University Hospital, Firenze, Italy

  Alessandro Gringeri

  14-10-2026

  https://doi.org/10.4081/btvb.2026.617

  94

  PDF: 17

• CO-87 | SPONTANEOUS HEMATOMA IN A PATIENT WITH POLYCYTHEMIA VERA: A CASE OF ACQUIRED VON WILLEBRAND DISEASE? A. Strangio, A. Ierardi, M. Leotta, R.C. Santoro | Hemophilia center, AOU Renato Dulbecco, Catanzaro, Italy

  Alessandra Strangio

  14-10-2026

  https://doi.org/10.4081/btvb.2026.697

  50

  PDF: 17

• PO042 | ACQUIRED HEMOPHILIA A AND ANTIPHOSPHOLIPID SYNDROME: CONCURRENCY OR OVERLAPPING? E. Galimberti¹, C. Ambaglio¹, T. Zollner¹, F. Schieppati^1|2, O.C. Cretu¹, F. Zunino¹, V. Brusegan¹, M. Marchetti^1|2, A. Falanga^1|2, L. Barcella¹ | ¹Immunohematology and Transfusion Medicine, Department of Transfusion Medicine and Hematology, ERN-EuroBloodNet - European Reference Network in Rare Hematological Diseases, ASST Papa Giovanni XXIII, Bergamo, Italy; ²School of Medicine and Surgery, University of Milano-Bicocca, Milano, Italy

  Elisa Galimberti

  26-10-2026

  https://doi.org/10.4081/btvb.2026.858

  25

  PDF: 8

• PO024 | IMPLEMENTATION OF 4PL SIGMOIDAL REGRESSION FOR FACTOR VIII INHIBITOR QUANTIFICATION IN ACQUIRED HEMOPHILIA M. Sebastiani¹, M. Bovara², L. Valdrè³, L. Piscitelli³, R. Mancini² | ¹IRCCS Istituto delle Scienze Neurologiche, Bologna, Italy; ²Laboratorio Unico Metropolitano Ospedale Maggiore, Bologna, Italy; ³Malattie Emorragiche Congenite, Dipartimento Malattie Oncologiche ed Ematologiche IRCCS Azienda Ospedaliero-Universitaria di Bologna, Italy

  Monica Bovara

  26-10-2026

  https://doi.org/10.4081/btvb.2026.840

  18

  PDF: 10

• CO-29 | A RARE BLEEDING PRESENTATION IN MODERATE HEMOPHILIA A: PARAVESICAL HEMATOMA WITH PENOSCROTAL EXTENSION MIMICKING A UROLOGICAL EMERGENCY B. Stocco, C. Simion, E. Zanon, E. Dalla Porta, P. Simioni | Hemophilia Center, University Hospital of Padua, Italy

  Benedetta Stocco

  14-10-2026

  https://doi.org/10.4081/btvb.2026.639

  39

  PDF: 15

• CO-02 | NEONATAL GENOMIC SCREENING ENABLES PRE-SYMPTOMATIC DIAGNOSIS AND PREVENTIVE MANAGEMENT OF HEMOPHILIA B. Borsellino¹, B. Pollio¹, P. Quarello^2|3, T. Martini¹, C. Linari⁴, M. Carabotta⁵, C. Cagnazzo², S. Minucci⁶, F. Fagioli^2|3 | ¹Paediatric Haemophilia Centre, Immune-Haematology and Transfusion Medicine, University Hospital "Città della Salute e della Scienza", Torino, Italy; ²Paediatric Onco-Hematology, Stem Cell Transplantation and Cellular Therapy Division, Regina Margherita Children’s Hospital, Torino, Italy; ³Department of Paediatric and Public Health Sciences, University of Turin, Italy; ⁴Department of Laboratory Medicine, Azienda Ospedaliera Universitaria Città della Salute e della Scienza, Torino, Italy; ⁵Department of Pediatrics, G. d'Annunzio University, Chieti, Italy; ⁶Italian Institute for Genomic Medicine, IRCCS, Candiolo, Italy

  Beatrice Borsellino

  14-10-2026

  https://doi.org/10.4081/btvb.2026.612

  92

  PDF: 17

• CO-39 | MYELOID CELL FUNCTION AND CYTOKINE PROFILES IN PEDIATRIC HEMOPHILIA A: INSIGHTS FROM FACTOR VIII AND EMICIZUMAB PROPHYLAXIS T. Martini¹, A. Cottonaro², S. Akula², B. Pollio¹, I. Ricca³, J. Agnelli Giacchello⁴, P. Sciancalepore⁴, R. Santi⁴, A. Follenzi^2|4, S. Merlin² | ¹Haemophilia Centre, Immune-Haematology and Transfusion Medicine, University Hospital “Città della Salute e della Scienza”, Torino, Italy; ²Department of Health Sciences, Università del Piemonte Orientale, Novara, Italy; ³Transfusion Medicine, Ivrea Hospital, Ivrea, Italy; ⁴Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo, Alessandria, Italy

  Tiziano Martini

  14-10-2026

  https://doi.org/10.4081/btvb.2026.649

  53

  PDF: 13

• CO15 | Longitudinal coagulation profiling of individuals undergoing gender-affirming hormone therapy: the hyper-gender study A. Napolitano, E. Campello, A. Scala, C. Simion, C. Bulato, S. Gavasso, C. Samà, A. Benetti, S. Toffanin, G. Faggian, R. Scafa, A. Garolla, P. Simioni | First Chair of Internal Medicine, Department of Medicine, University Hospital of Padua; Unit of Andrology and Reproductive Medicine, Department of Medicine, University Hospital of Padua, Italy

  22-10-2025

  https://doi.org/10.4081/btvb.2025.219

  675

  PDF: 18

• PO019 | LONGITUDINAL COAGULATION PROFILING BY THROMBIN GENERATION AND CIRCULATING MICROVESISCLES OF INDIVIDUALS UNDERGOING GENDER-AFFIRMING HORMONE THERAPY E. Campello, A. Scala, A. Napolitano, C. Simion, C. Bulato, S. Toffanin, S. Gavasso, B. Serena, A. Montagna, A. Garolla, P. Simioni | Department of Medicine, University of Padova, Italy

  Elena Campello

  26-10-2026

  https://doi.org/10.4081/btvb.2026.835

  26

  PDF: 9

• CO-57 | NXT007 PROPHYLAXIS IN PEOPLE WITH HEMOPHILIA A WITH OR WITHOUT FACTOR VIII INHIBITORS: COMBINED ANALYSIS OF TWO PHASE I/II MULTIPLE-ASCENDING-DOSE STUDIES M.E. Mancuso^1|2, M. Shima³, J.M. Staber⁴, Y.C. Chen⁵, F.J. López-Jaime⁶, M.C. Shen⁷, G. Ventriglia⁸, M. Takeyama⁹, C. Schmitt⁸, Y.S. Park¹⁰, A. Kiialainen⁸, N. Mizuno¹¹, M. Niggli⁸, T. Miyake¹¹, D. Matino¹², T. Saito¹¹, V. Jiménez-Yuste¹³, R. Kobayashi¹¹, D. Hart¹⁴, K. Nogami¹⁵ | ¹Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milano, Italy; ²Center for Thrombosis and Hemorrhagic Diseases, IRCCS Humanitas Research Hospital, Rozzano, Milano, Italy; ³Thrombosis and Hemostasis Research Center, Nara Medical University, Kashihara, Nara, Japan; ⁴Stead Family Department of Pediatrics, Carver College of Medicine, University of Iowa, Iowa City, USA; ⁵Hemophilia Care and Research Center, Tri-Service General Hospital, National Defense Medical University, Taipei, Taiwan; ⁶Servicio de Hematología, Hospital Universitario Regional de Málaga / Instituto de Investigación Biomédica de Málaga (IBIMA), Málaga, Spain; ⁷Department of Internal Medicine, Changhua Christian Hospital, Changhua, Taiwan; ⁸F. Hoffmann-La Roche Ltd, Basel, Switzerland; ⁹Division of Hemophilia, National Hospital Organization, Osaka National Hospital, Osaka, Japan; ¹⁰Department of Pediatrics, Kyung Hee University Hospital at Gangdong, Seoul, South Korea; ¹¹Chugai Pharmaceutical Co., Ltd, Tokyo, Japan; ¹²McMaster University, Hamilton, Ontario, Canada; ¹³La Paz University Hospital-IdiPAZ, Autónoma University, Madrid, Spain; ¹⁴Roche Products Ltd, Welwyn Garden City, UK; ¹⁵Department of Pediatrics, Nara Medical University, Kashihara, Nara, Japan

  Maria Elisa Mancuso

  14-10-2026

  https://doi.org/10.4081/btvb.2026.667

  46

  PDF: 17

• CO082 | IN SILICO ANALYSIS THROUGH A NEW-GENERATED FACTOR VIII MODEL SUPPORTS TOLERANCE OF B DOMAIN TO MULTIPLE AMINO ACID SUBSTITUTIONS, LIMITING THE LOCAL IMPACT OF MISSENSE VARIANTS A. Branchini¹, M.F. Testa¹, M. Pinotti¹, R. De Cristofaro^2|3 | ¹Department of Life Sciences and Biotechnology, University of Ferrara, Italy; ²Department of Translational Medicine and Surgery, Catholic University of the Sacred Heart, Roma, Italy; ³Center for Hemorrhagic and Thrombotic Diseases, Foundation University Hospital “A. Gemelli” IRCCS, Roma, Italy

  Alessio Branchini

  26-10-2026

  https://doi.org/10.4081/btvb.2026.784

  23

  PDF: 10
• 

  Tailored therapy with turoctocog alfa pegol according to patient’s lifestyle and hemorrhagic phenotype: from clinical trial to real-life

  Ilaria Nichele, Giuseppe Carli, Alberto Tosetto

  22-04-2024

  https://doi.org/10.4081/btvb.2024.104

  1081

  PDF: 386
• 

  Safety of COVID-19 mRNA vaccination in patients with history of acquired hemophilia A: a case series

  Luca Puccetti, Vincenzo Sammartano, Federico Caroni, Margherita Malchiodi, Paola Calzoni, Eleonora Franceschini, Lucrezia Galasso, Monica Bocchia

  17-10-2022

  https://doi.org/10.4081/btvb.2022.40

  3064

  PDF: 434

• CO-05 | IN SILICO ANALYSIS THROUGH A NEWLY GENERATED FACTOR VIII MODEL SUPPORTS TOLERANCE OF B DOMAIN TO MULTIPLE AMINO ACID SUBSTITUTIONS LIMITING THE LOCAL IMPACT OF MISSENSE VARIANTS A. Branchini¹, M.F. Testa¹, M. Pinotti¹, R. De Cristofaro^2|3 | ¹Department of Life Sciences and Biotechnology, University of Ferrara, Italy; ²Department of Translational Medicine and Surgery, Catholic University of the Sacred Heart, Roma, Italy; ³Center for Hemorrhagic and Thrombotic Diseases, Foundation University Hospital “A. Gemelli” IRCCS, Roma, Italy

  Alessio Branchini

  14-10-2026

  https://doi.org/10.4081/btvb.2026.615

  88

  PDF: 15

• PO044 | UPDATING MANAGEMENT OF ACQUIRED HEMOPHILIA A USING EMICIZUMAB: REAL-WORLD OUTCOMES BY A COLLABORATIVE NETWORK OF 3 ITALIAN CENTERS MI. Tassoni¹, BM. Roccon¹, A. Dalla Salda², R. Benedetti³, R. Rossi⁴, C. Cattabiani⁴, G. Quintavalle¹, A. Casali², D. Imberti³, A. Coppola¹ | ¹SSD Centro Hub Emofilia e Malattie Emorragiche Congenite, Azienda Ospedaliero-Universitaria di Parma, Italy; ²SOC Medicina Interna per acuti ad indirizzo metabolico ed emocoagulativo, Azienda USL IRCCS Reggio Emilia, Italy; ³Centro Emostasi e Trombosi, Medicina Interna, Azienda USL Piacenza, Italy; ⁴Lab. di Coagulazione, UOC Diagnostica Ematochimica, Azienda Ospedaliero-Universitaria di Parma, Italy

  Antonio Coppola

  26-10-2026

  https://doi.org/10.4081/btvb.2026.860

  24

  PDF: 8

• PO126 | HIGH-DOSE INTRAVENOUS IMMUNOGLOBULINS FOR LONG-TERM PREVENTION OF RECURRENT GASTROINTESTINAL BLEEDING IN A PATIENT WITH ACQUIRED VON WILLEBRAND SYNDROME ASSOCIATED WITH MGUS R. Benedetti¹, G. Quintavalle², V. Della Corte¹, M.I. Tassoni¹, B.M. Roccon¹, D. Imberti¹, A. Coppola² | ¹Centro Emostasi e Trombosi, Medicina Interna, Azienda USL di Piacenza, Italy; ²SSD Centro Hub Emofilia e Malattie Emorragiche Congenite, Azienda Ospedaliero-Universitaria di Parma, Italy

  Antonio Coppola

  26-10-2026

  https://doi.org/10.4081/btvb.2026.942

  24

  PDF: 7

• BEST-02 | PERIOPERATIVE BLEEDING IN CHILDREN WITH LOW VON WILLEBRAND FACTOR UNDERGOING ADENOID AND TONSIL SURGERY: A 15-YEAR SINGLE-CENTER EXPERIENCE T. Martini¹, B. Borsellino^1|2, B. Pollio¹ | ¹Haemophilia Centre, Immune-Haematology and Transfusion Medicine, University Hospital “Città della Salute e della Scienza”, Torino, Italy; ²Department of Biomedicine and Prevention, PhD in Immunology, Molecular Medicine and Applied Biotechnology, University of Rome Tor Vergata, Roma, Italy

  Tiziano Martini

  14-10-2026

  https://doi.org/10.4081/btvb.2026.602

  101

  PDF: 19

• CO39 | Artificial intelligence in hemophilia management: challenging the need for experts G. Sottilotta¹, D. Megalizzi¹, F. Luise² | ¹UOSD Microcitemie - Emostasi e Trombosi. Grande Ospedale Metropolitano Bianchi-Melacrino-Morelli, Reggio Calabria; ²Laboratorio Analisi, Grande Ospedale Metropolitano Bianchi-Melacrino-Morelli, Reggio Calabria, Italy

  22-10-2025

  https://doi.org/10.4081/btvb.2025.246

  615

  PDF: 14

• CO-76 | MILD HEMOPHILIA A CARRIER WITH CONCOMITANT STORAGE POOL DISEASE: DIAGNOSTIC CHALLENGES IN A SYMPTOMATIC FEMALE PATIENT A. Strangio, M. Leotta. A. Ierardi, R.C. Santoro | Hemophilia center, AOU Renato Dulbecco, Catanzaro, Italy

  Alessandra Strangio

  14-10-2026

  https://doi.org/10.4081/btvb.2026.686

  34

  PDF: 19

• PO059 | HYPERCOAGULABILITY AND THROMBOTIC RISK IN MODERATE-TO-SEVERE OBSTRUCTIVE SLEEP APNEA: A PROSPECTIVE OBSERVATIONAL STUDY L. Spiezia¹, S. Carraro², E. Bicego¹, A. Napolitano¹, C. Samà¹, A. Benetti¹, B. Serena¹, R. Marchese Ragona², P. Simioni¹ | ¹Dipartimento di Medicina, Azienda Osp. Università di Padova, Italy; ²Dipartimento di Neuroscienze, Azienda Osp. Università di Padova, Italy

  Luca Spiezia

  26-10-2026

  https://doi.org/10.4081/btvb.2026.875

  21

  PDF: 8

• PO143 | GENDER DIFFERENCES IN COAGULATION PROFILE IN OBSTRUCTIVE CORONARY ARTERY DISEASE: PRELIMINARY RESULTS FROM AN ANGIOGRAPHICALLY CONTROLLED COHORT STUDY N. Osti¹, G. Musuraca¹, M. Spizzo², P. Pattini², G. Mango², F. Ambrosani², G. Poli³, C. Brocco¹, C. Angheben¹, M. Donini¹, F. Presa², M. Grusse⁴, P. Van Dreden⁴, A. Anesi¹, G. Lippi³, M. Del Greco¹, A. Castagna², S. Friso², A. Ferro¹, N. Martinelli² | ¹Azienda Sanitaria Universitaria Integrata del Trentino, Trento, Italy; ²Dip. di Medicina, Università di Verona, Verona, Italy; ³Sez. di Biochimica Clinica, Università di Verona, Verona, Italy; ⁴Clinical Research, Diagnostica STAGO, Gennevillers, France

  Nicola Osti

  26-10-2026

  https://doi.org/10.4081/btvb.2026.959

  21

  PDF: 7

• PO55 | Evaluation of safety and efficacy of emicizumab prophylaxis in pediatric patients with hemophilia A – a single centre experience M.L. Tramontano, M. Coppola, S. Coppola, M. Schiavulli | UOSD Centro Regionale Pediatrico Malattie della Coagulazione, Santobono Pausilipon Children Hospital, AORN, Napoli, Italy

  22-10-2025

  https://doi.org/10.4081/btvb.2025.324

  573

  PDF: 24

• PO085 | ACQUIRED HEMOPHILIA A IN THE SURGICAL PATIENT: DIAGNOSTIC AND THERAPEUTIC COMPLEXITY M. Luongo¹, P. Massaro¹, M. Di Mascio¹, P.G. Simeone², F. Santilli², S. Verna¹ | ¹Immunohematology Service, Asl 02 Abruzzo, Chieti, Italy; ²Department of Medicine and Aging Sciences, and Center for Advanced Studies and Technology, “G. d’Annunzio” University of Chieti–Pescara, Italy

  Myriam Luongo

  26-10-2026

  https://doi.org/10.4081/btvb.2026.901

  25

  PDF: 7

• CO-78 | REAL-WORLD MANAGEMENT OF ACQUIRED HEMOPHILIA A: FOCUS ON RECOMBINANT PORCINE FVIII AS FIRST-LINE HEMOSTATIC TREATMENT AND LONG-TERM OUTCOMES M. Leotta, A. Strangio, A. Ierardi, R.C. Santoro | Hemophilia, Hemostasis and Thrombosis Centre, Azienda Ospedaliero Universitaria Renato Dulbecco, Catanzaro, Italy

  Marzia Leotta

  14-10-2026

  https://doi.org/10.4081/btvb.2026.688

  44

  PDF: 16

• PO49 | Use of emicizumab in two patients with acquired hemophilia A: a new therapeutic approach S. Sorella, J. Micozzi, E. Baldacci, M. Biglietto, R. Mormile, A. Chistolini, R. Ciciani, L. Torrieri, N. Zhdanovskaya, M. Lorenzon, A. Delli Paoli, S. Ligia, C. Santoro | Hematology, Department of Translational and Precision Medicine, Policlinico Umberto I, Sapienza University of Roma, Italy

  22-10-2025

  https://doi.org/10.4081/btvb.2025.318

  665

  PDF: 25
• 

  Growing weapons to fight hemophilia

  Pier Mannuccio Mannucci

  23-02-2023

  https://doi.org/10.4081/btvb.2023.64

  1490

  PDF: 585

• PO24 | Emicizumab prophylaxis and bleeding outcomes: a single center clinical experience A. Taglietti¹, S. Ligia¹, F. Paoletti¹, R. Mormile¹, E. Baldacci², A. Chistolini¹, C. Santoro^1,2 | ¹Hematology, Department of Translational and Precision Medicine, Sapienza University of Roma; ²Hematology, Azienda Ospedaliera Universitaria Policlinico Umberto I, Roma, Italy

  22-10-2025

  https://doi.org/10.4081/btvb.2025.285

  625

  PDF: 22

• PO082 | HEMOPHILIA AND LOW BONE MINERAL DENSITY: AN OBSERVATIONAL STUDY D. Fumarulo, R. Corrado, M. Canfora, M. Mazzetti, M. Littera, D. Prisco, C. Tamburini | Internal Medicine, Careggi Hospital, University of Florence, Firenze, Italy

  Daniela Fumarulo

  26-10-2026

  https://doi.org/10.4081/btvb.2026.898

  27

  PDF: 8

• PO65 | Utilization of emicizumab in acquired hemophilia A: a case report C. Caputo, P. Conca, I.L. Calcaterra, E. Cimino, M. Romeo, M. Aversano, E. Franco, C. De Luca, G. D’errico, L. Jr Valletta, M. Di Minno, A. Tufano | Department of Clinical Medicine and Surgery, Federico II University, Naples, Italy

  22-10-2025

  https://doi.org/10.4081/btvb.2025.334

  628

  PDF: 26

• PO90 | Acquired hemophilia A with high-titer inhibitor in a patient with cardiovascular and metabolic comorbidities M.G. Mazzone, G. Chiarelli, R. Russo, L. Valletta Jr, G. D’Errico, C. De Luca, P. Rufolo, A. Tufano, E. Cimino, P. Conca, M.N.D. Di Minno | Department of Clinical Medicine and Surgery, Federico II University of Naples, Italy

  22-10-2025

  https://doi.org/10.4081/btvb.2025.360

  665

  PDF: 27

• PO048 | EFFICACY OF RITUXIMAB TREATMENT IN A CASE OF A RELAPSED AND REFRACTORY ACQUIRED VON WILLEBRAND DISEASE SECONDARY TO PRIMARY CUTANEOUS MARGINAL ZONE B-CELL LYMPHOMA L. Gurgoglione¹, F. Saladino², E. Morsia², N. Viola³, S. Rupoli¹, A. Poloni² | ¹Clinical Hematology, AOU delle Marche, Ancona, Italy; ²Università Politecnica delle Marche, Ancona, Italy; ³Clinical Immulogy, AOU delle Marche, Ancona, Italy

  Laura Gurgoglione

  26-10-2026

  https://doi.org/10.4081/btvb.2026.864

  23

  PDF: 10
• 

  The changing landscape of treatment for acquired hemophilia A

  Massimo Franchini, Daniele Focosi

  30-01-2025

  https://doi.org/10.4081/btvb.2025.157

  2073

  PDF: 548

• PO149 | MANAGEMENT OF ANTITHROMBOTIC THERAPY IN A PATIENT WITH HEMOPHILIA C AND ATRIAL FIBRILLATION E. Marrone¹, G. Ruggiero², E. Cimino³, P. Conca³, C. Miele⁴, F. Gallucci¹, A. Abate¹, C. Romano¹, D. Leosco², U. Valentino¹ | ¹Department of Medicine 3, Cardarelli Hospital, Napoli, Italy; ²School of Specialization in Geriatrics; ³Department of Internal Medicine and Blood Coagulation; ⁴Department of Laboratory Medicine and Transfusion, Federico II University, Napoli, Italy

  Emiliana Marrone

  26-10-2026

  https://doi.org/10.4081/btvb.2026.965

  24

  PDF: 8

• PO081 | FROM VON WILLEBRAND DISEASE TO MILD HEMOPHILIA A AND BACK: THREE ILLUSTRATIVE CASES HIGHLIGHTING THE ROLE OF GENETIC TESTING IN IMPROVING DIAGNOSTIC ACCURACY E. Zacchi^1|2, L. Piscitelli¹, A. Vaisfeld^2|3, C. Manzi¹, L. Godino², P. Magini², F. Riccardi⁴, L. Valdrè¹ | ¹Inherited Bleeding Disorders Unit, IRCCS AOUBO, Bologna, Italy; ²Medical Genetics Unit, IRCCS AOUBO, Bologna, Italy; ³Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy; ⁴Regional Reference Centre for Inherited Bleeding Disorders, University Hospital of Parma, Parma, Italy

  Eliana Zacchi

  26-10-2026

  https://doi.org/10.4081/btvb.2026.897

  24

  PDF: 7

• CO37 | Assessment of clotting factor activity and sterility in thawed fresh frozen plasma supplied to helicopter emergency medical services for prehospital transfusion D. Romeo¹, M. Marchetti^1,2, M. Testa¹, A. Motta¹, P. Gomez-Rosas¹, G. Ravasio¹, F. Daminelli³, L. Barcella¹, A. Falanga^1,2 | ¹Immunohematology and Transfusion Medicine Department, Hospital Papa Giovanni XXIII, Bergamo; ²School of Medicine and Surgery, University Milano Bicocca, Milan; ³Anesthesia and Resuscitation Department, Hospital Papa Giovanni XXIII, Bergamo, Italy

  22-10-2025

  https://doi.org/10.4081/btvb.2025.244

  685

  PDF: 18
• 

  Expanding the genetic landscape of hereditary thrombophilia: classical defects, novel variants, and genomic perspectives. A narrative review

  Chiara Simion, Elena Campello, Walter Ageno, Paolo Simioni

  28-08-2026

  https://doi.org/10.4081/btvb.2026.427

  1228

  PDF: 156

  SUPPLEMENTARY FILES: 110

• CO-75 | ASSAY DISCREPANCY IN HEMOPHILIA A CARRIERS: CLINICAL AND GENETIC INSIGHTS M. Leotta, A. Strangio, A. Ierardi, R.C. Santoro | Hemophilia Treatment Center AOU Dulbecco, Catanzaro, Italy

  Marzia Leotta

  14-10-2026

  https://doi.org/10.4081/btvb.2026.685

  43

  PDF: 20

• PO86 | Emicizumab in patients with moderate hemophilia A and severe bleeding phenotype: single-center real-world experience A.L. Faccini, M. Biglietto, S. Sorella, E. Crisanti, M. Antonacci, R. Mormile, R. Ciciani, E. Baldacci, C. Santoro, S. Ligia | Hematology, Department of Translational and Precision Medicine Sapienza University of Roma, Italy

  22-10-2025

  https://doi.org/10.4081/btvb.2025.355

  754

  PDF: 26

• PO047 | TRANSIENT IDIOPHATIC ACQUIRED VON WILLEBRAND SYNDROME: A RARE CHALLENGING CONDITION WITH A POSSIBLE RAPIDLY AND FAVOURABLE EVOLUTION G. Murante^1|2|4, S. Bergonzi^1|2|4, M. Capetta^1|2|4, F. Valeri^1|2, C. Dainese^1|2, A. Valpreda³, R. Pastorino^1|4, F. Bocchi^1|4, B. Bruno^2|4, A. Borchiellini^1|2 | ¹Regional Centre for Hemorrhagic and Thrombotic Diseases; ²Division of Hematology; ³Central Lab. Baldi and Riberi, AOU Città della Salute e della Scienza di Torino, Italy; ⁴Dep. of Molecular Biotechnology and Health Sciences, University of Turin, Italy

  Giovanni Murante

  26-10-2026

  https://doi.org/10.4081/btvb.2026.863

  25

  PDF: 10

• PO012 | RECURRENT CENTRAL RETINAL VEIN THROMBOSIS IN A PATIENT WITH MILD HEMOPHILIA A AND HETEROZYGOSITY FOR THE PROTHROMBIN G20210A VARIANT I. Zatta¹, E. Pacquola¹, L. Di Daniel², C. Simion³, E. Zanon³, P. Simioni³, S. Villalta², L. Abbruzzese¹ | ¹Medicina Trasfusionale Osp. Ca’ Foncello, Treviso, Italy; ²Medicina Generale Osp. S. Giacomo, Castelfranco V.to, Italy; ³Clinica Medica 1° Azienda-Ospedale Università, Padova, Italy

  Enrica Pacquola

  26-10-2026

  https://doi.org/10.4081/btvb.2026.828

  22

  PDF: 9
• 

  Is non-alcoholic fatty liver disease a prothrombotic risk factor?

  Niccolò Bitto, Vincenzo La Mura, Anna Ludovica Fracanzani, Armando Tripodi

  19-05-2023

  https://doi.org/10.4081/btvb.2023.81

  1138

  PDF: 549

• PO058 | IMMUNOMODULATORY EFFECTS OF FOSTAMATINIB IN A PATIENT WITH EVANS SYNDROME, TRIPLE-POSITIVE ANTIPHOSPHOLIPID ANTIBODIES AND RELATED COAGULATION ABNORMALITIES S. Bergonzi^1|2|4, G. Murante^1|2|4, M. Capetta^1|2|4, F. Valeri^1|2, C. Dainese^1|2, A. Valpreda^3|4, R. Pastorino^3|4, F. Bocchi^3|4, B. Bruno^2|4, A. Borchiellini^1|2 | ¹Regional Centre for Hemorrhagic and Thrombotic Diseases; ²Division of Hematology; ³Central Laboratory Baldi and Riberi, AOU Città della Salute e della Scienza, Università di Torino, Italy; ⁴Department of Molecular Biotechnology and Health Sciences, University of Turin, Italy

  Sara Bergonzi

  26-10-2026

  https://doi.org/10.4081/btvb.2026.874

  22

  PDF: 10

• CO-88 | TRANSIENT IDIOPHATIC ACQUIRED VON WILLEBRAND DISEASE: A RARE, CHALLENGING CONDITION WITH A POSSIBLE RAPID AND FAVORABLE EVOLUTION G. Murante^1|2|3, S. Bergonzi^1|2|3, M. Capetta^1|2|3, F. Valeri^1|2, C. Dainese^1|2, A. Valpreda⁴, R. Pastorino^1|3, F. Bocchi^1|3, B. Bruno^2|3, A. Borchiellini^1|2 | ¹Regional Centre for Hemorrhagic and Thrombotic Diseases, AOU Città della Salute e della Scienza of Turin, Italy; ²Division of Hematology, AOU Città della Salute e della Scienza, University of Turin, Italy; ³Dep. of Molecular Biotechnology and Health Sciences, University of Turin, Italy; ⁴Central Lab. Baldi and Riberi, AOU Città della Salute e della Scienza of Turin, Italy

  Giovanni Murante

  14-10-2026

  https://doi.org/10.4081/btvb.2026.698

  41

  PDF: 20

• PO131 | BEYOND THE INHIBITOR TITER: THE IMPORTANCE OF EARLY COMBINED IMMUNOSUPPRESSIVE THERAPY IN THE MANAGEMENT OF ACQUIRED HEMOPHILIA A M. Luongo¹, P. Massaro¹, M. Di Mascio¹, P.G. Simeone², F. Santilli², S. Verna¹ | ¹Immunohematology Service, Asl 02 Abruzzo, Chieti, Italy; ²Department of Medicine and Aging Sciences, and Center for Advanced Studies and Technology, “G. d’Annunzio” University of Chieti–Pescara, Italy

  Myriam Luongo

  26-10-2026

  https://doi.org/10.4081/btvb.2026.947

  26

  PDF: 8

• CO109 | THE ROLE OF SELECTED LDLR AND LRP1 VARIANTS IN MODULATING LDL AND FVIII LEVELS IN METABOLIC SYNDROME P. Agosti^1|2, A. Cairo², S. Spena², S. Pelusi³, F. Malvestiti¹, D. Prati³, M. Clerici², E. Scalambrino², A. Tripodi^1|2, V. La Mura^1|2, L. Valenti^1|3, F. Peyvandi^1|2 | ¹Università degli Studi di Milano, Department of Pathophysiology and Transplantation, Milano, Italy; ²Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, and Fondazione Luigi Villa, Milano, Italy; ³Biological Resource Center and Department of Transfusion Medicine, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano, Italy

  Pasquale Agosti

  26-10-2026

  https://doi.org/10.4081/btvb.2026.811

  19

  PDF: 10

• CO079 | FVIII DEFICIENCY COMPROMISES IN VITRO OSTEOBLASTS MINERALIZATION AND THEIR SECRETOME PROFILE B. Terkawi, P.E. Di Simone, V. Kalandadze, A. Follenzi, C. Borsotti | Histology lab, upo, novara, Italy

  Baker Terkawi

  26-10-2026

  https://doi.org/10.4081/btvb.2026.781

  22

  PDF: 10

• CO-22 | CLINICAL FEATURES IN PATIENTS WITH NON-SEVERE HEMOPHILIA A: THE DISCOVERY SCORE PROPOSAL FOR PROPHYLAXIS PRESCRIPTION M.N.D. Di Minno¹, E. Baldacci², C. Biasoli³, A. Borchiellini⁴, F. Daniele⁵, P. Di Gregorio⁶, C. Gorio⁷, G. Malcangi⁸, E. Marchesini⁹, I. Ricca¹⁰, R. Santoro¹¹, S. Siragusa¹², M.R. Villa¹³, E. Zanon¹⁴, A. Tagliaferri¹⁵, A. Coppola¹⁵ | ¹Hub Centre for Thrombotic and Hemorrhagic Disorders, Federico II University Hospital, Napoli, Italy; ²Haematology, University Hospital Policlinico Umberto I, Roma, Italy; ³Interdepartmental Simple Structure for the Management of Hemorrhagic and Thromboembolic Diseases, M. Bufalini Hospital, Cesena, Italy; ⁴Regional Centre for Hemorrhagic and Thrombotic Diseases, AOU Città della Salute e della Scienza, Torino, Italy; ⁵Haemostasis and Thrombosis Service, Ospedale Civile dell'Annunziata, Cosenza, Italy; ⁶Transfusion Medicine Department, "SS. Annunziata" Hospital, Chieti, Italy; ⁷Pediatric Onco-Hematology Unit, Children's Hospital, ASST-Spedali Civili, Brescia, Italy; ⁸Haemophilia and Thrombosis Center, University Hospital Policlinico-Giovanni XXIII, Bari, Italy; ⁹Hemophilia Centre, SC Vascular and Emergency Department, University of Perugia, Italy; ¹⁰Centro Emofilia, Città della Salute e della Scienza, Torino, Italy; ¹¹Hemostasis and Thrombosis Unit, Azienda Ospedaliero Universitaria Dulbecco, Catanzaro, Italy; ¹²Centro di Riferimento Regionale per le Emocoagulopatie Congenite, Palermo, Italy; ¹³Hematology Unit, Ospedale Santa Maria di Loreto, Napoli, Italy; ¹⁴Hemophilia and Thrombosis Center, University Hospital of Padua, Italy; ¹⁵Hemophilia and Thrombosis Center, Azienda Ospedaliera di Parma, Italy

  Matteo Di Minno

  14-10-2026

  https://doi.org/10.4081/btvb.2026.632

  55

  PDF: 15

• PO05 | Intensive FVIII replacement in haemophilia patients with hypertrophic synovium: a randomized study I.L. Calcaterra¹, E. Baldacci², R. Marino³, F. Valeri⁴, R.C. Santoro⁵, G. Pasta⁶, C. Martinoli⁷, M. Di Minno¹ | ¹Department of Clinical Medicine and Surgery, Federico II University, Naples; ²Haematology, University Hospital Policlinico Umberto I, Roma; ³Haemophilia Center and thrombosis, Policlinico, Bari; ⁴Regional Centre for Haemorrhagic and Thrombotic Diseases, AOU Città Della Salute e Della Scienza; Turin; ⁵Centre for Hemorrhagic and Thrombotic Disorders, Pugliese Ciaccio Hospital, Catanzaro; ⁶Fondazione IRCCS San Matteo Hospital, Pavia; ⁷Department of Health Science DISSAL, University of Genoa, Unit of Radiology and IRCCS San Martino Hospital, Genoa, Italy

  22-10-2025

  https://doi.org/10.4081/btvb.2025.267

  600

  PDF: 17

• BEST-03 | CRISPR-CAS9 CORRECTION IN SEVERE HEMOPHILIA A A. Benetti¹, C.M. Radu¹, M. Trevisan², C. Samà¹, C. Simion¹, E. Campello¹, P. Simioni¹ | ¹First Chair of Internal Medicine and Thrombotic and Haemorrhagic Diseases Unit, Department of Medicine, Padova University Hospital, Italy; ²Department of Molecular Medicine, University of Padua, Italy

  Andrea Benetti

  14-10-2026

  https://doi.org/10.4081/btvb.2026.603

  83

  PDF: 16

• PO14 | Searching for safer rescue immunosuppressive therapy protocols in acquired hemophilia A: two case reports G. Quintavalle¹, I.M. Tassoni¹, B.M. Roccon¹, G. Lucchini², F. Magalini², M. Zardo², R. Rossi³, C. Cattabiani³, A. Tagliaferri¹, A. Coppola¹ | ¹SSD Centro HUB Emofilia e MEC; ²UOS Medicina Interna e Reumatologia; ³UO Diagnostica Ematochimica, Azienda Ospedaliero Universitaria, Parma, Italy

  22-10-2025

  https://doi.org/10.4081/btvb.2025.275

  554

  PDF: 20

• CO33 | Acquired hemophilia A in Liguria, Italy: what six years of data reveal C. Vernarecci¹, A. C. Molinari¹, P. Ballarino², M. Caiti², E. Cenni², P. Moscatelli², L. Banov¹ | ¹IRCCS Istituto Giannina Gaslini, Genova; ²IRCCS Policlinico San Martino, Genova, Italy

  22-10-2025

  https://doi.org/10.4081/btvb.2025.240

  616

  PDF: 30
• 

  Development of a shared decision-making tool for gene therapy in hemophilia A in Italy

  Giovanni Di Minno, Sarah Bigi, Serena Barello, Enrico Ferri Grazzi, Marco Follino, Maria Francesca Mansueto, Mariasanta Napolitano, Rita Carlotta Santoro, Giancarlo Castaman

  22-06-2026

  https://doi.org/10.4081/btvb.2026.426

  933

  PDF: 139

  SUPPLEMENTARY MATERIAL: 78

• CS06 | Patient specific iPSCs-derived sinusoidal endothelial cells for phenotypic correction of haemophilia A A. Benetti¹, C.M. Radu¹, C. Samà¹, M. Trevisan², C. Simion¹, E. Campello¹, P. Simioni¹ | ¹Department of Medicine - DIMED, Padua University Hospital; ²Department of Molecular Medicine, University of Padua, Italy

  22-10-2025

  https://doi.org/10.4081/btvb.2025.203

  730

  PDF: 20

• CO030 | MILD HEMOPHILIA A AND JOINT HEALTH IN REAL LIFE: IS THAT AN EMERGING ISSUE? A SINGLE CENTER EXPERIENCE G. Murante^1|2|3, F. Valeri^1|2, S. Bergonzi^1|2|3, M. Capetta^1|2|3, C. Dainese^1|2, A. Valpreda⁴, R. Pastorino^1|3, F. Bocchi^1|3, B. Bruno^2|3, A. Borchiellini^1|2 | ¹Regional Centre for Hemorrhagic and Thrombotic Diseases, AOU Città della Salute e della Scienza di Torino, Italy; ²Division of Hematology, AOU Città della Salute e della Scienza, Università di Torino, Italy; ³Dep. of Molecular Biotechnology and Health Sciences, University of Turin, Italy; ⁴Central Lab. Baldi and Riberi, AOU Città della Salute e della Scienza di Torino, Italy

  Giovanni Murante

  26-10-2026

  https://doi.org/10.4081/btvb.2026.732

  26

  PDF: 10

• BEST-09 | IMMUNOGENIC IMPLICATIONS OF TRANSLATIONAL READTHROUGH MODULATE THE ASSOCIATION OF F8 NONSENSE MUTATIONS WITH INHIBITORS IN HEMOPHILIA A D. Balestra¹, M.F. Testa¹, M. Pinotti¹, A. Branchini¹, M.E. Mancuso², F. Bernardi¹ | ¹Department of Life Sciences and Biotechnology and LTTA Center, University of Ferrara, Italy; ²IRCCS, Humanitas Research Hospital, Center for Thrombosis and Hemorrhagic diseases, Milano, Italy

  Dario Balestra

  14-10-2026

  https://doi.org/10.4081/btvb.2026.609

  80

  PDF: 16

• CO32 | Major surgery in patients with severe hemophilia A without inhibitors receiving prophylaxis with fitusiran E. Zanon, C. Simion, A. Napolitano, L. Spiezia, P. Simioni | Haemophilia Center, First Chair of Internal Medicine, Department of Medicine, University-Hospital of Padua Medical School, Padua, Italy

  22-10-2025

  https://doi.org/10.4081/btvb.2025.239

  566

  PDF: 24

• PO053 | PLATELET AGGREGATION AND THROMBIN GENERATION IN MULTIPLE MYELOMA: A PROSPECTIVE STUDY M. Biglietto, M. Mormile, A. Piciocchi, F. Fazio, M. Capriata, S. Sorella, E. Baldacci, A. Chistolini, M.T. Petrucci, C. Santoro | Sapienza University of Roma, Italy

  Mario Biglietto

  26-10-2026

  https://doi.org/10.4081/btvb.2026.869

  20

  PDF: 9

• CO-85 | ACQUIRED HEMOPHILIA A IN LIVER CIRRHOSIS: BALANCING HEMOSTASIS BETWEEN HIGH HEMORRHAGIC AND THROMBOTIC RISKS N. Portesi, G. Martini | ASST Spedali Civili di Brescia, Italy

  Nicola Portesi

  14-10-2026

  https://doi.org/10.4081/btvb.2026.695

  43

  PDF: 19

• CS02 | Functional and structural impairments of the cerebral microcirculation in a mouse model of hemophilia A G. Venturin¹, C. Olgasi², C. Borsotti¹, P.E. Di Simone¹, E. Spicuglia¹ A. Cucci¹, C. Sgromo¹, A. Follenzi^2,3 | ¹Department of Health Science, Università del Piemonte Orientale, Novara; ²Department of Translational Medicine, Università del Piemonte Orientale, Novara; ³Department of Attività Integrate Ricerca Innovazione, Azienda Ospedaliero-Universitaria SS. Antonio e Biagio e C. Arrigo, Alessandria, Italy

  22-10-2025

  https://doi.org/10.4081/btvb.2025.197

  753

  PDF: 21

• CO005 | HEPATIC ENDOTHELIUM AS A SAFE AND DURABLE TARGET FOR LENTIVIRAL GENE THERAPY OF HEMOPHILIA A E. Borroni, F. Antony, S. Merlin, V. Kalandadze, C. Borsotti, A. Follenzi | Università del Piemonte Orientale, Novara, Italy

  Ester Borroni

  26-10-2026

  https://doi.org/10.4081/btvb.2026.707

  38

  PDF: 9

• CO30 | Joint prosthetic surgery in patients with hemophilia A: clinical-functional outcomes and quality of life E. Zanon¹, A. Napolitano¹, A. Berizzi², P. Simioni¹ | ¹Haemophilia Center, First Chair of Internal Medicine, Department of Medicine, University-Hospital of Padua Medical School, Padua; ²Orthopedics and Traumatology Unit, University-Hospital of Padua Medical School, Padua, Italy

  22-10-2025

  https://doi.org/10.4081/btvb.2025.236

  695

  PDF: 33

• PO112 | REFRAMING THE ENIGMA: ACQUIRED HEMOPHILIA A AS A HARBINGER OF HHV-8–ASSOCIATED MULTICENTRIC CASTLEMAN DISEASE M. Palladino¹, G. Gammaitoni¹, C. Santoro², M. Muscaritoli¹ | ¹Medicina Interna e Nutrizione Clinica-Dip. Medicina Traslazionale e di Precisione; ²Ematologia- Dip. Medicina Traslazionale e di Precisione, Umberto I Roma, Italy

  Mariangela Palladino

  26-10-2026

  https://doi.org/10.4081/btvb.2026.928

  22

  PDF: 9

• CO38 | Management of pregnancy, delivery, and postpartum in Italian carriers and women with hemophilia A and B S. Linari¹, B. Pollio², A. Ferretti³, M. Napolitano⁴, E. Grandone⁵, S. Siboni⁶, Ab. Aru⁷, E. Bertoni⁸, C. Biasoli⁹, I. Cantori¹⁰, P. Di Gregorio¹¹, G. Lassandro¹², G. Sottilotta¹³, A. Strangio¹⁴, Mr. Villa¹⁵, A. Rocino¹⁶, G. Castaman¹ | ¹Center for Bleeding Disorders and Coagulation, Careggi University Hospital, Firenze; ²Regional Reference Center for Inherited Bleeding and Thrombotic Disorders, Transfusion Medicine, Regina Margherita Children Hospital, Turin; ³Center for Hemorrhagic and Thrombotic Diseases, IRCCS A. Gemelli University Hospital Foundation, Roma; ⁴Department of Health Promotion, Maternal-Childhood, Internal Medicine of Excellence G. D’Alessandro, University of Palermo; ⁵Thrombosis and Hemostasis Unit, Fondazione IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo; ⁶Angelo Bianchi Bonomi Hemophilia and Thrombosis Center and Fondazione Luigi Villa, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan; ⁷Pediatric Onco-Hematology Center, Microcitemico Hospital Cagliari; ⁸Pediatric Oncohematology and Bone Marrow Transplant “BMT” Unit, Children’s Hospital, Spedali Civili, Brescia; ⁹Hemophilia and Transfusion Center, Bufalini Hospital, Cesena; ¹⁰Hemophilia Center, Department of Transfusion Medicine, Hospital of Macerata; ¹¹Transfusion Medicine Department, SS. Annunziata Hospital, Chieti; ¹²B. Trambusti General and Specialised Pediatrics Unit, Giovanni XXIII Hospital, University of Bari; ¹³Hemophilia Center, Grande Ospedale Metropolitano, Reggio Calabria; ¹⁴Center for Hemorrhagic and Thrombotic Disorders, Pugliese Ciaccio Hospital, Catanzaro; ¹⁵Hemophilia and Thrombosis Center, Haematology Unit, Ospedale del Mare Hospital, Naples; ¹⁶Past President of the Italian Association of Hemophilia Centers, Italy

  22-10-2025

  https://doi.org/10.4081/btvb.2025.245

  586

  PDF: 15

• CO004 | A NOVEL GENETIC CLASSIFICATION OF INHIBITOR RISK FOR F8 NONSENSE MUTATIONS BASED ON IMMUNOGENIC PROFILING OF RIBOSOMAL READTHROUGH M.F. Testa¹, M. Pinotti¹, A. Branchini¹, M.E. Mancuso², F. Bernardi¹, D. Balestra² | ¹Department of Life Sciences and Biotechnology and LTTA Center, University of Ferrara, Ferrara, Italy; ²IRCCS, Humanitas Research Hospital, Center for Thrombosis and Hemorrhagic diseases, Milano, Italy

  Maria Francesca Testa

  26-10-2026

  https://doi.org/10.4081/btvb.2026.706

  33

  PDF: 10

• CO-44 | EVALUATION OF THE DEVIATION BETWEEN PRESCRIBED AND RECOMMENDED EMICIZUMAB DOSING IN PATIENTS WITH CONGENITAL HEMOPHILIA A A.C. Giuffrida¹, S. Abeysinghe Gunawardhana¹, S. Amato², F. Casoli², C. Recchi², M. Saggioro², E. Bonetti³, M. Bodini¹, G. Poli² | ¹Centro Emofilia, UOC Medicina Trasfusionale, AOUI Verona, Italy; ²UOC Laboratorio Analisi, AOUI Verona, Italy; ³UOC Oncoematologia Pediatrica, AOUI Verona, Italy

  Marco Bodini

  14-10-2026

  https://doi.org/10.4081/btvb.2026.654

  44

  PDF: 14

• PO041 | VARIABLE CLINICAL RESPONSE TO RECOMBINANT PORCINE FVIII IN ACQUIRED HAEMOPHILIA A: A TWO CASE EXPERIENCE WITH LABORATORY SUPPORTED MONITORING AM. Pizzini¹, M. Bovara², M. Sebastiani², A. Fusco¹, C. Fantoni¹, M. Silingardi¹, R. Mancini², A. Coppola³ | ¹Ambulatorio Emostasi & Trombosi, Dipartimento Medico - Ospedale Maggiore Bologna, Italy; ²Laboratorio Unico Metropolitano - Ospedale Maggiore Bologna, Italy; ³SDD Centro Hub Emofilia e MEC, Azienda Ospedaliero-Universitaria di Parma, Italy

  Attilia Maria Pizzini

  26-10-2026

  https://doi.org/10.4081/btvb.2026.857

  23

  PDF: 7

• CO-26 | CLINICAL, LABORATORY AND METABOLIC CHARACTERISTICS OF ADULT PATIENTS WITH HEMOPHILIA A J. Di Paolo, M. Di Loreto, R. Malizia, M. Luongo, P. Massaro, M. Di Mascio, S. Verna | Immunohematology Service, Asl 02 Abruzzo, Chieti, Italy

  Josephine Di Paolo

  14-10-2026

  https://doi.org/10.4081/btvb.2026.636

  36

  PDF: 15

• CO081 | RESTORATION OF CEREBRAL MICROVASCULAR STRUCTURE AND FUNCTION IN HEMOPHILIA A MICE THROUGH FVIII GENE THERAPY G. Venturin¹, E. Spicuglia¹, S. Assanelli¹, C. Borsotti¹, A. Cucci¹, N. Keivan¹, E. Borroni¹, C. Sgromo¹, C. Olgasi², A. Follenzi^1|3 | ¹Department of Health Science, Università del Piemonte Orientale, Novara, 28100, Italy; ²Department of Translational Medicine, Università del Piemonte Orientale, Novara, 28100, Italy; ³Department of Attività Integrate Ricerca Innovazione, Azienda Ospedaliero-Universitaria SS. Antonio e Biagio e C. Arrigo, Alessandria, Italy

  Giorgia Venturin

  26-10-2026

  https://doi.org/10.4081/btvb.2026.783

  32

  PDF: 11

• PO039 | CLINICAL AND LABORATORY CHARACTERISTICS OF ACQUIRED HEMOPHILIA A: PRELIMINARY RESULTS FROM A RETROSPECTIVE OBSERVATIONAL MONOCENTRIC STUDY S. Suardi¹, M. Bodini², A.C. Giuffrida², A. Zanzanelli³, S. Moruzzi¹, L. Delfino¹, F. Pizzolo¹, S. Genesini², M. Cantini², C. Spillere¹, L. Panepinto¹, F. Zoccatelli¹, E. Malloggi¹, F. Presa¹, A. Moschella¹, M. Merlo¹, G. Gandini², S. Friso¹, N. Martinelli¹ | ¹Department of Medicine, Unit of Internal Medicine B, Azienda Ospedaliera Universitaria Integrata di Verona, Italy; ²Department of Transfusion Medicine, Hemophilia Center, Azienda Ospedaliera Universitaria Integrata di Verona, Italy; ³Division of Internal Medicine, IRCCS Azienda Ospedaliero Universitaria Bologna, Italy

  Silvia Suardi

  26-10-2026

  https://doi.org/10.4081/btvb.2026.855

  22

  PDF: 8

• CO-32 | TRAUMA MANAGEMENT IN SEVERE HEMOPHILIA A: A CASE REPORT J. Di Paolo, R. Malizia, M. Luongo, P. Massaro, M. Di Mascio, S. Verna | Immunohematology Service, ASL 02 Abruzzo, Chieti, Italy

  Josephine Di Paolo

  14-10-2026

  https://doi.org/10.4081/btvb.2026.642

  38

  PDF: 14

• CO36 | Inhibitor titer at diagnosis and clinical course in acquired hemophilia A: a single-center experience C. Simion, B. Stocco, E. Dalla Porta, E. Campello, G. Furlan, L. Spiezia, G. Saggiorato, F. Sartorello, E. Zanon, P. Simioni | Department of Medicine – DIMED, University of Padua, Italy

  22-10-2025

  https://doi.org/10.4081/btvb.2025.243

  588

  PDF: 33