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PO008 | HISTORY OF CANCER IN VTE PATIENTS WITH AND WITHOUT HEREDITARY THROMBOPHILIA: A SINGLE CENTER COHORT STUDY A. Napolitano, E. Campello, C. Simion, G. Furlan, S. Gavasso, C. Bulato, C. Samà, S. Toffanin, B. Serena, L. Spiezia, P. Simioni | Department of Medicine, University of Padova, Italy
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CO030 | MILD HEMOPHILIA A AND JOINT HEALTH IN REAL LIFE: IS THAT AN EMERGING ISSUE? A SINGLE CENTER EXPERIENCE G. Murante1|2|3, F. Valeri1|2, S. Bergonzi1|2|3, M. Capetta1|2|3, C. Dainese1|2, A. Valpreda4, R. Pastorino1|3, F. Bocchi1|3, B. Bruno2|3, A. Borchiellini1|2 | 1Regional Centre for Hemorrhagic and Thrombotic Diseases, AOU Città della Salute e della Scienza di Torino, Italy; 2Division of Hematology, AOU Città della Salute e della Scienza, Università di Torino, Italy; 3Dep. of Molecular Biotechnology and Health Sciences, University of Turin, Italy; 4Central Lab. Baldi and Riberi, AOU Città della Salute e della Scienza di Torino, Italy
71PDF: 23 -
BEST-09 | IMMUNOGENIC IMPLICATIONS OF TRANSLATIONAL READTHROUGH MODULATE THE ASSOCIATION OF F8 NONSENSE MUTATIONS WITH INHIBITORS IN HEMOPHILIA A D. Balestra1, M.F. Testa1, M. Pinotti1, A. Branchini1, M.E. Mancuso2, F. Bernardi1 | 1Department of Life Sciences and Biotechnology and LTTA Center, University of Ferrara, Italy; 2IRCCS, Humanitas Research Hospital, Center for Thrombosis and Hemorrhagic diseases, Milano, Italy
144PDF: 23 -
PO02 | SYNERGISTIC INTERACTION OF ENDOTHELIAL AND CANCER CELLS IN THE FORMATION AND STRUCTURE OF THE FIBRIN CLOT SHIELDS M.A. Baghdadi1|2, E. Mbemba1, P. Las Casa1, P. Van Dreden1|3, N. Saleem1|4, J. Fareed4, P. Kempaiah4, M. Sabbah1, G. Gerotziafas1|4 | 1Sorbonne University, INSERM UMR_S_938, CRSA, Research Department "Cancer, Vessels, Biology and Therapeutics" (CaVITE), Research Group "Cancer-Angiogenesis-Thrombosis and Haemostasis," Thrombosis Center, University Institute of Cancerology (UIC), Saint Antoine University Hospital Assistance Publique Hôpitaux de Paris (AP-HP) Paris France; 2Research Center, King Faisal Specialist Hospital and Research Center, Jeddah, Saudi Arabia; 3Diagnostica Stago, clinical research, Gennevilliers, France; 4Center of Translational Research and Education, Department of Pathology and Laboratory Medicine, Loyola University Stritch School of Medicine, Maywood, Ill., USA
476PDF: 104 -
CO32 | Major surgery in patients with severe hemophilia A without inhibitors receiving prophylaxis with fitusiran E. Zanon, C. Simion, A. Napolitano, L. Spiezia, P. Simioni | Haemophilia Center, First Chair of Internal Medicine, Department of Medicine, University-Hospital of Padua Medical School, Padua, Italy
579PDF: 32 -
PO114 | A CASE OF ACQUIRED HEMOPHILIA AFTER TAVI AND CORONARY ANGIOPLASTY IN PATIENT WITH ATRIAL FIBRILLATION AND MULTIPLES CARDIOVASCULAR RISK FACTORS – THE ART AND SCIENCE OF THERAPEUTIC CONFLICT M.M. Poggi1, C. Tamburini2, M. Littera2, M. Mazzetti2 | 1SOC Medicina 1, Nuovo Ospedale Prato, Prato, Italy; 2SOD Medicina Interna Interdisciplinare, Azienda Ospedaliera Universitaria Careggi, Firenze, Italy
57PDF: 21 -
PO053 | PLATELET AGGREGATION AND THROMBIN GENERATION IN MULTIPLE MYELOMA: A PROSPECTIVE STUDY M. Biglietto, M. Mormile, A. Piciocchi, F. Fazio, M. Capriata, S. Sorella, E. Baldacci, A. Chistolini, M.T. Petrucci, C. Santoro | Sapienza University of Roma, Italy
60PDF: 26 -
CO-85 | ACQUIRED HEMOPHILIA A IN LIVER CIRRHOSIS: BALANCING HEMOSTASIS BETWEEN HIGH HEMORRHAGIC AND THROMBOTIC RISKS N. Portesi, G. Martini | ASST Spedali Civili di Brescia, Italy
59PDF: 29 -
CS02 | Functional and structural impairments of the cerebral microcirculation in a mouse model of hemophilia A G. Venturin1, C. Olgasi2, C. Borsotti1, P.E. Di Simone1, E. Spicuglia1 A. Cucci1, C. Sgromo1, A. Follenzi2,3 | 1Department of Health Science, Università del Piemonte Orientale, Novara; 2Department of Translational Medicine, Università del Piemonte Orientale, Novara; 3Department of Attività Integrate Ricerca Innovazione, Azienda Ospedaliero-Universitaria SS. Antonio e Biagio e C. Arrigo, Alessandria, Italy
761PDF: 28 -
CO054 | ULTRA-PROCESSED FOOD CONSUMPTION IS ASSOCIATED WITH AN INCREASED RISK OF UNPROVOKED VENOUS THROMBOEMBOLISM IN THE MOLI-SANI STUDY M. Bonaccio1, A. Di Castelnuovo1, S. Costanzo1|2, T. Panzera1, C. Cerletti1, MB. Donati1, G. de Gaetano1, W. Ageno3, L. Iacoviello1|4 | 1Research Unit of Epidemiology and Prevention, IRCCS NEUROMED, Pozzilli (IS), Italy; 2Dep. of Medicine and Surgery, University of Insubria, Varese, Italy; 3Dep. of Medicine, Università degli Studi di Padova, Padova, Italy; 4Dep. of Medicine and Surgery LUM University, Casamassima (BA), Italy
71PDF: 24 -
CO-19 | A CASE OF LOSS OF EFFICACY OF EMICIZUMAB AFTER 6 YEARS OF REGULAR USE M.R. Fasulo1, I. Quaglia1, A. Colombo1, C. Lodigiani1, M.E. Mancuso1|2 | 1Center for Thrombosis and Hemorrhagic Diseases, IRCCS Humanitas Research Hospital, Rozzano, Milano, Italy; 2Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milano, Italy
65PDF: 21 -
PO19 | THE INTER-RELATIONSHIP BETWEEN NETOSIS, THE ADAMTS-13/VWF AXIS, AND HEMOSTATIC ACTIVATION IN PATIENTS WITH GYNECOLOGICAL MALIGNANCIES: PROGNOSTIC SIGNIFICANCE AND IMPACT OF CHEMOTHERAPY A. Makatsariya1, E. Beloborodova2,V. Bitsadze1, J. Khizroeva1, A. Vorobev1, A. Solopova1, M. Tretyakova1, N. Gashimova1, K. Grigoreva1, A. Oskolkova1, J. Christophe Gris1|3, I. Elalamy1|4|5, G. Gerotziafas1|4|5 | 1Department of Obstetrics, Gynecology and Perinatal Medicine, N. F. Filatov Clinical Institute of Children’s Health, I. M. Sechenov First Moscow State Medical University Sechenov University, Moscow, Russia; 2MEDSI Network of Medical Centers, Moscow, Russia; 3Faculty of Pharmaceutical and Biological Sciences, Montpellier University, France; 4Department Hematology and Thrombosis Center, Medicine Sorbonne University, Paris, France; 5Hospital Tenon, Paris, France
479PDF: 98 -
PO68 | Whole blood hypercoagulable profiles in a patient with markedly elevated lipoprotein(A) plasma levels and thrombotic complications: a case report C. Portinari, M. Biolo, A. Napolitano, L. Spiezia, A. Colpo, S. Zambon, A. Zambon, P. Simioni | Department of Medicine, Padova University Hospital, Padova, Italy
652PDF: 31 -
PO063 | EVALUATION OF PLATELET ACTIVATION MARKERS IN PATIENTS WITH THROMBOTIC THROMBOCYTOPENIC PURPURA M. Di Fuorti1, M.R. Cozzi2, A. Steffan3, I. Quaglia1, C. Sacco1, C. Lodigiani1, M. Bacci1 | 1Center for Thrombosis and Hemorrhagic Diseases, IRCCS Humanitas Research Hospital, Rozzano, Italy; 2Immunopathology and Cancer Biomarkers Unit, Centro di Riferimento Oncologico di Aviano IRCCS, Aviano, Italy; 3Clinical Pathology Unit, ASFO General Hospital, Pordenone, Italy
52PDF: 24 -
CO098 | ANTI-β2GPI AND ANTI-PS/PT ANTIBODIES, AND THEIR COMBINATION, EXERT A DISTINCT PLATELET ACTIVATION PROFILE M. Camera1|2, A. Becchetti2, M.O. Borghi3|4, M. Brambilla2, P.A. Lonati4, C. Bodio4, E. Pontara5, M.G. Cattini5, E. Bison5, M. Tonello6, N. Pozzi7, P. Meroni4, V. Pengo5 | 1Department of Pharmaceutical Sciences, University of Milano, Milano, Italy; 2Unit of Cell and Molecular Biology in Cardiovascular Diseases, Centro Cardiologico Monzino IRCCS, Milano, Italy; 3Dipartimento di Scienze Cliniche e di Comunità, Dipartimento di Eccellenza 2023-2027, University of Milano, Milano, Italy; 4IRCCS Istituto Auxologico Italiano, Milano, Italy; 5Department of Cardiac-Thoracic-Vascular Sciences and Public Health, University of Padua, Padova, Italy; 6Department of Medicine, University of Padua, Padova, Italy; 7Saint Louis University School of Medicine, St. Louis, United States
63PDF: 21 -
CO005 | HEPATIC ENDOTHELIUM AS A SAFE AND DURABLE TARGET FOR LENTIVIRAL GENE THERAPY OF HEMOPHILIA A E. Borroni, F. Antony, S. Merlin, V. Kalandadze, C. Borsotti, A. Follenzi | Università del Piemonte Orientale, Novara, Italy
163PDF: 21 -
BEST-01 | IDENTIFICATION OF NOVEL HYPERACTIVE rFVIIa BYPASSING MOLECULES INFERRED BY ANCESTRAL SEQUENCE RECONSTRUCTION APPROACH M.F. Testa, I. Passerini, P. Santos, A. Benazzo, S. Ghirotto, F. Bernardi, A. Branchini, M. Pinotti, D. Balestra | Dep. of LSB, University of Ferrara, Italy
173PDF: 29 -
PO42 | Acquired Von Willebrad syndrome in patients with myeloproliferative syndrome: literature review and single-center experience A. Strangio, M. Leotta, A. Ierardi, R C. Santoro | UO Emofilia, Emostasi e Trombosi, AOU R Dulbecco, Catanzaro, Italy
565PDF: 31 -
CO12 | Left internal carotid artery thrombosis in a patient with antiphospholipid antibody syndrome successfully treated with eculizumab A. Hoxha1, L. Nico2, F. Viaro3, L. Fabris1, Y.F. Herrera1, M. Munari4, C. Baracchini3, F. Causin2, P. Simioni1 | 1Internal Medicine Unit, Thrombotic and Haemorrhagic Centre, Department of Medicine - DIMED, University of Padua; 2Neuradiology Unit, University Hospital of Padua; 3Stroke Unit, Neurology Department, University of Padua; 4Intensive Care Unit, University Hospital of Padua, Italy
691PDF: 27 -
PO097 | DETERMINANTS OF PLATELET COUNT IN A LARGE SINGLE TERTIARY CARE COHORT: IMPACT OF AGE, SEX, PLATELET REACTIVITY, CARDIOVASCULAR RISK FACTORS AND ANTIPLATELET THERAPY S. De Corci, N. Manganello, E. Schiera, S. Terracina, A. Di Battista, F.M. Pulcinelli | Experimental Medicine, Sapienza University of Rome, Italy
56PDF: 19 -
PO042 | ACQUIRED HEMOPHILIA A AND ANTIPHOSPHOLIPID SYNDROME: CONCURRENCY OR OVERLAPPING? E. Galimberti1, C. Ambaglio1, T. Zollner1, F. Schieppati1|2, O.C. Cretu1, F. Zunino1, V. Brusegan1, M. Marchetti1|2, A. Falanga1|2, L. Barcella1 | 1Immunohematology and Transfusion Medicine, Department of Transfusion Medicine and Hematology, ERN-EuroBloodNet - European Reference Network in Rare Hematological Diseases, ASST Papa Giovanni XXIII, Bergamo, Italy; 2School of Medicine and Surgery, University of Milano-Bicocca, Milano, Italy
41PDF: 23 -
PO94 | The use of antidepressant drugs and benzodiazepine hypnotics as an unusual risk factor for VTE G. Chiarelli, F. Strano, P. Conca, P. Rufolo, M. G. Mazzone, R. Russo, L. Jr Valletta, G. D’Errico, C. De Luca, E. Cimino, A. Tufano, M.N.D. Di Minno | Department of Clinical Medicine and Surgery, Federico II University of Naples, Italy
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PO11 | Neutrophil cathepsin G and risk of cardiovascular events in patients with diabetes mellitus V. Cammisotto1, F. Baratta2, S. Bartimoccia3, D. Pastori1, N. Cocomello4, V. Castellani5, C. Nocella1, R. Carnevale3, G. Desideri1, F. Violi1, P. Pignatelli1 | 1Department of Clinical, Internal Medicine, Anesthesiological and Cardiovascular Sciences, Sapienza University of Roma; 2Geriatric Unit, Department of Internal Medicine and Medical Specialties, AOU Policlinico Umberto I, Roma; 3Department of Medical-Surgical Sciences and Biotechnologies, Sapienza University of Roma; 4Department of Anatomical Sciences, Histological, Legal Medical and Locomotor, Sapienza University of Roma; 5Department of Experimental Medicine, Sapienza University of Roma, Italy
606PDF: 29 -
PO137 | SMAD3 VARIANTS IN LOEYS-DIETZ SYNDROME: RELATIONSHIP WITH NON-AORTIC CARDIOVASCULAR FEATURES E. Sticchi1, L. Squillantini1, P. Cantini1, S. Suraci1, F. Basso1, G. Barbieri1, A. Kura1, F. Gensini2, E. Fiorentini2, S. Nistri3, G. Pepe1, A.M. Gori1, M. Berteotti1, R. Marcucci1, B. Giusti1 | 1Atherothrombotic Diseases Center, Dpt. Experimental and Clinical Medicine, University of Florence - Careggi Hospital, Firenze, Italy; 2Dpt. Experimental and Clinical Biomedical Sciences 'Mario Serio', Medical Genetics Unit, University of Florence, Firenze, Italy; 3Cardiology Service CMSR Veneto Medica Altavilla Vicentina, Vicenza, Italy
40PDF: 27 -
PO46 | Intravitreal treatment with faricimab in patients with age-related macular degeneration M. Alfonsetti1, R. Liani1, P.G.M. Simeone1, M. Frezza1, A. Ricci3, S. Lattanzio1, R. D’Aloisio2, L. Toto2, F. Santilli1 | 1Department of Medicine and Aging, Center for Advanced Studies and Technology “CAST”; 2Ophthalmology Clinic, Department of Medicine and Aging; 3Department of Pharmacy, University “G. d’Annunzio” of Chieti Pescara, Chieti, Italy
493PDF: 20 -
CO30 | Joint prosthetic surgery in patients with hemophilia A: clinical-functional outcomes and quality of life E. Zanon1, A. Napolitano1, A. Berizzi2, P. Simioni1 | 1Haemophilia Center, First Chair of Internal Medicine, Department of Medicine, University-Hospital of Padua Medical School, Padua; 2Orthopedics and Traumatology Unit, University-Hospital of Padua Medical School, Padua, Italy
704PDF: 40 -
PO112 | REFRAMING THE ENIGMA: ACQUIRED HEMOPHILIA A AS A HARBINGER OF HHV-8–ASSOCIATED MULTICENTRIC CASTLEMAN DISEASE M. Palladino1, G. Gammaitoni1, C. Santoro2, M. Muscaritoli1 | 1Medicina Interna e Nutrizione Clinica-Dip. Medicina Traslazionale e di Precisione; 2Ematologia- Dip. Medicina Traslazionale e di Precisione, Umberto I Roma, Italy
44PDF: 20 -
PO052 | VALIDATION OF THROMBIN GENERATION MEASUREMENT IN PLATELET- RICH-PLASMA: EVOLUTION IN THE ST GENESIA® SYSTEM F. Bocchi1|2, R. Pastorino1|2, G. Murante1|2|3, S. Bergonzi1|2|3, M. Capetta1|2|3, F. Valeri2|3, C. Dainese2|3, A. Valpreda4, B. Bruno1|3, A. Borchiellini2|3 | 1Department of Molecular Biotechnology and Health Sciences, University of Turin, Torino, Italy; 2Regional Centre for Thrombotic and Hemorrhagic Diseases, AOU Città della salute e della Scienza di Torino, Torino, Italy; 3Division of Hematology, AOU Città della Salute e della Scienza, Università di Torino, Torino, Italy; 4Central Lab Baldi and Riberi, AOU Città della salute e della Scienza di Torino, Torino, Italy
54PDF: 28 -
CO-36 | PLATELETS MATTER: THROMBIN GENERATION IN PLATELET‐RICH-PLASMA VS. PLATELET‐POOR‐PLASMA UNDER NON-REPLACEMENT THERAPIES IN HEMOPHILIA F. Bocchi1|2, R. Pastorino1|2, G. Murante1|2|3, S. Bergonzi1|2|3, M. Capetta1|2|3, F. Valeri2|3, C. Dainese2|3, A. Valpreda4, B. Bruno1|3, A. Borchiellini2|3 | 1Department of Molecular Biotechnology and Health Sciences, University of Turin, Italy; 2Regional Centre for Thrombotic and Hemorrhagic Diseases, AOU Città della salute e della Scienza di Torino, Italy; 3Division of Hematology, AOU Città della Salute e della Scienza, University of Turin, Italy; 4Central Lab Baldi and Riberi, AOU Città della salute e della Scienza di Torino, Italy
59PDF: 17 -
CO050 | INTERACTION BETWEEN DIRECT ORAL ANTICOAGULANTS AND ANTIEPILEPTIC DRUGS: A MULTICENTER OBSERVATIONAL STUDY A. Lipari1, S. Sorrentino1, M. De Siati1, L. D'Innocenzo1, A. Ferretti1, D. Menichelli2, V. Cammisotto2, P. Pignatelli2, G. Ragna3, MC. Vedovati3, C. Becattini3, G. Frisullo4, V. Forte5, T. Pirozzi1, L. Di Gennaro1, M. Basso1, E. De Candia1 | 1Unit of Haemostasis and Thrombosis Diseases, Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italy; 2Department of Clinical Internal, Anesthesiological and Cardiovascular Sciences, Sapienza University of Roma, Roma, Italy; 3Department of Internal and Cardiovascular Medicine and Stroke Unit, University of Perugia, Perugia, Italy; 4Dipartimento di Neuroscienze, Organi di Senso e Torace, Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italy; 5Hematology, Department of Biomedicine and Prevention, University of Rome Tor Vergata, Roma, Italy
66PDF: 26 -
CO-13 | USE OF THE MULTIDIMENSIONAL HEMOPHILIA PAIN QUESTIONNAIRE IN PATIENTS WITH SEVERE HEMOPHILIA A TREATED WITH EMICIZUMAB: A PILOT CROSS-SECTIONAL, SINGLE-CENTER STUDY I.L. Calcaterra, S. Donnarumma, G. D’Errico, C. De Luca, C. Caputo, P. Ciciola, E. Cimino, M. Di Minno | Università Federico II di Napoli, Italy
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PO17 | PREDICTIVE VALUE OF INFLAMMATORY AND ENDOTHELIAL BIOMARKERS FOR CANCER RISK IN HEALTHY INDIVIDUALS: EVIDENCE FROM THE HYPERCAN STUDY C. Ticozzi1, S. Bolognini1|2, P. Gomez-Rosas1|3, F. Schieppati1|2, G. Sampietro4, L. Barcella1, M. Marchetti1|2, A. Falanga1|2 | 1Immunohematology and Transfusion Medicine, Hospital Papa Giovanni XXIII, Bergamo, Italy; 2School of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy; 3Maastricht University Medical Center, Cardiovascular Research Institute Maastricht (CARIM), Maastricht, The Netherlands; 4Unit of Epidemiology and Statistics, ATS Bergamo, Italy
455PDF: 102 -
CO38 | Management of pregnancy, delivery, and postpartum in Italian carriers and women with hemophilia A and B S. Linari1, B. Pollio2, A. Ferretti3, M. Napolitano4, E. Grandone5, S. Siboni6, Ab. Aru7, E. Bertoni8, C. Biasoli9, I. Cantori10, P. Di Gregorio11, G. Lassandro12, G. Sottilotta13, A. Strangio14, Mr. Villa15, A. Rocino16, G. Castaman1 | 1Center for Bleeding Disorders and Coagulation, Careggi University Hospital, Firenze; 2Regional Reference Center for Inherited Bleeding and Thrombotic Disorders, Transfusion Medicine, Regina Margherita Children Hospital, Turin; 3Center for Hemorrhagic and Thrombotic Diseases, IRCCS A. Gemelli University Hospital Foundation, Roma; 4Department of Health Promotion, Maternal-Childhood, Internal Medicine of Excellence G. D’Alessandro, University of Palermo; 5Thrombosis and Hemostasis Unit, Fondazione IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo; 6Angelo Bianchi Bonomi Hemophilia and Thrombosis Center and Fondazione Luigi Villa, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan; 7Pediatric Onco-Hematology Center, Microcitemico Hospital Cagliari; 8Pediatric Oncohematology and Bone Marrow Transplant “BMT” Unit, Children’s Hospital, Spedali Civili, Brescia; 9Hemophilia and Transfusion Center, Bufalini Hospital, Cesena; 10Hemophilia Center, Department of Transfusion Medicine, Hospital of Macerata; 11Transfusion Medicine Department, SS. Annunziata Hospital, Chieti; 12B. Trambusti General and Specialised Pediatrics Unit, Giovanni XXIII Hospital, University of Bari; 13Hemophilia Center, Grande Ospedale Metropolitano, Reggio Calabria; 14Center for Hemorrhagic and Thrombotic Disorders, Pugliese Ciaccio Hospital, Catanzaro; 15Hemophilia and Thrombosis Center, Haematology Unit, Ospedale del Mare Hospital, Naples; 16Past President of the Italian Association of Hemophilia Centers, Italy
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CO088 | LONG-TERM EXPOSURE TO AIR POLLUTION AND RISK OF INCIDENT VENOUS THROMBOEMBOLISM: A SYSTEMATIC REVIEW AND META-ANALYSIS L. Vulcano1, M.P. Donadini1|2, F. Moioli1, D. Santagata1, A. Tufano4, G. Veronesi3 | 1Ctr. Ric. Malattie Tromboemboliche e Terapie Antitrombotiche, Univ. Insubria, Varese, Italy; 2SSD Centro Trombosi e TAO, ASST Sette Laghi, Varese, Italy; 3Ctr. Ric. Epidemiologia e Med. Preventiva (EPIMED), Univ. Insubria, Varese, Italy; 4Dip. Med. Clinica e Chirurgia, Univ. Federico II, Napoli, Italy
53PDF: 19 -
CO004 | A NOVEL GENETIC CLASSIFICATION OF INHIBITOR RISK FOR F8 NONSENSE MUTATIONS BASED ON IMMUNOGENIC PROFILING OF RIBOSOMAL READTHROUGH M.F. Testa1, M. Pinotti1, A. Branchini1, M.E. Mancuso2, F. Bernardi1, D. Balestra2 | 1Department of Life Sciences and Biotechnology and LTTA Center, University of Ferrara, Ferrara, Italy; 2IRCCS, Humanitas Research Hospital, Center for Thrombosis and Hemorrhagic diseases, Milano, Italy
155PDF: 26 -
CO-44 | EVALUATION OF THE DEVIATION BETWEEN PRESCRIBED AND RECOMMENDED EMICIZUMAB DOSING IN PATIENTS WITH CONGENITAL HEMOPHILIA A A.C. Giuffrida1, S. Abeysinghe Gunawardhana1, S. Amato2, F. Casoli2, C. Recchi2, M. Saggioro2, E. Bonetti3, M. Bodini1, G. Poli2 | 1Centro Emofilia, UOC Medicina Trasfusionale, AOUI Verona, Italy; 2UOC Laboratorio Analisi, AOUI Verona, Italy; 3UOC Oncoematologia Pediatrica, AOUI Verona, Italy
56PDF: 21 -
PO041 | VARIABLE CLINICAL RESPONSE TO RECOMBINANT PORCINE FVIII IN ACQUIRED HAEMOPHILIA A: A TWO CASE EXPERIENCE WITH LABORATORY SUPPORTED MONITORING AM. Pizzini1, M. Bovara2, M. Sebastiani2, A. Fusco1, C. Fantoni1, M. Silingardi1, R. Mancini2, A. Coppola3 | 1Ambulatorio Emostasi & Trombosi, Dipartimento Medico - Ospedale Maggiore Bologna, Italy; 2Laboratorio Unico Metropolitano - Ospedale Maggiore Bologna, Italy; 3SDD Centro Hub Emofilia e MEC, Azienda Ospedaliero-Universitaria di Parma, Italy
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CO-26 | CLINICAL, LABORATORY AND METABOLIC CHARACTERISTICS OF ADULT PATIENTS WITH HEMOPHILIA A J. Di Paolo, M. Di Loreto, R. Malizia, M. Luongo, P. Massaro, M. Di Mascio, S. Verna | Immunohematology Service, Asl 02 Abruzzo, Chieti, Italy
51PDF: 18 -
PO10 | Clinical and laboratory features of long-Covid syndrome: a cross-sectional study of 1,337 Covid-19 survivors C. Ambaglio1, S. V. Benatti2, C. J. Tartari1,3, L. Russo1,3, S. Bolognini1,3, C. Ticozzi1, F. Schieppati1, V. Brusegan1, S. Venturelli2, L. Barcella1, M. Rizzi2, M. Marchetti1,3, A. Falanga1,3 | 1Department of Immunohematology and Transfusion Medicine, Papa Giovanni XXIII Hospital, Bergamo; 2Division of Infectious Diseases, Papa Giovanni XXIII Hospital, Bergamo; 3Department of Medicine and Surgery, University of Milan Bicocca, Monza, Italy
667PDF: 25 -
PO133 | RECURRENT SUPERFICIAL VENOUS THROMBOSIS AS AN ATYPICAL MANIFESTATION OF WHIPPLE’S DISEASE: A CASE REPORT C. Spillere, S. Suardi, F. Zoccatelli, L. Delfino, S. Moruzzi, F. Pizzolo, L. Marzano, E. Malloggi, F. Presa, L. Panepinto, M. Merlo, A. Moschella, S. Friso, N. Martinelli | U.O.C. Medicina Generale B, AOUI Verona, Italy. C. Spillere and S. Suardi contributed equally
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PO071 | WHEN SJÖGREN’S DISEASE MIMICS TTP A. Castoldi, R. Rossio, F. Peyvandi | Medicina generale Osp. Maggiore Policlinico, Milano, Italy
43PDF: 22 -
CO021 | TIME COURSE OF LP(a) LEVELS AFTER ACUTE CORONARY SYNDROME: A LONGITUDINAL STUDY G. Barbieri1, A.M. Gori1, G. Ciarrocca Taranta1, M. Di Gioia1, F. Alfano1, E. Lotti1, A. Rogolino1, F. Cesari1, B. Giusti1, M. Berteotti1, R. Marcucci1 | 1Atherothrombotic Diseases Center, Department of Experimental and Clinical Medicine, University of Florence - Careggi Hospital, Firenze, Italy
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CO24 | Extracellular vesicles profiles in patients with wild-type transthyretin amyloidosis S. Toffanin1, L. Spiezia1, C.M. Radu1, A. Napolitano1, A. Benetti1, C. Samà1, E. Campello1, L. De Michieli2, G. Sinigiani2, A. Cipriani2, P. Simioni1 | 1First Chair of Internal Medicine, Department of Medicine, University-Hospital of Padua Medical School, Padua; 2Department of Cardiac, Thoracic and Vascular Sciences and Public Health, University of Padua, Italy
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CO081 | RESTORATION OF CEREBRAL MICROVASCULAR STRUCTURE AND FUNCTION IN HEMOPHILIA A MICE THROUGH FVIII GENE THERAPY G. Venturin1, E. Spicuglia1, S. Assanelli1, C. Borsotti1, A. Cucci1, N. Keivan1, E. Borroni1, C. Sgromo1, C. Olgasi2, A. Follenzi1|3 | 1Department of Health Science, Università del Piemonte Orientale, Novara, 28100, Italy; 2Department of Translational Medicine, Università del Piemonte Orientale, Novara, 28100, Italy; 3Department of Attività Integrate Ricerca Innovazione, Azienda Ospedaliero-Universitaria SS. Antonio e Biagio e C. Arrigo, Alessandria, Italy
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CO-34 | SIMPLIFIED PERIOPERATIVE MANAGEMENT WITH N8-GP (TUROCTOCOG ALFA PEGOL) IN MAJOR ABDOMINAL SURGERY IN MILD HEMOPHILIA A WITH SEVERE BLEEDING PHENOTYPE: A CASE REPORT J. Di Paolo, R. Malizia, M. Luongo, P. Massaro, M. Di Mascio, S. Verna | Immunohematology Service, ASL 02 Abruzzo, Chieti, Italy
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PO70 | HEMOSTATIC ABNORMALITIES IN A PATIENT WITH WALDENSTRÖM'S MACROGLOBULINEMIA M. Gagliardi, L. Capone, A. Ciampa | Haemostasis Centre, AORN Moscati, Avellino, Italy
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CO046 | BLEEDING RISK FACTOR–BASED PHENOTYPES AND THEIR ASSOCIATION WITH MORTALITY AND HEMORRHAGIC OUTCOMES IN ATRIAL FIBRILLATION T. Bucci1, A.G. Rigutini1, A. Perrotta1, A. Moffa1, C. Seviroli1, M. Giustozzi2, M.C. Vedovati1, C. Becattini1 | 1Internal, Vascular and Emergency Medicine - Stroke Unit, University of Perugia, Perugia, Italy; 2SSD Angiology, San Giovanni Battista Hospital, Foligno, Italy
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CO-65 | COVID-19-ASSOCIATED HYPERCOAGULABILITY IN TYPE 2B VON WILLEBRAND DISEASE: INSIGHTS FROM GLOBAL HEMOSTATIC ASSAYS I. Condonato, C. Simion, E. Zanon, P. Simioni | Hemophilia Center, University Hospital of Padua, Italy
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PO63 | Atypical venous thrombosis in young patient with systemic lupus erythematosus and high-risk APL profile: provoked or not? E. Marrone, A. Parisi, G. Di Monda, F. Gallucci, D. Morelli, C. Romano, U. Malgeri, D. D’Auria, P. Morella | Internal Medicine Unit 3, Cardarelli Hospital, Naples, Italy
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CO-89 | FEMORAL FRACTURE SURGERY IN AN ELDERLY, FRAIL PATIENT WITH ACQUIRED HEMOPHILIA A RECEIVING EMICIZUMAB PROPHYLAXIS: A CASE REPORT C. Simion1|2, E. Zanon1|2, B. Stocco1|2, F. Sartorello1, C. Bulato1, G. Saggiorato1, P. Simioni1|2 | 1First Chair of Internal Medicine and Thrombotic and Haemorrhagic Diseases Unit, Department of Medicine, Padova University Hospital, Italy; 2Hemophilia Center, Padova University Hospital, Italy
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CO-43 | VALIDATION OF THROMBIN GENERATION MEASUREMENT IN PLATELET-RICH PLASMA: EVOLUTION IN THE ST GENESIA® SYSTEM F. Bocchi1|2, R. Pastorino1|2, G. Murante1|2|3, S. Bergonzi1|2|3, M. Capetta1|2|3, F. Valeri2|3, C. Dainese2|3, A. Valpreda4, B. Bruno1|3, A. Borchiellini2|3 | 1Department of Molecular Biotechnology and Health Sciences, University of Turin, Italy; 2Regional Centre for Thrombotic and Hemorrhagic Diseases, AOU Città della salute e della Scienza di Torino, Italy; 3Division of Hematology, AOU Città della Salute e della Scienza, University of Turin, Italy; 4Central Lab Baldi and Riberi, AOU Città della salute e della Scienza di Torino, Italy
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PO39 | Bleeding events in Von Willebrand disease type 1 yearly treatable with desmopressin A. Gringeri1,2, P.M. Mannucci3, M. Gringeri4, G. Castaman5, F. Peyvandi3,6 | 1Fondazione Charta, Milan; 2Centro di Sanità Solidale, Lucca; 3Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Angelo Bianchi Bonomi Hemophilia and Thrombosis Center and Fondazione Luigi Villa, Milan; 4Department of Medical Biotechnologies and Translational Medicine, Postgraduate School of Clinical Pharmacology and Toxicology, University of Milan; 5Centre for Bleeding Disorders and Coagulation, Careggi University Hospital, Firenze; 6Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Italy
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PO091 | RESPONSE AND CARDIOVASCULAR SAFETY OF FOSTAMATINIB IN CHRONIC IMMUNE THROMBOCYTOPENIA: A REAL WORLD ANALYSIS C. Giubbilei, G. Giustini, A. Baffioni, V. Carrai | SOD Ematologia, Azienda Universitaria Ospedaliera Careggi, Firenze, Italy
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PO039 | CLINICAL AND LABORATORY CHARACTERISTICS OF ACQUIRED HEMOPHILIA A: PRELIMINARY RESULTS FROM A RETROSPECTIVE OBSERVATIONAL MONOCENTRIC STUDY S. Suardi1, M. Bodini2, A.C. Giuffrida2, A. Zanzanelli3, S. Moruzzi1, L. Delfino1, F. Pizzolo1, S. Genesini2, M. Cantini2, C. Spillere1, L. Panepinto1, F. Zoccatelli1, E. Malloggi1, F. Presa1, A. Moschella1, M. Merlo1, G. Gandini2, S. Friso1, N. Martinelli1 | 1Department of Medicine, Unit of Internal Medicine B, Azienda Ospedaliera Universitaria Integrata di Verona, Italy; 2Department of Transfusion Medicine, Hemophilia Center, Azienda Ospedaliera Universitaria Integrata di Verona, Italy; 3Division of Internal Medicine, IRCCS Azienda Ospedaliero Universitaria Bologna, Italy
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CO070 | PLASMIN GENERATION AND ITS INTERPLAY WITH COAGULATION AND FIBRINOLYSIS IN ATRIAL FIBRILLATION: IMPACT OF ANTICOAGULANT THERAPY G. Ciarrocca Taranta1, F. Alfano1, M. Di Gioia2, M. Berteotti1|2, E. Lotti2, F. Cesari2, A. Rogolino2, F.A. Barbuto1, A. M Gori1|2, E. Sticchi1|2, B. Giusti1|2, R. Marcucci1|2 | 1Dep of Experimental and Clinical Medicine, University of Florence, Italy; 2Atherothrombotic Diseases, Careggi University Hospital, Firenze, Italy
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PO50 | SUB-ANALYSIS OF INTERIM RESULTS FROM A PHASE 2 STUDY INVESTIGATING REGN9933A2 AND REGN7508CAT FOR THE PREVENTION OF CONTACT-MEDIATED VENOUS THROMBOEMBOLISM IN PATIENTS WITH ACTIVE CANCER UNDERGOING PERIPHERALLY INSERTED CENTRAL CATHETER PLACEMENT (ROXI-CATH) J. Zwicker1,2, A.P. Kithcart3, J. Kaplan3, Y-C. Cheng3, J.G. Raya3, J. Xiao3, S. Li3, K. Musgrave4, D.E. Gutstein3, G. Piazza5 | 1Memorial Sloan Kettering Cancer Center, New York, NY, USA; 2Weill Cornell Medical Center, New York, NY, USA; 3Regeneron Pharmaceuticals, Inc. , Tarrytown, NY, USA; 4Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK; 5Brigham and Women’s Hospital, Boston, MA, USA
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PO09 | Comparison of different aggregometry methods for evaluation of platelet function in patients with myeloproliferative neoplasms C. Fortino, I. Bertozzi, D. Regazzo, L. Gianesello, G. Nuozzi, F. Sartorello, V. Azzaro, G. Saggiorato, A. Bertomoro, P. Simioni | First Medical Clinic, Department of Medicine – DIMED, Università degli Studi di Padova, Italy
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PO132 | POST KIDNEY TRANSPLANT PRESENTATION OF ACQUIRED THROMBOTIC THROMBOCYTOPENIC PURPURA: A CASE OF PRE-EXISTING ADAMTS13 INHIBITORS G. Murante1|2|5, S. Bergonzi1|2|5, M. Capetta1|2|5, F. Valeri1|2, C. Dainese1|2, A. Valpreda4, R. Pastorino1|5, F. Bocchi1|5, L. Biancone3, E. Gallo3, B. Bruno2|5, A. Borchiellini1|2 | 1Regional Centre for Hemorrhagic and Thrombotic Diseases; 2Division of Hematology; 3Nephrology Dialysis and Transplant U; 4Central Lab. Baldi and Riberi, AOU Città della Salute e della Scienza di Torino, Italy; 5Dep. of Molecular Biotechnology and Health Sciences, University of Turin, Italy
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PO070 | INFECTIVE ENDOCARDITIS AND ISCHEMIC CEREBRAL EVENTS IN A PATIENT WITH SYSTEMIC LUPUS ERYTHEMATOSUS AND TRIPLE ANTIPHOSPHOLIPID POSITIVITY: THE ROLE OF ANTICOAGULATION IN PRIMARY PREVENTION T. Marrazzo1, M.P. Ursi2, R. Andini1, R. Albisinni3 | 1UOC Med Interna e dei Trapianti; 2UOC Mecau; 3UOC CCH generale, Osp. Monaldi AORN dei Colli, Napoli, Italy
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CO111 | ROLE OF CONSTITUTIVE ENDOTHELIAL DYSFUNCTION IN THE PATHOGENESIS OF UNPROVOKED VENOUS THROMBOEMBOLISM: CHARACTERIZATION OF ENDOTHELIAL COLONY-FORMING CELLS AND ASSOCIATION WITH RISK OF RECURRENCE F. Calcaterra1|2, R. Ciceri1|2, M. Bacci1, A. Cancellara1|2, E. Romualdi3, L. Guerrieri1|2, F. Tumminello1, C. Lodigiani1, W. Ageno4, S. Della Bella1|2, D. Mavilio1|2, M.P. Donadini3|5 | 1IRCCS Humanitas Research Hospital, Italy; 2University of Milano, Italy; 3ASST Sette Laghi, Varese, Italy; 4University of Padua, Padova, Italy; 5University of Insubria, Varese, Italy
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CO-55 | DEVELOPMENT OF ENGINEERED LONG-ACTING BYPASSING FX VIA ALBUMIN FUSION FOR HEMOPHILIA WITH INHIBITORS A. Martucci1, R. Tarantino1, K.H. Aaen2, M. Pinotti1, J.T. Andersen2, A. Branchini1 | 1Department of Life Sciences and Biotechnology, University of Ferrara, Ferrara, Italy; 2Institute of Clinical Medicine, Department of Pharmacology, University of Oslo, Norway
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CO23 | Markers of inflammation and hypofibrinolysis are associated with cognitive dysfunction and motor performances in atrial fibrillation patients on oral anticoagulant therapy: insights from the Strat-AF study F. Alfano1,2, F. Cesari1,2, A.M. Gori1,2, M. Berteotti1,2, E. Salvadori3, B. Giusti1,2, A. Bertelli1,2, F. Fratini4, A. Rogolino1,2, B. Formelli4,5, F. Pescini4,5, E. Fainardi6, E. Barucci4, G. Salti5, A. Cavaliere4, A. Ginestroni6, A. Poggesi4,5, R. Marcucci1,2 | 1Department of Experimental and Clinical Medicine, University of Firenze; 2Center for Atherothrombotic Diseases, Careggi University Hospital, Firenze; 3Department of Biomedical and Clinical Sciences, University of Milan; 4NEUROFARBA Department, Neuroscience Section, University of Firenze; 5Stroke Unit, Careggi University Hospital, Firenze; 6Neuroradiology Unit, Careggi University Hospital, Department of Experimental and Clinical Biomedical Sciences, University of Firenze, Italy
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PO107 | OUTCOME AND RISK OF CANCER IN SUPERFICIAL VENOUS THROMBOSIS WITH AND WITHOUT VARICOSE VEINS M. Sartori, E. Zanata, S. Cavara, M. Soldati, B. Cosmi | Angiology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Italy
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CO080 | INVESTIGATING MECHANISMS OF ACQUIRED VON WILLEBRAND SYNDROME ACROSS HEMATOLOGICAL DISEASES: THE CONTRIBUTION OF INTRAPLATELET VWF A. Ciavarella1, L. Baronciani1, O. Seidizadeh1, P. Colpani1, F. Boggio1, D. Cattaneo2|3, S. Ceglie1, M.T. Pagliari1, A. Iurlo2, S.M. Siboni1, F. Peyvandi1|4 | 1Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Milano, Italy; 2Hematology Division, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano, Italy; 3Department of Oncology and Hemato-Oncology, University of Milano, Milano, Italy; 4Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Milano, Italy
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CO-32 | TRAUMA MANAGEMENT IN SEVERE HEMOPHILIA A: A CASE REPORT J. Di Paolo, R. Malizia, M. Luongo, P. Massaro, M. Di Mascio, S. Verna | Immunohematology Service, ASL 02 Abruzzo, Chieti, Italy
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PO68 | RISK OF VENOUS THROMBOEMBOLISM IN PATIENTS WITH CANCER AND MIGRAINE: A COHORT ANALYSIS AMONG DANISH NATIONAL HEALTH SURVEY PARTICIPANTS O. Rosenkrantz1, P. Szentkúti1, L. Amdisen1, E. Horváth-Puhó1, A.L. Pedersen1, H.E. Bøtker2, H. Elser1|3, J.P. Vandenbroucke1|4|5, H.T. Sørensen1 | 1Department of Clinical Epidemiology and Center for Population Medicine, Aarhus University Hospital and Aarhus University, Denmark; 2Department of Cardiology, Aarhus University Hospital, Department of Clinical Medicine, University of Aarhus, Denmark; 3Department of Neurology, Hospital of the University of Pennsylvania, Philadelphia, PA, USA; 4Department of Clinical Epidemiology, Leiden University Medical School Leiden, The Netherlands; 5School of Hygiene and Tropical Medicine, London, UK
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CO037 | PERFORMANCE OF A QUALITATIVE POINT-OF-CARE TEST IN PATIENTS EXPERIENCING ACUTE THROMBOEMBOLIC OR MAJOR BLEEDING EVENTS TREATED WITH DOACs: THE T-BLEEDOAC MULTICENTER PROSPECTIVE COHORT STUDY M. Vedovati1, G. Pepe2, S. Vanni3, E. Campello4, F. Morello5, S. Beccatini1, D. Giudici1, F. Lucarini2, L. Parmeggiani3, G. Fabiani3, P. Simioni4, M. Santoro5, P. Nazerian6, M. Mosconi1, C. Becattini1 | 1University of Perugia, Perugia, Italy; 2Versilia Hospital, Tuscany North West Health System, Lido di Camaiore (LU), Italy; 3Università di Firenze, Firenze, Italy; 4University of Padua, Padova, Italy; 5A.O.U. Città della Salute e della Scienza, Torino, Italy; 6Careggi University Hospital, Firenze, Italy
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PO05 | DESIGN, SYNTHESIS, AND BIOLOGICAL EVALUATION OF NOVEL IMATINIB AND NILOTINIB ANALOGUES EXPRESSING ENHANCED ANTIPLATELET AND ANTICANCER ACTIVITIES D. Pantazi1, L. Pechlivani1, A. Kosma1, K. Lalechou1, M.G. Siskos2, D. Alivertis3, A.D. Tselepis1 | 1Atherothrombosis Research Centre, Laboratory of Biochemistry, Department of Chemistry, University of Ioannina, Greece; 2Laboratory of Organic Chemistry, Department of Chemistry, University of Ioannina, Greece; 3Department of Biological Applications and Technology, University of Ioannina, Greece
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PO58 | Gender differences in primary haemostasis A. Becchetti2, M. Brambilla2, M. Conti2, D. Trabattoni2, E. Tremoli3, M. Camera1,2 | 1Department of Pharmaceutical Sciences, Università degli Studi di Milano; 2Centro Cardiologico Monzino IRCCS, Milan; 3Maria Cecilia Hospital, Cotignola (RA), Italy
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CO36 | Inhibitor titer at diagnosis and clinical course in acquired hemophilia A: a single-center experience C. Simion, B. Stocco, E. Dalla Porta, E. Campello, G. Furlan, L. Spiezia, G. Saggiorato, F. Sartorello, E. Zanon, P. Simioni | Department of Medicine – DIMED, University of Padua, Italy
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PO120 | UNEXPLAINED BLEEDING IN A YOUNG WOMAN: A CASE REPORT OF SUPERWARFARIN TOXICITY M. Guarascio1, A. Ferretti2, L. Di Gennaro2, M. Comand2, E. De Candia2 | 1Internal Medicine Unit, Vito Fazzi Hospital, Lecce, Italy; 2Department of Translational Medicine and Surgery, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Roma, Italy
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CO-42 | LONGITUDINAL THROMBIN GENERATION PROFILING IN A PATIENT WITH SEVERE HEMOPHILIA A DURING ANTITHROMBIN-LOWERING THERAPY, CANCER, AND MAJOR SURGERY C. Simion1|2, C. Bulato1, E. Campello1|2, E. Zanon1|2, B. Serena1, S. Toffanin1, P. Simioni1|2 | 1First Chair of Internal Medicine and Thrombotic and Haemorrhagic Diseases Unit, Department of Medicine, Padova University Hospital, Italy; 2Hemophilia Center, Padova University Hospital, Italy
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CS08 | A combination of two rapid immunoassays improves HIT diagnosis G. Ciarrocca Taranta1, A. Rogolino2, A. Bertelli1, A. Sorrentino1, M. Di Gioia2, F. Cesari2, B. Giusti1,2, E. Sticchi1,2, M. Berteotti1,2, A.M. Gori1,2, R. Marcucci1,2 | 1Department of Experimental and Clinical Medicine, University of Firenze; 2Atherothrombotic Disease Unit, Careggi University Hospital, Firenze, Italy
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PO161 | A REGIONAL DIGITAL NETWORK FOR THE MANAGEMENT OF ACQUIRED HEMOPHILIA A: A MODEL FOR INTEGRATED CARE M. Mattana1, S. Raso1, R. Tomasello1, MF. Mansueto1, C. Cammarata2, S. Siragusa3, M. Napolitano1|3 | 1A.O.O.R. Villa Sofia Cervello P.O. Cervello-UOC di Ematologia per le Malattie Rare del Sangue e degli Organi Ematopoietici, Italy; 2PO Sant'Elia, Caltanissetta, Italy; 3Dipartimento di Promozione della Salute, Materno-Infantile, Medicina Interna e Specialistica di Eccellenza (ProMISE), Università degli Studi di Palermo, Italy
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PO087 | BEYOND POSITIVITY: THE HIERARCHICAL ROLE OF IMMUNOASSAYS IN HEPARIN INDUCED THROMBOCYTOPENIA G. Murante1|2|3, S. Bergonzi1|2|3, M. Capetta1|2|3, F. Valeri1|2, C. Dainese1|2, A. Valpreda4, R. Pastorino1|3, F. Bocchi1|3, A. Porreca5, B. Bruno2|3, A. Borchiellini1|2 | 1Regional Centre for Hemorrhagic and Thrombotic Diseases, AOU Città della Salute e della Scienza di Torino, Italy; 2Division of Hematology, AOU Città della Salute e della Scienza, Università di Torino, Italy; 3Dep. of Molecular Biotechnology and Health Sciences, University of Turin, Italy; 4Central Lab. Baldi and Riberi, AOU Città della Salute e della Scienza di Torino, Italy; 5Dep. of Human Sciences and Quality of Life Promotion, Clinical and Molecular Epidemiology, IRCCS San Raffaele Roma, Italy
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CO067 | ELUCIDATING THE EVIL RELATIONSHIP OF METABOLIC DYSFUNCTION–ASSOCIATED FATTY LIVER DISEASE WITH CARDIOVASCULAR COMORBIDITIES: THE COMPLEX INTERPLAY AMONG HYPERCOAGULABILITY, INFLAMMATION, AND LIVER FIBROSIS G. Gagliardi, E. Campello, A. Napolitano, B. Stocco, C. Di Gesù, G. Gobbo, I. Condonato, M. Allegra, G. Antonello, C. Portinari, C. Goffi, G. Camporese, P. Scarinzi, R. Pesavento, F. Bilora, M. Di Pascoli, C. Bulato, A. Montagna, D. Regazzo, A. Zambon, L. Fabris, P. Simioni | Department of Medicine, University of Padova, Italy
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CO-74 | WHAT WOMEN ARE NOT ASKED A MODEL OF CARE FOR WOMEN AND GIRLS WITH BLEEDING DISORDERS S. Pancetti, A.C. Ferrini, E. Magnani, P. Pedrazzi, C. Biasoli | Osp. M.Bufalini, Cesena, Italy
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PO42 | DIFFERENTIAL EXPRESSION OF HEMOSTATIC BIOMARKERS ACROSS CANCER TYPE AND DISEASE STAGE: A PROSPECTIVE ANALYSIS OF 4,292 PATIENTS FROM THE HYPERCAN STUDY P. Gómez-Rosas1|2|, D. Romeo1, S. Bolognini1, C. Ticozzi1, F. Schieppati1, A. D’Alessio4, R. Labianca4, A. Falanga1|5|6, M. Marchetti1|5|6 | 1Hospital Papa Giovanni XXIII, Bergamo, Italy; 2Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, the Netherlands; 3Hospital de Oncologia, Unidad Medica de Alta Especialidad (UMAE), Centro Medico Nacional Siglo XXI, Instituto Mexicano del Seguro Social (IMSS), Mexico City, Mexico; 4Fondazione ARTET Onlus, Bergamo, Italy; 5ERN EuroBloodNet; 6School of Medicine and Surgery, University of Milan Bicocca, Italy; *On Behalf Of The Hypercan Investigators
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PO06 | Extracellular vesicles profiles in patients with porto-sinusoidal vascular disease S. Toffanin1, E. Campello1, A. Zanetto2, C. M. Radu1, E. Pinto2, K. Fernande2, C. Bulato1, B. Serena1, L. Spiezia1, P. Burra2, M. Senzolo2, P. Simioni1 | 1First Chair of Internal Medicine, Department of Medicine, University Hospital of Padua Medical School, Padua; 2Department of Surgery Oncology and Gastroenterology, Gastroenterology and Multivisceral Transplant Unit, University Hospital of Padua, Italy
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PO069 | PERIOPERATIVE CHALLENGES IN ACQUIRED THROMBOTIC THROMBOCYTOPENIC PURPURA DURING CAPLACIZUMAB TREATMENT J. Agnelli Giacchello1, P. Sciancalepore1, N.F. Trincheri2, L. Contino1, M. Ladetto3, R.M. Santi1 | 1SSD Emostasi e trombosi e malattie rare; 2SC Laboratorio Analisi; 3SCDU Ematologia, AOU SS. Antonio e Biagio e Cesare Arrigo, Alessandria, Italy
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CO012 | LONG-TERM RISK OF RECURRENT VENOUS THROMBOEMBOLISM IN ADULT PATIENTS WITH ACTIVE CANCER AND FIRST CATHETER-RELATED UPPER EXTREMITY DEEP VEIN THROMBOSIS AFTER DISCONTINUATION OF ANTICOAGULANT TREATMENTS AND LINE REMOVAL: A RETROSPECTIVE MULTI-CENTER COHORT STUDY – CANCER-CRT STUDY L. Girardi1|2, W. Ageno3, L. Bertù1, C. Lodigiani4, L.A. Ciuffini4, M.C. Vedovati5, C. Becattini5, A. Sammarco6, G. Camporese6, G. Cuni1|7, C. Ambaglio7, M.P. Donadini1 | 1Research Center on Thromboembolic Diseases and Antithrombotic Treatment, Department of Medicine and Surgery, University of Insubria, Varese, Italy; 2Department of Medicine, The Ottawa Hospital Research Institute, University of Ottawa, Ontario, Canada; 3Department of Medicine, University of Padua, Padova, Italy; 4Center for Thrombosis and Hemorrhagic Diseases, IRCCS Humanitas Research Hospital, Rozzano, Milano, Italy; 5Internal and Cardiovascular Medicine-Stroke Unit, University of Perugia, Perugia, Italy; 6Clinica Medica 1, Department of Medicine, DIMED, Padova University Hospital, Padova, Italy; 7Immunohematology and Transfusion Medicine, Department of Transfusion Medicine and Hematology, ASST Papa Giovanni XXIII, Bergamo, Italy
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CO-53 | LIVER FIBROSIS, STEATOSIS AND SUBCLINICAL ATHEROSCLEROSIS IN PATIENTS WITH HEMOPHILIA: A CROSS-SECTIONAL STUDY C. Simion1|2, B. Stocco1|2, I. Condonato1|2, E. Dalla Porta1|2, A. Napolitano1|2, E. Zanon1|2, L. Fabris1, L. Spiezia1|2, P. Simioni1|2 | 1First Chair of Internal Medicine and Thrombotic and Haemorrhagic Diseases Unit, Department of Medicine, Padova University Hospital, Italy; 2Hemophilia Center, Padova University Hospital, Italy
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BEST-04 | MAJOR ORTHOPEDIC SURGERY WITH EMICIZUMAB: A SERIES OF 22 PATIENTS (40 PROCEDURES) WITH A MID-TERM FOLLOW-UP G. Daniele1, C. Carulli1, S. Linari2, L. Pieri2, G. Castaman2 | 1Clinica Ortopedica, Azienda Ospedaliero-Universitaria Careggi, Università degli Studi di Firenze, Italy; 2Centro Malattie Emorragiche e della Coagulazione, Azienda Ospedaliero-Universitaria Careggi, Firenze, Italy
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OC09 | BLEEDING RISK ASSOCIATED WITH FACTOR XI MONOCLONAL ANTIBODIES IN COMBINATION WITH ASPIRIN IN HEALTHY VOLUNTEERS AND ORTHOPEDIC SURGERY PATIENTS: ANALYSIS FROM RECENT PHASE 1 AND PHASE 2 STUDIES A.P. Kithcart1, M.E. Burczynski1, P. Banerjee1, M. Onisko1, Y. Wang1, K. Mohammadi1, D. Li1, S. Li1, J. Ackroyd2, B.A. Olenchock1, D.E. Gutstein1, J. I. Weitz3 | 1Regeneron Pharmaceuticals, Inc., Tarrytown, NY, USA; 2Clinical Research, Fortrea Clinical Research Unit Ltd, Leeds, UK; 3McMaster University, Hamilton, ON, Canada
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PO45 | Routine prophylaxis with PD-FX concentrate in severe inherited FX deficiency: a case report S. Linari, L. Pieri, M. Attanasio, F. Salvianti, M. Coppo, E. Grisanti, F. Demartis, R. Fjerza, G. Castaman | Centre for Bleeding Disorders and Coagulation, Azienda Ospedaliera Universitaria Careggi, Firenze, Italy
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CO21 | Viscoelastic testing in inherited bleeding disorders: a cross-sectional comparison between viscoelastic coagulation monitoring and rotational thromboelastometry C. Simion, C. Samà, C. Bulato, G. Gottardi, D. Regazzo, E. Campello, P. Simioni | Department of Medicine – DIMED, University of Padua, Italy
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PO103 | THE EFFECT OF ALBUMIN ON SERUM CONCENTRATION OF DIRECT ORAL ANTICOAGULANTS: A CROSS-SECTIONAL STUDY A. Pannunzio1, E. Valeriani2, I.M. Palumbo1, V. Cammisotto3, S. Bartimoccia3, V. Castellani3, S. Marucci3, D. Pastori3, D. Menichelli3, P. Pignatelli3 | 1Dip. di Chirurgia generale, specialistica ed anestesiologia - Università degli studi di Roma La Sapienza, Italy; 2Dip. di Medicina Interna, Scienze Endocrino-metaboliche e Malattie Infettive - Università degli Studi di Roma La Sapienza, Italy; 3Dip. di Medicina e Scienze Cardiovascolari - Università degli Studi di Roma La Sapienza, Italy
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PO045 | FROM PROPHYLAXIS TO ENDOGENOUS CONTROL: A SIX-MONTH REAL-WORLD EXPERIENCE WITH VALOCTOCOGENE ROXAPARVOVEC GENE THERAPY M. Basso1, A. Ferretti1, M. Sacco1, S. Lancellotti1, T. Pirozzi1, L. Di Gennaro1, R. De Cristofaro1|2 | 1Servizio Malattie Emorragiche e Trombotiche, Fondazione Policlinico Universitario Gemelli IRCCS, Italy; 2Dipartimento di Medicina e Chirurgia Traslazionale, Università Cattolica S. Cuore, Roma, Italy
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