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When a feminist platelet went to the convention of prostaglandins and thromboxanes
1272PDF: 164HTML: 189Italian version: 105 -
PO26 | Non-canonical coagulation platelets function: monocyte-platelet interaction a bridge between inflammation and coagulation A. Benetti1, A. Galbiati1, M. Cola2, L. Calandrino2, C. Samà1, D. Regazzo1, S. Ferrari1, C.M. Radu1, A. Cattelan2, P. Simioni1 | 1Department of Medicine - DIMED; 2Infectious and Tropical Diseases Unit, Padua University Hospital, Padua, Italy
657PDF: 25 -
CO069 | POLYSTYRENE NANOPLASTICS PRIME PLATELET TO DRIVE PRO-INFLAMMATORY AND PRO-FIBROTIC ACTIVATION OF CARDIAC FIBROBLASTS Z. Saeed1|2, M. Dovizio1|3, C. Milillo1|3, P. Lanuti1|4, S. Porro1|4, F. D’Ascanio1|4, A. Bruno1|3, P. Ballerini1|3, G. Renda1|2 | 1Center for Advanced Studies and Technology (CAST), “G. d’Annunzio” University of Chieti-Pescara, Chieti, Italy; 2Department of Neurosciences, Imaging and Clinical Sciences, "G. d'Annunzio" University of Chieti-Pescara, Chieti, Italy; 3Department of Innovative Technologies in Medicine & Dentistry, “G. d’Annunzio” University of Chieti-Pescara, Chieti, Italy; 4Department of Medicine and Aging Sciences, “G. d’Annunzio” University of Chieti-Pescara, Chieti, Italy
82PDF: 17 -
CO091 | DOWNREGULATION OF MARKERS OF PLATELET ACTIVATION, PLATELET TURNOVER, AND PLATELET DESIALYLATION IN GOOD RESPONDERS TO FIRST-LINE TREATMENT(S) FOR IMMUNE THROMBOCYTOPENIA B. Clerici1|2, C. Ghali2, M. Scavone2, A. Fioretti2, E.G. Bossi2, S. Birocchi1, E. Tarasconi1|2, G. D'Avanzo1, M. Carpenedo3, S. Caberlon2, G.M. Podda1|2 | 1.S.C. Medicina Generale SP, Ospedale San Paolo, ASST Santi Paolo e Carlo, Milano, Italy; 2Dipartimento di Scienze della Salute (DISS), Università degli Studi di Milano, Italy; 3S.S. Ematologia Non Oncologica, ASST Grande Ospedale Metropolitano Niguarda, Milano, Italy. B. Clerici and C. Ghali contributed as co-first authors
53PDF: 17 -
CO107 | PREGNANCY IN A YOUNG WOMAN WITH SEVERE THROMBOCYTOPENIA ASSOCIATED WITH GNE GENE MUTATION S. Bonafini1, A. Meneguzzi1, A. Savoia2, S. Uccella3, V. Tamborrino3, S. Cesaro3, E. Bonetti3, A. Giuffrida4, P. Minuz1, C. Fava1 | 1Dip. Medicina, Azienda Ospedaliera Universitaria Integrata Verona, Italy; 2Dip di Ingegneria per la Medicina di innovazione, Università di Verona, Italy; 3Dip. Materno-Infantile, Azienda Ospedaliera Universitaria Integrata Verona, Italy; 4Dip. Medicina trasfusionale, Azienda Ospedaliera Universitaria Integrata Verona, Italy
61PDF: 19 -
PO46 | Intravitreal treatment with faricimab in patients with age-related macular degeneration M. Alfonsetti1, R. Liani1, P.G.M. Simeone1, M. Frezza1, A. Ricci3, S. Lattanzio1, R. D’Aloisio2, L. Toto2, F. Santilli1 | 1Department of Medicine and Aging, Center for Advanced Studies and Technology “CAST”; 2Ophthalmology Clinic, Department of Medicine and Aging; 3Department of Pharmacy, University “G. d’Annunzio” of Chieti Pescara, Chieti, Italy
491PDF: 19 -
PO027 | IGFBP-6 REGULATES PLATELET PROCOAGULANT ACTIVITY AT THE INTERFACE BETWEEN INFLAMMATION AND COAGULATION L. Bury1, E. Falcinelli1, E. Petito1, L. Leijonancker2, H. van Ooijen2, S. Petkov2, A.R.D. Coda3, C. Raucci1, V. Fazzi1, D. Sarnà1, C. Becattini1, P. Gresele1, A. Liso4 | 1Department of Medicine and Surgery, Section of Internal and Cardiovascular Medicine, University of Perugia, Perugia, Italy; 2Pixelgen Technologies AB, Stockholm, Sweden; 3C.R.E.A.T.E.-Center for Research and Innovation in Medicine, Department of Medical and Surgical Sciences, University of Foggia, Italy; 4Department of Medicine and Surgery, University of Perugia, Perugia and Hematology/Oncology Unit, Terni Hospital, Terni, Italy
45PDF: 21 -
The key to fibrinolysis and thrombolysis
1707PDF: 531HTML: 264 -
PO090 | INCOMPLETE THROMBIN INHIBITION: BIOCHEMICAL AND FUNCTIONAL EVIDENCE OF ADP P2Y1 RECEPTOR DESENSITIZATION IN HUMAN PLATELETS E. Schiera, S. De Corci, A. Di Battista, F.M. Pulcinelli | Experimental Medicine Sapienza University of Rome, Italy
31PDF: 18 -
PO148 | ANALYTICAL DISCREPANCY IN PLATELET COUNTING REVEALING MYH9-RD: A CASE REPORT M. De Girolamo, A. Marrocchi, F. Vitone, M. Scapaticci, M. Bovara, T. Papillo, R. Mancini | Laboratorio Unico Metropolitano, Bologna, Italy
32PDF: 22 -
PO021 | PLATELETS MATTER: THROMBIN GENERATION IN PLATELET‐RICH PLASMA VERSUS PLATELET-POOR-PLASMA UNDER NON-REPLACEMENT THERAPIES IN HAEMOPHILIA F. Bocchi1|2, R. Pastorino1|2, G. Murante1|2|3, S. Bergonzi1|2|3, M. Capetta1|2|3, F. Valeri2|3, C. Dainese2|3, A. Valpreda4, B. Bruno1|3, A. Borchiellini2|3 | 1Department of Molecular Biotechnology and Health Sciences, University of Turin, Torino, Italy; 2Regional Centre for Thrombotic and Hemorrhagic Diseases; 3Division of Hematology; 4Central Lab Baldi and Riberi, AOU Città della salute e della Scienza di Torino, Torino, Italy
36PDF: 20 -
PO06 | ACTIVATED PLATELETS INDUCE THE FORMATION OF NEUTROPHIL EXTRACELLULAR TRAPS VIA TOLL-LIKE RECEPTOR-4 AND P-SELECTIN GLYCOPROTEIN LIGAND-1 I.C. Moschonas, A.D. Tselepis | Atherothrombosis Research Centre, University of Ioannina, Greece
495PDF: 102 -
CO-36 | PLATELETS MATTER: THROMBIN GENERATION IN PLATELET‐RICH-PLASMA VS. PLATELET‐POOR‐PLASMA UNDER NON-REPLACEMENT THERAPIES IN HEMOPHILIA F. Bocchi1|2, R. Pastorino1|2, G. Murante1|2|3, S. Bergonzi1|2|3, M. Capetta1|2|3, F. Valeri2|3, C. Dainese2|3, A. Valpreda4, B. Bruno1|3, A. Borchiellini2|3 | 1Department of Molecular Biotechnology and Health Sciences, University of Turin, Italy; 2Regional Centre for Thrombotic and Hemorrhagic Diseases, AOU Città della salute e della Scienza di Torino, Italy; 3Division of Hematology, AOU Città della Salute e della Scienza, University of Turin, Italy; 4Central Lab Baldi and Riberi, AOU Città della salute e della Scienza di Torino, Italy
58PDF: 17 -
PO58 | Gender differences in primary haemostasis A. Becchetti2, M. Brambilla2, M. Conti2, D. Trabattoni2, E. Tremoli3, M. Camera1,2 | 1Department of Pharmaceutical Sciences, Università degli Studi di Milano; 2Centro Cardiologico Monzino IRCCS, Milan; 3Maria Cecilia Hospital, Cotignola (RA), Italy
656PDF: 16 -
PO029 | IMPACT OF HEPATOCELLULAR CARCINOMA ON CIRCULATING RETICULATED PLATELETS IN PATIENTS WITH AND WITHOUT LIVER CIRRHOSIS S. Toffanin1, P. Guerra2, B. Serena1, C. Bulato1, A. Montagna1, C.M. Radu1, A. Bonaldo2, S. Cagnin2, C. Soldà3, M.D. Rizzato3, S. Lonardi3, F. Bergamo3, A. Zanetto4, E. Pinto4, M. Senzolo4, S. Montagnese2, E. Campello1, A. Martini2, P. Simioni1 | 1Thrombotic and Hemorrhagic Diseases Unit, General Internal Medicine, Department of Medicine, University of Padua, Padova, Italy; 2Internal Medicine and Hepatology Unit, Department of Medicine, University of Padua, Padova, Italy; 3Department of Oncology, Veneto Institute of Oncology IOV-IRCCS, Padova, Italy; 4Oncology, and Gastroenterology Unit, Department of Surgery, University of Padua, Padova, Italy
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CO016 | PLATELET HYPER-REACTIVITY AND PROCOAGULANT PHENOTYPE IN ESSENTIAL THROMBOCYTHEMIA: INSIGHTS FROM ADVANCED PLATELET FUNCTION TESTING A. Pozzi, G. Rosati, C. Barale, M. Padrini, R.M. Medici, G. Ferrari, E. Mordohovich, M. Tamietti, M. Armenio, M. Geminiani, M. De Gobbi, I. Russo, A. Morotti | Dip. Scienze Cliniche e Biologiche, Torino, Italy
62PDF: 24 -
CO075 | PLATELET ACTIVATION PROFILE IN RELAPSING-REMITTING MULTIPLE SCLEROSIS AND ITS RELATIONSHIP WITH NEURONAL AND ASTROGLIAL BIOMARKERS A. Fioretti1, M. Scavone1, A. Mingione2|3, C. Monzani2|3, M. Miozzo4, F. Martinelli-Boneschi2|3|5, G.M. Podda1 | 1Division of Medicina Generale SP, ASST Santi Paolo e Carlo, Laboratory of Haemostasis and Thrombosis, Dipartimento di Scienze della Salute, Università degli Studi di Milano, Milano, Italy; 2Laboratory of Precision Medicine of Neurological Diseases, Department of Health Science, University of Milano, Milano, Italy; 3CRC “Aldo Ravelli” for Experimental Brain Therapeutics, Department of Health Science, University of Milano, Milano, Italy; 4Department of Health Sciences, Division of Medical Genetics, University of Milano, ASST Santi Paolo e Carlo, Milano, Italy; 5Clinical Neurology Unit, ASST Santi Paolo e Carlo and Department of Health Sciences, University of Milano, Milano, Italy
65PDF: 16 -
CO46 | Comparison of reticulated platelet procoagulant role in liver cirrhosis vs. fibrosis S. Toffanin1, E. Campello1, A. Zanetto2, G. Gagliardi1, A. Napolitano1, E. Stocco1, G. Gobbo1, E. Pinto2, C. M. Radu1, M. Senzolo2, L. Fabris1, P. Simioni1 | 1First Chair of Internal Medicine, Department of Medicine, University-Hospital of Padua Medical School, Padova; 2Department of Surgery Oncology and Gastroenterology, Gastroenterology and Multivisceral Transplant Unit, Padova University Hospital, Padova, Italy
607PDF: 21 -
CO098 | ANTI-β2GPI AND ANTI-PS/PT ANTIBODIES, AND THEIR COMBINATION, EXERT A DISTINCT PLATELET ACTIVATION PROFILE M. Camera1|2, A. Becchetti2, M.O. Borghi3|4, M. Brambilla2, P.A. Lonati4, C. Bodio4, E. Pontara5, M.G. Cattini5, E. Bison5, M. Tonello6, N. Pozzi7, P. Meroni4, V. Pengo5 | 1Department of Pharmaceutical Sciences, University of Milano, Milano, Italy; 2Unit of Cell and Molecular Biology in Cardiovascular Diseases, Centro Cardiologico Monzino IRCCS, Milano, Italy; 3Dipartimento di Scienze Cliniche e di Comunità, Dipartimento di Eccellenza 2023-2027, University of Milano, Milano, Italy; 4IRCCS Istituto Auxologico Italiano, Milano, Italy; 5Department of Cardiac-Thoracic-Vascular Sciences and Public Health, University of Padua, Padova, Italy; 6Department of Medicine, University of Padua, Padova, Italy; 7Saint Louis University School of Medicine, St. Louis, United States
56PDF: 17 -
PO52 | Comprehensive assessment of variables affecting spontaneous platelet aggregation C. Ghali1, A. Fioretti1, M. Scavone1, E. Bossi1, B. Clerici1, S. Birocchi1, E. Popov2, M. Centola3, G.M. Podda1, M. Cattaneo4 | 1Divisione di Medicina Generale II, ASST Santi Paolo e Carlo, DISS, Università degli Studi di Milano, Italy; 2National Medical Research Center of Cardiology, Ministry of Health of the Russian Federation, Moscow; 3Division of Cardiology, Pio XI Hospital, ASST Brianza, Desio, Italy; 4Fondazione Arianna Anticoagulazione, Bologna, Italy
687PDF: 27 -
CO43 | Early platelet dysfunction in sepsis: an ICU pilot study S. Sorrentino1, C. Gori2, L. D’Innocenzo1, M. De Siati1, Mg. Bocci3, E. De Candia1 | 1Unit of Haemostasis and Thrombosis Diseases, Fondazione Policlinico Universitario A. Gemelli, IRCCS, Roma; 2UOC Shock & Trauma, Azienda Ospedaliera San Camillo Forlanini, Roma; 3National Institute for Infectious Diseases, Lazzaro Spallanzani, IRCCS, Roma, Italy
663PDF: 21 -
PO093 | HOW LONG IS TOO LONG? A CASE OF SEVERE PERSISTENT THROMBOCYTOPENIA B. Clerici1|2, C. Ghali2, M. Scavone2, A. Fioretti2, M. Perego1, C. Mondini1|2, E. Fiorini1, L. Catarini1, C. Pescia3, S. Caberlon1, U. Gianelli2|3, G.M. Podda1|2 | 1S.C. Medicina Generale SP, Ospedale San Paolo, ASST Santi Paolo e Carlo, Milano, Italy; 2Dipartimento di Scienze della Salute (DISS), Università degli Studi di Milano, Milano, Italy; 3S.C. Anatomia Patologica, Ospedale San Paolo, ASST Santi Paolo e Carlo, Milano, Italy
38PDF: 17 -
CO40 | The co-inheritance of two ITGB3 variants exerting additive detrimental effects on platelets leads to variant Glanzmann thrombasthenia N. Arndt1, E. Falcinelli1, A. Zamora-Cánovas2, A. Sánchez Fuentes2, A. Marín-Quilez2, I. Tano1, M.D.M. Nieto-Hernández3, J.M. Bastida4, J. Rivera2, P. Gresele1, L. Bury1 | 1Department of Medicine and Surgery, Section of Internal and Cardiovascular Medicine, University of Perugia, Italy; 2Servicio de Hematología y Oncología Médica, Hospital Universitario Morales Meseguer, Centro Regional de Hemodonación, Universidad de Murcia, IMIB-Pascual Parrilla, ISCIII-CIBERER, Murcia, Spain; 3Servicio de Hematología, Hospital Universitario de Jaen, Spain; 4Departamento de Hematología, Complejo Asistencial Universitario de Salamanca “CAUSA”, Instituto de Investigación Biomédica de Salamanca “IBSAL”, Centro de Investigación del Cáncer, IBMCC-CSIC, Universidad de Salamanca “USAL”, Salamanca, Spain
631PDF: 21 -
Platelet-driven remodeling of cancer cell glycoproteins fuels inflammation and metastasis
548PDF: 145Extra Tables: 74Extra Figure 1: 75Extra Figure 2: 65 -
PO07 | PLATELET INHIBITION BY THE NOVEL NITRIC OXIDE-DONOR NITROSOOXYPROPANOL M. Lindkvist, J. Jakobsson, F. Lynfeldt, B. Sandberg, K. Fransén, K. Nilsson, M. Grenegård | Cardiovascular Research Centre, Faculty of Medicine and Health, Örebro University, Örebro, Sweden
449PDF: 110 -
CO50 | Diagnostic accuracy of the heparin-induced multiple electrode aggregometry (HIMEA) functional test for heparin-induced thrombocytopenia M. Bovara1, M. Sebastiani2, Am. Gori3,4, A. Rogolino3,4, A. Bertelli3,4, G. Ciarrocca Taranta3,4, R. Marcucci3,4, M. Sartori5, B. Cosmi5, M. Silingardi6, A. M. Pizzini6, A. Marrocchi1, R. Mancini1 | 1Laboratorio Unico Metropolitano Ospedale Maggiore, AUSL Bologna; 2IRCCS Istituto delle Scienze Neurologiche, Bologna; 3Centro Malattie Aterotrombotiche Azienda Ospedaliera Universitaria Careggi, Firenze; 4Dipartimento di Medicina Sperimentale e Clinica, Università di Firenze; 5U.O. di Angiologia e Malattie della Coagulazione dell’Azienda Ospedaliero Universitaria Policlinico S. Orsola-Malpighi, Bologna; 6Medicina Interna Ospedale Maggiore, Bologna, Italy
632PDF: 22 -
Platelet distribution width is associated with cardiovascular mortality in an adult general population
3096PDF: 521Supplementary Material: 144 -
PO086 | INHERITED PLATELET GPIV DEFICIENCY: FIRST DESCRIPTION OF TWO PATIENTS WITH BLEEDING DIATHESIS L. Bury1, S. Sorrentino2, E. Falcinelli1, G. Guglielmini1, V. Fazzi1, A. Ferretti2, P. Concolino3|4, F. Cirillo5, P. Gresele1, E. De Candia2|6 | 1Department of Medicine and Surgery, Section of Internal and Cardiovascular Medicine, University of Perugia, Perugia, Italy; 2Dipartimento di Medicina e Chirurgia Traslazionale, Università Cattolica del Sacro Cuore, Facoltà di Medicina, Roma, Italy; 3Departmental Unit of Molecular and Genomic Diagnostics, Fondazione Policlinico Gemelli IRCCS, Roma, Italy; 4Genomics Core Facility, G-STeP, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Roma, Italy; 5Department of Clinical Medicine and Surgery, Federico II University of Naples, Naples, Italy; 6Dipartimento di Scienze di Laboratorio ed Ematologiche, Policlinico Universitario A. Gemelli IRCCS, Roma, Italy. L. Bury first authorship, P. Gresele senior authorship
54PDF: 21 -
CO068 | FACTORS AFFECTING SPONTANEOUS PLATELET AGGREGATION IN HEALTHY SUBJECTS AND PATIENTS WITH STABLE CORONARY ARTERY DISEASE M. Scavone1, A. Fioretti1, C. Ghali1, B. Clerici1, E. Popov2, G.M. Podda1, M. Cattaneo3 | 1Laboratorio di emostasi e trombosi, Dipartimento di Scienze della Salute, Università degli Studi di Milano, Divisione di Medicina Generale II, ASST Santi Paolo e Carlo, Italy; 2National Medical Research Center of Cardiology, Ministry of Health of the Russian Federation, Moscow, Russia; 3Fondazione Arianna Anticoagulazione, Bologna, Italy
73PDF: 22 -
PO032 | INHIBITION OF PLATELET ACTIVATION BY SMALL MOLECULE SYNTHETIC AGONISTS OF THE BILE ACID RECEPTOR: A NOVEL APPROACH TO ANTIPLATELET THERAPY L. Bury1, E. Falcinelli1, V. Fazzi1, C. Tili1, P. Gresele1, S. Fiorucci2 | 1Department of Medicine and Surgery, Section of Internal and Cardiovascular Medicine; 2Section of Gastroenterology, University of Perugia, Italy
34PDF: 17 -
PO05 | DESIGN, SYNTHESIS, AND BIOLOGICAL EVALUATION OF NOVEL IMATINIB AND NILOTINIB ANALOGUES EXPRESSING ENHANCED ANTIPLATELET AND ANTICANCER ACTIVITIES D. Pantazi1, L. Pechlivani1, A. Kosma1, K. Lalechou1, M.G. Siskos2, D. Alivertis3, A.D. Tselepis1 | 1Atherothrombosis Research Centre, Laboratory of Biochemistry, Department of Chemistry, University of Ioannina, Greece; 2Laboratory of Organic Chemistry, Department of Chemistry, University of Ioannina, Greece; 3Department of Biological Applications and Technology, University of Ioannina, Greece
562PDF: 107 -
CO101 | PLATELET ACTIVATION AND THROMBOGENICITY IN ANTI-PHOSPHOLIPID ANTIBODY-POSITIVE SUBJECTS: AN INTEGRATED TGA AND T-TAS ANALYSIS G. Rosati1, A. Pozzi1, C. Barale1, M. Padrini1, R.M. Medici1, G. Ferrari1, E. Mordohovich1, M. Tamietti1, A. Barinotti2, M. Radin2, M. Geminiani1, M. De Gobbi1, I. Russo1, A. Morotti1 | 1Dip. Scienze Cliniche e Biologiche, Torino, Italy; 2Osp. San Giovanni Bosco, Torino, Italy
72PDF: 19 -
PO132 | POST KIDNEY TRANSPLANT PRESENTATION OF ACQUIRED THROMBOTIC THROMBOCYTOPENIC PURPURA: A CASE OF PRE-EXISTING ADAMTS13 INHIBITORS G. Murante1|2|5, S. Bergonzi1|2|5, M. Capetta1|2|5, F. Valeri1|2, C. Dainese1|2, A. Valpreda4, R. Pastorino1|5, F. Bocchi1|5, L. Biancone3, E. Gallo3, B. Bruno2|5, A. Borchiellini1|2 | 1Regional Centre for Hemorrhagic and Thrombotic Diseases; 2Division of Hematology; 3Nephrology Dialysis and Transplant U; 4Central Lab. Baldi and Riberi, AOU Città della Salute e della Scienza di Torino, Italy; 5Dep. of Molecular Biotechnology and Health Sciences, University of Turin, Italy
36PDF: 21 -
PO01 | MELANOMA-DERIVED EXTRACELLULAR VESICLES DRIVE VON WILLEBRAND FACTOR–DEPENDENT THROMBOSIS AND METASTASIS Y. Wang1|2, X. Liu1, T. Downar3, A. Topuz4, A. Bauer1, J. Kött1|5, K. Nekipelov6, S. Brenna7, G. Bendas6, B. Puig7, S. Schneider1, D. Fedosov4, C. Gorzelanny1 | 1Department of Dermatology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; 2Mildred Scheel Cancer Career Center HaTriCS4, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; 3Experimental Dermatology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany; 4Institute for Advanced Simulation (IAS-2), Forschungszentrum Jülich, Jülich, Germany; 5Fleur Hiege Center for Skin Cancer Research, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; 6Pharmaceutical Institute, University of Bonn, Bonn, Germany; 7Neurology Department, Experimental Research in Stroke and Inflammation (ERSI), University Medical Center Hamburg-Eppendorf, Hamburg, Germany
505PDF: 115 -
CO113 | AN OBSERVATIONAL STUDY ON THE EFFECT OF HEMODIALYSIS MEMBRANES ON ENDOGENOUS THROMBIN POTENTIAL IN END-STAGE RENAL DISEASE PATIENTS Z. Saeed1|4, O. Ndrecka2, V. Sirolli2, M. Bonomini2, P. Lanuti1|3, S. Gallina4, G. Rend1|4 | 1Center for Advanced Studies and Technology, G. d’Annunzio University of Chieti-Pescara, Chieti, Italy; 2Nephrology and Dialysis Unit, Department of Medicine, G. d’Annunzio University of Chieti-Pescara, SS. Annunziata Hospital, Chieti, Italy; 3Department of Medicine and Aging Sciences, G. d’Annunzio University of Chieti-Pescara, Chieti, Italy; 4Department of Neuroscience, Imaging and Clinical Sciences, G. d’Annunzio University of Chieti-Pescara, Chieti, Italy
65PDF: 17 -
CO057 | THROMBOPOIETIN-PLATELET AXIS IN METABOLIC-ASSOCIATED STEATOTIC LIVER DISEASE M. Alfonsetti1, P. Simeone1, R. Liani1, M. Frezza1, B. Di Marco1, A. Cipollone1, C. Della Penna1, L. Cantagallo1, G. Ciferni1, L. Del Rosso1, M. Caporale1, S. Brandolino2, E. Vitacolonna2, P. Di Carlo3, F. Cipollone1, F. Santilli1 | 1Department of Medicine and Aging Sciences, Center for Advanced Studies and Technology (CAST), University of Chieti, Chieti, Italy, University General Medicine Division, Medical Department, SS. Annunziata Hospital, Chieti, Italy; 2Department of Medicine and Aging, School of Medicine and Health Sciences, G. d'Annunzio University, Chieti, Italy; 3Department of Innovative Technologies in Medicine & Dentistry, "G. d'Annunzio" University of Chieti-Pescara, Chieti, Italy
63PDF: 19 -
PO071 | WHEN SJÖGREN’S DISEASE MIMICS TTP A. Castoldi, R. Rossio, F. Peyvandi | Medicina generale Osp. Maggiore Policlinico, Milano, Italy
42PDF: 20 -
PO09 | Comparison of different aggregometry methods for evaluation of platelet function in patients with myeloproliferative neoplasms C. Fortino, I. Bertozzi, D. Regazzo, L. Gianesello, G. Nuozzi, F. Sartorello, V. Azzaro, G. Saggiorato, A. Bertomoro, P. Simioni | First Medical Clinic, Department of Medicine – DIMED, Università degli Studi di Padova, Italy
563PDF: 17 -
PO95 | Idiopathic thrombocytopenic purpura in tuberculosis M. Shani | Università di Medicina Tirana, Albania
654PDF: 21 -
PO162 | A RARE CASE OF PLATELET DISORDER MIMICKING HEMOPHILIA A M. Shani, T. Goxhaj | Mother Theresa University Hospital, Università Nostra Signora Dell Buon Consiglio, Tirana, Albania
30PDF: 23 -
PO91 | Disseminated intravascular coagulation with deep vein thrombosis in a frail patient: an extreme manifestation triggered by sepsis during SGLT2i therapy M. Vacca1, M.V. Cherchi1, S. Che1, G.A.M.L. Costanzo2, D. Firinu2, M. Mantega1, S. Del Giacco2 | 1Ospedale Sirai, ASL Sulcis, 2Università degli Studi di Cagliari, Italy
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CO25 | Thromboinflammation and ros accumulation in individuals with high lipoprotein(a) levels M. Frezza1, P.G.M. Simeone1, M. Alfonsetti1, R. Liani1, M. Cellini1, P. Del Boccio2, M.C. Cufaro3, O. Iuliani4, A. Quaglietta4, F. Cipollone1, F. Santilli1 | 1Department of Medicine and Ageing Sciences, Center for Advanced Studies and Technology “CAST”, University of Chieti; 2Department of Pharmacy, Center for Advanced Studies and Technology “CAST”, Chieti; 3Department of Innovative Technologies in Medicine and Dentistry, Center for Advanced Studies and Technology “CAST”, Chieti; 4Department of Haematolgy and Oncology, Center of Transfusion Medicine, Pescara General Hospital, Pescara. Italy
590PDF: 15 -
PO62 | Management of anticoagulation during extracorporeal circulation in a patient with APS T. Marrazzo1, C. Marra2, A. Caiazzo2, I. Mattucci2, L. Verniero3, N. Galdieri3, M.P. Ursi4, R. Albisinni5 | 1UOC Medicina Interna e dei Trapianti, Ospedale Monaldi Azienda dei Colli, Napoli; 2UOSD di Cardiochirurgia dei Trapianti, Ospedale Monaldi Azienda dei Colli, Napoli; 3UOSD Terapia Intensiva di CCH Ospedale Monaldi Azienda dei Colli, Napoli; 4UOC MECAU Ospedale CTO Azienda dei Colli, Napoli; 5UOC CCH generale Ospedale Monaldi Azienda dei Colli, Napoli, Italy
641PDF: 19 -
PO063 | EVALUATION OF PLATELET ACTIVATION MARKERS IN PATIENTS WITH THROMBOTIC THROMBOCYTOPENIC PURPURA M. Di Fuorti1, M.R. Cozzi2, A. Steffan3, I. Quaglia1, C. Sacco1, C. Lodigiani1, M. Bacci1 | 1Center for Thrombosis and Hemorrhagic Diseases, IRCCS Humanitas Research Hospital, Rozzano, Italy; 2Immunopathology and Cancer Biomarkers Unit, Centro di Riferimento Oncologico di Aviano IRCCS, Aviano, Italy; 3Clinical Pathology Unit, ASFO General Hospital, Pordenone, Italy
50PDF: 18 -
CO106 | ENDOTHELIAL DYSFUNCTION AS A POSSIBLE ADDITIONAL DRIVER OF BLEEDING IN HERMANSKY–PUDLAK SYNDROME F. Tondi1, G. Purgatorio1, E. Giglio1, E. Petito1, E. Falcinelli1, G. Guglielmini1, P. Gresele1, C. Olgasi2, L. Bury1 | 1Dep. of Medicine and Surgery, Section of Internal and Cardiovascular Medicine, University of Perugia, Perugia, Italy; 2Dep. of Translational Medicine, School of Medicine, University of Piemonte Orientale, Novara, Italy
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PO85 | Acute retinal ischemia in hemoglobin SC disease: a case report and review of the literature G. Bogoni1, A. Bertomoro1, E. Cosi1, M.T. Sartori1, R. Colombatti2, G. Reggiani2, M.P. Boaro2, I. Bertozzi1, P. Simioni1 | 1Clinica Medica 1, Dipartimento di Medicina DIMED, Università degli Studi di Padova; 2Clinica di Onco-Ematologia Pediatrica, Università degli Studi di Padova, Italy
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PO087 | BEYOND POSITIVITY: THE HIERARCHICAL ROLE OF IMMUNOASSAYS IN HEPARIN INDUCED THROMBOCYTOPENIA G. Murante1|2|3, S. Bergonzi1|2|3, M. Capetta1|2|3, F. Valeri1|2, C. Dainese1|2, A. Valpreda4, R. Pastorino1|3, F. Bocchi1|3, A. Porreca5, B. Bruno2|3, A. Borchiellini1|2 | 1Regional Centre for Hemorrhagic and Thrombotic Diseases, AOU Città della Salute e della Scienza di Torino, Italy; 2Division of Hematology, AOU Città della Salute e della Scienza, Università di Torino, Italy; 3Dep. of Molecular Biotechnology and Health Sciences, University of Turin, Italy; 4Central Lab. Baldi and Riberi, AOU Città della Salute e della Scienza di Torino, Italy; 5Dep. of Human Sciences and Quality of Life Promotion, Clinical and Molecular Epidemiology, IRCCS San Raffaele Roma, Italy
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CO-83 | ACQUIRED FACTOR V DEFICIENCY IN A HIGH-THROMBOTIC-RISK PATIENT: DIAGNOSTIC DILEMMA AND SUCCESSFUL MANAGEMENT G. Gazzelli1, L. Banov1, Y. Azzanelli1, C. Vernarecci1, F. Marotta1, F. Giacopelli1, E. Cenni2, V. Agostini2, A.C. Molinari1 | 1IRCCS Istituto Giannina Gaslini, Italy; 2IRCSS AOM S. Martino, Genova, Italy
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PO42 | Acquired Von Willebrad syndrome in patients with myeloproliferative syndrome: literature review and single-center experience A. Strangio, M. Leotta, A. Ierardi, R C. Santoro | UO Emofilia, Emostasi e Trombosi, AOU R Dulbecco, Catanzaro, Italy
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PO023 | CLOPIDOGREL USE IN ANTIPLATELET MANAGEMENT OF ESSENTIAL THROMBOCYTHEMIA (TECLA STUDY): DESIGN AND FEASIBILITY OF A SINGLE-CENTRE STUDY P. Ranalli1|2, D. Bruno3, G. Petrucci4, M. D'Uva1|2, M. Di Marco5, P. Vitulli5, B. Rocca6, M. Di Ianni1|2 | 1Hematology Unit, S. Spirito Hospital, Pescara, Italy; 2Department of Medicine and Aging Sciences D’Annunzio University, Chieti, Italy; 3Hemostasis Laboratory, Transfusion Medicine Unit, S. Spirito Hospital, Pescara, Italy; 4Departmental Faculty of Medicine, Unicamillus, Rome, Italy; 5Cardiology Unit, S. Spirito Hospital, Pescara, Italy; 6Department of Medicine and Surgery, LUM University, Casamassima (BA), Italy
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CS07 | Endothelial dysfunction and impaired angiogenesis in Hermansky-Pudlak syndrome (HPS) type 1: studies with endothelial colony forming cells F. Tondi1, G. Purgatorio1, C. Sgromo2, E. Giglio1, E. Petito1, E. Falcinelli1, G. Guglielmini1, A. Follenzi2, P. Gresele1, L. Bury1*, C. Olgasi3* | *Shared senior authorship; 1Department of Medicine and Surgery, Section of Internal and Cardiovascular Medicine, University of Perugia; 2Department of Health Sciences, School of Medicine, University of Piemonte Orientale, Novara; 3Department of Translational Medicine, School of Medicine, University of Piemonte Orientale, Novara, Italy
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PO145 | KINETIC ASSESSMENT OF PLATELET REACTIVITY DURING DUAL ANTIPLATELET THERAPY IN ACUTE CORONARY SYNDROMES: PRELIMINARY RESULTS FROM AN ONGOING STUDY B. Di Marco1|2, R. Liani1, F. D’Ambrosio1|2, M. Alfonsetti1, P.G. Simeone1, M. Frezza1, S. Porro1, M. Brambilla3, P. Lanuti1, M. Camera3, F. Santilli1 | 1Department of Medicine and Aging Sciences, Center for Advanced Studies and Technology (CAST), University of Chieti, Chieti, Italy; 2ASL 2 Abruzzo, SS. Annunziata Hospital, Chieti, Italy; 3Unit of Cell and Molecular Biology in Cardiovascular Diseases, Centro Cardiologico Monzino IRCCS, Milano, Italy
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PO61 | ACTN1-related thrombocytopenia and severe hyperhomocysteinemia: a case report A. Pozzi, G. Rosati, M. Padrini, S. Laurenti, G. Ferrari, R.M. Medici, C. Barale, I. Russo, A. Morotti | University of Turin, San Luigi Hospital, Orbassano (TO), Italy
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PO041 | VARIABLE CLINICAL RESPONSE TO RECOMBINANT PORCINE FVIII IN ACQUIRED HAEMOPHILIA A: A TWO CASE EXPERIENCE WITH LABORATORY SUPPORTED MONITORING AM. Pizzini1, M. Bovara2, M. Sebastiani2, A. Fusco1, C. Fantoni1, M. Silingardi1, R. Mancini2, A. Coppola3 | 1Ambulatorio Emostasi & Trombosi, Dipartimento Medico - Ospedale Maggiore Bologna, Italy; 2Laboratorio Unico Metropolitano - Ospedale Maggiore Bologna, Italy; 3SDD Centro Hub Emofilia e MEC, Azienda Ospedaliero-Universitaria di Parma, Italy
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CO103 | DIAGNOSTIC VALUE OF PLATELET GRANULE CONTENT AND RELEASE IN PATIENTS WITH INHERITED PLATELET FUNCTION DISORDERS WITH NORMAL PLATELET AGGREGATION L. Bury, E. Petito, E. Falcinelli, V. Fazzi, A.M. Mezzasoma, P. Gresele | Department of Medicine and Surgery, Section of Internal and Cardiovascular Medicine, University of Perugia, Italy
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PO84 | Beyond the scores: unmasking a silent pulmonary embolism in essential thrombocythemia N. Battino | ASL Sulcis Iglesiente PO CTO, Italy
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CO-63 | ACQUIRED VON WILLEBRAND SYNDROME IN AN ELDERLY PATIENT WITH EARLY-STAGE B-CLL A. Casson1, I. Ricca1, A. Barchieri1, G. Guido1, P. Ocello1, M. Tucciarone1, S. Prestigio2, A. Alfano2, G. Delios1 | 1Centro Malattie Trombotiche ed Emorragiche - SC Servizio Trasfusionale ASL TO4, Ivrea, Italy; 2SC Laboratorio Analisi ASL TO4, Ivrea, Italy
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PO41 | Comparison of the haemorrhagic phenotype between female and male patients affected by autosomal inherited bleeding disorders in a single-centre cohort B. Borsellino1,3, C. Zuccotti2, L. Guarnera3,4, C. Biasoli5, P. Pedrazzi5, T. Martini1 | 1Haemophilia Centre, Immune-Haematology and Transfusion Medicine, University Hospital “Città della Salute e della Scienza”, Turin, Italy; 2Department of Clinical Pathology, Bufalini Hospital, Cesena, Italy; 3Department of Biomedicine and Prevention, PhD in Immunology, Molecular Medicine and Applied Biotechnology, University of Roma Tor Vergata, Roma, Italy; 4Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, USA; 5Haemophilia and Transfusion Centre, Bufalini Hospital, Cesena, Italy
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PO139 | PFO-LIKE INTRACARDIAC FLOW IS SUFFICIENT TO INDUCE A PROTHROMBOTIC PLATELET PHENOTYPE: EVIDENCE FROM A MICROFLUIDIC MODEL OF PATENT FORAMEN OVALE M. Conti1, V. Guadagno2, D. Trabattoni1, A. Becchetti1, F. Morelli2, L. Fusini1, M. Brambilla1, S. Bozzi2, A. Redaelli2, M. Camera1|3 | 1Centro Cardiologico Monzino IRCCS, Milano, Italy; 2Politecnico di Milano, Department of Electronics, Informatics and Bioengineering (DEIB), Milano, Italy; 3Università degli Studi di Milano, Department of Pharmaceutical Sciences, Milano, Italy
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PO60 | Asymptomatic PNH clone in acquired aplasia (AA) E. Marrone1, U. Valentino1, C. Mastrobuoni1, A. Abate1, A. Magliocca1, F. Cinque1, R. Buono1, M. Annunziata2, A. Picardi3, P. Morella1 | 1UOC Medicina 3, 2UOC Ematologia, 3UOC Ematologia, e Trapianto, AORN A. Cardarelli, Napoli, Italy
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CO45 | Role of urinary 11-dehydro-thromboxane B2 as a predictor of preeclampsia in pregnant high-risk women on low-dose aspirin treatment P.G.M. Simeone1, R. Liani1, M. Alfonsetti1, A. Ricci1, V. Cianci1, S. Zeeba2, M. Molino3, S. Palma2, R. Malizia4, M. Luongo4, A. Di Castelnuovo5, F. Cipollone1, F. D’antonio6, F. Ricci2, G. Renda2, F. Santilli1 | 1Department of Medicine and Aging Sciences, Center for Advanced Studies and Technology, University of Chieti; 2Department of Neuroscience, Imaging and Clinical Sciences, G D’Annunzio University of Chieti-Pescara, Chieti; University Cardiology Division, Heart Department, Policlinico SS Annunziata, Chieti; 3Clinical Pathology of Chieti University Hospital; 4Immunotransfusion Service, Clinical Haematology of Chieti University Hospital, Chieti; 5Mediterranea Cardiocentro, Napoli; 6Centre for Fetal Care and High-Risk Pregnancy, Department of Obstetrics and Gynecology, University of Chieti, Italy
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PO79 | Trying to hit the hit in the shadow of renal failure: a complex case managed with danaparoid S. Chessa1,2, M. Anedda2, M.V. Cherchi2, M. Vacca1,2, M. Caboni2, J. Pilia2, A.M. Bussu2, M. Mantega2, G. Costanzo1, D. Firinu1, S. Del Giacco1, A. Mameli3, D. Barcellona3 | 1Department of Medical Science and Public Health, University of Cagliari; 2Internal Medicine, ASL Sulcis, PO Sirai, Carbonia; 3Department of Medical Sciences and Public Health, Hemostasis and Thrombosis Unit, University of Cagliari and AOU of Cagliari, Italy
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PO076 | ACQUIRED FACTOR V INHIBITOR WITH CONCOMITANT LUPUS ANTICOAGULANT: DIAGNOSTIC PITFALLS AND THERAPEUTIC CHALLENGES G. Gazzelli1, Y. Azzanelli1, C. Vernarecci1, F. Marotta1, F. Giacopelli1, E. Cenni2, V. Agostini2, L. Banov1, AC Molinari1 | 1IRCCS Istituto Giannina Gaslini, Italy; 2IRCSS AOM S. Martino Genova, Italy
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PO33 | Whole blood hypercoagulable profiles in patients with rheumatoid arthritis L. Spiezia1, A. Giollo2, C. Samà1, A. Benetti1, L. Di Luozzo2, M. Salvato2, A. Doria2, P. Simioni1 | 1First Chair of Internal Medicine, Thrombotic and Hemorrhagic Diseases Unit, Department of Medicine, University Hospital of Padova; 2Rheumatology Unit, Department of Medicine, University Hospital of Padova, Italy
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PO014 | DETERGENT AND GANGLIOSIDE GM1-BINDING PROPERTIES OF PLATELET FACTOR 4 AS ASSESSED BY CHARGE-SHIFT ELECTROPHORESIS P. Ames1, A. Arcaro2, A. Lepore2, S. Nourooz-Zadeh2, M. Graf3, F. Gentile2 | 1Immune Response & Vascular Disease Unit, CEDOC, Nova University Lisbon, Portugal; 2Department of Medicine and Health Sciences 'V. Tiberio', University of Molise, Campobasso, Italy; 3Immunohaematology and Transfusion Medicine Unit, Federico II University Hospital, Napoli, Italy
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CO059 | EXTRACELLULAR VESICLES AS BIOMARKERS IN FAMILIAL HYPERCHOLESTEROLEMIAS TREATED WITH EVINACUMAB C. Samà1, A. Benetti1, M.G. Lupo2, M. Biolo1, C. Portinari1, S. Zambon1, A. Zambon1, N. Ferri2, C.M. Radu1, P. Simioni1 | 1First Chair of Internal Medicine and Thrombotic and Haemorrhagic Diseases Unit, Department of Medicine, Padova University Hospital, Padova, Italy; 2Department of Medicine, Padova University Hospital, Padova, Italy
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PO031 | IMBALANCE OF PLATELET PRODUCTION AND DESTRUCTION IN PREECLAMPSIA P. Simeone1, R. Liani1, M. Alfonsetti1, A. Ricci1, V. Cianci1, L. Cantagallo1, Z. Saeed2, M. Molino3, S. Palma2, R. Malizia4, M. Luongo4, A. Di Castelnuovo5, S. Gallina2, F. Cipollone1, F. Ricci2, G. Renda2, F. D’ Antonio6, F. Santilli1 | 1Department of Medicine and Aging Sciences, Center for Advanced Studies and Technology, G. d’Annunzio University of Chieti-Pescara, Chieti, Italy University General Medicine Division, Medical Department, SS. Annunziata Hospital, Chieti, Italy; 2Department of Neuroscience, Imaging and Clinical Sciences and Center for Advanced Studies and Technology, G. d'Annunzio University of Chieti-Pescara, Chieti, Italy University Cardiology Division, Heart Department, SS. Annunziata Hospital, Chieti, Italy; 3Clinical Pathology, SS. Annunziata Hospital, Chieti, Italy; 4Immunotransfusion Service, Clinical Haematology, SS. Annunziata Hospital, Chieti, Italy; 5Research Unit of Epidemiology and Prevention, IRCCS NEUROMED, Pozzilli (IS), Italy; 6Centre for Fetal Care and High-Risk Pregnancy, SS. Annunziata Hospital, Chieti, Italy
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CO44 | First interlaboratory validation workshop of immunofluorescence microscopy on the peripheral blood smear for recognizing patients with inherited platelet disorders C. Zaninetti1, L. Bury2, V. Bozzi3, A. Zamora-Cánovas4, K. Althaus5, G. Uzun5, S. Brown6, A. Norman6, D. Faille7, A. Stepanian8, C. Freyer1, L. Kager9, T. Bakchoul5, A. Pecci3, P. Gresele2, T. Thiele1, J. Rivera4, A. Greinacher1 | 1Institut für Immunologie und Transfusionsmedizin, Universitätsmedizin Greifswald, Germany; 2Department of Medicine, Section of Internal and Cardiovascular Medicine, University of Perugia, Italy; 3Department of Internal Medicine, University of Pavia, Italy; General Medicine 1, IRCCS Policlinico San Matteo Foundation, Pavia, Italy; 4Servicio de Hematología, Hospital Universitario Morales Meseguer, Centro Regional de Hemodonacio´n, Universidad de Murcia, Spain; 5Institute for Clinical and Experimental Transfusion Medicine, University Hospital of Tuebingen, Germany; Center for Clinical Transfusion Medicine, Tuebingen, Germany; 6Centre for Children’s Health and Research CCHR, South Brisbane, Australia; 7Laboratoire d’Hématologie, Assistance Publique Hôpitaux de Paris, Hôpital Bichat-Claude-Bernard, Paris, France; 8AP-HP, Service d’Hématologie Biologique, Hôpital Lariboisière, Paris Cité University, Paris, France; 9St. Anna Kinderspital, Universitätsklinik für Kinder- und Jugendheilkunde der Medizinischen Universität Wien, Austria
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Inherited platelet function disorders: a comprehensive narrative review focusing on diagnostic and management aspects
90PDF: 46SUPPLEMENTARY MATERIAL: 18 -
PO78 | Acquired hemophilia A as a paraneoplastic syndrome: two cases report on a rare coexistence M. Gagliardi, L. Capone, A. Ciampa | Centro Emostasi, AORN Moscati, Avellino, Italy
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PO072 | DIAGNOSTIC CHALLENGES IN THROMBOTIC MICROANGIOPATHY: A CASE OF ATYPICAL HEMOLYTIC UREMIC SYNDROME M. Moretti1, R. Gervasi2, E. Rossini2, G.F. Romiti1, P. Carfagna2, S. Basili1, P. Battisti2 | 1Azienda Ospedaliero-Universitaria Policlinico Umberto I, Roma, Italy; 2Azienda Ospedaliera San Giovanni Addolorata, Roma, Italy
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CO-34 | SIMPLIFIED PERIOPERATIVE MANAGEMENT WITH N8-GP (TUROCTOCOG ALFA PEGOL) IN MAJOR ABDOMINAL SURGERY IN MILD HEMOPHILIA A WITH SEVERE BLEEDING PHENOTYPE: A CASE REPORT J. Di Paolo, R. Malizia, M. Luongo, P. Massaro, M. Di Mascio, S. Verna | Immunohematology Service, ASL 02 Abruzzo, Chieti, Italy
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PO097 | DETERMINANTS OF PLATELET COUNT IN A LARGE SINGLE TERTIARY CARE COHORT: IMPACT OF AGE, SEX, PLATELET REACTIVITY, CARDIOVASCULAR RISK FACTORS AND ANTIPLATELET THERAPY S. De Corci, N. Manganello, E. Schiera, S. Terracina, A. Di Battista, F.M. Pulcinelli | Experimental Medicine, Sapienza University of Rome, Italy
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PO030 | PLATELET AGGREGOMETRY AS POTENTIAL TOOL TO EVALUATE ANTI-PLATELET RESPONSE IN MYELOPROLIFERATIVE NEOPLASMS: COMPARISON OF DIFFERENT TECHNIQUES AND INITIAL RESULTS A. Galbiati, I. Bertozzi, C. Fortino, D. Regazzo, L. Gianesello, F. Sartorello, V. Azzaro, G. Saggiorato, A. Napolitano, L. Fabris, P. Simioni | Department of Medicine, University of Padova, Italy
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PO75 | Prophylaxis with RFXIII: a clinical case in a pediatric patient with congenital FXIII deficiency and delayed diagnosis M.L. Tramontano, M. Coppola, S. Coppola, M. Schiavulli | UOSD Centro Regionale Pediatrico Malattie della Coagulazione. Santobono Pausilipon Children Hospital, AORN, Napoli, Italy
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CO110 | FLOW-BASED WHOLE-BLOOD THROMBUS PROFILING DISCRIMINATES ANTITHROMBOTIC DRUG EFFECTS AND UNCOVERS PLATELET-DEPENDENT COAGULATION DEFECTS AFTER CARDIOPULMONARY BYPASS A. Foladore1, S. Lattanzio1, E. Baryshnikova2, M. Anguissola2, E. Lombardi3, M. Valvasori3, R. Vettori3, F. Agostini3, R. Tassan Toffola4, L. Rota1, M. Ranucci2, M. Mazzucato3 | 1Sedicidodici s.r.l., Pordenone, Italy; 2IRCCS Policlinico San Donato, San Donato Milanese, Italy; 3Centro di Riferimento Oncologico (CRO) IRCCS, Aviano, Italy; 4Azienda Sanitaria Friuli Occidentale, Pordenone, Italy
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CO035 | THE ROLE OF INFLAMMATORY BIOMARKERS IN IMMUNE THROMBOTIC THROMBOCYTOPENIC PURPURA F. Schieppati1|2, S. Bolognini1|2, C. Ticozzi1, O.C. Cretu1, P. Gomez-Rosas1|3, M. D’Adda4, V. Cancelli4, C. Ambaglio1, E. Galimberti1, L. Barcella1, A. Falanga1|2, M. Marchetti1|2 | 1Immunohematology and Transfusion Medicine, Department of Transfusion Medicine and Hematology, ERN-EuroBloodNet - European Reference Network in Rare Hematological Diseases, ASST Papa Giovanni XXIII, Bergamo, Italy; 2School of Medicine and Surgery, University of Milano-Bicocca, Milano, Italy; 3Maastricht University Medical Center, Cardiovascular Research Institute Maastricht, Maastricht, The Netherlands; 4Hematology, Hospital Spedali Civili di Brescia, Brescia, Italy
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PO51 | Thrombocythemia associated with a non-canonical JAK2 mutation: a case report G. Rosati, A. Pozzi, M. Padrini, S. Laurenti, G. Ferrari, R.M. Medici, C. Barale, I. Russo, A. Morotti | University of Turin, AUO San Luigi Gonzaga, Orbassano (TO), Italy
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CO080 | INVESTIGATING MECHANISMS OF ACQUIRED VON WILLEBRAND SYNDROME ACROSS HEMATOLOGICAL DISEASES: THE CONTRIBUTION OF INTRAPLATELET VWF A. Ciavarella1, L. Baronciani1, O. Seidizadeh1, P. Colpani1, F. Boggio1, D. Cattaneo2|3, S. Ceglie1, M.T. Pagliari1, A. Iurlo2, S.M. Siboni1, F. Peyvandi1|4 | 1Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Milano, Italy; 2Hematology Division, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano, Italy; 3Department of Oncology and Hemato-Oncology, University of Milano, Milano, Italy; 4Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Milano, Italy
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PO69 | Whole blood thrombin generation hypercoagulable profile in a patient with hemolytic crisis due to paroxysmal nocturnal hemoglobinuria: a case report A. Napolitano, L. Spiezia, C. Bulato, E. Campello, P. Simioni | First Chair of Internal Medicine, Department of Medicine, University-Hospital of Padua Medical School, Padua, Italy
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