Mini-reviews
Vol. 3 No. 2 (2024)
Role of platelet autophagy in cardiovascular diseases
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All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Received: 25 March 2024
Accepted: 7 August 2024
Accepted: 7 August 2024
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Platelet hyperactivity leads to thrombosis, the primary cause of cardiovascular and cerebrovascular adverse events. Emerging evidence suggests that autophagy plays a fundamental role in platelet function, both at baseline and in response to stress. Autophagy is an intracellular mechanism devoted to the removal and recycling of damaged cytoplasmic cargoes. Basal level of autophagy ensures physiological platelet aggregation and hemostasis. Autophagy is impaired in platelets isolated from subjects at high cardiovascular risk whereas autophagy stimulation reduces platelet hyperactivity, along with an overall amelioration of oxidative stress status. In this mini-review, we explore the current literature on the role of autophagy in platelet biology and its relevance as a therapeutic target for counteracting cardiovascular diseases.
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Citations
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How to Cite
1.
D'Ambrosio L, Forte M, Frati G, Sciarretta S. Role of platelet autophagy in cardiovascular diseases. Bleeding Thromb Vascul Biol [Internet]. 2024 Aug. 26 [cited 2026 Jan. 27];3(2). Available from: https://www.btvb.org/btvb/article/view/133
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