Mini-reviews
26 August 2024
Vol. 3 No. 2 (2024)
https://doi.org/10.4081/btvb.2024.133

Role of platelet autophagy in cardiovascular diseases

Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Platelets, autophagy, thrombosis, spermidine, trehalose
828
Views
221
Downloads

Authors

Luca D'Ambrosio
Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Italy.
Maurizio Forte
https://orcid.org/0000-0003-0739-0534
Department of AngioCardioNeurology, IRCCS Neuromed, Pozzilli, Italy.
Giacomo Frati
https://orcid.org/0000-0003-2703-3761
Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome; Department of AngioCardioNeurology, IRCCS Neuromed, Pozzilli, Italy.
Sebastiano Sciarretta
sebastiano.sciarretta@uniroma1.it
Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome; Department of AngioCardioNeurology, IRCCS Neuromed, Pozzilli, Italy.

Platelet hyperactivity leads to thrombosis, the primary cause of cardiovascular and cerebrovascular adverse events. Emerging evidence suggests that autophagy plays a fundamental role in platelet function, both at baseline and in response to stress. Autophagy is an intracellular mechanism devoted to the removal and recycling of damaged cytoplasmic cargoes. Basal level of autophagy ensures physiological platelet aggregation and hemostasis. Autophagy is impaired in platelets isolated from subjects at high cardiovascular risk whereas autophagy stimulation reduces platelet hyperactivity, along with an overall amelioration of oxidative stress status. In this mini-review, we explore the current literature on the role of autophagy in platelet biology and its relevance as a therapeutic target for counteracting cardiovascular diseases.

Altmetrics

Downloads

Download data is not yet available.

Citations

Crossref
Scopus
Google Scholar
Europe PMC
Feng W, Chang C, Luo D, et al. Dissection of autophagy in human platelets. Autophagy 2014;10:642-51. DOI: https://doi.org/10.4161/auto.27832
Lucchesi A, Napolitano R, Bochicchio MT, et al. Platelets contribution to thrombin generation in philadelphia‐negative myeloproliferative neoplasms: the circulating wound model. Int J Mol Sci 2021;22:11343. DOI: https://doi.org/10.3390/ijms222111343
Violi F, Pastori D, Pignatelli P, Carnevale R. Nutrition, thrombosis, and cardiovascular disease. Circ Res 2020;126:1415-42. DOI: https://doi.org/10.1161/CIRCRESAHA.120.315892
Koupenova M, Kehrel BE, Corkrey HA, Freedman JE. Thrombosis and platelets: an update. Eur Heart J 2017;38:785-91. DOI: https://doi.org/10.1093/eurheartj/ehw550
Koupenova M, Clancy L, Corkrey HA, Freedman JE. Circulating platelets as mediators of immunity, inflammation, and thrombosis. Circ Res 2018;122:337-51. DOI: https://doi.org/10.1161/CIRCRESAHA.117.310795
Galluzzi L, Baehrecke EH, Ballabio A, et al. Molecular definitions of autophagy and related processes. EMBO J 2017;36:1811-36. DOI: https://doi.org/10.15252/embj.201796697
Klionsky DJ, Petroni G, Amaravadi RK, et al. Autophagy in major human diseases. EMBO J 2021;40.
Forte M, Bianchi F, Cotugno M, et al. Pharmacological restoration of autophagy reduces hypertension-related stroke occurrence. Autophagy 2020;16:1468-81. DOI: https://doi.org/10.1080/15548627.2019.1687215
Sciarretta S, Maejima Y, Zablocki D, Sadoshima J. The role of autophagy in the heart. Ann Rev Physiol 2018;80:1-26. DOI: https://doi.org/10.1146/annurev-physiol-021317-121427
Schwertz H, Rowley JW, Portier I, et al. Human platelets display dysregulated sepsis-associated autophagy, induced by altered LC3 protein-protein interaction of the Vici-protein EPG5. Autophagy 2022;18. DOI: https://doi.org/10.1080/15548627.2021.1990669
Ouseph MM, Huang Y, Banerjee M, et al. Autophagy is induced upon platelet activation and is essential for hemostasis and thrombosis. Blood 2015;126:1224-33. DOI: https://doi.org/10.1182/blood-2014-09-598722
Paul M, Hemshekhar M, Kemparaju K, Girish KS. Aggregation is impaired in starved platelets due to enhanced autophagy and cellular energy depletion. Platelets 2019;30:487-97. DOI: https://doi.org/10.1080/09537104.2018.1475630
Carnevale R, Nocella C, Schiavon S, et al. Beneficial effects of a combination of natural product activators of autophagy on endothelial cells and platelets. Br J Pharmacol 2021;178:2146-59. DOI: https://doi.org/10.1111/bph.15399
Zhang W, Ren H, Xu C, et al. Hypoxic mitophagy regulates mitochondrial quality and platelet activation and determines severity of I/R heart injury. Elife 2016;5:e21407. DOI: https://doi.org/10.7554/eLife.21407
Versaci F, Valenti V, Forte M, et al. Aging-related decline of autophagy in patients with atrial fibrillation: a post hoc analysis of the ATHERO-AF study. Antioxidants 2022;11:698. DOI: https://doi.org/10.3390/antiox11040698
Lee SH, Du J, Stitham J, et al. Inducing mitophagy in diabetic platelets protects against severe oxidative stress. EMBO Mol Med 2016;8:779. DOI: https://doi.org/10.15252/emmm.201506046
Ma L, Sun W, Li J, et al. Regulation of platelet activation and thrombus formation in acute non-ST segment elevation myocardial infarction: role of Beclin1. Clin Transl Sci 2024;17:e13823. DOI: https://doi.org/10.1111/cts.13823
Pastori D, Pignatelli P, Carnevale R, Violi F. Nox-2 up-regulation and platelet activation: novel insights. Prostaglandins Other Lipid Mediat 2015;120:50-5. DOI: https://doi.org/10.1016/j.prostaglandins.2015.03.010

How to Cite



Role of platelet autophagy in cardiovascular diseases. (2024). Bleeding, Thrombosis and Vascular Biology, 3(2). https://doi.org/10.4081/btvb.2024.133
Copyright (c) 2024 The Author(s) Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

PAGEPress has chosen to apply the Creative Commons Attribution NonCommercial 4.0 International License (CC BY-NC 4.0) to all manuscripts to be published.