Commentaries
Vol. 3 No. 3 (2024)
Synthetic platelets: can bioengineering realize in few years what evolution made in over 200 million years?
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All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Received: 9 July 2024
Accepted: 1 October 2024
Accepted: 1 October 2024
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Citations
1. Duke W. The relation of blood platelets to hemorrhagic disease: description of a method for determining the bleeding time and coagulation time and report of three cases of hemorrhagic disease relieved by transfusion. JAMA 1910;55:1185-92. DOI: https://doi.org/10.1001/jama.1910.04330140029009
2. Kaufman RM, Djulbegovic B, Gernsheimer T, et al. Platelet transfusion: a clinical practice guideline from the AABB. Ann Intern Med 2015;162:205-13. DOI: https://doi.org/10.7326/M14-1589
3. Garraud O, Hamzeh-Cognasse H, Chalayer E, et al. Platelet transfusion in adults: An update. Transfus Clin Biol 2023;30:147-65. DOI: https://doi.org/10.1016/j.tracli.2022.08.147
4. Nellenbach K, Brown AC. Platelet-mimicking procoagulant nanoparticles: Potential strategies for mitigating blood shortages. J Thromb Haemost 2022;20:1756-8. DOI: https://doi.org/10.1111/jth.15720
5. Sugimoto N, Kanda J, Nakamura S, et al. iPLAT1: the first-in-human clinical trial of iPSC-derived platelets as a phase 1 autologous transfusion study. Blood 2022;140:2398-402. DOI: https://doi.org/10.1182/blood.2022017296
6. Sugimoto N, Eto K. Ex vivo production of platelets from iPSC: the iPLAT1 study and beyond. Hemasphere 2023;7:e884. DOI: https://doi.org/10.1097/HS9.0000000000000884
7. Martinez-Botía P, Acebes-Huerta A, Seghatchian J, Gutierrez L. In vitro platelet production for transfusion purposes: where are we now? Transfus Apher Sci 2020;59:102864. DOI: https://doi.org/10.1016/j.transci.2020.102864
8. Nellenbach K, Mihalko E, Nandi S, et al. Ultrasoft platelet-like particles stop bleeding in rodent and porcine models of trauma. Sci Transl Med 2024;16:eadi4490. DOI: https://doi.org/10.1126/scitranslmed.adi4490
9. Gupta S, Konradt C, Corken A, et al. Hemostasis vs. homeostasis: Platelets are essential for preserving vascular barrier function in the absence of injury or inflammation. Proc Natl Acad Sci USA 2020;117:24316-25. DOI: https://doi.org/10.1073/pnas.2007642117
10. Gaertner F, Ahmad Z, Rosenberger G, et al. Migrating platelets are mechano-scavengers that collect and bundle bacteria. Cell 2017;171:1368-82.e23. DOI: https://doi.org/10.1016/j.cell.2017.11.001
11. Semple JW, Italiano J, Freedman J. Platelets and the immune continuum. Nat Rev Immunol 2011;11:264-74. DOI: https://doi.org/10.1038/nri2956
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13. Momi S, Gresele P. Blood platelets and Charles Darwin’s natural selection. Bleeding Thromb Vasc Biol 2023;2:63. DOI: https://doi.org/10.4081/btvb.2023.63
14. Gresele P, Malvestiti M, Momi S. Antiplatelet treatments in cancer: basic and clinical research. Thromb Res 2018;164:S106-111. DOI: https://doi.org/10.1016/j.thromres.2017.12.016
15. Chan V, Sarkari M, Sunderland R, et al. Platelets loaded with liposome-encapsulated thrombin have increased coagulability. J Thromb Haemost 2018;16:1226-35. DOI: https://doi.org/10.1111/jth.14006
How to Cite
1.
Gresele P. Synthetic platelets: can bioengineering realize in few years what evolution made in over 200 million years?. Bleeding Thromb Vascul Biol [Internet]. 2024 Oct. 24 [cited 2025 Dec. 4];3(3). Available from: https://www.btvb.org/btvb/article/view/148
Copyright (c) 2024 The Author(s)
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
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