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Bleeding, Thrombosis and Vascular Biology

Editor-in-Chief: Giovanni de Gaetano, Italy | eISSN: 2785-5309

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  • CO-25 | MILD HEMOPHILIA A AND JOINT HEALTH IN REAL LIFE: IS THAT AN EMERGING ISSUE? A SINGLE CENTER EXPERIENCE F. Valeri1, G. Murante1, C. Dainese1, M. Capetta1, S. Bergonzi1, R. Pastorino1, F. Bocchi1, B. Bruno2, A. Borchiellini1 | 1Regional Centre for Haemorrhagic and Thrombotic Disease, Hematology Division, AOU Città della Salute e della Scienza, Torino, Italy; 2Division of Hematology, AOU Città della Salute e della Scienza, Department of Molecular Biotechnology and Health sciences, University of Turin, Italy

    Federica Valeri
    14-10-2026
    https://doi.org/10.4081/btvb.2026.635
    48
    PDF: 14
  • CO-89 | FEMORAL FRACTURE SURGERY IN AN ELDERLY, FRAIL PATIENT WITH ACQUIRED HEMOPHILIA A RECEIVING EMICIZUMAB PROPHYLAXIS: A CASE REPORT C. Simion1|2, E. Zanon1|2, B. Stocco1|2, F. Sartorello1, C. Bulato1, G. Saggiorato1, P. Simioni1|2 | 1First Chair of Internal Medicine and Thrombotic and Haemorrhagic Diseases Unit, Department of Medicine, Padova University Hospital, Italy; 2Hemophilia Center, Padova University Hospital, Italy

    Chiara Simion
    14-10-2026
    https://doi.org/10.4081/btvb.2026.699
    42
    PDF: 19
  • CO-54 | DECREASED BONE MINERAL DENSITY IN HEMOPHILIA IS NOT CORRELATED WITH INCREASED RISK OF FRACTURES M.R. Fasulo1, F. Carrone2, G. Mazziotti3|4, A. Colombo1, C. Lodigiani1, M.E. Mancuso1|4 | 1Center for Thrombosis and Hemorrhagic Diseases, IRCCS Humanitas Research Hospital, Rozzano, Milano, Italy; 2Endocrinology and Diabetology Unit, Humanitas Mater Domini, Castellanza, Varese, Italy; 3Endocrinology, Diabetology and Medical Andrology Unit, Metabolic Bone Diseases and Osteoporosis Section, IRCCS Humanitas Research Hospital, Rozzano, Milano, Italy; 4Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milano, Italy

    Maria Rosaria Fasulo
    14-10-2026
    https://doi.org/10.4081/btvb.2026.664
    38
    PDF: 16
  • CO-78 | REAL-WORLD MANAGEMENT OF ACQUIRED HEMOPHILIA A: FOCUS ON RECOMBINANT PORCINE FVIII AS FIRST-LINE HEMOSTATIC TREATMENT AND LONG-TERM OUTCOMES M. Leotta, A. Strangio, A. Ierardi, R.C. Santoro | Hemophilia, Hemostasis and Thrombosis Centre, Azienda Ospedaliero Universitaria Renato Dulbecco, Catanzaro, Italy

    Marzia Leotta
    14-10-2026
    https://doi.org/10.4081/btvb.2026.688
    44
    PDF: 16
  • CO-38 | CALIBRATION OF HUMAN COAGULATION FACTOR VIII IN NOVEL QUALITY CONTROL MATERIALS: A COLLABORATIVE STUDY G. Gullifa1, A. Carocci1, C. Albertini1|2, L. Luchetti1, M.T. Pasquino1, M. Simeoni1, L. Mandarino1, C. Adriano1|3, R. Risoluti3, S. Massimi1 | 1Centro Nazionale per il Controllo e la Valutazione dei Farmaci, Istituto Superiore di Sanità, Roma, Italy; 2Centro Nazionale Sangue, Istituto Superiore di Sanità, Roma, Italy; 3Sapienza Università di Roma, Italy

    Giuseppina Gullifa
    14-10-2026
    https://doi.org/10.4081/btvb.2026.648
    40
    PDF: 15
  • PO49 | Use of emicizumab in two patients with acquired hemophilia A: a new therapeutic approach S. Sorella, J. Micozzi, E. Baldacci, M. Biglietto, R. Mormile, A. Chistolini, R. Ciciani, L. Torrieri, N. Zhdanovskaya, M. Lorenzon, A. Delli Paoli, S. Ligia, C. Santoro | Hematology, Department of Translational and Precision Medicine, Policlinico Umberto I, Sapienza University of Roma, Italy

    22-10-2025
    https://doi.org/10.4081/btvb.2025.318
    665
    PDF: 25
  • Development of a shared decision-making tool for gene therapy in hemophilia A in Italy

    Giovanni Di Minno, Sarah Bigi, Serena Barello, Enrico Ferri Grazzi, Marco Follino, Maria Francesca Mansueto, Mariasanta Napolitano, Rita Carlotta Santoro, Giancarlo Castaman
    22-06-2026
    https://doi.org/10.4081/btvb.2026.426
    933
    PDF: 139
    SUPPLEMENTARY MATERIAL: 78
  • CO36 | Inhibitor titer at diagnosis and clinical course in acquired hemophilia A: a single-center experience C. Simion, B. Stocco, E. Dalla Porta, E. Campello, G. Furlan, L. Spiezia, G. Saggiorato, F. Sartorello, E. Zanon, P. Simioni | Department of Medicine – DIMED, University of Padua, Italy

    22-10-2025
    https://doi.org/10.4081/btvb.2025.243
    588
    PDF: 33
  • Safety of COVID-19 mRNA vaccination in patients with history of acquired hemophilia A: a case series

    Luca Puccetti, Vincenzo Sammartano, Federico Caroni, Margherita Malchiodi, Paola Calzoni, Eleonora Franceschini, Lucrezia Galasso, Monica Bocchia
    17-10-2022
    https://doi.org/10.4081/btvb.2022.40
    3064
    PDF: 434
  • CO35 | Bleeding phenotype characterization in patients with congenital bleeding disorders: a multigenic approach using next generation sequencing to identify coagulation-modulating variants C. Simion, L. Gianesello, C. Bulato, A. Benetti, E. Campello, A. Giannella, G. Ceolotto, E. Zanon, L. Spiezia, P. Simioni | Department of Medicine – DIMED, University of Padua, Italy

    22-10-2025
    https://doi.org/10.4081/btvb.2025.242
    544
    PDF: 31
  • PO060 | DISCREPANCY IN FACTOR VIII LEVELS AMONG HEMOPHILIA A CARRIERS: ONE-STAGE VS. CHROMOGENIC ASSAY A. Strangio, M. Leotta, A. Ierardi, L. Elia, M. Falbo, C. Condina, G. Procopio, RC Santoro | Centro Emofilia AOU R. Dulbecco Catanzaro, Italy

    Alessandra Strangio
    26-10-2026
    https://doi.org/10.4081/btvb.2026.876
    24
    PDF: 8
  • The changing landscape of treatment for acquired hemophilia A

    Massimo Franchini, Daniele Focosi
    30-01-2025
    https://doi.org/10.4081/btvb.2025.157
    2073
    PDF: 548
  • CO-70 | CONGENITAL AFIBRINOGENEMIA: BLEEDING PHENOTYPE, THROMBOTIC COMPLICATIONS, AND LONG-TERM MANAGEMENT IN A MULTICENTER COHORT M. Biglietto1|2, M. Presti1, R.C. Santoro3, I. Nichele4, M. Napolitano5, S. Pasca6, A. Borchiellini7, B. Pollio8, E. Zanon9, G. Barillari10, A. Poz10, S. Sorella1, S. Ligia1, R. Mormile1, E. Baldacci1, G. Castaman11, F. Peyvandi12|13, C. Santoro1 | 1Hematology, Department of Translational and Precision Medicine, Sapienza University of Rome, Italy; 2Department of Molecular Biology, Sapienza University of Rome, Italy; 3Hemostasis and Thrombosis Unit, Azienda Ospedaliera Pugliese-Ciaccio, Catanzaro, Italy; 4Hematology Unit, Azienda ULSS 8 Berica - San Bortolo Hospital, Vicenza, Italy; 5Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, University of Palermo, Italy; 6Coagulation Diseases Center, Transfusion Medicine Department - Azienda Sanitaria Universitaria Integrata del Trentino, Trento, Italy; 7Centro di Riferimento Regionale Malattie Emorragiche e Trombotiche dell'Adulto, Divisione di Ematologia, Università Città della Salute e della Scienza di Torino, Italy; 8SIMT Immunohematology and Transfusion Medicine Service, Diagnostic Department, A.O. Città della Salute e della Scienza, Torino, Italy; 9Department of Medicine, Haemophilia Centre, University Hospital of Padua, Italy; 10Center for Hemorrhagic and Thrombotic Diseases, General and University Hospital S. Maria della Misericordia, Udine, Italy; 11Centre for Bleeding Disorders and Coagulation, Careggi University Hospital, Firenze, Italy; 12IRCCS Fondazione Ca' Granda Ospedale Maggiore Policlinico, Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Milano, Italy; 13Università degli Studi di Milano, Department of Pathophysiology and Transplantation, Milano, Italy

    Mario Biglietto
    14-10-2026
    https://doi.org/10.4081/btvb.2026.680
    43
    PDF: 16
  • BEST-05 | LONG-TERM EMICIZUMAB PROPHYLAXIS IN PEOPLE WITH HEMOPHILIA A: REAL-WORLD EXPERIENCE ACROSS ALL AGES A. Colombo1, I. Quaglia1, M.R. Fasulo1, C. Lodigiani1, M.E. Mancuso1|2 | 1Center for Thrombosis and Hemorrhagic Diseases, IRCCS Humanitas Research Hospital, Rozzano, Milano, Italy; 2Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milano, Italy

    Arianna Colombo
    14-10-2026
    https://doi.org/10.4081/btvb.2026.605
    93
    PDF: 14
  • PO12 | Characterisation and real word clinical data of HEM006, a newly formulated intranasal spray desmopressin (DDAVP) to address a global treatment gap G. De Giorgi1, A. Gringeri2, R. Franceschini1, A. Koganti3 | 1Hemorare Srl, Italy; 2Fondazione Charta, Milan, Italy; 3Quenya LLC, USA

    22-10-2025
    https://doi.org/10.4081/btvb.2025.274
    580
    PDF: 12
  • PO039 | CLINICAL AND LABORATORY CHARACTERISTICS OF ACQUIRED HEMOPHILIA A: PRELIMINARY RESULTS FROM A RETROSPECTIVE OBSERVATIONAL MONOCENTRIC STUDY S. Suardi1, M. Bodini2, A.C. Giuffrida2, A. Zanzanelli3, S. Moruzzi1, L. Delfino1, F. Pizzolo1, S. Genesini2, M. Cantini2, C. Spillere1, L. Panepinto1, F. Zoccatelli1, E. Malloggi1, F. Presa1, A. Moschella1, M. Merlo1, G. Gandini2, S. Friso1, N. Martinelli1 | 1Department of Medicine, Unit of Internal Medicine B, Azienda Ospedaliera Universitaria Integrata di Verona, Italy; 2Department of Transfusion Medicine, Hemophilia Center, Azienda Ospedaliera Universitaria Integrata di Verona, Italy; 3Division of Internal Medicine, IRCCS Azienda Ospedaliero Universitaria Bologna, Italy

    Silvia Suardi
    26-10-2026
    https://doi.org/10.4081/btvb.2026.855
    22
    PDF: 8
  • Is non-alcoholic fatty liver disease a prothrombotic risk factor?

    Niccolò Bitto, Vincenzo La Mura, Anna Ludovica Fracanzani, Armando Tripodi
    19-05-2023
    https://doi.org/10.4081/btvb.2023.81
    1138
    PDF: 549
  • CO-59 | CONCIZUMAB IN A YOUNG CHILD WITH SEVERE HEMOPHILIA B WITH INHIBITOR: EFFECTIVE BLEED CONTROL AND SAFE HOME MANAGEMENT T. Martini1, B. Borsellino1|2, B. Pollio1 | 1Hemophilia Centre, Immune-Haematology and Transfusion Medicine, University Hospital “Città della Salute e della Scienza”, Torino, Italy; 2Department of Biomedicine and Prevention, PhD in Immunology, Molecular Medicine and Applied Biotechnology, University of Rome Tor Vergata, Roma, Italy

    Tiziano Martini
    14-10-2026
    https://doi.org/10.4081/btvb.2026.669
    44
    PDF: 13
  • CO-22 | CLINICAL FEATURES IN PATIENTS WITH NON-SEVERE HEMOPHILIA A: THE DISCOVERY SCORE PROPOSAL FOR PROPHYLAXIS PRESCRIPTION M.N.D. Di Minno1, E. Baldacci2, C. Biasoli3, A. Borchiellini4, F. Daniele5, P. Di Gregorio6, C. Gorio7, G. Malcangi8, E. Marchesini9, I. Ricca10, R. Santoro11, S. Siragusa12, M.R. Villa13, E. Zanon14, A. Tagliaferri15, A. Coppola15 | 1Hub Centre for Thrombotic and Hemorrhagic Disorders, Federico II University Hospital, Napoli, Italy; 2Haematology, University Hospital Policlinico Umberto I, Roma, Italy; 3Interdepartmental Simple Structure for the Management of Hemorrhagic and Thromboembolic Diseases, M. Bufalini Hospital, Cesena, Italy; 4Regional Centre for Hemorrhagic and Thrombotic Diseases, AOU Città della Salute e della Scienza, Torino, Italy; 5Haemostasis and Thrombosis Service, Ospedale Civile dell'Annunziata, Cosenza, Italy; 6Transfusion Medicine Department, "SS. Annunziata" Hospital, Chieti, Italy; 7Pediatric Onco-Hematology Unit, Children's Hospital, ASST-Spedali Civili, Brescia, Italy; 8Haemophilia and Thrombosis Center, University Hospital Policlinico-Giovanni XXIII, Bari, Italy; 9Hemophilia Centre, SC Vascular and Emergency Department, University of Perugia, Italy; 10Centro Emofilia, Città della Salute e della Scienza, Torino, Italy; 11Hemostasis and Thrombosis Unit, Azienda Ospedaliero Universitaria Dulbecco, Catanzaro, Italy; 12Centro di Riferimento Regionale per le Emocoagulopatie Congenite, Palermo, Italy; 13Hematology Unit, Ospedale Santa Maria di Loreto, Napoli, Italy; 14Hemophilia and Thrombosis Center, University Hospital of Padua, Italy; 15Hemophilia and Thrombosis Center, Azienda Ospedaliera di Parma, Italy

    Matteo Di Minno
    14-10-2026
    https://doi.org/10.4081/btvb.2026.632
    55
    PDF: 15
  • CO006 | PREVALENCE OF GASTROINTESTINAL BLEEDING IN GLANZMANN THROMBASTHENIA PATIENTS: RESULTS OF A WORLDWIDE SURVEY E. Falcinelli1, L. Bury1, S. Morais2, M. de Oliveira2, M. Kannan3, M. Faranoush4, D. Desprez5, V. Jean-Baptiste6, C. Santoro7, C. Falaise8, P. Saultier8, M. Fiore9, C. Albayrak10, A. Sánchez11, J.M. Bastida12, A. Artoni13, G. Castaman14, K. Gomez15, R. Schutgens16, L. Spiezia17, M. Sridharan18, N. Butta19, P. Buur van Kooten Niekerk20, E. Leinøe21, B. Guillet22, C. Panagiotis23, S. Crivelli24, E. De Candia25, M. Lewandowska26, P. De Bonis27, G. Kenet28, F. Heubel-Moenen29, J. Payne30, L. Banov31, L. Puccetti32, M. Olivieri33, M. Chitlur34, M. Lambert35, A. Pecci36, D. Martínez-Carballeira37, E. Zetterberg38, J. Curnow39, M. Napolitano40, A. Morotti41, R.C. Santoro42, R. Johann43, S. Saulyte Trakymiene44, A. Falanga45, C. Casas46, E. Zanon47, J. Moppet48, N.M. Popa-Fotea49, P. Gresele1 | 1Department of Medicine and Surgery, Section of Internal and Cardiovascular Medicine, University of Perugia, Italy; 2Centro Hospitalar Universitário de Santo António, Portugal; 3Blood and Vascular Biology Research Lab, Department of Biotechnology, Central University of Tamil Nadu, India; 4Iranian Hemophilia and Thrombophilia Association, MAHTA, Iran; 5CRC MHC Hopital Universaitire de Strasbourg, France; 6CHRU de Tours, University Hospital of Tours, France; 7UOC Ematologia, Azienda Ospedaliero Universitaria Policlinico Umberto I, Roma, Italy; 8AP-HM Timone, Marseille, France; 9CHU Bordeaux, France; 10Mayıs University Medical Faculty Pediatric Hematology and Oncology Dept, Türkiye; 11Hospital Universitario Morales Meseguer – Centro Regional de Hemodonación, Murcia, Spain; 12Complejo Asistencial Universitario De Salamanca, Spain; 13Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milano, Italy; 14Azienda Ospedaliera Universitaria Careggi Florence, Italy; 15Royal Free Hospital, London, UK; 16Center for Benign Haematology, Thrombosis and Haemostasis, Van Creveldkliniek, UMC Utrecht, The Netherlands; 17University of Padova, Italy; 18Mayo Clinic, Rochester, USA; 19Hospital Universitario La Paz-IdiPAZ, Madrid, Spain; 20Aarhus University Hospital, Denmark; 21Department of Hematology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark; 22University Hospital of Rennes, France; 23Blood unit and National Reference Center for Congenital Bleeding Disorders, ''Laiko'' General Hospital, Greece; 24Ospedale L. Sacco e Polo Universitario, Milano, Italy; 25Università Cattolica del Sacro Cuore-Roma, Fondazione Policlinico Universitario A. Gemelli IRCCS, Italy; 26Indiana Hemophilia and Thrombosis Center Innovative Hematology, USA; 27IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy; 28Sheba Medical Center, Israel; 29Department of Hematology Internal Medicine, Maastricht University Medical Center and Hemophilia Treatment Center Nijmegen Eindhoven Maastricht and CARIM, Maastricht University, Maastricht, Netherlands; 30Sheffield Children’s NHS foundation Trust, UK; 31Hemostasis and Thrombosis Unit, Gaslini Children’s Hospital, Italy; 32University Teaching Hospital of Siena, Italy; 33Pediatric Thrombosis and Hemostasis Unit, Dr. von Hauner Childreńs Hospital, LMU Munich, Munich, Germany; 34Children's Hospital of Michigan, USA; 35Children’s Hospital of Philadelphia, USA; 36IRCCS Policlinico San Matteo Foundation and University of Pavia, Italy; 37Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Spain; 38Department of Hematology, Coagulation Unit, Skane University hospital, Sweden; 39Westmead Hospital, Sydney, Australia; 40PROMISE Department, University of Palermo, Italy; 41AOU San Luigi Gonzaga Hospital, University of Turin, Italy; 42Hemostasis and Thrombosis, Az. Osp. Univ. Dulbecco, Catanzaro, Italy; 43Hospital Center of Le Mans, France; 44Vilnius University Hospital Santaros Klinikos, Lithuania; 45ASST Papa Giovanni XXIII, Bergamo, Italy; 46Hospital San José, Bogotà, Colombia; 47Haemophilia Center-General Medicine, Padova University Hospital, Padova, Italy; 48University Hospitals Bristol NHS Foundation Trust, UK; 49University of Medicine and Pharmacy “Carol Davila”, Bucharest, Romania

    Loredana Bury
    26-10-2026
    https://doi.org/10.4081/btvb.2026.708
    39
    PDF: 11
  • CO-75 | ASSAY DISCREPANCY IN HEMOPHILIA A CARRIERS: CLINICAL AND GENETIC INSIGHTS M. Leotta, A. Strangio, A. Ierardi, R.C. Santoro | Hemophilia Treatment Center AOU Dulbecco, Catanzaro, Italy

    Marzia Leotta
    14-10-2026
    https://doi.org/10.4081/btvb.2026.685
    43
    PDF: 20
  • CO-34 | SIMPLIFIED PERIOPERATIVE MANAGEMENT WITH N8-GP (TUROCTOCOG ALFA PEGOL) IN MAJOR ABDOMINAL SURGERY IN MILD HEMOPHILIA A WITH SEVERE BLEEDING PHENOTYPE: A CASE REPORT J. Di Paolo, R. Malizia, M. Luongo, P. Massaro, M. Di Mascio, S. Verna | Immunohematology Service, ASL 02 Abruzzo, Chieti, Italy

    Josephine Di Paolo
    14-10-2026
    https://doi.org/10.4081/btvb.2026.644
    36
    PDF: 13
  • PO44 | Emicizumab in acquired haemophilia A M. Leotta, A. Strangio, A. Ierardi, S. Prejanò, R C. Santoro | Hemostasis and Thrombosis Unit, Department Hemato-Oncology, Azienda Ospedaliero-Universitaria Renato; Dulbecco, Catanzaro, Italy

    22-10-2025
    https://doi.org/10.4081/btvb.2025.307
    628
    PDF: 20
  • PO114 | A CASE OF ACQUIRED HEMOPHILIA AFTER TAVI AND CORONARY ANGIOPLASTY IN PATIENT WITH ATRIAL FIBRILLATION AND MULTIPLES CARDIOVASCULAR RISK FACTORS – THE ART AND SCIENCE OF THERAPEUTIC CONFLICT M.M. Poggi1, C. Tamburini2, M. Littera2, M. Mazzetti2 | 1SOC Medicina 1, Nuovo Ospedale Prato, Prato, Italy; 2SOD Medicina Interna Interdisciplinare, Azienda Ospedaliera Universitaria Careggi, Firenze, Italy

    Matteo Maria Poggi
    26-10-2026
    https://doi.org/10.4081/btvb.2026.930
    26
    PDF: 7
  • CO33 | Acquired hemophilia A in Liguria, Italy: what six years of data reveal C. Vernarecci1, A. C. Molinari1, P. Ballarino2, M. Caiti2, E. Cenni2, P. Moscatelli2, L. Banov1 | 1IRCCS Istituto Giannina Gaslini, Genova; 2IRCCS Policlinico San Martino, Genova, Italy

    22-10-2025
    https://doi.org/10.4081/btvb.2025.240
    616
    PDF: 30
  • PO67 | Pancreatic cancer in a 71-year-old severe hemophilia A patient with inhibitors and sustained zero bleeding during emicizumab prophylaxis M. Biglietto, A.L. Faccini, S. Sorella, E. Crisanti, M. Antonacci, A. Taglietti, M. Gherardini, A. Tirnetta, S. Ligia, R. Mormile, R. Ciciani, E. Baldacci, C. Santoro | Hematology, Department of Translational and Precision Medicine Sapienza University of Roma, Italy

    22-10-2025
    https://doi.org/10.4081/btvb.2025.336
    668
    PDF: 29
  • BEST-03 | CRISPR-CAS9 CORRECTION IN SEVERE HEMOPHILIA A A. Benetti1, C.M. Radu1, M. Trevisan2, C. Samà1, C. Simion1, E. Campello1, P. Simioni1 | 1First Chair of Internal Medicine and Thrombotic and Haemorrhagic Diseases Unit, Department of Medicine, Padova University Hospital, Italy; 2Department of Molecular Medicine, University of Padua, Italy

    Andrea Benetti
    14-10-2026
    https://doi.org/10.4081/btvb.2026.603
    83
    PDF: 16
  • CO005 | HEPATIC ENDOTHELIUM AS A SAFE AND DURABLE TARGET FOR LENTIVIRAL GENE THERAPY OF HEMOPHILIA A E. Borroni, F. Antony, S. Merlin, V. Kalandadze, C. Borsotti, A. Follenzi | Università del Piemonte Orientale, Novara, Italy

    Ester Borroni
    26-10-2026
    https://doi.org/10.4081/btvb.2026.707
    38
    PDF: 9
  • BEST-10 | CHANGES IN HYPERTROPHIC SYNOVIUM STATUS IN ADULT PATIENTS WITH SEVERE HEMOPHILIA A RECEIVING EMICIZUMAB PROPHYLAXIS: THE RESOLVE STUDY I.L. Calcaterra1, M. Di Minno1, E. Baldacci2, G. D’Errico1, C. Santoro2, A. Strangio3, S. Sorella2, M. Leotta3, R.C. Santoro3 | 1Department of Clinical Medicine and Surgery, Federico II University, Napoli, Italy; 2Haematology, University Hospital Policlinico Umberto I, Roma, Italy; 3Hemostasis and Thrombosis Centre, Azienda Ospedaliero Universitaria Renato Dulbecco, Catanzaro, Italy

    Ilenia Lorenza Calcaterra
    14-10-2026
    https://doi.org/10.4081/btvb.2026.610
    88
    PDF: 17
  • PO112 | REFRAMING THE ENIGMA: ACQUIRED HEMOPHILIA A AS A HARBINGER OF HHV-8–ASSOCIATED MULTICENTRIC CASTLEMAN DISEASE M. Palladino1, G. Gammaitoni1, C. Santoro2, M. Muscaritoli1 | 1Medicina Interna e Nutrizione Clinica-Dip. Medicina Traslazionale e di Precisione; 2Ematologia- Dip. Medicina Traslazionale e di Precisione, Umberto I Roma, Italy

    Mariangela Palladino
    26-10-2026
    https://doi.org/10.4081/btvb.2026.928
    22
    PDF: 9
  • PO131 | BEYOND THE INHIBITOR TITER: THE IMPORTANCE OF EARLY COMBINED IMMUNOSUPPRESSIVE THERAPY IN THE MANAGEMENT OF ACQUIRED HEMOPHILIA A M. Luongo1, P. Massaro1, M. Di Mascio1, P.G. Simeone2, F. Santilli2, S. Verna1 | 1Immunohematology Service, Asl 02 Abruzzo, Chieti, Italy; 2Department of Medicine and Aging Sciences, and Center for Advanced Studies and Technology, “G. d’Annunzio” University of Chieti–Pescara, Italy

    Myriam Luongo
    26-10-2026
    https://doi.org/10.4081/btvb.2026.947
    26
    PDF: 8
  • CO081 | RESTORATION OF CEREBRAL MICROVASCULAR STRUCTURE AND FUNCTION IN HEMOPHILIA A MICE THROUGH FVIII GENE THERAPY G. Venturin1, E. Spicuglia1, S. Assanelli1, C. Borsotti1, A. Cucci1, N. Keivan1, E. Borroni1, C. Sgromo1, C. Olgasi2, A. Follenzi1|3 | 1Department of Health Science, Università del Piemonte Orientale, Novara, 28100, Italy; 2Department of Translational Medicine, Università del Piemonte Orientale, Novara, 28100, Italy; 3Department of Attività Integrate Ricerca Innovazione, Azienda Ospedaliero-Universitaria SS. Antonio e Biagio e C. Arrigo, Alessandria, Italy

    Giorgia Venturin
    26-10-2026
    https://doi.org/10.4081/btvb.2026.783
    32
    PDF: 11
  • CO-65 | COVID-19-ASSOCIATED HYPERCOAGULABILITY IN TYPE 2B VON WILLEBRAND DISEASE: INSIGHTS FROM GLOBAL HEMOSTATIC ASSAYS I. Condonato, C. Simion, E. Zanon, P. Simioni | Hemophilia Center, University Hospital of Padua, Italy

    Irene Condonato
    14-10-2026
    https://doi.org/10.4081/btvb.2026.675
    43
    PDF: 16
  • CO002 | RETROSPECTIVE LONGITUDINAL ASSESSMENT OF JOINT HEALTH AND QUALITY OF LIFE IN ADOLESCENT AND ADULT PATIENTS AFFECTED BY MODERATE OR SEVERE HAEMOPHILIA A WITH OR WITHOUT INHIBITOR SWITCHING FROM INTRAVENOUS FVIII TREATMENT TO SUBCUTANEOUS PROPHYLAXIS WITH EMICIZUMAB S. Ceglie1, R. Gualtierotti1|2, S. Arcudi1, A. Ciavarella1, S.M. Siboni1, F. Peyvandi1|2 | 1Centro Emofilia e Trombosi Angelo Bianchi Bonomi, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano, Italy; 2Dipartimento di Fisiopatologia Medico-Chirurgica e dei Trapianti, Università degli Studi di Milano, Milano, Italy

    Sara Ceglie
    26-10-2026
    https://doi.org/10.4081/btvb.2026.704
    51
    PDF: 12
  • CS02 | Functional and structural impairments of the cerebral microcirculation in a mouse model of hemophilia A G. Venturin1, C. Olgasi2, C. Borsotti1, P.E. Di Simone1, E. Spicuglia1 A. Cucci1, C. Sgromo1, A. Follenzi2,3 | 1Department of Health Science, Università del Piemonte Orientale, Novara; 2Department of Translational Medicine, Università del Piemonte Orientale, Novara; 3Department of Attività Integrate Ricerca Innovazione, Azienda Ospedaliero-Universitaria SS. Antonio e Biagio e C. Arrigo, Alessandria, Italy

    22-10-2025
    https://doi.org/10.4081/btvb.2025.197
    753
    PDF: 21
  • BEST-09 | IMMUNOGENIC IMPLICATIONS OF TRANSLATIONAL READTHROUGH MODULATE THE ASSOCIATION OF F8 NONSENSE MUTATIONS WITH INHIBITORS IN HEMOPHILIA A D. Balestra1, M.F. Testa1, M. Pinotti1, A. Branchini1, M.E. Mancuso2, F. Bernardi1 | 1Department of Life Sciences and Biotechnology and LTTA Center, University of Ferrara, Italy; 2IRCCS, Humanitas Research Hospital, Center for Thrombosis and Hemorrhagic diseases, Milano, Italy

    Dario Balestra
    14-10-2026
    https://doi.org/10.4081/btvb.2026.609
    80
    PDF: 16
  • PO085 | ACQUIRED HEMOPHILIA A IN THE SURGICAL PATIENT: DIAGNOSTIC AND THERAPEUTIC COMPLEXITY M. Luongo1, P. Massaro1, M. Di Mascio1, P.G. Simeone2, F. Santilli2, S. Verna1 | 1Immunohematology Service, Asl 02 Abruzzo, Chieti, Italy; 2Department of Medicine and Aging Sciences, and Center for Advanced Studies and Technology, “G. d’Annunzio” University of Chieti–Pescara, Italy

    Myriam Luongo
    26-10-2026
    https://doi.org/10.4081/btvb.2026.901
    25
    PDF: 7
  • PO043 | MULTICENTRE REAL‑WORLD EXPERIENCE OF EMICIZUMAB PROPHYLAXIS IN AN ITALIAN COHORT OF 49 CHILDREN WITH SEVERE HEMOPHILIA A - EMIPED STUDY L. Pieri1, B. Pollio2, P. Giordano3, G. Lassandro4, S. Linari1, R. Pasquino1, E. Piellucci1, MC. Di Stefano1, F. Demartis1, R. Fjerza1, G. Castaman1 | 1Center for Bleeding Disorders, Careggi University Hospital, Firenze, Italy; 2Center for Inherited Bleeding and Thrombotic Disorders, Transfusion Medicine, "Regina Margherita" Children Hospital, Torino, Italy; 3Department of Interdisciplinary of Medicine, University of Bari 'Aldo Moro', Bari, Italy; 4General and Specialised Pediatrics Unit, "Giovanni XXIII" Hospital, University of Bari, Bari, Italy

    Lisa Pieri
    26-10-2026
    https://doi.org/10.4081/btvb.2026.859
    27
    PDF: 8
  • CO-06 | ENHANCING SHARED DECISION-MAKING IN INHERITED BLEEDING DISORDERS: A SINGLE-CENTER QUALITY IMPROVEMENT INITIATIVE C. Manzi, L. Piscitelli, E. Zacchi, V. Caldi, L. Valdrè | Inherited Bleeding Disorders Unit, IRCCS AOU, Bologna, Italy

    Chiara Manzi
    14-10-2026
    https://doi.org/10.4081/btvb.2026.616
    76
    PDF: 16
  • PO55 | Evaluation of safety and efficacy of emicizumab prophylaxis in pediatric patients with hemophilia A – a single centre experience M.L. Tramontano, M. Coppola, S. Coppola, M. Schiavulli | UOSD Centro Regionale Pediatrico Malattie della Coagulazione, Santobono Pausilipon Children Hospital, AORN, Napoli, Italy

    22-10-2025
    https://doi.org/10.4081/btvb.2025.324
    573
    PDF: 24
  • CO-47 | JOINT ULTRASOUND FOLLOW-UP IN PEDIATRIC PATIENTS WITH HEMOPHILIA: A 12-YEAR PROSPECTIVE SINGLE-CENTER EXPERIENCE I. Ricca1, B. Borsellino2|3, T. Martini2, C. Martinoli4, B. Pollio2 | 1Transfusion Medicine, Ivrea Hospital, Ivrea, Italy; 2Haemophilia Centre, Immune-Haematology and Transfusion Medicine, University Hospital “Città della Salute e della Scienza”, Torino, Italy; 3Department of Biomedicine and Prevention, PhD in Immunology, Molecular Medicine and Applied Biotechnology, University of Rome Tor Vergata, Roma, Italy; 4Department of Health Science DISSAL, University of Genova, Unit of Radiology and IRCCS San Martino Hospital, Genova, Italy

    Tiziano Martini
    14-10-2026
    https://doi.org/10.4081/btvb.2026.657
    50
    PDF: 17
  • PO19 | Joint health status in patients with moderate hemophilia A: a cross-sectional multi-center study I.L. Calcaterra1, F. Picasso2, F. Valeri3, E. Baldacci4, M. Napolitano5, C. Guerrino1, E. Zanon6, C. Santoro4, S. Siragusa7, C. Martinoli2, M. Di Minno1 | 1Department of Clinical Medicine and Surgery, Regional Reference Centre for Coagulation Disorders, Federico II University, Naples; 2Department of Health Sciences “DISSAL”, Università di Genova; 3Regional Centre for Hemorrhagic and Thrombotic Diseases, AOU Città della Salute e della Scienza, Turin; 4Haematology, Department of Translational and Precision Medicine, Sapienza University, Roma; 5Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, University of Palermo and Haematology Unit and Rare Disorders Hospital “V. Cervello”, Palermo; 6Haemophilia Centre, General Medicine, Padua University Hospital, Padua; 7Department PROMISE, University of Palermo, Italy

    22-10-2025
    https://doi.org/10.4081/btvb.2025.279
    601
    PDF: 25
  • PO042 | ACQUIRED HEMOPHILIA A AND ANTIPHOSPHOLIPID SYNDROME: CONCURRENCY OR OVERLAPPING? E. Galimberti1, C. Ambaglio1, T. Zollner1, F. Schieppati1|2, O.C. Cretu1, F. Zunino1, V. Brusegan1, M. Marchetti1|2, A. Falanga1|2, L. Barcella1 | 1Immunohematology and Transfusion Medicine, Department of Transfusion Medicine and Hematology, ERN-EuroBloodNet - European Reference Network in Rare Hematological Diseases, ASST Papa Giovanni XXIII, Bergamo, Italy; 2School of Medicine and Surgery, University of Milano-Bicocca, Milano, Italy

    Elisa Galimberti
    26-10-2026
    https://doi.org/10.4081/btvb.2026.858
    25
    PDF: 8
  • CO-11 | MAPPING THE COMPETENCIES OF NURSES IN ITALIAN HEMOPHILIA CENTERS: CURRENT STATUS AND PERSPECTIVES FOR THE IDENTIFICATION OF NURSE-SENSITIVE OUTCOMES M.V. Puliga1, A.C. Ferrini2, C. Manzi3, D. Meneghini4, E. Tosi4, P. Berto5, M. Amelotti-Botta6, E. Quercio6, M.E. Mancuso7, R.C. Santoro8 | 1SODc Malattie Emorragiche e della Coagulazione, AOU Careggi, Firenze, Italy; 2SSI Malattie Emorragiche e Tromboemboliche, Osp. Bufalini, Cesena, Italy; 3SSD Malattie Emorragiche Congenite, IRCCS Policlinico Sant'Orsola, Bologna, Italy; 4Centro Emofilia e UOC Medicina Trasfusionale, AOU Integrata, Verona, Italy; 5Centro Emofilia Hub, AO di Padova, Italy; 6SSD Emostasi e Coordinamento Malattie Rare, AO SS. Antonio e Biagio, Alessandria, Italy; 7UOC Centro Trombosi e Malattie Emorragiche, IRCCS Humanitas Research Hospital, Rozzano, Milano, Italy; 8UOD Emofilia, Emostasi e Trombosi, AOU Renato Dulbecco, Catanzaro, Italy

    Maria-Virginia Puliga
    14-10-2026
    https://doi.org/10.4081/btvb.2026.621
    89
    PDF: 16
  • PO90 | Acquired hemophilia A with high-titer inhibitor in a patient with cardiovascular and metabolic comorbidities M.G. Mazzone, G. Chiarelli, R. Russo, L. Valletta Jr, G. D’Errico, C. De Luca, P. Rufolo, A. Tufano, E. Cimino, P. Conca, M.N.D. Di Minno | Department of Clinical Medicine and Surgery, Federico II University of Naples, Italy

    22-10-2025
    https://doi.org/10.4081/btvb.2025.360
    665
    PDF: 27
  • BEST-06 | OPTIMIZING LABORATORY MONITORING OF EFANESOCTOCOG ALFA: IMPACT OF APTT REAGENTS AND CHROMOGENIC ASSAYS ON DIAGNOSTIC ACCURACY A. Strangio, A. Ierardi, M. Leotta, L.C. Elia, M. Falbo, C. Condina, G. Procopio, R.C. Santoro | Hemophilia Hemostasis and Thrombosis Unit, Azienda Ospedaliero Universitaria Renato Dulbecco, Catanzaro, Italy

    Alessandra Strangio
    14-10-2026
    https://doi.org/10.4081/btvb.2026.606
    86
    PDF: 16
  • PO14 | Searching for safer rescue immunosuppressive therapy protocols in acquired hemophilia A: two case reports G. Quintavalle1, I.M. Tassoni1, B.M. Roccon1, G. Lucchini2, F. Magalini2, M. Zardo2, R. Rossi3, C. Cattabiani3, A. Tagliaferri1, A. Coppola1 | 1SSD Centro HUB Emofilia e MEC; 2UOS Medicina Interna e Reumatologia; 3UO Diagnostica Ematochimica, Azienda Ospedaliero Universitaria, Parma, Italy

    22-10-2025
    https://doi.org/10.4081/btvb.2025.275
    554
    PDF: 20
  • CO-17 | EMBODIED SELF-MANAGEMENT IN HEMOPHILIA: PSYCHOSOMATIC EFFECTS OF A SUPERVISED PHYSICAL ACTIVITY PROGRAM F. Valeri1, M. Miniotti2, M.G. Bailon2, C. Dainese1, B. Bruno3, P. Leombruni2, A. Borchiellini1 | 1Regional Centre for Haemorrhagic and Thrombotic Disease, Hematology Division, AOU Città della Salute e della Scienza, Torino, Italy; 2Departement of Neurosciences Rita Levi Montalcini, University of Turin, Italy; 3Division of Hematology, AOU Città della Salute e della Scienza, Department of Molecular Biotechnology and Health sciences, University of Turin, Italy

    Federica Valeri
    14-10-2026
    https://doi.org/10.4081/btvb.2026.627
    37
    PDF: 11
  • PO040 | PHARMACODYNAMIC CHARACTERIZATION OF THROMBIN GENERATION IN SEVERE HEMOPHILIA A PATIENTS ON EMICIZUMAB PROPHYLAXIS: A REAL-WORLD LONGITUDINAL STUDY M. Bergamaschi, A. Pallotta, M. Biglietto, S. Sorella, S. Ligia, E. Baldacci, A. Chistolini, C. Santoro, R. Mormile | Department of translational and precision Medicine, Sapienza, University of Rome, Italy

    Martina Bergamaschi
    26-10-2026
    https://doi.org/10.4081/btvb.2026.856
    24
    PDF: 8
  • PO149 | MANAGEMENT OF ANTITHROMBOTIC THERAPY IN A PATIENT WITH HEMOPHILIA C AND ATRIAL FIBRILLATION E. Marrone1, G. Ruggiero2, E. Cimino3, P. Conca3, C. Miele4, F. Gallucci1, A. Abate1, C. Romano1, D. Leosco2, U. Valentino1 | 1Department of Medicine 3, Cardarelli Hospital, Napoli, Italy; 2School of Specialization in Geriatrics; 3Department of Internal Medicine and Blood Coagulation; 4Department of Laboratory Medicine and Transfusion, Federico II University, Napoli, Italy

    Emiliana Marrone
    26-10-2026
    https://doi.org/10.4081/btvb.2026.965
    24
    PDF: 8
  • CO-36 | PLATELETS MATTER: THROMBIN GENERATION IN PLATELET‐RICH-PLASMA VS. PLATELET‐POOR‐PLASMA UNDER NON-REPLACEMENT THERAPIES IN HEMOPHILIA F. Bocchi1|2, R. Pastorino1|2, G. Murante1|2|3, S. Bergonzi1|2|3, M. Capetta1|2|3, F. Valeri2|3, C. Dainese2|3, A. Valpreda4, B. Bruno1|3, A. Borchiellini2|3 | 1Department of Molecular Biotechnology and Health Sciences, University of Turin, Italy; 2Regional Centre for Thrombotic and Hemorrhagic Diseases, AOU Città della salute e della Scienza di Torino, Italy; 3Division of Hematology, AOU Città della Salute e della Scienza, University of Turin, Italy; 4Central Lab Baldi and Riberi, AOU Città della salute e della Scienza di Torino, Italy

    Francesca Bocchi
    14-10-2026
    https://doi.org/10.4081/btvb.2026.646
    47
    PDF: 14
  • CO34 | Evaluation of emicizumab concentration and thrombin generation in a cohort of severe hemophilia A patients with and without inhibitor A. Taglietti1, S. Ligia1, F. Paoletti1, R. Mormile1, E. Baldacci2, A. Chistolini1, C. Santoro1,2 | 1Hematology, Department of Translational and Precision Medicine, Sapienza University of Roma; 2Hematology, Azienda Ospedaliera Universitaria Policlinico Umberto I, Roma, Italy

    22-10-2025
    https://doi.org/10.4081/btvb.2025.241
    676
    PDF: 12
  • CO-85 | ACQUIRED HEMOPHILIA A IN LIVER CIRRHOSIS: BALANCING HEMOSTASIS BETWEEN HIGH HEMORRHAGIC AND THROMBOTIC RISKS N. Portesi, G. Martini | ASST Spedali Civili di Brescia, Italy

    Nicola Portesi
    14-10-2026
    https://doi.org/10.4081/btvb.2026.695
    43
    PDF: 19
  • CO-09 | THE POSSIBLE ROLE OF THE PSYCHOLOGIST IN THE MANAGEMENT OF PATIENTS WITH CONGENITAL BLEEDING DISORDERS: THE EXPERIENCE OF A SINGLE HEMOPHILIA CENTER D. Meneghini1, E. Tosi1, B. Pernice2, L. Del Piccolo2, M. Bodini1, A.C. Giuffrida1 | 1Transfusion Medicine Dep., Integrated University Hospital, Verona, Italy; 2Dep. of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Italy

    Marco Bodini
    14-10-2026
    https://doi.org/10.4081/btvb.2026.619
    89
    PDF: 13
  • BEST-04 | MAJOR ORTHOPEDIC SURGERY WITH EMICIZUMAB: A SERIES OF 22 PATIENTS (40 PROCEDURES) WITH A MID-TERM FOLLOW-UP G. Daniele1, C. Carulli1, S. Linari2, L. Pieri2, G. Castaman2 | 1Clinica Ortopedica, Azienda Ospedaliero-Universitaria Careggi, Università degli Studi di Firenze, Italy; 2Centro Malattie Emorragiche e della Coagulazione, Azienda Ospedaliero-Universitaria Careggi, Firenze, Italy

    Giovanna Daniele
    14-10-2026
    https://doi.org/10.4081/btvb.2026.604
    86
    PDF: 13
  • Inherited platelet function disorders: a comprehensive narrative review focusing on diagnostic and management aspects

    Antonietta Ferretti, Nicola Portesi, Chiara Gorio, Marzia Leotta, Alessandra Strangio, Antonella Ierardi, Bianca Maria Roccon, Giulia Albrici, Giulia Carracchia, Marta Mattana, Chiara Biasoli, Cristina Santoro, Tiziano Martini, Rita Carlotta Santoro
    21-10-2026
    https://doi.org/10.4081/btvb.2026.581
    56
    PDF: 38
    SUPPLEMENTARY MATERIAL: 12
  • Gene transfer in hemophilia B: a big step forward

    Giancarlo Castaman
    17-05-2023
    https://doi.org/10.4081/btvb.2023.70
    1436
    PDF: 659
  • PO136 | PHENOTYPE CHARACTERIZATION OF PATIENTS HOSPITALIZED FOR ACUTE SARS-COV2 INFECTION WITH AND WITHOUT ACUTE CEREBRAL ISCHEMIA P. Agosti1|2, R. Gualtierotti1|2, C. Suffritti1, L. Valenti2|3, M. Morena2, M. Tettamanti4, A. Nobili4, A. Bandera2|5, F. Peyvandi1|2 | 1Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Milano, Italy; 2Università degli Studi di Milano, Department of Pathophysiology and Transplantation, Milano, Italy; 3Department of Transfusion Medicine and Biological Resource Center, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano, Italy; 4Department of Health Policy, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milano, Italy; 5Department of Infectious Diseases, Fondazione IRCCS Ca’ Granda, Ospedale Maggiore Policlinico, Milano, Italy

    Pasquale Agosti
    26-10-2026
    https://doi.org/10.4081/btvb.2026.952
    26
    PDF: 11
  • CO49 | The burden of cerebral small vessel disease in ITTP patients from acute phase to remission A. Truma1,2, F. M. Lo Russo1, G. Conte1,2, I. Mancini1, M. Abbattista1, J. A. Giannotta1, A. Artoni1, B. Ferrari1, P. Agosti1,2, F. M. Triulzi1,2, F. Peyvandi1,2 | 1Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Milan; 2Università degli Studi di Milano, Department of Pathophysiology and Transplantation, Milan, Italy

    22-10-2025
    https://doi.org/10.4081/btvb.2025.259
    628
    PDF: 15
  • Rationale and design of a study on D-dimer use to stratify patients after a first unprovoked venous thromboembolism for their risk of recurrence: extended low-dose Apixaban given only to patients with positive D-dimer results The Apidulcis study

    Gualtiero Palareti, Paolo Prandoni, Cristina Legnani, Emilia Antonucci, Serena Zorzi, Alberto Tosetto, Lorenza Bertù, Sophie Testa, Vittorio Pengo, Walter Ageno, Ida Martinelli, Benilde Cosmi, Eugenio Bucherini, Daniela Poli
    22-03-2022
    https://doi.org/10.4081/btvb.2022.10
    1890
    PDF: 564
    APPENDIX: 144
  • CO-14 | BEYOND BLEEDING: NARRATIVE MEDICINE AS A METHODOLOGICAL TOOL FOR INVESTIGATION AND CARE IN CONGENITAL BLEEDING DISORDERS V. Grippa1, S. Riva2, A. Gringeri3 | 1Centro Malattie Emorragiche Salerno, Italy; 2St. Mary's University, London, UK; 3Fondazione Charta, Milano, Centro di Solidarietà Solidale, Lucca, Italy

    Silvia Riva
    14-10-2026
    https://doi.org/10.4081/btvb.2026.624
    72
    PDF: 19
  • CS05 | Joint ultrasound follow-up in pediatric patients with haemophilia: a 12-year prospective single-center experience B. Borsellino1,2, B. Pollio1, C. Martinoli3, T. Martini1, R. Albiani1, I. Ricca1 | 1Haemophilia Centre, Immune-Haematology and Transfusion Medicine, University Hospital “Città della Salute e della Scienza”, Turin; 2Department of Biomedicine and Prevention, PhD in Immunology, Molecular Medicine and Applied Biotechnology, University of Roma Tor Vergata, Roma; 3Department of Health Science DISSAL, University of Genoa, Unit of Radiology and IRCCS San Martino Hospital, Genoa, Italy

    22-10-2025
    https://doi.org/10.4081/btvb.2025.202
    683
    PDF: 28
  • CO-74 | WHAT WOMEN ARE NOT ASKED A MODEL OF CARE FOR WOMEN AND GIRLS WITH BLEEDING DISORDERS S. Pancetti, A.C. Ferrini, E. Magnani, P. Pedrazzi, C. Biasoli | Osp. M.Bufalini, Cesena, Italy

    Saverio Pancetti
    14-10-2026
    https://doi.org/10.4081/btvb.2026.684
    45
    PDF: 13
  • PO39 | Bleeding events in Von Willebrand disease type 1 yearly treatable with desmopressin A. Gringeri1,2, P.M. Mannucci3, M. Gringeri4, G. Castaman5, F. Peyvandi3,6 | 1Fondazione Charta, Milan; 2Centro di Sanità Solidale, Lucca; 3Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Angelo Bianchi Bonomi Hemophilia and Thrombosis Center and Fondazione Luigi Villa, Milan; 4Department of Medical Biotechnologies and Translational Medicine, Postgraduate School of Clinical Pharmacology and Toxicology, University of Milan; 5Centre for Bleeding Disorders and Coagulation, Careggi University Hospital, Firenze; 6Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Italy

    22-10-2025
    https://doi.org/10.4081/btvb.2025.302
    645
    PDF: 23
  • CO-41 | COMPARISON OF COAGULATION AND CHROMOGENIC METHODS IN PHARMACOKINETICS WITH EXTENDED HALF-LIFE FACTOR VIII R. Pastorino1|2, F. Bocchi1|2, G. Murante1|2|3, S. Bergonzi1|2|3, M. Capetta1|2|3, F. Valeri2|3, C. Dainese2|3, A. Valpreda4, B. Bruno1|3, A. Borchiellini2|3 | 1Department of Molecular Biotechnology and Health Sciences, University of Turin, Italy; 2Regional Centre for Thrombotic and Hemorrhagic Diseases, AOU Città della salute e della Scienza di Torino, Italy; 3Division of Hematology, AOU Città della Salute e della Scienza, University of Turin, Italy; 4Central Lab Baldi and Riberi, AOU Città della salute e della Scienza di Torino, Italy

    Rebecca Pastorino
    14-10-2026
    https://doi.org/10.4081/btvb.2026.651
    39
    PDF: 14
  • Diagnosis and management of abnormal uterine bleeding in adolescence An expert Consensus Statement of SIGO (Italian Society of Gynecology and Obstetrics) and SISET (Italian Society for the Study of Hemostasis and Thrombosis)

    Roberto Mario Santi, Annamaria Fulghesu, Ezio Zanon, Erica De Candia, Elvira Grandone, Giancarlo Di Renzo, Claudia Succu, Valentina Tosto, Vincenzina Bruni, Paolo Gresele
    08-05-2024
    https://doi.org/10.4081/btvb.2024.106
    2859
    PDF: 739
  • BEST-01 | IDENTIFICATION OF NOVEL HYPERACTIVE rFVIIa BYPASSING MOLECULES INFERRED BY ANCESTRAL SEQUENCE RECONSTRUCTION APPROACH M.F. Testa, I. Passerini, P. Santos, A. Benazzo, S. Ghirotto, F. Bernardi, A. Branchini, M. Pinotti, D. Balestra | Dep. of LSB, University of Ferrara, Italy

    Maria Francesca Testa
    14-10-2026
    https://doi.org/10.4081/btvb.2026.601
    112
    PDF: 24
  • PO24 | Emicizumab prophylaxis and bleeding outcomes: a single center clinical experience A. Taglietti1, S. Ligia1, F. Paoletti1, R. Mormile1, E. Baldacci2, A. Chistolini1, C. Santoro1,2 | 1Hematology, Department of Translational and Precision Medicine, Sapienza University of Roma; 2Hematology, Azienda Ospedaliera Universitaria Policlinico Umberto I, Roma, Italy

    22-10-2025
    https://doi.org/10.4081/btvb.2025.285
    625
    PDF: 22
  • Attitude to clinical research among health professionals affiliated with the Italian Federation of Centers for the Diagnosis of Thrombotic Disorders and the Surveillance of the Antithrombotic Therapies (FCSA)

    Daniela Poli, Riccardo Tartaglia, Doris Barcellona , Paolo Bucciarelli , Antonio Ciampa, Elvira Grandone, Giuseppe Malcangi, Giuseppe Rescigno, Vincenzo Toschi, Sophie Testa, Alessandro Squizzato
    21-03-2023
    https://doi.org/10.4081/btvb.2023.59
    1307
    PDF: 393
  • CO-19 | A CASE OF LOSS OF EFFICACY OF EMICIZUMAB AFTER 6 YEARS OF REGULAR USE M.R. Fasulo1, I. Quaglia1, A. Colombo1, C. Lodigiani1, M.E. Mancuso1|2 | 1Center for Thrombosis and Hemorrhagic Diseases, IRCCS Humanitas Research Hospital, Rozzano, Milano, Italy; 2Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milano, Italy

    Maria Rosaria Fasulo
    14-10-2026
    https://doi.org/10.4081/btvb.2026.629
    45
    PDF: 16
  • CO31 | Immune system profiling in FVIII-treated and emicizumab-treated pediatric HA patients A. Cottonaro1, S. Akula1, B. Pollio2, I. Ricca2, T. Martini2, J. Agnelli Giacchello3, P. Sciancalepore3, R. Santi3, A. Follenzi1,3, S. Merlin1 | 1Università del Piemonte Orientale, Health Sciences, Novara; 2A.O. Città della Salute e della Scienza, SIMT Immunohematology and Transfusion Medicine Service, Diagnostic Department, Torino; 3Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo, Alessandria, Italy

    22-10-2025
    https://doi.org/10.4081/btvb.2025.238
    644
    PDF: 15
  • PO127 | ANAPHYLACTIC REACTION TO RECOMBINANT ACTIVATED FVII IN A MILD HEMOPHILIA A PATIENT WITH INHIBITOR: A CASE REPORT I. Nichele, G. Carli, G. Marchesini, A. Tosetto | Haematology Department, S. Bortolo Hospital, Vicenza, Italy

    Ilaria Nichele
    26-10-2026
    https://doi.org/10.4081/btvb.2026.943
    19
    PDF: 11
  • CO080 | INVESTIGATING MECHANISMS OF ACQUIRED VON WILLEBRAND SYNDROME ACROSS HEMATOLOGICAL DISEASES: THE CONTRIBUTION OF INTRAPLATELET VWF A. Ciavarella1, L. Baronciani1, O. Seidizadeh1, P. Colpani1, F. Boggio1, D. Cattaneo2|3, S. Ceglie1, M.T. Pagliari1, A. Iurlo2, S.M. Siboni1, F. Peyvandi1|4 | 1Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Milano, Italy; 2Hematology Division, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano, Italy; 3Department of Oncology and Hemato-Oncology, University of Milano, Milano, Italy; 4Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Milano, Italy

    Alessandro Ciavarella
    26-10-2026
    https://doi.org/10.4081/btvb.2026.782
    30
    PDF: 10
  • Availability of direct oral anticoagulants testing among Italian anticoagulation clinics: a rapid evolution of clinical practice On behalf of the Italian Federation of Centers for the Diagnosis of Thrombotic Disorders and the Surveillance of the Antithrombotic Therapies

    Daniela Poli, Antonio Ciampa, Valeria De Micheli, Angela Maria Iannone, Giuseppe Malcangi, Giuseppe Rescigno, Cinzia Scarone, Sophie Testa, Marco Marietta
    26-06-2026
    https://doi.org/10.4081/btvb.2026.485
    874
    PDF: 101
  • 29th National Conference of the Italian Society for the Study of Hemostasis and Thrombosis, 2025

    Guest Editor: Valerio De Stefano
    22-10-2025
    https://doi.org/10.4081/btvb.2025.408
    883
  • Remembering the XXVI SISET Congress and the 50th anniversary of its foundation, 2020

    Armando Tripodi
    17-01-2025
    https://doi.org/10.4081/btvb.2025.171
    1687
    PDF: 317
  • PO021 | PLATELETS MATTER: THROMBIN GENERATION IN PLATELET‐RICH PLASMA VERSUS PLATELET-POOR-PLASMA UNDER NON-REPLACEMENT THERAPIES IN HAEMOPHILIA F. Bocchi1|2, R. Pastorino1|2, G. Murante1|2|3, S. Bergonzi1|2|3, M. Capetta1|2|3, F. Valeri2|3, C. Dainese2|3, A. Valpreda4, B. Bruno1|3, A. Borchiellini2|3 | 1Department of Molecular Biotechnology and Health Sciences, University of Turin, Torino, Italy; 2Regional Centre for Thrombotic and Hemorrhagic Diseases; 3Division of Hematology; 4Central Lab Baldi and Riberi, AOU Città della salute e della Scienza di Torino, Torino, Italy

    Francesca Bocchi
    26-10-2026
    https://doi.org/10.4081/btvb.2026.837
    21
    PDF: 10
  • CO-72 | HEREDITARY FACTOR X DEFICIENCY UNMASKED BY NECROTIZING HEMORRHAGIC PANCREATITIS: A CASE REPORT M. Leotta, A. Strangio, A. Ierardi, R.C. Santoro | Hemophilia Treatment Center AOU Dulbecco, Catanzaro, Italy

    Marzia Leotta
    14-10-2026
    https://doi.org/10.4081/btvb.2026.682
    33
    PDF: 16
  • Interaction between adenosine diphosphate receptors and protein-kinase C isoforms in platelet adhesion under flow condition

    Boris Shenkman, Ivan Budnik, Yulia Einav
    16-02-2023
    https://doi.org/10.4081/btvb.2023.51
    1882
    pdf: 492
  • Direct oral anticoagulants: does one dose fit all? Why, when and how testing

    Armando Tripodi
    15-01-2026
    https://doi.org/10.4081/btvb.2026.418
    1435
    PDF: 296
  • Influence of emicizumab on protein C-mediated clotting regulation

    Federica Mancazzo, Antonia Vitulli, Lavinia Dirienzo, Concetta T. Ammollo, Fabrizio Semeraro, Mario Colucci
    25-10-2023
    https://doi.org/10.4081/btvb.2023.89
    2654
    PDF: 447
    Supplementary Material: 141
  • CO079 | FVIII DEFICIENCY COMPROMISES IN VITRO OSTEOBLASTS MINERALIZATION AND THEIR SECRETOME PROFILE B. Terkawi, P.E. Di Simone, V. Kalandadze, A. Follenzi, C. Borsotti | Histology lab, upo, novara, Italy

    Baker Terkawi
    26-10-2026
    https://doi.org/10.4081/btvb.2026.781
    22
    PDF: 10
  • PO074 | DEVELOPMENT OF INNOVATIVE LONG-ACTING FACTOR IX AND FACTOR X VARIANTS VIA CONDITIONAL ALBUMIN FUSION A. Martucci1, R. Tarantino1, K.H. Aaen2, M. Pinotti1, J.T. Andersen2, A. Branchini1 | 1Department of Life Sciences and Biotechnology, University of Ferrara, Ferrara, Italy; 2Institute of Clinical Medicine, Department of Pharmacology, University of Oslo, Oslo, Norway

    Alessandro Martucci
    26-10-2026
    https://doi.org/10.4081/btvb.2026.890
    27
    PDF: 8
  • CO-87 | SPONTANEOUS HEMATOMA IN A PATIENT WITH POLYCYTHEMIA VERA: A CASE OF ACQUIRED VON WILLEBRAND DISEASE? A. Strangio, A. Ierardi, M. Leotta, R.C. Santoro | Hemophilia center, AOU Renato Dulbecco, Catanzaro, Italy

    Alessandra Strangio
    14-10-2026
    https://doi.org/10.4081/btvb.2026.697
    50
    PDF: 17
  • The introduction of the international normalized ratio as a breakthrough event in the history of thrombosis

    Armando Tripodi
    23-01-2025
    https://doi.org/10.4081/btvb.2025.169
    1473
    PDF: 420
  • PO015 | OSA VS. CHA FOR RPFVIII MEASURE: STILL AN ISSUE? G. Gazzelli, Y. Azzanelli, C. Vernarecci, F. Marotta, F. Giacopelli, B. Tappino, L. Banov, A.C. Molinari | IRCCS Istituto Giannina Gaslini Genova, Italy

    Angelo Claudio Molinari
    26-10-2026
    https://doi.org/10.4081/btvb.2026.831
    24
    PDF: 7
  • CO-71 | ACQUIRED FACTOR XIII DEFICIENCY IN A PATIENT POST-CAR-T THERAPY FOR NON-HODGKIN LYMPHOMA: A CASE REPORT A. Strangio, M. Leotta, A. Ierardi, R.C. Santoro | Hemophilia, Hemostasis and Thrombosis Unit, Azienda Ospedaliero Universitaria Renato Dulbecco, Catanzaro, Italy

    Alessandra Strangio
    14-10-2026
    https://doi.org/10.4081/btvb.2026.681
    41
    PDF: 19
  • Launch of a National Registry for Congenital Hematological Disorders in Palestine: the Haemo-PAL Initiative

    Fabio Candura, Emanuela Marchesini, Gian Luca Forni, Alessandro Gringeri, Ilaria Gentilini, Mirko Tricoli, Osama Najjar, Luciana Teofili
    15-01-2026
    https://doi.org/10.4081/btvb.2026.417
    1146
    PDF: 236
  • Management of anticoagulation in atrial fibrillation patients in Italy: insight from the Atrial Fibrillation-Survey on Anticoagulated Patients Register (AF-START)

    Daniela Poli, Walter Ageno, Emilia Antonucci, Salvatore Bradamante, Eugenio Bucherini, Paolo Chiarugi, Antonio Chistolini, Benilde Cosmi, Anna Falanga, Antonio Insana, Domenico Lione, Rosa Maria Lombardi, Giuseppe Malcangi, Rossella Marcucci, Giuliana Martini, Lucilla Masciocco, Carmelo Paparo, Daniele Pastori, Simona Pedrini, Vittorio Pengo, Pasquale Pignatelli, Andrea Toma, Sophie Testa, Gualtiero Palareti
    27-06-2023
    https://doi.org/10.4081/btvb.2023.84
    2164
    PDF: 648
    Supplementary File: 289
  • CO036 | NEUROCOGNITIVE ASSESSMENT OF IMMUNE-MEDIATED THROMBOTIC THROMBOCYTOPENIC PURPURA PATIENTS USING A COMPREHENSIVE TEST BATTERY IN A CROSS-SECTIONAL MRI-INTEGRATED STUDY A. Truma1, T. Difonzo2, F. Lo Russo3, G. Conte3|4, I. Mancini1, E. Cesari1, M. Gagliardi1, J.A. Giannotta1, A. Artoni1, E. Piccin3, P. Agosti4, F. Triulzi3|4, F. Peyvandi1|4 | 1Fondazione IRCCS Ca’ Granda ospedale maggiore policlinico, Angelo Bianchi Bonomi hemophilia and thrombosis center, Milano, Italy; 2Fondazione IRCCS Ca’ Granda ospedale maggiore policlinico, neurology unit, Milano, Italy; 3Fondazione IRCCS Ca’ Granda ospedale maggiore policlinico, neuroradiology unit, Milano, Italy; 4Università degli studi di Milano, Milano, Italy

    Addolorata Truma
    26-10-2026
    https://doi.org/10.4081/btvb.2026.738
    25
    PDF: 9
  • CO-44 | EVALUATION OF THE DEVIATION BETWEEN PRESCRIBED AND RECOMMENDED EMICIZUMAB DOSING IN PATIENTS WITH CONGENITAL HEMOPHILIA A A.C. Giuffrida1, S. Abeysinghe Gunawardhana1, S. Amato2, F. Casoli2, C. Recchi2, M. Saggioro2, E. Bonetti3, M. Bodini1, G. Poli2 | 1Centro Emofilia, UOC Medicina Trasfusionale, AOUI Verona, Italy; 2UOC Laboratorio Analisi, AOUI Verona, Italy; 3UOC Oncoematologia Pediatrica, AOUI Verona, Italy

    Marco Bodini
    14-10-2026
    https://doi.org/10.4081/btvb.2026.654
    44
    PDF: 14
  • CO033 | THE BURDEN OF CEREBRAL SMALL VESSEL DISEASE AND GLOBAL CORTICAL ATROPHY IN PATIENTS WITH IMMUNE-MEDIATED THROMBOTIC THROMBOCYTOPENIC PURPURA DURING REMISSION A. Truma1, F. Lo Russo2, G. Conte2|3, I. Mancini1, E. Cesari1, M. Gagliardi1, J.A. Giannotta1, A. Artoni1, E. Piccin2, P. Agosti3, F. Triulzi2|3, F. Peyvandi1|3 | 1Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Milano, Italy; 2Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Neuroradiology Unit, Milano, Italy; 3Università degli Studi di Milano, Milano, Italy

    Addolorata Truma
    26-10-2026
    https://doi.org/10.4081/btvb.2026.735
    26
    PDF: 8
  • CO-43 | VALIDATION OF THROMBIN GENERATION MEASUREMENT IN PLATELET-RICH PLASMA: EVOLUTION IN THE ST GENESIA® SYSTEM F. Bocchi1|2, R. Pastorino1|2, G. Murante1|2|3, S. Bergonzi1|2|3, M. Capetta1|2|3, F. Valeri2|3, C. Dainese2|3, A. Valpreda4, B. Bruno1|3, A. Borchiellini2|3 | 1Department of Molecular Biotechnology and Health Sciences, University of Turin, Italy; 2Regional Centre for Thrombotic and Hemorrhagic Diseases, AOU Città della salute e della Scienza di Torino, Italy; 3Division of Hematology, AOU Città della Salute e della Scienza, University of Turin, Italy; 4Central Lab Baldi and Riberi, AOU Città della salute e della Scienza di Torino, Italy

    Francesca Bocchi
    14-10-2026
    https://doi.org/10.4081/btvb.2026.653
    34
    PDF: 14
  • PO146 | COMPARISON OF COAGULATION AND CHROMOGENIC METHODS IN PHARMACOKINETICS WITH EXTENDED HALF-LIFE FACTOR VIII R. Pastorino1|2, F. Bocchi1|2, G. Murante1|2|3, S. Bergonzi1|2|3, M. Capetta1|2|3, F. Valeri2|3, C. Dainese2|3, A. Valpreda4, B. Bruno1|3, A. Borchiellini2|3 | 1Department of Molecular Biotechnology and Health Sciences, University of Turin, Torino, Italy; 2Regional Centre for Thrombotic and Hemorrhagic Diseases; 3Division of Hematology; 4Central Lab Baldi and Riberi, AOU Città della salute e della Scienza di Torino, Torino, Italy

    Rebecca Pastorino
    26-10-2026
    https://doi.org/10.4081/btvb.2026.962
    23
    PDF: 9
  • CO109 | THE ROLE OF SELECTED LDLR AND LRP1 VARIANTS IN MODULATING LDL AND FVIII LEVELS IN METABOLIC SYNDROME P. Agosti1|2, A. Cairo2, S. Spena2, S. Pelusi3, F. Malvestiti1, D. Prati3, M. Clerici2, E. Scalambrino2, A. Tripodi1|2, V. La Mura1|2, L. Valenti1|3, F. Peyvandi1|2 | 1Università degli Studi di Milano, Department of Pathophysiology and Transplantation, Milano, Italy; 2Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, and Fondazione Luigi Villa, Milano, Italy; 3Biological Resource Center and Department of Transfusion Medicine, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano, Italy

    Pasquale Agosti
    26-10-2026
    https://doi.org/10.4081/btvb.2026.811
    19
    PDF: 10
  • CO-68 | ACQUIRED FACTOR XIII DEFICIENCY ASSOCIATED WITH CROHN’S DISEASE: A CHALLENGING DIAGNOSTIC AND THERAPEUTIC CASE A. Colombo1, A. Dal Buono2|3, I. Quaglia1, C. Novembrino4, M.R. Fasulo1, C. Lodigiani1, M.E. Mancuso1|2 | 1Center for Thrombosis and Hemorrhagic Diseases, IRCCS Humanitas Research Hospital, Rozzano, Milano, Italy; 2Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milano, Italy; 3IBD Center, IRCCS Humanitas Research Hospital, Rozzano, Milano, Italy; 4Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico Angelo Bianchi Bonomi, Hemophilia and Thrombosis Center and Fondazione Luigi Villa, Milano, Italy

    Arianna Colombo
    14-10-2026
    https://doi.org/10.4081/btvb.2026.678
    45
    PDF: 12
  • CO51 | Novel biomarkers of neurological damage in acute immune-mediated thrombotic thrombocytopenic purpura A. Truma1,2, I. Mancini1, F. Verde2,3, J. A. Giannotta1, A. Artoni1, B. Ferrari1, P. Agosti1,2, M. Gagliardi1, A. Ratti3,4, N. Ticozzi2,3, F. Peyvandi1,2 | 1Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Milan; 2Università degli Studi di Milano, Department of Pathophysiology and Transplantation, Milan; 3Department of Neurology and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, Milan; 4Università degli Studi di Milano, Department of Medical Biotechnology and Translational Medicine, Milan, Italy

    22-10-2025
    https://doi.org/10.4081/btvb.2025.261
    590
    PDF: 14
  • An ecological alliance against air pollution and cardiovascular disease

    Pier Mannuccio Mannucci
    22-03-2022
    https://doi.org/10.4081/btvb.2022.21
    2161
    PDF: 499
  • CS06 | Patient specific iPSCs-derived sinusoidal endothelial cells for phenotypic correction of haemophilia A A. Benetti1, C.M. Radu1, C. Samà1, M. Trevisan2, C. Simion1, E. Campello1, P. Simioni1 | 1Department of Medicine - DIMED, Padua University Hospital; 2Department of Molecular Medicine, University of Padua, Italy

    22-10-2025
    https://doi.org/10.4081/btvb.2025.203
    730
    PDF: 20
  • CO-84 | PARAPROTEIN-DRIVEN ACQUIRED VON WILLEBRAND SYNDROME IN A PATIENT WITH MONOCLONAL GAMMOPATHY OF UNDETERMINED SIGNIFICANCE AND UROTHELIAL CARCINOMA A. Ierardi, A. Strangio, M. Leotta, R.C. Santoro | Hemostasis Unit, AOU Dulbecco, Catanzaro, Italy

    Antonella Ierardi
    14-10-2026
    https://doi.org/10.4081/btvb.2026.694
    38
    PDF: 15
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