Editorials
23 January 2025
Vol. 4 No. 1 (2025)
The introduction of the international normalized ratio as a breakthrough event in the history of thrombosis
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All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
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Very few among the youngest readers of this Journal would think about the introduction of the international normalized ratio (INR) as a breakthrough event in the history of thrombosis...
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Citations
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3. Poller l. Standardization of anticoagulant treatment: the Manchester regional thromboplastin scheme. Br Med J 1964;2:565-6. DOI: https://doi.org/10.1136/bmj.2.5408.565
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6. Chantarangkul V, Tripodi A, van den Besselaar AMHP. Guidelines for thromboplastins and plasma used to control oral anticoagulant therapy with vitamin K antagonists. WHO Technical Report Series 2013; No.979:273-305.
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10. Chantarangkul V, van den Besselaar AM, Witteveen E, et al. International collaborative study for the calibration of a proposed international standard for thromboplastin, rabbit, plain. J Thromb Haemost 2006;4:1339-45. DOI: https://doi.org/10.1111/j.1538-7836.2006.01910.x
11. van den Besselaar AMHP, Chantarangkul V, Angeloni F, et al. International collaborative study for the calibration of proposed International Standards for thromboplastin, rabbit, plain, and for thromboplastin, recombinant, human, plain. J Thromb Haemost 2018;16:142-9. DOI: https://doi.org/10.1111/jth.13879
12. Tripodi A, Chantarangkul V, Van Den Besselaar AM, et al. International collaborative study for the calibration of a proposed international standard for thromboplastin, human, plain. J Thromb Haemost 2010;8:2066-8. DOI: https://doi.org/10.1111/j.1538-7836.2010.03980.x
13. Tripodi A, Chantarangkul V, Clerici M, et al. Determination of the International Sensitivity Index of a new near-patient testing device to monitor oral anticoagulant therapy--overview of the assessment of conformity to the calibration model. Thromb Haemost 1997;78:855-8. DOI: https://doi.org/10.1055/s-0038-1657641
14. Tripodi A, Chantarangkul V, Primignani M, et al. The international normalized ratio calibrated for cirrhosis (INR(liver)) normalizes prothrombin time results for model for end-stage liver disease calculation. Hepatology 2007;46:520-7. DOI: https://doi.org/10.1002/hep.21732
15. Raza S, Pinkerton P, Hirsh J, et al. The historical origins of modern international normalized ratio targets. J Thromb Haemost 2024;22:2184-94. DOI: https://doi.org/10.1016/j.jtha.2024.05.013
Supporting Agencies
Italian Ministry of HealthHow to Cite
The introduction of the international normalized ratio as a breakthrough event in the history of thrombosis. (2025). Bleeding, Thrombosis and Vascular Biology, 4(1). https://doi.org/10.4081/btvb.2025.169
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