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CO014 | INCIDENCE OF NEW OR RECURRENT MALIGNANCY AFTER SUPERFICIAL VEIN THROMBOSIS: A SYSTEMATIC REVIEW AND META-ANALYSIS D. Santagata1, D. Todorovic1, G. Di Cugno1, G. Bassanese1, L. Girardi1|2, A. Abenante1, O. Cohen3, P. Santini4, M.P. Donadini1, A. Squizzato1 | 1Department of Medicine and Surgery, University of Insubria, Varese and Como, Italy; 2Department of Medicine, the Ottawa Hospital Research Institute, University of Ottawa, Ottawa, Canada; 3Kaplan Medical Center and Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel; 4Thrombosis Unit, Department of Geriatric, Orthopedic, and Rheumatologic Sciences, Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica del Sacro Cuore, Roma, Italy
144PDF: 28 -
CO33 | Acquired hemophilia A in Liguria, Italy: what six years of data reveal C. Vernarecci1, A. C. Molinari1, P. Ballarino2, M. Caiti2, E. Cenni2, P. Moscatelli2, L. Banov1 | 1IRCCS Istituto Giannina Gaslini, Genova; 2IRCCS Policlinico San Martino, Genova, Italy
628PDF: 41 -
PO31 | Comparative analysis of anticoagulant therapy in patients over 90 years old: vitamin K antagonists versus direct oral anticoagulants G. Sottilotta1, P. Arrigo2, S. Cuzzocrea1, D. Megalizzi1, F. Luise3 | 1UOSD Microcitemie, Emostasi e Trombosi, Grande Ospedale Metropolitano di Reggio Calabria; 2Associazione Italiana Pazienti Anticoagulati, Sezione di Reggio Calabria; 3Laboratorio Analisi. Grande Ospedale Metropolitano di Reggio Calabria, Italy
611PDF: 22 -
Still unmet problems with low molecular weight heparin prophylaxis of venous thromboembolism. An Italian survey
1465PDF: 317HTML: 214Supplementary: 104 -
PO43 | Extended treatment with reduced dose of direct oral anticoagulants in patients with venous thromboembolism: a retrospective study A. Pannunzio1, E. Valeriani1, I.M. Palumbo1, D. Menichelli1, T. Brogi2, S. Marucci2, D. Pastori2, P. Pignatelli2 | 1Department of General Surgery and Surgical Specialty, Sapienza University of Roma; 2Department of Clinical Internal, Anesthesiological and Cardiovascular Sciences, Sapienza University of Roma, Italy
672PDF: 33 -
CO064 | THROMBOTIC AND BLEEDING EVENTS IN PATIENTS WITH VASCULAR INVASION BY ADVANCED HEPATOCELLULAR CARCINOMA: A SYSTEMATIC REVIEW L. Leoni1, G. Tosti2, F.R. Ponziani2, A. Porfidia2, F. Landi2, A. Gasbarrini2, R. Pola2, F. Santopaolo2, R. Talerico2 | 1Internal Medicine Department, Vita-Salute San Raffaele University, IRCCS, Milano, Italy; 2Department of Medical and Surgical Sciences, Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica del Sacro Cuore, Roma, Italy
67PDF: 23 -
PO39 | RISK OF VENOUS THROMBOEMBOLISM ASSOCIATED WITH PERIPHERALLY INSERTED CENTRAL CATHETERS IN CANCER PATIENTS RECEIVING CHEMOTHERAPY: A REAL-WORLD SINGLE-CENTRE EXPERIENCE S. Gilani, H. Rubbani, A. Mackie | Cancer Centre, University Hospitals of North Midlands, Staffordshire, UK
530PDF: 114 -
PO38 | PERICATHETER AND SYSTEMIC THROMBOSIS DURING CAR-T LYMPHOCYTAPHERESIS: INCIDENCE AND CLINICAL CORRELATES I. Pansini1|2, E. Galli1, A. Corrente2, N. Piccirillo1|2, M. Viscovo1|2, S. Hohaus1|2, P. Chiusolo1|2, F. Sorà1|2, S. Sica1|2 | 1Department of Laboratory and Hematologic Sciences, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome; 2Hematology Section, Department of Radiologic and Hematologic Sciences, Università Cattolica del Sacro Cuore, Rome, Italy
457PDF: 103 -
PO104 | BLEEDING AND THROMBOTIC OUTCOMES DURING EXTENDED DIRECT ORAL ANTICOAGULANT THERAPY: AN EIGHT YEAR RETROSPECTIVE ANALYSIS G. Sottilotta1, G. Praticò1, S. Cuzzocrea1, D. Megalizzi1, F. Luise2 | 1UOSD Microcitemie - Emostasi e Trombosi. Grande Ospedale Metropolitano di Reggio Calabria, Italy; 2Laboratorio Analisi. Grande Ospedale Metropolitano di Reggio Calabria, Italy
69PDF: 27 -
PO005 | EXTENDED ANTICOAGULATION WITH DOACS IN PATIENTS AFFECTED BY HEMATOLOGIC MALIGNANCIES AND VENOUS THROMBOEMBOLISM: DOES LOW DOSE FIT ALL? M. Biglietto, S. Sorella, L.V. Cappelli, B. Mandelli, D. Kasmi, E. Baldacci, A. Chistolini | Sapienza University of Roma, Italy
41PDF: 37 -
CO09 | Long term effectiveness and safety of direct oral anticoagulants in patients with factor V Leiden and/or prothrombin gene mutation and venous thromboembolism: a single centre, retrospective cohort study I.M. Palumbo1, E. Valeriani1,2, A. Pannunzio1, S. Marucci3, D. Menichelli1, D. Pastori3,4, P. Pignatelli3 | 1Department of General Surgery and Surgical Specialty, Sapienza University of Roma; 2Department of Infectious Disease, Azienda Ospedaliero-Universitaria Policlinico Umberto I, Roma; 3Department of Clinical Internal, Anaesthesiologic and Cardiovascular Sciences, Sapienza University of Roma; 4IRCCS Neuromed, Pozzilli, Italy
769PDF: 32 -
PO08 | Efficacy and safety of thromboprophylaxis in hospitalized hematological patients: a monocenter retrospective study S. Cordella1,2, V. Coluccio3, M. Luppi1, M. Marietta1 | 1Department of Medical and Surgical Sciences, Section of Hematology. University of Modena and Reggio Emilia, Azienda Ospedaliero-Universitaria di Modena; 2Clinical and Experimental Medicine PhD Programme, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena; 3Department of Hematology, Unità Sanitaria Locale di Modena, Italy
590PDF: 21 -
OC02 | INCIDENCE AND PREDICTORS OF ARTERIAL THROMBOSIS IN CANCER PATIENTS: RESULTS FROM THE PROSPECTIVE COMPASS-ARTERIAL CANCER ASSOCIATED THROMBOSIS (COMPASS-ARTECAT) STUDY M. Drakopoulou1, I. Diamandoulaki2, P. Baglaridis1, P. Las Casa3, P. Van Dreden4, K. Toutouzas1, G. Gerotziafas4|5 | 1First Department of Cardiology, School of Medicine, National and Kapodistrian University of Athens, Hippokration General Hospital, Athens, Greece; 2Department of Electrical and Computer Engineering, Aristotle University of Thessaloniki, Thessaloniki, Greece; 3Sorbonne University, INSERM UMR_S_938, CRSA, Research Department "Cancer, Vessels, Biology and Therapeutics" (CaVITE), Research Group "Cancer-Angiogenesis-Thrombosis and Haemostasis," Thrombosis Center, University Institute of Cancerology (UIC), Saint Antoine University Hospital Assistance Publique Hôpitaux de Paris (AP-HP) Paris France; 4Diagnostica Stago, clinical research, Gennevilliers, France; 5Center of Translational Research and Education, Department of Pathology and Laboratory Medicine, Loyola University Stritch School of Medicine, Maywood, Ill., USA
527PDF: 136 -
PO10 | RISK OF VENOUS THROMBOEMBOLISM IN CANCER PATIENTS WITH CENTRAL VENOUS CATHETERS: RESULTS FROM THE VIENNA CAT-BLED STUDY B. Sunder-Plassmann 1, N, Vladic1, C. Englisch1, F. Moik1|3, V. Sunder-Plassmann2, A. Berghoff2, M. Preusser2, I. Pabinger1, C. Ay1 | 1Division of Hematology and Haemostaseology, Department of Medicine I, Medical University of Vienna; Vienna, Austria; 2Division of Oncology, Department of Medicine I, Medical University of Vienna; Vienna, Austria; 3Division of Oncology, Department of Internal Medicine, Medical University of Graz; Graz, Austria
499PDF: 125 -
PO72 | CATHETER-RELATED THROMBOSIS VS. FIBROBLASTIC SLEEVE. INCIDENCE AND IMPACT IN ONCOLOGICAL AND HEMATOLOGICAL PATIENTS WITH PERIPHERALLY INSERTED CENTRAL CATHETER M. Nunziata1, S. Mangiacapra1, F.P. Damiano1, N. Iuliano1, V. Iorio1, R. Natale2, L. Santarpia2, M. Amitrano1 | 1Internal Medicine, A.O.R.N. San Giuseppe Moscati, Avellino, Italy; 2Internal Medicine, Department of Clinical Medicine and Surgery, Federico II University Hospital, Naples, Italy
536PDF: 123 -
PO68 | RISK OF VENOUS THROMBOEMBOLISM IN PATIENTS WITH CANCER AND MIGRAINE: A COHORT ANALYSIS AMONG DANISH NATIONAL HEALTH SURVEY PARTICIPANTS O. Rosenkrantz1, P. Szentkúti1, L. Amdisen1, E. Horváth-Puhó1, A.L. Pedersen1, H.E. Bøtker2, H. Elser1|3, J.P. Vandenbroucke1|4|5, H.T. Sørensen1 | 1Department of Clinical Epidemiology and Center for Population Medicine, Aarhus University Hospital and Aarhus University, Denmark; 2Department of Cardiology, Aarhus University Hospital, Department of Clinical Medicine, University of Aarhus, Denmark; 3Department of Neurology, Hospital of the University of Pennsylvania, Philadelphia, PA, USA; 4Department of Clinical Epidemiology, Leiden University Medical School Leiden, The Netherlands; 5School of Hygiene and Tropical Medicine, London, UK
537PDF: 114 -
OC06 | PRIMARY THROMBOPROPHYLAXIS IN ADVANCED PANCREATIC DUCTAL ADENOCARCINOMA UNDERGOING SYSTEMIC ANTICANCER TREATMENT: A CANCER-CENTER COHORT STUDY ON CLINICAL PRACTICE AND OUTCOMES F. Haque1|2, A. Adekeye1|2, Z. Mohtashim2, K. Page1, M. Goodman1, A. Maraveyas 1|2 | 1Hull University Teaching Hospital NHS Trust, UK; 2Hull York Medical School, UK
499PDF: 112 -
CO16 | The predictive value of high-sensitivity C-reactive protein for assessing thrombosis risk in non-small cell lung cancer P. Gomez-Rosas1,2, M. Marchetti1,3, L. Russo1, C.J. Tartari1, S. Bolognini1, C. Ticozzi1, F. Schieppati1, A. D’Alessio4, R. Labianca5, A. Falanga1,3 All on behalf of the Hypercan Investigators | 1Hospital Papa Giovanni XXIII, Bergamo, Italy; 2Cardiovascular Research Institute Maastricht, CARIM, Maastricht University, Maastricht, the Netherlands; 3School of Medicine and Surgery, University of Milan Bicocca, Italy; 4University Vita-Salute San Raffaele, Milan, Italy; 5Fondazione ARTET Onlus, Bergamo, Italy
649PDF: 26 -
PO60 | VEXAS SYNDROME AS A NEW SEVERE THROMBOPHILIC CLONAL CONDITION: A SINGLE CENTRE EXPERIENCE C. Ambaglio1, E. Galimberti1, F. Schieppati1, M. Frigeni2, M. Marchetti1, L. Barcella1, A. Falanga 1|3 | 1Immunohematology and Transfusion Medicine Unit, ASST Papa Giovanni XXIII, Bergamo; 2Hematology and Bone Marrow Transplant Unit, ASST Papa Giovanni XXIII, Bergamo; 3School of Medicine and Surgery, University of Milano-Bicocca, Milano, Italy
517PDF: 114 -
PO95 | Idiopathic thrombocytopenic purpura in tuberculosis M. Shani | Università di Medicina Tirana, Albania
660PDF: 24 -
CO01 | Statin therapy for the prevention of venous thromboembolism in cancer patients: a systematic review and meta-analysis F. Catalani, R. Del Giorno, R. Canevascini, W. Ageno, L. Gabutti, G. Prouse, L. Giovannacci | Ospedale Regionale di Bellinzona, Switzerland.
715PDF: 22 -
CO017 | LIFE'S SIMPLE 7 FOR CARDIOVASCULAR HEALTH IS ASSOCIATED WITH LOWER CANCER RISK IN THE MOLI-SANI STUDY M. Bonaccio1, A. Di Castelnuovo1, S. Costanzo1|2, CF. Martinez1, T. Panzera1, A. De Curtis1, S. Magnacca1, C. Cerletti1, MB. Donati1, G. de Gaetano1, L. Iacoviello1|3 | 1Research Unit of Epidemiology and Prevention, IRCCS NEUROMED, Pozzilli (IS), Italy; 2Dep. of Medicine and Surgery, University of Insubria, Varese, Italy; 3Dep. of Medicine and Surgery LUM University, Casamassima (BA), Italy
70PDF: 28 -
PO13 | OUTPATIENT TREATMENT OF VENOUS THROMBOEMBOLISM AND SUBSEQUENT RISK OF CANCER S. Sørensen, D. Farkas, H. Sørensen | Department of Clinical Epidemiology, Aarhus University Hospital and Aarhus University, Aarhus, Denmark
462PDF: 110 -
PO11 | THROMBOEMBOLIC EVENTS DURING PERIOPERATIVE THERAPY FOR RESECTABLE AND BORDERLINE RESECTABLE PANCREATIC CANCER IN THE PREOPANC-2 TRIAL R.A.L. Willems1|5, A.E. Van Diepen1|2|6, EN. Dekker7, Q.P. Janssen7, J.L. Van Dam7, N. Michiels8, C.W.F. Van Eijck9, K.E.P.E. Hermans1|2, B.A. Bonsing8, K.P. Bosscha10, S.A.W. Bouwense11|12, O. R. Busch13|14, H. Ten Cate4|5|15|16, P.P.L.O. Coene17, C.H.J. Van Eijck7, N. Van Es18|19, E. Van Der Harst17, I.H.J.T. De Hingh20, T.M. Karsten21, G. Kazemier13|14, M.B. Van Der Kolk22, B. De Laat3|5, M.S.L. Liem22, J.S.D. Mieog8, V.B. Nieuwenhuijs24, G.A. Patijn24, M. Roest3, H.C. Van Santvoort25, L. Valkenburg-Van Iersel1|2, R. F. De Wilde7, F. Wit26, B.M. Zonderhuis13|14, M.G. Besselink13|14, M.Y.V. Homs6, G. Van Tienhoven14|27, J. W. Wilmink14|28, B. Groot Koerkamp7, J. De Vos-Geelen1|2 | 1Maastricht University Medical Center, Department of Internal Medicine, Division of Medical Oncology; 2GROW – Research Institute for Oncology & Reproduction, Maastricht University, Maastricht; 3Synapse Research Institute, Department of Functional Coagulation, Maastricht; 4Maastricht University Medical Center, Thrombosis Expert Center Maastricht, Maastricht; 5Maastricht University Medical Center, Cardiovascular Research Institute Maastricht (CARIM), School for Cardiovascular Diseases, Maastricht; 6Erasmus MC Cancer Institute, Department of Medical Oncology, Rotterdam; 7Erasmus MC Cancer Institute Rotterdam, University Medical Center Rotterdam, Department of Surgery; 8Leiden University Medical Center, Department of Surgery, Leiden; 9Solid Tumour Immunology Research Rotterdam (STIRR), Department of Pulmonary Medicine, Erasmus University Medical Centre, Rotterdam; 10Jeroen Bosch Hospital, Department of Surgery, Den Bosch; 11Maastricht University Medical Center, Department of Surgery, Maastricht; 12Maastricht University Medical Center, NUTRIM School for Nutrition and Translational Research in Metabolism, Maastricht; 13Amsterdam UMC, location University of Amsterdam, Department of Surgery, Amsterdam; 14Cancer Center Amsterdam; 15Maastricht University Medical Center, Department of Internal Medicine, Division Vascular Medicine, Maastricht; 16Maastricht University, Department of Biochemistry, Laboratory for Clinical Thrombosis and Hemostasis, Maastricht; 17Maasstad Hospital, Department of Surgery, Rotterdam; 18Amsterdam UMC, location University of Amsterdam, Department of Vascular Medicine, Amsterdam; 19Amsterdam UMC, location University of Amsterdam, Amsterdam Cardiovascular Sciences, Pulmonary Hypertension & Thrombosis, Amsterdam; 20Catharina Hospital, Department of Surgery, Eindhoven; 21OLVG, Department of Surgery, Amsterdam; 22Radboud University Medical Center, Department of Surgery, Nijmegen; 23Medisch Spectrum Twente, Department of Surgery, Enschede; 24Isala Oncology Center, Department of Surgery, Zwolle; 25Regional Academic Cancer Center Utrecht, St. Antonius Hospital and University Medical Center Utrecht, Department of Surgery, Utrecht; 26Frisius MC, location Leeuwarden, Department of Surgery, Leeuwarden; 27Amsterdam UMC, location University of Amsterdam, Department of Radiation Oncology, Amsterdam; 28Amsterdam UMC, location University of Amsterdam, Department of Medical Oncology, Amsterdam, the Netherlands
454PDF: 99 -
PO35 | Cerebral veins thrombosis in patients with and without myeloproliferative neoplasm: a real life retrospective monocentric study I. Bertozzi, M.T. Sartori, M. Zerbinati, G. Libralon, A. Galbiati, P. Simioni | First Medical Clinic, Department of Medicine - DIMED, Università degli Studi di Padova, Italy
615PDF: 36 -
PO110 | CLINICAL OUTCOMES AND SURVIVAL OF UNUSUAL SITE VENOUS THROMBOSIS IN PATIENTS WITH AND WITHOUT MYELOPROLIFERATIVE NEOPLASMS: A RETROSPECTIVE SINGLE-CENTER STUDY I. Bertozzi, M.T. Sartori, G. Libralon, M. Zerbinati, A. Galbiati, P. Simioni | Department of Medicine, University of Padova, Italy
55PDF: 30 -
CO012 | LONG-TERM RISK OF RECURRENT VENOUS THROMBOEMBOLISM IN ADULT PATIENTS WITH ACTIVE CANCER AND FIRST CATHETER-RELATED UPPER EXTREMITY DEEP VEIN THROMBOSIS AFTER DISCONTINUATION OF ANTICOAGULANT TREATMENTS AND LINE REMOVAL: A RETROSPECTIVE MULTI-CENTER COHORT STUDY – CANCER-CRT STUDY L. Girardi1|2, W. Ageno3, L. Bertù1, C. Lodigiani4, L.A. Ciuffini4, M.C. Vedovati5, C. Becattini5, A. Sammarco6, G. Camporese6, G. Cuni1|7, C. Ambaglio7, M.P. Donadini1 | 1Research Center on Thromboembolic Diseases and Antithrombotic Treatment, Department of Medicine and Surgery, University of Insubria, Varese, Italy; 2Department of Medicine, The Ottawa Hospital Research Institute, University of Ottawa, Ontario, Canada; 3Department of Medicine, University of Padua, Padova, Italy; 4Center for Thrombosis and Hemorrhagic Diseases, IRCCS Humanitas Research Hospital, Rozzano, Milano, Italy; 5Internal and Cardiovascular Medicine-Stroke Unit, University of Perugia, Perugia, Italy; 6Clinica Medica 1, Department of Medicine, DIMED, Padova University Hospital, Padova, Italy; 7Immunohematology and Transfusion Medicine, Department of Transfusion Medicine and Hematology, ASST Papa Giovanni XXIII, Bergamo, Italy
148PDF: 31 -
PO54 | CANCER-ASSOCIATED THROMBOSIS IN ASPIRIN-TREATED PATIENTS AFTER ARTERIAL THROMBOSIS: THE COMPASS-ARTECAT-ASA PROSPECTIVE COHORT STUDY G. Gerotziafas1|3|4|5, S. Allakhverdieva6, P. Henrique Fernandes Do Carmo Las Casa1, P. Van Dreden1|2, J. Fareed3, N. Lomakin6 , I. Zotova6, L. Buryachkovskaya7 | 1Sorbonne University, INSERM UMR_S_938, CRSA, Research Department "Cancer, Vessels, Biology and Therapeutics" (CaVITE), Research Group "Cancer-Angiogenesis-Thrombosis and Haemostasis," Thrombosis Center, University Institute of Cancerology (UIC), Saint Antoine University Hospital Assistance Publique Hôpitaux de Paris (AP-HP), Paris, France; 2Clinical Research, Diagnostica Stago, Gennevilliers, France; 3Center of Translational Research and Education, Department of Pathology and Laboratory Medicine, Loyola University Stritch School of Medicine, Maywood, Chicago, USA; 4Thrombosis Center, Department of Obstetrics, Gynecology and Perinatal Medicine, The I. M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia; 5VAS-European Independent Foundation in Angiology/Vascular Medicine Milan, Italy; 6Federal State Budgetary Educational Institution of Further Professional Education "Russian Medical Academy of Continuous Professional Education" of the Ministry of Healthcare of the Russian Federation, Moscow, Russia; 7Federal State Budgetary Institution «National Medical Research Centre of Cardiology Named After Academician E. I. Chazov» of the Ministry of Health of the Russian Federation, Moscow, Russia
476PDF: 108 -
PO56 | Safety of anticoagulant treatment in patients with splanchnic vein thrombosis and history of portal hypertension-related bleeding R. Talerico1, S. Pellegrino1, A. Plessier2, F.R. Ponziani3, A. Porfidia1, F. Landi1, A. Gasbarrini3, R. Pola1, F. Santopaolo3 | 1Department of Geriatric, Orthopedic, and Rheumatologic Sciences, Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica del Sacro Cuore, Roma, Italy; 2Université de Paris, AP-HP, C, DMU DIGEST, Centre de Référence des Maladies Vasculaires du Foie, FILFOIE, ERN RARE-LIVE. Centre de recherche sur l’inflammation, Inserm, Paris, France; 3Department of Medical and Surgical Sciences, Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica del Sacro Cuore, Roma, Italy
629PDF: 31 -
CO041 | GLOBAL COAGULATION ASSESSMENT FOR THE RISK OF HEAVY MENSTRUAL BLEEDING IN WOMEN ON ORAL ANTICOAGULANT THERAPY – THE COHMBO STUDY M. Abbattista, E. Scalambrino, M. Clerici, A. Truma, A. Artoni, P. Bucciarelli | Fondazione IRCCS Ca' Granda Policlinico, Italy
101PDF: 32 -
BEST-02 | PERIOPERATIVE BLEEDING IN CHILDREN WITH LOW VON WILLEBRAND FACTOR UNDERGOING ADENOID AND TONSIL SURGERY: A 15-YEAR SINGLE-CENTER EXPERIENCE T. Martini1, B. Borsellino1|2, B. Pollio1 | 1Haemophilia Centre, Immune-Haematology and Transfusion Medicine, University Hospital “Città della Salute e della Scienza”, Torino, Italy; 2Department of Biomedicine and Prevention, PhD in Immunology, Molecular Medicine and Applied Biotechnology, University of Rome Tor Vergata, Roma, Italy
168PDF: 29 -
CO062 | REDUCED-DOSE DOACs IN EXTENDED TREATMENT OF CANCER-ASSOCIATED THROMBOSIS (RED-CAT): INTERIM ANALYSIS FROM A MULTICENTER RETROSPECTIVE OBSERVATIONAL STUDY (COORDINATING CENTER DATA) S. Bergonzi1|2|3, A. Ghigo4, L. Carpisassi4, G. Murante1|2|3, M. Capetta1|2|3, F. Valeri1|2, C. Dainese1|2, A. Valpreda3|5, R. Pastorino3|5, F. Bocchi3|5, A. Porreca6|7, B. Bruno2|3, A. Borchiellini1|2 | 1Regional Centre for Hemorrhagic and Thrombotic Diseases, AOU Città della Salute e della Scienza, Turin, Italy; 2Division of Hematology, AOU Città della Salute e della Scienza, Università di Torino, Italy; 3Department of Molecular Biotechnology and Health Sciences, University of Turin, Italy; 4Division of Internal Medicine, AOU Città della Salute e della Scienza, Università di Torino, Italy; 5Central Laboratory Baldi and Riberi, AOU Città della Salute e della Scienza, Università di Torino, Italy; 6Department of Human Sciences and Quality of Life Promotion, San Raffaele University, Roma, Italy; 7Clinical and Molecular Epidemiology, IRCCS San Raffaele, Roma, Italy
54PDF: 32 -
PO50 | SUB-ANALYSIS OF INTERIM RESULTS FROM A PHASE 2 STUDY INVESTIGATING REGN9933A2 AND REGN7508CAT FOR THE PREVENTION OF CONTACT-MEDIATED VENOUS THROMBOEMBOLISM IN PATIENTS WITH ACTIVE CANCER UNDERGOING PERIPHERALLY INSERTED CENTRAL CATHETER PLACEMENT (ROXI-CATH) J. Zwicker1,2, A.P. Kithcart3, J. Kaplan3, Y-C. Cheng3, J.G. Raya3, J. Xiao3, S. Li3, K. Musgrave4, D.E. Gutstein3, G. Piazza5 | 1Memorial Sloan Kettering Cancer Center, New York, NY, USA; 2Weill Cornell Medical Center, New York, NY, USA; 3Regeneron Pharmaceuticals, Inc. , Tarrytown, NY, USA; 4Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK; 5Brigham and Women’s Hospital, Boston, MA, USA
535PDF: 131 -
CO089 | LONG-TERM RISK OF VENOUS THROMBOEMBOLISM IN AUTOIMMUNE HEMOLYTIC ANEMIA: A SYSTEMATIC REVIEW AND META-ANALYSIS L. Panepinto, M. Merlo, F. Zoccatelli, G. Costa, N. Martinelli, S. Friso, L. Marzano | Department of Medicine, Unit of Internal Medicine B, University of Verona, Verona, Italy
77PDF: 23 -
OC09 | BLEEDING RISK ASSOCIATED WITH FACTOR XI MONOCLONAL ANTIBODIES IN COMBINATION WITH ASPIRIN IN HEALTHY VOLUNTEERS AND ORTHOPEDIC SURGERY PATIENTS: ANALYSIS FROM RECENT PHASE 1 AND PHASE 2 STUDIES A.P. Kithcart1, M.E. Burczynski1, P. Banerjee1, M. Onisko1, Y. Wang1, K. Mohammadi1, D. Li1, S. Li1, J. Ackroyd2, B.A. Olenchock1, D.E. Gutstein1, J. I. Weitz3 | 1Regeneron Pharmaceuticals, Inc., Tarrytown, NY, USA; 2Clinical Research, Fortrea Clinical Research Unit Ltd, Leeds, UK; 3McMaster University, Hamilton, ON, Canada
466PDF: 123 -
Anticoagulation in obese patients: challenges and strategies
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CO088 | LONG-TERM EXPOSURE TO AIR POLLUTION AND RISK OF INCIDENT VENOUS THROMBOEMBOLISM: A SYSTEMATIC REVIEW AND META-ANALYSIS L. Vulcano1, M.P. Donadini1|2, F. Moioli1, D. Santagata1, A. Tufano4, G. Veronesi3 | 1Ctr. Ric. Malattie Tromboemboliche e Terapie Antitrombotiche, Univ. Insubria, Varese, Italy; 2SSD Centro Trombosi e TAO, ASST Sette Laghi, Varese, Italy; 3Ctr. Ric. Epidemiologia e Med. Preventiva (EPIMED), Univ. Insubria, Varese, Italy; 4Dip. Med. Clinica e Chirurgia, Univ. Federico II, Napoli, Italy
57PDF: 24 -
CO044 | QUALITY AND SAFETY OF VITAMIN K ANTAGONIST TREATMENT IN PEDIATRIC PATIENTS: A RETROSPECTIVE CLINICAL AUDIT FROM A SINGLE CENTER C. Ambaglio1, T. Zollner1, G. Cuni1, S. Bolognini1, C. Ticozzi1, F. Schieppati1, E. Galimberti1, O.C. Cretu1, V. Brusegan1, F. Zunino1, F. Duca2, M. Marchetti1, A. Falanga1|2, L. Barcella1 | 1Immunohematology and Transfusion Medicine, Department of Transfusion Medicine and Hematology, ERN-EuroBloodNet - European Reference Network in Rare Hematological Diseases, ASST Papa Giovanni XXIII, Bergamo, Italy; 2School of Medicine and Surgery, University of Milano-Bicocca, Milano, Italy
69PDF: 27 -
PO16 | Antithrombotic treatment and outcomes in retinal vein occlusion: a retrospective cohort study and comparison with historical group S.A. Malerba1,2, M.T. Sartori1, G. Libralon1, C. Dalla Porta1, P. Simioni1 | 1First Medical Clinic, Department of medicine- DIMED, Università degli Studi di Padova; 2Medicina Generale, Ospedale dell’Angelo, Mestre, Italy
625PDF: 21 -
CO066 | COAGULOPATHY IN CAR-T CELL-TREATED PATIENTS WITH LYMPHOPROLIFERATIVE DISORDERS: A RETROSPECTIVE, SINGLE-CENTER OBSERVATIONAL STUDY I. Santo1, R. Morganti2, G. Leoni3, G. Tancredi3, L. Contino4, S. Galimberti3, R.M. Santi4, E. Orciuolo5 | 1Azienda Toscana Nord Ovest, Versilia Hospital, Italy; 2Hematology Division AOUP, Pisa, Italy; 3University of Pisa, Hematology Pisa, Italy; 4Azienda Ospedaliera Universitaria Alessandria, Italy; 5Azienda Ospedaliera Universitaria Pisana, Hematology Pisa, Italy
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OC03 | THROMBOEMBOLIC PREVALENCE IN MULTIPLE MYELOMA BEFORE AND AFTER THE INTRODUCTION OF DIRECT ORAL ANTICOAGULANTS: A LONGITUDINAL COHORT STUDY A. Ramírez1, A. Orozco2, A. Sánchez3, F. Villalpa1, S. Burgos2, G. Cesarman3, G. Rodríguez1, D. Vieyra2, J. Álvarez4, G.M. Flores3, S. González1, D. Martínez2, B. Cabello3, R. Espinoza3, O. Fernández3 | 1Myeloma-clinic Hematology service, Centro Médico Nacional La Raza, Instituto Mexicano del Seguro Social, México City, México; 2Myeloma-clinic Hematology service, Instituto Nacional de Nutrición Salvador Zubirán, México City, México; 3Myeloma-clinic Hematology service, Instituto Nacional de Cancerologçia, México City, Mexico; 4Centro Médico Nacional 20 de Noviembre, México City, Mexico
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CO108 | MECHANOCHEMICAL REPROGRAMMING OF VWF–GPIB INTERACTIONS UNCOUPLES AFFINITY FROM AVIDITY AND LINKS THROMBOCYTOPENIA TO ANGIODYSPLASIA IN TYPE 2B VON WILLEBRAND DISEASE A. Ferretti1, M. Sacco1, S. Lancellotti1, P. Concolino2, A. Minucci2, R. De Cristofaro1|3 | 1Center for Hemorrhagic and Thrombotic Diseases; 2Molecular and Genomic Diagnostics Unit, Fondazione Policl.nico Univ. Gemelli IRCCS, Roma, Italy; 3Department of Translational Medicine and Surgery, Catholic University of the Sacred Heart, Roma, Italy
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PO56 | EXTERNAL VALIDATION OF THE SAVED SCORE IN A CANADIAN REGIONAL CANCER CENTER COHORT: A REAL-WORLD ANALYSIS A. Naassan, R. Fatima, M. Naassan, C. Chisholm | Lakeridge Health, R.S. McLaughlin Durham Regional Cancer Centre, Department of Oncology, Oshawa, ON, Canada
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PO76 | Thrombosis associated with midline in autoimmune patient: a case report on the use of apixaban in a real-world setting M.V. Cherchi, M. Anedda, S. Che, M. Vacca, M. Caboni, M. Mantega | Department of Internal Medicine, ASL Sulcis, Italy
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CO042 | BLEEDING RISK IN PATIENTS RECEIVING CONCURRENT TREATMENT WITH DIRECT ORAL ANTICOAGULANTS AND CORTICOSTEROIDS: A SYSTEMATIC REVIEW M.A. Capparella1, R. Talerico2, C. Cavallaro2, M. Iorio2, F. Bossi1, A. Porfidia2, K. Abe3, M. Biglietto4, A. Chistolini4, A. Holt5, L. Lahousse6|7, R. Pola2, C. Becattini1, M.C. Vedovati1 | 1Internal, Vascular and Emergency Medicine – Stroke Unit, University of Perugia, Italy; 2Thrombosis Unit, Department of Geriatric, Orthopedic, and Rheumatologic Sciences, Fondazione Policlinico A. Gemelli IRCCS, Roma, Italy; 3Division of Gastroenterology, Department of Medicine, Teikyo University School of Medicine, Tokyo, Japan; 4Hematology, Department of Translational and Precision Medicine, Sapienza University of Roma, Italy; 5Department of Cardiology, Copenhagen University Hospital – Herlev and Gentofte, Copenhagen, Denmark; 6Department of Bioanalysis, Pharmaceutical Care Unit, Faculty of Pharmaceutical Sciences, Ghent University, Ghent, Belgium; 7Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands
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CO39 | Artificial intelligence in hemophilia management: challenging the need for experts G. Sottilotta1, D. Megalizzi1, F. Luise2 | 1UOSD Microcitemie - Emostasi e Trombosi. Grande Ospedale Metropolitano Bianchi-Melacrino-Morelli, Reggio Calabria; 2Laboratorio Analisi, Grande Ospedale Metropolitano Bianchi-Melacrino-Morelli, Reggio Calabria, Italy
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PO067 | LONG‑TERM SAFETY AND EFFECTIVENESS OF VITAMIN K ANTAGONISTS IN PATIENTS WITH ANTIPHOSPHOLIPID ANTIBODIES: A RETROSPECTIVE COHORT ANALYSIS G. Sottilotta1, G. Praticò1, D. Megalizzi1, F. Luise2 | 1UOSD Centro per le Microcitemie - Servizio Emostasi e Trombosi; 2Laboratorio Analisi, Grande Ospedale Metropolitano di Reggio Calabria, Italy
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BEST-08 | PERIOPERATIVE MANAGEMENT OF CHILDREN WITH MILD FACTOR VII DEFICIENCY UNDERGOING SURGERY: A RETROSPECTIVE COHORT STUDY B. Borsellino1, T. Martini1, I. Ricca2, B. Pollio1 | 1Haemophilia Centre, Immune-Haematology and Transfusion Medicine, University Hospital “Città della Salute e della Scienza”, Torino, Italy; 2Transfusion Medicine, Ivrea Hospital, Ivrea, Italy
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Diagnostic and management practices for inherited fibrinogen disorders: a nationwide survey of Italian Hemophilia Treatment Centers
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CO04 | Direct oral anticoagulants in antiphospholipid syndrome: a single center real-life experience A. Hoxha1, E. Campello1, F. Ahmad2, L. Spiezia1, P. Scarinzi1, G. Gobbo1, S. Gavasso1, F. Sartorello1, C. Simion1, E. Zanon1, P. Simioni1 | 1Internal Medicine Unit, Thrombotic and Haemorrhagic Centre, Department of Medicine - DIMED; 2Department of Statistical Sciences) University of Padova, Italy
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CO104 | PERIOPERATIVE BLEEDING IN CHILDREN WITH LOW VON WILLEBRAND FACTOR UNDERGOING ENT SURGERY: A 15-YEAR SINGLE-CENTER EXPERIENCE T. Martini1, B. Borsellino1, C. Linari2, U. Miglio2, B. Pollio1 | 1Hemophilia Centre, Immune-Hematology and Transfusion Medicine, University Hospital "Città della Salute e della Scienza", Torino, Italy; 2Laboratory Medicine, Regina Margherita Children's Hospital, 10126 Turin, Italy
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PO066 | ONE IN TWO MILLION: A 'DOUBLE-HIT' CASE OF INFRARENAL VENA CAVA AGENESIS AND TRIPLE-POSITIVE ANTIPHOSPHOLIPID SYNDROME N. Portesi, S. Pontoglio, G. Martini | ASST Spedali Civili di Brescia, Italy
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PO107 | OUTCOME AND RISK OF CANCER IN SUPERFICIAL VENOUS THROMBOSIS WITH AND WITHOUT VARICOSE VEINS M. Sartori, E. Zanata, S. Cavara, M. Soldati, B. Cosmi | Angiology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Italy
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CO007 | TPO-RECEPTOR AGONISTS AS AN INDEPENDENT RISK FACTOR FOR VENOUS THROMBOTIC EVENT IN IMMUNE THROMBOCYTOPENIA PATIENTS WITH PERSISTENT ANTIPHOSPHOLIPID ANTIBODIES POSITIVITY M. Biglietto, B. Mandelli, S. Sorella, S. Ligia, C. Andriola, R. Mormile, E. Baldacci, A. Chistolini, S. Truglia, C. Santoro | Sapienza, University of Rome, Italy
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CO02 | Hepatic fibrosis as predictor of cancer-associated thrombosis in patients with intrahepatic cholangiocarcinoma Y. Frion-Herrera1,2, C. Venturin1,3, M. Cadamuro4, J. Gasparello5, C.M. Radu1, M. Fassan5, C. Mescoli6, U. Cillo7, E. Gringeri7, G. Zanus8, L. Fabris1,3, P. Simioni1 | 1Clinical Medicine and Thrombotic and Haemorrhagic Disease Unit, and Haemophilia Center, Padua University-Hospital, Department of Medicine [DIMED], University of Padua, Italy; 2Department of Biology [DiBio], University of Padua, Italy; 3Department of Internal Medicine, Digestive Disease Section, Liver Center, Yale University, New Haven, CT, USA; 4School of Medicine and Surgery, University of Milan-Bicocca, Milan, Italy; 5Department of Pathology Ca’ Foncello Hospital, ULSS2 Marca Trevigiana, Italy; 6Pathology Unit, Padua University-Hospital, Padua, Italy; 7Hepatobiliary Surgery and Liver Transplantation Unit, Padua University-Hospital, Department of Surgery, Oncology and Gastroenterology [DISCOG], University of Padua, Italy; 8General Surgery Unit, Ca’ Foncello Hospital, ULSS2 Marca Trevigiana, Department of Surgery, Oncology and Gastroenterology [DISCOG], University of Padua, Italy
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CO090 | DIRECT ORAL ANTICOAGULANTS IN THE SECONDARY PREVENTION OF VENOUS THROMBOEMBOLISM IN PATIENTS WITH SEVERE INHERITED THROMBOPHILIA: A REAL-WORLD MULTICENTER STUDY A. Tufano1, I.L. Calcaterra1, E. Valeriani2, E. Cimino1, P. Madonna3, A. Guida4, P. Rufolo1, F. Strano1, R. Russo1, A. Casoria5, M. Amitrano5, P. Pignatelli2, M. Di Minno1 | 1Department of Clinical Medicine and Surgery, University of Naples, Federico II, Napoli, Italy; 2Department of Internal Medicine, Endocrine and Metabolic Sciences, and Infectious Diseases. Umberto I Hospital of Roma, Italy; 3Thrombotic Unit, Ospedale del Mare, Napoli, Italy; 4Center for Congenital Bleeding Disorders and Thrombosis, AOU S.Giovanni di Dio and Ruggi d'Aragona, Salerno, Italy; 5UOC Medicina Interna, AORN Moscati, Avellino, Italy
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PO13 | Monitoring of anti-factor XA activity levels in patients treated with direct oral anticoagulants and concomitant tyrosine kinase inhibitors agents: a monocentric experience E. Santacroce1,2, C. Santoro1, E. Baldacci1, S. Ligia1, R. Mormile1, M. Biglietto1, M. Totaro1, F. R. Mauro1, M. Breccia1, A. Chistolini1 | 1Department of Translational and Precision Medicine, Haematology, Sapienza University of Roma; 2Department of Clinical and Molecular Medicine, Sapienza University of Roma, Italy
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CO039 | CLINICAL SAFETY AND MONITORING OF APIXABAN IN HEMODIALYSIS PATIENTS: A PROSPECTIVE STUDY S. Guglielmo1, M. Lovisotto1, E. De Bon2, E. Pierobon3, S. Barbar2 | 1Internal Medicine, Department of Medicine; 2Thrombosis and Haemostasis Unit, Department of Medicine; 3Nephrology and Dialysis Unit, Azienda Ulss 6 Euganea, Cittadella and Camposampiero, Padova, Italy
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PO03 | HEPATIC FIBROSIS–DRIVEN TISSUE FACTOR EXPRESSION BY MALIGNANT CHOLANGIOCYTES IS ASSOCIATED WITH CANCER-ASSOCIATED THROMBOSIS AND POOR SURVIVAL IN INTRAHEPATIC CHOLANGIOCARCINOMA L. Fabris1|2|3, Y. Frión-Herrera1, C. Venturin1|3, M. Cadamuro4, J. Gasparello5, C. M. Radu1|2, M. Fassan1|5, C. Mescoli6, U. Cillo7|8, E. Gringeri7|8, G. Zanus7|9, E. Campello1|2, M. Strazzabosco3, P. Simioni1|2 | 1Department of Medicine, University of Padua; 2Clinical Medicine 1 and Thrombotic and Haemorrhagic Disease Unit, and Haemophilia Center, Padua University-Hospital; 3Department of Internal Medicine, Digestive Disease Section, Liver Center, Yale University, New Haven, CT, USA; 4School of Medicine and Surgery, University of Milan-Bicocca, Milan, Italy; 5Pathology Unit, Ca' Foncello Hospital, ULSS2 Marca Trevigiana, Treviso; 6Pathology Unit, Padua University-Hospital; 7Department of Surgery, Oncology and Gastroenterology, University of Padua; 8Hepatobiliary Surgery and Liver Transplantation Unit, Padua University-Hospital; 9General Surgery Unit, Ca' Foncello Hospital, ULSS2 Marca Trevigiana, Treviso, Italy
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CO27 | Intracerebral hemorrhage in hemophilia A and B: a 10-year prospective multicenter study in Italy (2012–2022) E. Zanon1, A. Napolitano1, A. Porreca2, F. Demartis3, A. Coppola4, C. Santoro5, I. Cantori6, A. C. Molinari7, C. Biasioli8, M. Luciani9, G. Sottilotta10, B. Pollio11, A. Borchiellini12, A. Tosetto13, P. Flora14, P. Simioni1 | 1Haemophilia Center, First Chair of Internal Medicine, Department of Medicine, University-Hospital of Padua Medical School, Padua; 2Department of Human Sciences and Promotion of the Quality of Life, Unit of Clinical and Molecular Epidemiology IRCCS San Raffaele Roma Open University, Roma; Unit of Clinical and Molecular Epidemiology IRCCS San Raffaele, Roma; 3Centre for Bleeding Disorders, Careggi University Hospital of Firenze; 4Azienda Ospedaliero Universitaria di Parma; 5Hematology Division, Umberto I University Hospital of Roma; 6Haemophilia Center, Department of Transfusion Medicine, Hospital of Macerata; 7IRCCS Istituto Giannina Gaslini, Genova; 8Haemophilia and Transfusion Centre, Bufalini Hospital, Cesena; 9Children’s Hospital Bambino Gesù, Roma; 10Haemophilia Center, Department of Onco-Hematology and Radioterapy, Hospital of Reggio Calabria; 11Haemophilia Pediatric Center, Transfusion Medicine, City of Health and Science of Turin; 12City of Health and Science of Turin; 13Hemorrhagic and Thrombotic Diseases Unit, S. Bortolo Hospital of Vicenza; 14RCCS Foundation Ca’ Granda Maggiore Policlinico Hospital, Milan, Italy
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PO057 | IS PLATELET FUNCTION TESTING CLINICALLY USEFUL IN PATIENTS WITH CHRONIC SUBDURAL HEMATOMA UNDERGOING NEUROSURGERY WHILE ON ANTIPLATELET THERAPY? G. Ciarrocca Taranta1, G. Pansini2, S. Orlandini2, O. Para3, M. Di Gioia4, A. Rogolino4, G. Barbieri1, R. Marcucci1|4, A. Della Puppa2 | 1Dep of Experimental and Clinical Medicine, University of Florence, Italy; 2Neurosurgical Dep, Careggi University Hospital, Firenze, Italy; 3Internal Medicine 1 Careggi University Hospital, Firenze, Italy; 4Atherothrombotic Diseases, Careggi University Hospital, Firenze, Italy
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CO054 | ULTRA-PROCESSED FOOD CONSUMPTION IS ASSOCIATED WITH AN INCREASED RISK OF UNPROVOKED VENOUS THROMBOEMBOLISM IN THE MOLI-SANI STUDY M. Bonaccio1, A. Di Castelnuovo1, S. Costanzo1|2, T. Panzera1, C. Cerletti1, MB. Donati1, G. de Gaetano1, W. Ageno3, L. Iacoviello1|4 | 1Research Unit of Epidemiology and Prevention, IRCCS NEUROMED, Pozzilli (IS), Italy; 2Dep. of Medicine and Surgery, University of Insubria, Varese, Italy; 3Dep. of Medicine, Università degli Studi di Padova, Padova, Italy; 4Dep. of Medicine and Surgery LUM University, Casamassima (BA), Italy
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PO36 | EXTENDED DURATION REDUCED DOSE ANTICOAGULATION IN CANCER-ASSOCIATED THROMBOSIS: A REAL-WORLD COHORT WITH LONG TERM FOLLOW UP A. Bhide1, I. Welding1, O. Ogunbiyi1, S. Hawkins2, E. Greenlay1, N. Prasannan1, J. Westwood1, M. Thomas1 | 1Department of Clinical Haematology, University College London Hospital, London; 2Data Clinic, University College London, UK; A. Bhide and I. Welding joint First Authors
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PO29 | Quality of anticoagulation as a predictor of early left ventricular thrombosis resolution: a retrospective cohort study A. Pannunzio1, I.M. Palumbo1, M.P. Donadini2, D. Santagata2, W. Ageno2, F. Dragoni3, A. Chistolini3, C. Becattini4, K. Satula4, D. Menichelli1, D. Pastori1, P. Pignatelli5, E. Valeriani1 | 1Department of General Surgery and Surgical Specialty Paride Stefanini, Sapienza University of Roma; 2Department of Medicine and Surgery, University of Insubria, Varese; 3Hematology, Department of Translational and Precision Medicine, Sapienza University of Roma; 4Internal Vascular and Emergency Medicine - Stroke Unit, University of Perugia; 5Department of Clinical Internal, Anesthesiological and Cardiovascular Sciences, Sapienza University of Roma, Italy
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PO105 | IMPACT OF ECOG PERFORMANCE STATUS ON CANCER-ASSOCIATED THROMBOSIS TREATED WITH DOACS: DATA FROM A MULTICENTER COHORT STUDY R. Talerico1, F. Mancinetti1, C. Sacco2, M. Mazzetti3, E. Campello4, S. Birocchi5, S. Beccatini6, A. Porfidia1, C. Lodigiani2, P. Simioni4, G.M. Podda5, I. Mastandrea2, C. Becattini6, R. Pola1, M.C. Vedovati6 | 1Thrombosis Unit, Department of Geriatric, Orthopedic, and Rheumatologic Sciences, Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italy; 2Thrombosis and Hemorrhagic Diseases Unit, IRCCS Humanitas Research Hospital, Rozzano, Milano, Italy; 3Interdisciplinary Internal Medicine, Careggi University Hospital, Firenze, Italy; 4First Chair of Internal Medicine and Thrombotic and Hemorrhagic Diseases Unit, Department of Medicine, University of Padova, Italy; 5Medicine II Unit, ASST Santi Paolo e Carlo, Department of Health Sciences, University of Milano, Milano, Italy; 6Internal, Vascular and Emergency Medicine– Stroke Unit, University of Perugia, Perugia, Italy
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CO006 | PREVALENCE OF GASTROINTESTINAL BLEEDING IN GLANZMANN THROMBASTHENIA PATIENTS: RESULTS OF A WORLDWIDE SURVEY E. Falcinelli1, L. Bury1, S. Morais2, M. de Oliveira2, M. Kannan3, M. Faranoush4, D. Desprez5, V. Jean-Baptiste6, C. Santoro7, C. Falaise8, P. Saultier8, M. Fiore9, C. Albayrak10, A. Sánchez11, J.M. Bastida12, A. Artoni13, G. Castaman14, K. Gomez15, R. Schutgens16, L. Spiezia17, M. Sridharan18, N. Butta19, P. Buur van Kooten Niekerk20, E. Leinøe21, B. Guillet22, C. Panagiotis23, S. Crivelli24, E. De Candia25, M. Lewandowska26, P. De Bonis27, G. Kenet28, F. Heubel-Moenen29, J. Payne30, L. Banov31, L. Puccetti32, M. Olivieri33, M. Chitlur34, M. Lambert35, A. Pecci36, D. Martínez-Carballeira37, E. Zetterberg38, J. Curnow39, M. Napolitano40, A. Morotti41, R.C. Santoro42, R. Johann43, S. Saulyte Trakymiene44, A. Falanga45, C. Casas46, E. Zanon47, J. Moppet48, N.M. Popa-Fotea49, P. Gresele1 | 1Department of Medicine and Surgery, Section of Internal and Cardiovascular Medicine, University of Perugia, Italy; 2Centro Hospitalar Universitário de Santo António, Portugal; 3Blood and Vascular Biology Research Lab, Department of Biotechnology, Central University of Tamil Nadu, India; 4Iranian Hemophilia and Thrombophilia Association, MAHTA, Iran; 5CRC MHC Hopital Universaitire de Strasbourg, France; 6CHRU de Tours, University Hospital of Tours, France; 7UOC Ematologia, Azienda Ospedaliero Universitaria Policlinico Umberto I, Roma, Italy; 8AP-HM Timone, Marseille, France; 9CHU Bordeaux, France; 10Mayıs University Medical Faculty Pediatric Hematology and Oncology Dept, Türkiye; 11Hospital Universitario Morales Meseguer – Centro Regional de Hemodonación, Murcia, Spain; 12Complejo Asistencial Universitario De Salamanca, Spain; 13Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milano, Italy; 14Azienda Ospedaliera Universitaria Careggi Florence, Italy; 15Royal Free Hospital, London, UK; 16Center for Benign Haematology, Thrombosis and Haemostasis, Van Creveldkliniek, UMC Utrecht, The Netherlands; 17University of Padova, Italy; 18Mayo Clinic, Rochester, USA; 19Hospital Universitario La Paz-IdiPAZ, Madrid, Spain; 20Aarhus University Hospital, Denmark; 21Department of Hematology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark; 22University Hospital of Rennes, France; 23Blood unit and National Reference Center for Congenital Bleeding Disorders, ''Laiko'' General Hospital, Greece; 24Ospedale L. Sacco e Polo Universitario, Milano, Italy; 25Università Cattolica del Sacro Cuore-Roma, Fondazione Policlinico Universitario A. Gemelli IRCCS, Italy; 26Indiana Hemophilia and Thrombosis Center Innovative Hematology, USA; 27IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy; 28Sheba Medical Center, Israel; 29Department of Hematology Internal Medicine, Maastricht University Medical Center and Hemophilia Treatment Center Nijmegen Eindhoven Maastricht and CARIM, Maastricht University, Maastricht, Netherlands; 30Sheffield Children’s NHS foundation Trust, UK; 31Hemostasis and Thrombosis Unit, Gaslini Children’s Hospital, Italy; 32University Teaching Hospital of Siena, Italy; 33Pediatric Thrombosis and Hemostasis Unit, Dr. von Hauner Childreńs Hospital, LMU Munich, Munich, Germany; 34Children's Hospital of Michigan, USA; 35Children’s Hospital of Philadelphia, USA; 36IRCCS Policlinico San Matteo Foundation and University of Pavia, Italy; 37Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Spain; 38Department of Hematology, Coagulation Unit, Skane University hospital, Sweden; 39Westmead Hospital, Sydney, Australia; 40PROMISE Department, University of Palermo, Italy; 41AOU San Luigi Gonzaga Hospital, University of Turin, Italy; 42Hemostasis and Thrombosis, Az. Osp. Univ. Dulbecco, Catanzaro, Italy; 43Hospital Center of Le Mans, France; 44Vilnius University Hospital Santaros Klinikos, Lithuania; 45ASST Papa Giovanni XXIII, Bergamo, Italy; 46Hospital San José, Bogotà, Colombia; 47Haemophilia Center-General Medicine, Padova University Hospital, Padova, Italy; 48University Hospitals Bristol NHS Foundation Trust, UK; 49University of Medicine and Pharmacy “Carol Davila”, Bucharest, Romania
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CS04 | Association between elevated plasma levels of tissue plasminogen activator and occult cancer risk: a nested case-cohort analysis in 10,294 healthy subjects S. Bolognini1,2, C. Ticozzi1, P. Gomez-Rosas1,3, L. Russo1,2, Cj. Tartari1,2, F. Schieppati1,2, G. Sampietro4, L. Barcella1, M. Marchetti1,2, A. Falanga1,2 | 1Immunohematology and Transfusion Medicine, Hospital Papa Giovanni XXIII, Bergamo, Italy; 2School of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy; 3Maastricht University Medical Center, Cardiovascular Research Institute Maastricht, The Netherlands; 4Unit of Epidemiology and Statistics, ATS Bergamo, Italy
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PO47 | VENOUS THROMBOEMBOLISM IN BREAST CANCER: INSIGHTS FROM A SINGLE-CENTER COHORT S. Kozhukhov, N. Dovganych | SI “NSC “The M. D. Strazhesko Institute of Cardiology, Clinical and Regenerative Medicine of the National Academy of Medical Sciences of Ukraine, Kyiv, Ukraine; 2Cardio-Oncology Center, Kyiv, Ukraine
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CO05 | Long-term management of upper extremity catheter-related thrombosis in female patients with cancer: a retrospective cohort study Chiara Cavallaro1,2, Paolo Santini1,2, Laura Leoni3, Carolina Mosoni1,2, Silvia D’Ambrosio1,2, Francesco Mancinetti1,2, Nicola Coletta1,2, Michela Iorio1,2, Angelo Porfidia1,2, Alessandro D’Errico1,2, Rosa Talerico1,2, Roberto Pola1,2 | 1Department of Aging, Orthopedic, and Rheumatologic Sciences, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome; 2Università Cattolica del Sacro Cuore, Rome; 3Vita-Salute University, San Raffaele Hospital IRCCS, Milan, Italy
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CO032 | VENOUS THROMBOEMBOLISM IN ACUTE IMMUNE MEDIATED THROMBOTIC THROMBOCYTOPENIC PURPURA, A SINGLE-CENTER RETROSPECTIVE COHORT STUDY M. Zerbinati, E. Cosi, I. Bertozzi, G. Bogoni, A. Bertomoro, A. Galbiati, I. Cortella, L. Gianesello, D. Regazzo, S. Ferrari, P. Simioni | Department of Medicine, University of Padova, Italy
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CO20 | Coagulation alterations as prognostic indicators in septic patients L. Baratti1, S. N. Pasturenzi1, P. Onorato2, W. Ageno3, F. Cortellaro2, M.P. Donadini2,4 | 1Scuola di Medicina, Università degli Studi dell’Insubria, Varese; 2Pronto Soccorso e Medicina d’Urgenza, Ospedale di Circolo, Varese; 3Dipartimento di Medicina, Università degli Studi di Padova; 4Dipartimento di Medicina e Chirurgia, Università degli Studi dell’Insubria, Varese, Italy
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PO042 | ACQUIRED HEMOPHILIA A AND ANTIPHOSPHOLIPID SYNDROME: CONCURRENCY OR OVERLAPPING? E. Galimberti1, C. Ambaglio1, T. Zollner1, F. Schieppati1|2, O.C. Cretu1, F. Zunino1, V. Brusegan1, M. Marchetti1|2, A. Falanga1|2, L. Barcella1 | 1Immunohematology and Transfusion Medicine, Department of Transfusion Medicine and Hematology, ERN-EuroBloodNet - European Reference Network in Rare Hematological Diseases, ASST Papa Giovanni XXIII, Bergamo, Italy; 2School of Medicine and Surgery, University of Milano-Bicocca, Milano, Italy
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CO045 | BEYOND THE VISIBLE: LIPOPROTEIN(a) AS A SILENT DRIVER OF RETINAL VASCULAR DAMAGE L. Agrelli1, M. Berteotti2, E. Lotti2, F. Crudele2, D. Poli2, A.M. Gori2, A Rogolino2, D. Prisco2, R. Marcucci2 | 1Department of Internal Medicine, University of Salerno, Italy; 2Department of Medical and Surgical Critical Care, Thrombosis Centre, University of Florence, AOU Careggi, Firenze, Italy
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PO32 | ANTICOAGULANT THROMBOPROPHYLAXIS IN AGGRESSIVE LYMPHOMAS PATIENTS: PREDICTIVE THROMBOTIC RISK SCORES AND RISK FACTORS L. Gurgoglione1, G. Gini1, S. Rupoli1, A. Poloni1|2 | 1Hematology, AOU delle Marche, Ancona; 2Università Politecnica delle Marche, Ancona, Italy
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PO22 | Early detection and management of PICC-related thrombosis in oncohematologic patients through serial ultrasound monitoring: a prospective observational study S. Laurenti, M. Schneeberger, G. Rosati, A. Pozzi, M. Padrini, R. Vacchelli, A. Morotti | University of Turin, AUO San Luigi Gonzaga, Orbassano (TO), Italy
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CO-75 | ASSAY DISCREPANCY IN HEMOPHILIA A CARRIERS: CLINICAL AND GENETIC INSIGHTS M. Leotta, A. Strangio, A. Ierardi, R.C. Santoro | Hemophilia Treatment Center AOU Dulbecco, Catanzaro, Italy
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CS03 | Khorana risk score and genomic profiling for prediction of venous thromboembolism in ovarian cancer P. Santini, F. Mancinetti, S.M.P. D’Ambrosio, M. Bigossi, A. D’Errico, E. Fondi, G. Fracassa, E. Ianuà, L. Mastrantoni, G. Anderson, F. Camarda, I. Marino, J. Preziosi, M. Buttarelli, M. Manfredelli, A. Minucci, F. Persiani, L. Giacò, T. Pasciuto, I. Conti, I. Mozzetta, C. Marchetti, V. Salutari, G. Scambia, C. Nero, R. Pola | Agostino Gemelli University Polyclinic Foundation IRCCS, Roma, Italy
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PO45 | KHORANA RISK SCORE AND GENOMIC PROFILING FOR PREDICTION OF VENOUS THROMBOEMBOLISM IN OVARIAN CANCER P. Santini, L. Mastrantoni, G. Anderson, F. Camarda, I. Marino, J. Preziosi, M. Buttarelli, M. Manfredelli, A. Minucci, F. Persiani, L. Giacò, T. Pasciuto, I. Conti, I. Mozzetta, F. Mancinetti, S. M. P. D’Ambrosio, M. Bigossi, C. Marchetti, V. Salutari, G. Scambia, C. Nero, R. Pola | Agostino Gemelli University Hospital Foundation IRCCS, Rome, Italy
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PO136 | PHENOTYPE CHARACTERIZATION OF PATIENTS HOSPITALIZED FOR ACUTE SARS-COV2 INFECTION WITH AND WITHOUT ACUTE CEREBRAL ISCHEMIA P. Agosti1|2, R. Gualtierotti1|2, C. Suffritti1, L. Valenti2|3, M. Morena2, M. Tettamanti4, A. Nobili4, A. Bandera2|5, F. Peyvandi1|2 | 1Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Milano, Italy; 2Università degli Studi di Milano, Department of Pathophysiology and Transplantation, Milano, Italy; 3Department of Transfusion Medicine and Biological Resource Center, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano, Italy; 4Department of Health Policy, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milano, Italy; 5Department of Infectious Diseases, Fondazione IRCCS Ca’ Granda, Ospedale Maggiore Policlinico, Milano, Italy
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CO018 | THE MOLI-SANI RISK SCORE, A MEASURE OF MODIFIABLE CARDIOVASCULAR RISK, PREDICTS NON-CARDIOVASCULAR MORTALITY AND SELECTED CANCERS, BUT NOT NEURODEGENERATIVE DISEASES F. Bracone1, S. Costanzo1|2, M. Bonaccio1, T. Panzera1, A. De Curtis1, S. Magnacca1, C. Cerletti1, MB. Donati1, G. de Gaetano1, L. Iacoviello1|3, A. Di Castelnuovo1 | 1Unità di Ricerca di Epidemiologia e Prevenzione, IRCCS Neuromed, Pozzilli, Italy; 2Università della Insubria, Varese, Italy; 3Università LUM Giuseppe Degennaro, Casamassima, Italy
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PO30 | LONG-TERM ANTICOAGULANT THERAPY AND PREVENTION OF RECURRENT VENOUS THROMBOEMBOLISM IN ADVANCED OVARIAN CANCER V. Bitsadze 1, A. Vorobev 1, J. Khizroeva 1, A. Solopova 1, M. Tretyakova 1, N. Gashimova 1, K. Grigoreva 1, A. Khisamieva 1, J. Gris 1|2, I. Elalamy1|3|4, G. Gerotziafas1|3|4, A. Makatsariya1 | 1Department of Obstetrics, Gynecology and Perinatal Medicine, N. F. Filatov Clinical Institute of Children’s Health, I. M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia; 2Faculty of Pharmaceutical and Biological Sciences, Montpellier University, France; 3Department Hematology and Thrombosis Center, Medicine Sorbonne University, Paris, France; 4Hospital Tenon, Paris, France
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PO077 | BALANCING BLEEDING AND THROMBOSIS: SAFETY OF LOW-MOLECULAR-WEIGHT HEPARIN THROMBOPROPHYLAXIS IN PATIENTS WITH HEMOPHILIA UNDERGOING MAJOR SURGERY S. Bergonzi1|2|3, G. Murante1|2|3, M. Capetta1|2|3, F. Valeri1|2, C. Dainese1|2, A. Valpreda3|4, R. Pastorino3|4, F. Bocchi3|4, B. Bruno2|3, A. Borchiellini1|2 | 1Regional Centre for Hemorrhagic and Thrombotic Diseases, AOU Città della Salute e della Scienza, Turin, Italy; 2Division of Hematology, AOU Città della Salute e della Scienza, Università di Torino, Italy; 3Department of Molecular Biotechnology and Health Sciences, University of Turin, Italy; 4Central Laboratory Baldi and Riberi, AOU Città della Salute e della Scienza, Università di Torino, Italy
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CO-66 | PREGNANCY OUTCOMES AND PERIPARTUM MANAGEMENT IN WOMEN WITH CONGENITAL FIBRINOGEN DISORDERS: A SINGLE-CENTRE EXPERIENCE T. Martini1, B. Borsellino1|2, B. Pollio1 | 1Haemophilia Centre, Immune-Haematology and Transfusion Medicine, University Hospital “Città della Salute e della Scienza”, Torino, Italy; 2Department of Biomedicine and Prevention, PhD in Immunology, Molecular Medicine and Applied Biotechnology, University of Rome Tor Vergata, Roma, Italy
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PO44 | PREDICTORS OF ONE-YEAR MORTALITY IN NEWLY DIAGNOSED METASTATIC BREAST CANCER: THE PROGNOSTIC ROLE OF HEMOSTATIC BIOMARKERS AND EARLY THROMBOEMBOLISM M. Marchetti1|2|3, P. Gomez-Rosas1|4|5, S. Bolognini1, C. Ticozzi1, D. Romeo1, F. Schieppati1|3, L. Barcella1|3, F. Petrelli6, A. D'Alessio7, R. Labianca7, A. Falanga1|2|3 | 1Immunohematology and Transfusion Medicine, Hospital Papa Giovanni XXIII, Bergamo, Italy; 2School of Medicine and Surgery, University of Milan Bicocca, Milan, Italy; 3ERN EuroBloodNet; 4Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, The Netherlands; 5Hospital de Oncologia, Unidad Medica de Alta Especialidad (UMAE), Centro Medico Nacional Siglo XXI, Instituto Mexicano del Seguro Social (IMSS), Mexico City, Mexico; 6Oncology Unit, Hospital Treviglio-Caravaggio, Treviglio, Italy; 7Fondazione ARTET Onlus, Bergamo, Italy; *On behalf of the Hypercan Investigators
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PO41 | Comparison of the haemorrhagic phenotype between female and male patients affected by autosomal inherited bleeding disorders in a single-centre cohort B. Borsellino1,3, C. Zuccotti2, L. Guarnera3,4, C. Biasoli5, P. Pedrazzi5, T. Martini1 | 1Haemophilia Centre, Immune-Haematology and Transfusion Medicine, University Hospital “Città della Salute e della Scienza”, Turin, Italy; 2Department of Clinical Pathology, Bufalini Hospital, Cesena, Italy; 3Department of Biomedicine and Prevention, PhD in Immunology, Molecular Medicine and Applied Biotechnology, University of Roma Tor Vergata, Roma, Italy; 4Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, USA; 5Haemophilia and Transfusion Centre, Bufalini Hospital, Cesena, Italy
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PO134 | FAMILIAL HYPERCHOLESTEROLEMIA 57-GENE PANEL MUTATIONAL ANALYSIS: INSIGHT INTO CARDIOVASCULAR RISK GENETIC PREDISPOSITION A. Kura1, E. Sticchi1, G. Barbieri1, F. Basso1, P. Cantini1, S. Suraci1, M. Berteotti1, E. Lotti1, F. Crudele1, G.M. Scaturro2, A. Rogolino1, A.M. Gori1, R. Marcucci1, B. Giusti1 | 1Atherothrombotic Diseases Center, Department of Experimental and Clinical Medicine, University of Florence - Careggi Hospital, Firenze, Italy; 2Meyer Children's Hospital IRCCS, Metabolic and Neuromuscular Unit, Firenze, Italy
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PO003 | CATHETER-RELATED THROMBOSIS IN CANCER PATIENTS: A RETROSPECTIVE REAL-WORLD STUDY G. Autiero1|3, S.A. Malerba1|2|4, F. Busato1|2, D. Tolomio1|2, M. Dalla Vestra1|2, F. Presotto1|2 | 1U.O. Medicina Generale, Osp. Dell'Angelo, Venezia-Mestre, Italy; 2U.O. Angiologia, Osp. Dell'Angelo, Venezia-Mestre, Italy; 3Dip. Medicina Interna, Università degli Studi di Padova, Italy; 4U.O.C. Medicina Generale ad indirizzo trombotico ed emorragico, Università degli studi di Padova, Italy
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PO57 | A NOVEL RISK ASSESSMENT MODEL FOR CANCER DETECTION WITHIN ONE YEAR AFTER INCIDENT VENOUS THROMBOEMBOLISM C. Antoun1, J. Hansen1|3, S. Brækkan1|3, C. Langholm1, N. Eide1, V. Morelli1|3, K. Hveem2 | 1Department of Clinical Medicine, UiT The Arctic University of Norway, Tromsø; 2HUNT Center for Molecular and Clinical Epidemiology, Norwegian University of Science and Technology, Trondheim; 3Thrombosis Research Center, Division of Internal Medicine, University Hospital of North Norway, Tromsø, Norway
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PO81 | Direct oral anticoagulants in atypical site vein thrombosis: a single centre experience focused on cancer patients U. Mazzarelli1, A. Guida1, L. Agrelli1, M. Amato1, R. Guarrasi2, L. Santaniello2, C. Cardamone1, P. Vitale1, M. Triggiani1 | 1Centro per le Malattie Emorragiche Congenite e Malattie Trombotiche UOC Clinica Immunologica e Reumatologica AOU S. Giovanni di Dio e Ruggi d’Aragona, Salerno; 2UOC Clinica Oncologica AOU S. Giovanni di Dio e Ruggi d’Aragona, Salerno, Italy
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