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CO035 | THE ROLE OF INFLAMMATORY BIOMARKERS IN IMMUNE THROMBOTIC THROMBOCYTOPENIC PURPURA F. Schieppati1|2, S. Bolognini1|2, C. Ticozzi1, O.C. Cretu1, P. Gomez-Rosas1|3, M. D’Adda4, V. Cancelli4, C. Ambaglio1, E. Galimberti1, L. Barcella1, A. Falanga1|2, M. Marchetti1|2 | 1Immunohematology and Transfusion Medicine, Department of Transfusion Medicine and Hematology, ERN-EuroBloodNet - European Reference Network in Rare Hematological Diseases, ASST Papa Giovanni XXIII, Bergamo, Italy; 2School of Medicine and Surgery, University of Milano-Bicocca, Milano, Italy; 3Maastricht University Medical Center, Cardiovascular Research Institute Maastricht, Maastricht, The Netherlands; 4Hematology, Hospital Spedali Civili di Brescia, Brescia, Italy
71PDF: 30 -
PO101 | COMPREHENSIVE EVALUATION OF COAGULATION PROFILES IN REFRACTORY MODERATE-TO-SEVERE ULCERATIVE COLITIS L. Spiezia1, G. Di Lecce2, B. Barberio2, M. Zanconato2, E. Bicego1, C. Samà1, B. Serena1, M. De Bona3, A. Buda3, F. Zingone2, E.V. Savarino2, P. Simioni1 | 1First Chair of Internal Medicine, Department of Medicine (DIMED), Padova University Hospital, Padova, Italy; 2Gastroenterology Unit, Department of Surgery, Oncology and Gastroenterology (DISCOG), University of Padova, Padova, Italy; 3Gastroenterology Unit, Department of Oncological Gastrointestinal Surgery, S. Maria del Prato Hospital, Feltre, Italy
49PDF: 30 -
CS01 | Elucidating the evil relationship of metabolic dysfunction–associated fatty liver disease with cardiovascular comorbidities: the complex interplay among hypercoagulability, inflammation and liver fibrosis G. Gagliardi, E. Campello, A. Napolitano, B. Stocco, C. Di Gesù, G. Gobbo, I. Condonato, M. Allegra, G. Camporese, P. Scarinzi, R. Pesavento, F. Bilora, C. Bulato, A. Benetti, C. Samà, C. Portinari, G. Antonello, C. Goffi, L. Di Daniel, A. Zambon, L. Fabris, P. Simioni | First Chair of Internal Medicine, Department of Medicine, University-Hospital of Padua Medical School, Padua, Italy
834PDF: 26 -
PO027 | IGFBP-6 REGULATES PLATELET PROCOAGULANT ACTIVITY AT THE INTERFACE BETWEEN INFLAMMATION AND COAGULATION L. Bury1, E. Falcinelli1, E. Petito1, L. Leijonancker2, H. van Ooijen2, S. Petkov2, A.R.D. Coda3, C. Raucci1, V. Fazzi1, D. Sarnà1, C. Becattini1, P. Gresele1, A. Liso4 | 1Department of Medicine and Surgery, Section of Internal and Cardiovascular Medicine, University of Perugia, Perugia, Italy; 2Pixelgen Technologies AB, Stockholm, Sweden; 3C.R.E.A.T.E.-Center for Research and Innovation in Medicine, Department of Medical and Surgical Sciences, University of Foggia, Italy; 4Department of Medicine and Surgery, University of Perugia, Perugia and Hematology/Oncology Unit, Terni Hospital, Terni, Italy
57PDF: 26 -
CO25 | Thromboinflammation and ros accumulation in individuals with high lipoprotein(a) levels M. Frezza1, P.G.M. Simeone1, M. Alfonsetti1, R. Liani1, M. Cellini1, P. Del Boccio2, M.C. Cufaro3, O. Iuliani4, A. Quaglietta4, F. Cipollone1, F. Santilli1 | 1Department of Medicine and Ageing Sciences, Center for Advanced Studies and Technology “CAST”, University of Chieti; 2Department of Pharmacy, Center for Advanced Studies and Technology “CAST”, Chieti; 3Department of Innovative Technologies in Medicine and Dentistry, Center for Advanced Studies and Technology “CAST”, Chieti; 4Department of Haematolgy and Oncology, Center of Transfusion Medicine, Pescara General Hospital, Pescara. Italy
595PDF: 17 -
CO14 | Inflammation and fibrinolysis biomarkers as predictors of cancer risk in healthy subjects: results from the hypercan study C. Ticozzi1, S. Bolognini1,2, P. Gomez-Rosas1,3, L. Russo1,2, Cj. Tartari1,2, F. Schieppati1,2, G. Sampietro4, L. Barcella1, M. Marchetti1,2, A. Falanga1,2 | 1Immunohematology and Transfusion Medicine, Hospital Papa Giovanni XXIII, Bergamo, Italy; 2School of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy; 3Maastricht University Medical Center, Cardiovascular Research Institute Maastricht, Maastricht, The Netherlands; 4Unit of Epidemiology and Statistics, ATS Bergamo, Italy
681PDF: 28 -
PO54 | Resolvin response in bronchial asthma patients: endotype and clinical severity R. Liani1, I. Altomare2, P.G.M. Simeone1, M. Alfonsetti1, M. Mucci3, D. Madonna1, S. Lattanzio1, A. Ricci4, A.M. Draicchio2, A. De Sanctis2, P. Di Mattia2, F. Papa2, E. Cavallucci2, F. Cipollone1, A. Recchiuti3, F. Santilli1 | 1Department of Medicine and Aging, and Center for Advanced Studies and Technology “CAST”, G. d’Annunzio University of Chieti-Pescara, Chieti; 2Allergy and Immunology Section, Department Internal Medicine, G. d’Annunzio University, School of Medicine, Chieti; 3Department of Medical, Oral and Biotechnological Sciences, and Center for Advanced Studies and Technology “CAST”, G. d’Annunzio University, Chieti-Pescara; 4Department of Pharmacy, University G. d’Annunzio of Chieti Pescara, Chieti, Italy
593PDF: 23 -
CO24 | Extracellular vesicles profiles in patients with wild-type transthyretin amyloidosis S. Toffanin1, L. Spiezia1, C.M. Radu1, A. Napolitano1, A. Benetti1, C. Samà1, E. Campello1, L. De Michieli2, G. Sinigiani2, A. Cipriani2, P. Simioni1 | 1First Chair of Internal Medicine, Department of Medicine, University-Hospital of Padua Medical School, Padua; 2Department of Cardiac, Thoracic and Vascular Sciences and Public Health, University of Padua, Italy
694PDF: 18 -
CO23 | Markers of inflammation and hypofibrinolysis are associated with cognitive dysfunction and motor performances in atrial fibrillation patients on oral anticoagulant therapy: insights from the Strat-AF study F. Alfano1,2, F. Cesari1,2, A.M. Gori1,2, M. Berteotti1,2, E. Salvadori3, B. Giusti1,2, A. Bertelli1,2, F. Fratini4, A. Rogolino1,2, B. Formelli4,5, F. Pescini4,5, E. Fainardi6, E. Barucci4, G. Salti5, A. Cavaliere4, A. Ginestroni6, A. Poggesi4,5, R. Marcucci1,2 | 1Department of Experimental and Clinical Medicine, University of Firenze; 2Center for Atherothrombotic Diseases, Careggi University Hospital, Firenze; 3Department of Biomedical and Clinical Sciences, University of Milan; 4NEUROFARBA Department, Neuroscience Section, University of Firenze; 5Stroke Unit, Careggi University Hospital, Firenze; 6Neuroradiology Unit, Careggi University Hospital, Department of Experimental and Clinical Biomedical Sciences, University of Firenze, Italy
744PDF: 34 -
CO067 | ELUCIDATING THE EVIL RELATIONSHIP OF METABOLIC DYSFUNCTION–ASSOCIATED FATTY LIVER DISEASE WITH CARDIOVASCULAR COMORBIDITIES: THE COMPLEX INTERPLAY AMONG HYPERCOAGULABILITY, INFLAMMATION, AND LIVER FIBROSIS G. Gagliardi, E. Campello, A. Napolitano, B. Stocco, C. Di Gesù, G. Gobbo, I. Condonato, M. Allegra, G. Antonello, C. Portinari, C. Goffi, G. Camporese, P. Scarinzi, R. Pesavento, F. Bilora, M. Di Pascoli, C. Bulato, A. Montagna, D. Regazzo, A. Zambon, L. Fabris, P. Simioni | Department of Medicine, University of Padova, Italy
67PDF: 25 -
PO26 | Non-canonical coagulation platelets function: monocyte-platelet interaction a bridge between inflammation and coagulation A. Benetti1, A. Galbiati1, M. Cola2, L. Calandrino2, C. Samà1, D. Regazzo1, S. Ferrari1, C.M. Radu1, A. Cattelan2, P. Simioni1 | 1Department of Medicine - DIMED; 2Infectious and Tropical Diseases Unit, Padua University Hospital, Padua, Italy
659PDF: 26 -
CO076 | ASSOCIATION OF MATRIX METALLOPROTEINASE 2 PLASMA LEVELS WITH CARDIOVASCULAR EVENTS IN PATIENTS WITH ATRIAL FIBRILLATION: A NESTED CASE CONTROL STUDY FROM THE ATHERO-AF COHORT D. Menichelli1, E. Falcinelli2, P. Pignatelli3, R. Carnevale4|5, A. D’Amico4, F. Violi2, P. Gresele2, D. Pastori4|5, F. Paciullo6 | 1Dip. di Chirurgia Generale e Specialità Chirurgiche Paride Stefanini, Università La Sapienza, Roma, Italy; 2Dip. di Medicina e Chirurgia, Sez. di Medicina Interna Cardiovascolare, Università degli Studi di Perugia, Italy; 3Dip. di Scienze Medico-Chirurgiche e Biotecnologie, Università La Sapienza, Latina, Italy; 4IRCCS Neuromed, Pozzilli, Isernia, Italy; 5Dip. di Scienze Mediche e Cardiovascolari, Università La Sapienza, Roma, Italy; 6Fac. di Medicina e Chirurgia , Vita-Salute San Raffaele University, Milano, Italy
55PDF: 26 -
CO066 | COAGULOPATHY IN CAR-T CELL-TREATED PATIENTS WITH LYMPHOPROLIFERATIVE DISORDERS: A RETROSPECTIVE, SINGLE-CENTER OBSERVATIONAL STUDY I. Santo1, R. Morganti2, G. Leoni3, G. Tancredi3, L. Contino4, S. Galimberti3, R.M. Santi4, E. Orciuolo5 | 1Azienda Toscana Nord Ovest, Versilia Hospital, Italy; 2Hematology Division AOUP, Pisa, Italy; 3University of Pisa, Hematology Pisa, Italy; 4Azienda Ospedaliera Universitaria Alessandria, Italy; 5Azienda Ospedaliera Universitaria Pisana, Hematology Pisa, Italy
61PDF: 31 -
PO11 | Neutrophil cathepsin G and risk of cardiovascular events in patients with diabetes mellitus V. Cammisotto1, F. Baratta2, S. Bartimoccia3, D. Pastori1, N. Cocomello4, V. Castellani5, C. Nocella1, R. Carnevale3, G. Desideri1, F. Violi1, P. Pignatelli1 | 1Department of Clinical, Internal Medicine, Anesthesiological and Cardiovascular Sciences, Sapienza University of Roma; 2Geriatric Unit, Department of Internal Medicine and Medical Specialties, AOU Policlinico Umberto I, Roma; 3Department of Medical-Surgical Sciences and Biotechnologies, Sapienza University of Roma; 4Department of Anatomical Sciences, Histological, Legal Medical and Locomotor, Sapienza University of Roma; 5Department of Experimental Medicine, Sapienza University of Roma, Italy
609PDF: 30 -
PO119 | BARTONELLA HENSELAE INFECTION ASSOCIATED WITH A MULTISYSTEMIC THROMBO-INFLAMMATORY SYNDROME IN AN IMMUNOCOMPETENT ADULT G. Gobbo1|2, M. Zacchia1|2, F. Nalesso1|3, M. Fedrigo1|4, S. Da Pozzo5, L. Frison7, F. Vianello1|6, A. Angelini1|4, P. Simioni1|2, A. Hoxha1|2 | 1Department of Medicine - DIMED, University of Padua, Italy; 2Internal Medicine Unit, Thrombotic and Bleeding Disorder Center; 3Nephrology Unit; 4Pathology Unit; 5Radiology Unit; 6Hematology Unit, University-Hospital of Padua, Italy; 7Hematology Unit, Ospedale dell’Angelo, Mestre, Italy
51PDF: 24 -
PO82 | Retrospective application of the TH2 score in a multicenter cohort of ITP patients: a reliable predictive tool or a score in need of refinement? C. Giubbilei1, M. Defina2, S. Rosati3, M. Rocco3, A. Votto4, F. Simonetti5, F. Paoletti6, V. Carrai1 | 1Hematology Unit, AOU Careggi; 2Hematology unit AOU Senese; 3Hematology Unit Azienda Sanitaria Toscana Centro; 4Hematology Unit, AOU Pisana; 5Hematology Unit, Ospedale Versilia; 6Hematology Unit, Azienda Sanitaria Nord Ovest, Italy
583PDF: 21 -
Platelet-driven remodeling of cancer cell glycoproteins fuels inflammation and metastasis
556PDF: 147Extra Tables: 75Extra Figure 1: 77Extra Figure 2: 67 -
PO17 | PREDICTIVE VALUE OF INFLAMMATORY AND ENDOTHELIAL BIOMARKERS FOR CANCER RISK IN HEALTHY INDIVIDUALS: EVIDENCE FROM THE HYPERCAN STUDY C. Ticozzi1, S. Bolognini1|2, P. Gomez-Rosas1|3, F. Schieppati1|2, G. Sampietro4, L. Barcella1, M. Marchetti1|2, A. Falanga1|2 | 1Immunohematology and Transfusion Medicine, Hospital Papa Giovanni XXIII, Bergamo, Italy; 2School of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy; 3Maastricht University Medical Center, Cardiovascular Research Institute Maastricht (CARIM), Maastricht, The Netherlands; 4Unit of Epidemiology and Statistics, ATS Bergamo, Italy
457PDF: 103 -
CO074 | WHOLE-BLOOD COAGULATION AND PLATELET DYNAMICS IDENTIFY DIFFERENTIAL PROTHROMBOTIC STATES IN RHEUMATOID ARTHRITIS PATIENTS TREATED WITH JAK OR TNFⱭ INHIBITORS L. Spiezia, A. Giollo, L. Di Luozzo, M. Salvato, K. Khalid, R. D’Andrea, A. Benetti, C. Samà, R. Ramonda, P. Simioni | Dipartimento di Medicina, Azienda Osp. Università di Padova, Italy
63PDF: 31 -
PO56 | Safety of anticoagulant treatment in patients with splanchnic vein thrombosis and history of portal hypertension-related bleeding R. Talerico1, S. Pellegrino1, A. Plessier2, F.R. Ponziani3, A. Porfidia1, F. Landi1, A. Gasbarrini3, R. Pola1, F. Santopaolo3 | 1Department of Geriatric, Orthopedic, and Rheumatologic Sciences, Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica del Sacro Cuore, Roma, Italy; 2Université de Paris, AP-HP, C, DMU DIGEST, Centre de Référence des Maladies Vasculaires du Foie, FILFOIE, ERN RARE-LIVE. Centre de recherche sur l’inflammation, Inserm, Paris, France; 3Department of Medical and Surgical Sciences, Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica del Sacro Cuore, Roma, Italy
627PDF: 31 -
Anticoagulation in obese patients: challenges and strategies
2047PDF: 542HTML: 310XML: 196 -
CO045 | BEYOND THE VISIBLE: LIPOPROTEIN(a) AS A SILENT DRIVER OF RETINAL VASCULAR DAMAGE L. Agrelli1, M. Berteotti2, E. Lotti2, F. Crudele2, D. Poli2, A.M. Gori2, A Rogolino2, D. Prisco2, R. Marcucci2 | 1Department of Internal Medicine, University of Salerno, Italy; 2Department of Medical and Surgical Critical Care, Thrombosis Centre, University of Florence, AOU Careggi, Firenze, Italy
50PDF: 33 -
PO088 | INVESTIGATING THE MEAN PLATELET VOLUME OF PATIENTS WITH LIVER CIRRHOSIS AND CHRONIC LIVER DISEASE: A CASE-CONTROL STUDY B. Clerici1|2, C. Pisetta1, C. Urtis1|2, C. Brizio1, G. Vismara3, S. Vavassori4, A.L. Crosignani4, M. Scavone2, S. Birocchi1, S. De Matteis2|5, P.M. Battezzati2|4, M.N. Cattaneo6, G.M. Podda1|2 | 1S.C. Medicina Generale SP, Ospedale San Paolo, ASST Santi Paolo e Carlo, Milano, Italy; 2Dipartimento di Scienze della Salute (DISS), Università degli Studi di Milano, Milano, Italy; 3Servizio di Immunoematologia e Medicina Trasfusionale (SIMT), Ospedale San Paolo, ASST Santi Paolo e Carlo, Milano, Italy; 4S.C. Medicina ad indirizzo Epatologico e Gastroenterologia, Ospedale San Paolo, ASST Santi Paolo e Carlo, Università degli Studi di Milano, Milano, Italy; 5S.S. Medicina del Lavoro, Ospedale San Paolo, ASST Santi Paolo e Carlo, Università degli Studi di Milano, Milano, Italy; 6Fondazione Arianna Anticoagulazione, Bologna, Italy. B. Clerici contributed equally as co-first authors
43PDF: 19 -
CO071 | ATRIAL FIBRILLATION, CEREBRAL SMALL VESSEL DISEASE, AND GENDER MEDICINE: FOCUS ON BIOMARKERS AND NEUROIMAGING F. Alfano1|2, M. Berteotti1|2, F. Cesari1|2, AM. Gori1|2, E. Salvadori1, B. Giusti1|2, A. Bertelli1|2, L. Bicchi1|2, F. Fratini3, B. Formelli3, G. Salti3, E. Fainardi1|4, A. Ginestroni1|4, S. Chiti5, A. Poggesi1|3, R. Marcucci1|2 | 1Department of Experimental and Clinical Medicine, University of Florence, Firenze, Italy; 2Center for Atherothrombotic Diseases, Careggi University Hospital, Firenze, Italy; 3NEUROFARBA Department, Neuroscience Section, University of Florence, Firenze, Italy; 4Neuroradiology Unit, Careggi University Hospital, Firenze, Italy; 5Health Physics Unit, Careggi University Hospital, Firenze, Italy
72PDF: 36 -
PO147 | FEBRILE BILATERAL PULMONARY EMBOLISM IN A YOUNG ADULT WITH PFAPA SYNDROME: A POSSIBLE PROTHROMBO-INFLAMMATORY CONTRIBUTOR IN A MULTIFACTORIAL EVENT A. Dal Corso | Internal Medicine and Vascular Medicine, Pederzoli Hospital, Peschiera del Garda, Verona, Italy
44PDF: 20 -
PO014 | DETERGENT AND GANGLIOSIDE GM1-BINDING PROPERTIES OF PLATELET FACTOR 4 AS ASSESSED BY CHARGE-SHIFT ELECTROPHORESIS P. Ames1, A. Arcaro2, A. Lepore2, S. Nourooz-Zadeh2, M. Graf3, F. Gentile2 | 1Immune Response & Vascular Disease Unit, CEDOC, Nova University Lisbon, Portugal; 2Department of Medicine and Health Sciences 'V. Tiberio', University of Molise, Campobasso, Italy; 3Immunohaematology and Transfusion Medicine Unit, Federico II University Hospital, Napoli, Italy
42PDF: 25 -
PO92 | Challenging management of portal vein thrombosis in a cirrhotic patient on hormone therapy after breast cancer L. Jr Valletta, C. De Luca, M. Aversano, C. Caputo, E. Cimino, P. Conca, A. Tufano, M.D. Di Minno | AOU Federico II Napoli, Italy
581PDF: 24 -
PO082 | HEMOPHILIA AND LOW BONE MINERAL DENSITY: AN OBSERVATIONAL STUDY D. Fumarulo, R. Corrado, M. Canfora, M. Mazzetti, M. Littera, D. Prisco, C. Tamburini | Internal Medicine, Careggi Hospital, University of Florence, Firenze, Italy
61PDF: 25 -
CO069 | POLYSTYRENE NANOPLASTICS PRIME PLATELET TO DRIVE PRO-INFLAMMATORY AND PRO-FIBROTIC ACTIVATION OF CARDIAC FIBROBLASTS Z. Saeed1|2, M. Dovizio1|3, C. Milillo1|3, P. Lanuti1|4, S. Porro1|4, F. D’Ascanio1|4, A. Bruno1|3, P. Ballerini1|3, G. Renda1|2 | 1Center for Advanced Studies and Technology (CAST), “G. d’Annunzio” University of Chieti-Pescara, Chieti, Italy; 2Department of Neurosciences, Imaging and Clinical Sciences, "G. d'Annunzio" University of Chieti-Pescara, Chieti, Italy; 3Department of Innovative Technologies in Medicine & Dentistry, “G. d’Annunzio” University of Chieti-Pescara, Chieti, Italy; 4Department of Medicine and Aging Sciences, “G. d’Annunzio” University of Chieti-Pescara, Chieti, Italy
85PDF: 24 -
PO33 | Whole blood hypercoagulable profiles in patients with rheumatoid arthritis L. Spiezia1, A. Giollo2, C. Samà1, A. Benetti1, L. Di Luozzo2, M. Salvato2, A. Doria2, P. Simioni1 | 1First Chair of Internal Medicine, Thrombotic and Hemorrhagic Diseases Unit, Department of Medicine, University Hospital of Padova; 2Rheumatology Unit, Department of Medicine, University Hospital of Padova, Italy
643PDF: 22 -
PO133 | RECURRENT SUPERFICIAL VENOUS THROMBOSIS AS AN ATYPICAL MANIFESTATION OF WHIPPLE’S DISEASE: A CASE REPORT C. Spillere, S. Suardi, F. Zoccatelli, L. Delfino, S. Moruzzi, F. Pizzolo, L. Marzano, E. Malloggi, F. Presa, L. Panepinto, M. Merlo, A. Moschella, S. Friso, N. Martinelli | U.O.C. Medicina Generale B, AOUI Verona, Italy. C. Spillere and S. Suardi contributed equally
54PDF: 29 -
CO097 | IMPACT OF THE 2023 ACR/EULAR ANTIPHOSPHOLIPID SYNDROME CRITERIA IN 1200 WOMEN WITH PRIOR OBSTETRIC ANTIPHOSPHOLIPID SYNDROME J. Alijotas-Reig1|2|3, E. Esteve-Valverde4, L. Saez-Comet5, A. Anunciacion-Llunell3, R. Ferrer-Oliveras6, E. Lefkou7, A. Mekinian8, C. Belizna9, A. Hoxha10, A. Tincani11, L. Marozio12, G. Espinosa13, S. de Carolis14, S. Udry15, J.O. Latino15, E. Llurba16, C.B. Chighizola17|18, M. Gerosa19, V. Pengo20, K. Lundelin21, P. Rovere-Querini22, V. Canti22, K. Mayer-Pickel23, T. Reshetnyak24, S. Tabacco25, L. Stojanovich26, B.A. Gonçalves27, S. Morales-Perez1, F. Miro-Mur3 | 1Department of Medicine, Universitat Autonoma de Barcelona, Spain; 2Systemic Autoimmune Disease Unit, Department of Internal Medicine, Vall d’Hebron University Hospital, Spain; 3Systemic Autoimmune Diseases Research Unit, Vall d’Hebron Institut de Recerca, Barcelona, Spain; 4Systemic Autoimmune Diseases Unit, Department of Internal Medicine, Hospital Sant Camil, Consorci Sanitari del Garraf, Barcelona, Spain; 5Department of Internal Medicine, Hospital Universitario Miguel Servet, Zaragoza, Spain; 6Obstetrics Department, High-Risk Unit, Hospital Universitario Quironsalud, Barcelona, Spain; 7Haematology Unit, Hippokration Hospital of Thessaloniki, Greece; 8AP-HP, Hopital Saint-Antoine, Service de Medecine Interne and Inflammation-Immunopathology-Biotherapy Department (DHU i2B), Sorbonne Universites, Paris, France; 9Vascular and Coagulation Department, University Hospital Angers, Angers, France; 10Internal Medicine Unit, Thrombotic and Bleeding Disorder Center, University of Padua, Padova, Italy; 11Department of Clinical and Experimental Sciences, University of Brescia, Spedali Civili, Brescia, Italy; 12Department of Obstetrics and Gynaecology, Universita di Torino, Torino, Italy; 13Systemic Autoimmune Diseases Service, Hospital Clínic, Universitat de Barcelona, Barcelona, Spain; 14Department of Gynaecology, Gemelli Hospital, Catholic University, Roma, Italy; 15Autoimmune, Thrombophilic Diseases and Pregnancy Division, Dr. Carlos G. Durand Hospital, Buenos Aires, Argentina; 16Obstetrics and Gynaecology Department, High-Risk Unit, University Hospital de la Santa Creu i Sant Pau, Barcelona, Spain; 17Department of Clinical Science and Community Health, University of Milano, Milano, Italy; 18Unit of Pediatric Rheumatology, ASST G. Pini-CTO, Milano, Italy; 19Division of Rheumatology, Department of Clinical Sciences and Community Health, University of Milano, Milano, Italy; 20Cardiology Unit, Department of Cardiac, Thoracic and Vascular Sciences, University of Padua, Padova, Italy; 21Department of Pediatrics, Faculty of Medicine, University of Turku, Turku, Finland; 22Internal Medicine and Division of Immunology, Transplantation and Infectious Diseases, IRCCS Ospedale San Raffaele, Milano, Italy; 23Department of Obstetrics, Medical University of Graz, Graz, Austria; 24Department of Systemic Rheumatic Disease, V. A. Nasonova Research Institute of Rheumatology, Moscow, Russia; 25Department of Gynecology, Obstetrics and Urology, Sapienza University of Roma, Roma, Italy; 26University Medical Center, University of Belgrade, Belgrade, Serbia; 27Department of Internal Medicine, Hospital Sant Joan Despí Moises-Broggi, Barcelona, Spain
81PDF: 22 -
PO91 | Disseminated intravascular coagulation with deep vein thrombosis in a frail patient: an extreme manifestation triggered by sepsis during SGLT2i therapy M. Vacca1, M.V. Cherchi1, S. Che1, G.A.M.L. Costanzo2, D. Firinu2, M. Mantega1, S. Del Giacco2 | 1Ospedale Sirai, ASL Sulcis, 2Università degli Studi di Cagliari, Italy
814PDF: 23 -
CO022 | SUBOPTIMAL MEDITERRANEAN DIET ADHERENCE IN VASCULAR PREVENTION: BASELINE FINDINGS FROM THE NEUROMED CENTER OF THE CV-PREVITAL STUDY F. De Rita1, M. Bonaccio1, A. Di Castelnuovo1, S. Costanzo1|2, T. Panzera1, A. De Curtis1, S. Magnacca1, C. Cerletti1, M.B. Donati1, G. de Gaetano1, L. Iacoviello1|3, F. Bracone1 | 1Unità di Ricerca di Epidemiologia e Prevenzione, IRCCS Neuromed, Pozzilli, Italy; 2Università della Insubria, Varese, Italy; 3Università LUM Giuseppe Degennaro, Casamassima, Italy. On behalf of CV-PREVITAL Study Group
56PDF: 24 -
PO050 | HEMOSTATIC AND FIBRINOLYTIC PROFILES IN PATIENTS UNDERGOING TAVI: PRELIMINARY RESULTS ON HOMOCYSTEINE, D-DIMER, AND CLOT LYSIS TIME V. Scheggi1, A. Bertelli2, F. Cesari3, A. Rogolino3, G. Ciarrocca Taranta2, M. Di Gioia3, G. Barbieri2, A.M. Gori2|3, R. Marcucci2|3 | 1Dep of Cardiothoracovascular Medicine, Careggi University Hospital, Firenze, Italy; 2Dep of Experimental and Clinical Medicine, University of Florence, Italy; 3Atherothrombotic Diseases, Careggi University Hospital, Firenze, Italy
49PDF: 20 -
PO121 | IMMUNOTHROMBOSIS AND MULTIPLE-SITE VENOUS THROMBOEMBOLISM IN ACUTE TOXOPLASMOSIS: A CASE REPORT A. Grembiale1, A. Sabena1, G. Dettori1, C. Grendene1, S. Grazioli1, S. Venturini2 | 1SOC Medicina Interna 2 - Azienda Sanitaria Friuli Occidentale - Pordenone, Italy; 2SSD Malattie Infettive - Azienda Sanitaria Friuli Occidentale - Pordenone, Italy
39PDF: 22 -
PO30 | LONG-TERM ANTICOAGULANT THERAPY AND PREVENTION OF RECURRENT VENOUS THROMBOEMBOLISM IN ADVANCED OVARIAN CANCER V. Bitsadze 1, A. Vorobev 1, J. Khizroeva 1, A. Solopova 1, M. Tretyakova 1, N. Gashimova 1, K. Grigoreva 1, A. Khisamieva 1, J. Gris 1|2, I. Elalamy1|3|4, G. Gerotziafas1|3|4, A. Makatsariya1 | 1Department of Obstetrics, Gynecology and Perinatal Medicine, N. F. Filatov Clinical Institute of Children’s Health, I. M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia; 2Faculty of Pharmaceutical and Biological Sciences, Montpellier University, France; 3Department Hematology and Thrombosis Center, Medicine Sorbonne University, Paris, France; 4Hospital Tenon, Paris, France
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PO88 | Bacterial lysate “lantigen B” induces proliferation of B and NK cells and the release of related cytokines M. Alfonsetti1, R. Liani1, P. Di Mattia3, M. Tredicine4, F. Papa3, Q. Niu5, M. Di Gioacchino2, F. Santilli1,3 | 1Department of Medicine and Aging, Center for Advanced Studies and Technology, University of Chieti, Italy; 2Institute for Clinical Immunotherapy and Advanced Biological Treatments, Pescara, Italy; 3Specialization School of Allergy and Clinical Immunology, G. d’Annunzio University, Chieti, Italy; 4Department of Medical, Oral, and Biotechnology Science, University G. d’Annunzio, Chieti-Pescara, Chieti, Italy; 5Department of Occupational Health, School of Public Health, Shanxi Medical University, Taiyuan, Shanxi, China
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CO017 | LIFE'S SIMPLE 7 FOR CARDIOVASCULAR HEALTH IS ASSOCIATED WITH LOWER CANCER RISK IN THE MOLI-SANI STUDY M. Bonaccio1, A. Di Castelnuovo1, S. Costanzo1|2, CF. Martinez1, T. Panzera1, A. De Curtis1, S. Magnacca1, C. Cerletti1, MB. Donati1, G. de Gaetano1, L. Iacoviello1|3 | 1Research Unit of Epidemiology and Prevention, IRCCS NEUROMED, Pozzilli (IS), Italy; 2Dep. of Medicine and Surgery, University of Insubria, Varese, Italy; 3Dep. of Medicine and Surgery LUM University, Casamassima (BA), Italy
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PO032 | INHIBITION OF PLATELET ACTIVATION BY SMALL MOLECULE SYNTHETIC AGONISTS OF THE BILE ACID RECEPTOR: A NOVEL APPROACH TO ANTIPLATELET THERAPY L. Bury1, E. Falcinelli1, V. Fazzi1, C. Tili1, P. Gresele1, S. Fiorucci2 | 1Department of Medicine and Surgery, Section of Internal and Cardiovascular Medicine; 2Section of Gastroenterology, University of Perugia, Italy
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PO18 | THE THROMBO-INFLAMMATION AXIS AS PREDICTOR OF TOXICITY IN PATIENTS TREATED WITH CAR-T CELLS C. Fernández-Arias1, M. Marcos-Jubilar1, M. Panizo1, C. Vázquez-Puerta2, J.R. González-Porras2, M. Ibáñez1, A. Queralt1, M. Carrasco1, M.B. Villacrés1, C. Conde1, P. Elizalde1, S. Huerga1, A. Alfonso1, P. Rodríguez-Otero1, S. Villar1, M.A. Canales1, J. Rifón1, F. Prósper1, J.A. Páramo1, J. Orbe1, R. Lecumberri1 | 1Clínica Universidad de Navarra, Pamplona; 2Hospital Clínico Universitario de Salamanca, Salamanca, Spain
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CO075 | PLATELET ACTIVATION PROFILE IN RELAPSING-REMITTING MULTIPLE SCLEROSIS AND ITS RELATIONSHIP WITH NEURONAL AND ASTROGLIAL BIOMARKERS A. Fioretti1, M. Scavone1, A. Mingione2|3, C. Monzani2|3, M. Miozzo4, F. Martinelli-Boneschi2|3|5, G.M. Podda1 | 1Division of Medicina Generale SP, ASST Santi Paolo e Carlo, Laboratory of Haemostasis and Thrombosis, Dipartimento di Scienze della Salute, Università degli Studi di Milano, Milano, Italy; 2Laboratory of Precision Medicine of Neurological Diseases, Department of Health Science, University of Milano, Milano, Italy; 3CRC “Aldo Ravelli” for Experimental Brain Therapeutics, Department of Health Science, University of Milano, Milano, Italy; 4Department of Health Sciences, Division of Medical Genetics, University of Milano, ASST Santi Paolo e Carlo, Milano, Italy; 5Clinical Neurology Unit, ASST Santi Paolo e Carlo and Department of Health Sciences, University of Milano, Milano, Italy
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CO-72 | HEREDITARY FACTOR X DEFICIENCY UNMASKED BY NECROTIZING HEMORRHAGIC PANCREATITIS: A CASE REPORT M. Leotta, A. Strangio, A. Ierardi, R.C. Santoro | Hemophilia Treatment Center AOU Dulbecco, Catanzaro, Italy
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CO059 | EXTRACELLULAR VESICLES AS BIOMARKERS IN FAMILIAL HYPERCHOLESTEROLEMIAS TREATED WITH EVINACUMAB C. Samà1, A. Benetti1, M.G. Lupo2, M. Biolo1, C. Portinari1, S. Zambon1, A. Zambon1, N. Ferri2, C.M. Radu1, P. Simioni1 | 1First Chair of Internal Medicine and Thrombotic and Haemorrhagic Diseases Unit, Department of Medicine, Padova University Hospital, Padova, Italy; 2Department of Medicine, Padova University Hospital, Padova, Italy
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PO06 | Extracellular vesicles profiles in patients with porto-sinusoidal vascular disease S. Toffanin1, E. Campello1, A. Zanetto2, C. M. Radu1, E. Pinto2, K. Fernande2, C. Bulato1, B. Serena1, L. Spiezia1, P. Burra2, M. Senzolo2, P. Simioni1 | 1First Chair of Internal Medicine, Department of Medicine, University Hospital of Padua Medical School, Padua; 2Department of Surgery Oncology and Gastroenterology, Gastroenterology and Multivisceral Transplant Unit, University Hospital of Padua, Italy
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PO112 | REFRAMING THE ENIGMA: ACQUIRED HEMOPHILIA A AS A HARBINGER OF HHV-8–ASSOCIATED MULTICENTRIC CASTLEMAN DISEASE M. Palladino1, G. Gammaitoni1, C. Santoro2, M. Muscaritoli1 | 1Medicina Interna e Nutrizione Clinica-Dip. Medicina Traslazionale e di Precisione; 2Ematologia- Dip. Medicina Traslazionale e di Precisione, Umberto I Roma, Italy
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PO76 | Thrombosis associated with midline in autoimmune patient: a case report on the use of apixaban in a real-world setting M.V. Cherchi, M. Anedda, S. Che, M. Vacca, M. Caboni, M. Mantega | Department of Internal Medicine, ASL Sulcis, Italy
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CO-68 | ACQUIRED FACTOR XIII DEFICIENCY ASSOCIATED WITH CROHN’S DISEASE: A CHALLENGING DIAGNOSTIC AND THERAPEUTIC CASE A. Colombo1, A. Dal Buono2|3, I. Quaglia1, C. Novembrino4, M.R. Fasulo1, C. Lodigiani1, M.E. Mancuso1|2 | 1Center for Thrombosis and Hemorrhagic Diseases, IRCCS Humanitas Research Hospital, Rozzano, Milano, Italy; 2Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milano, Italy; 3IBD Center, IRCCS Humanitas Research Hospital, Rozzano, Milano, Italy; 4Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico Angelo Bianchi Bonomi, Hemophilia and Thrombosis Center and Fondazione Luigi Villa, Milano, Italy
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PO018 | IS VESSEL-ON-CHIP COMPLEXITY WORTH IT? A QUANTITATIVE COMPARISON OF SIMPLIFIED AND COMPLEX HIGH-FIDELITY VASCULAR MODELS V. Guadagno1, T. Mencarini1, F. Vicinanza1, S. Bozzi1, E. Raschi2, C. Bodio2, P. Meroni2, A. Redaelli1 | 1Politecnico di Milano, Italy; 2Istituto Auxologico Italiano, Milano, Italy
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CO057 | THROMBOPOIETIN-PLATELET AXIS IN METABOLIC-ASSOCIATED STEATOTIC LIVER DISEASE M. Alfonsetti1, P. Simeone1, R. Liani1, M. Frezza1, B. Di Marco1, A. Cipollone1, C. Della Penna1, L. Cantagallo1, G. Ciferni1, L. Del Rosso1, M. Caporale1, S. Brandolino2, E. Vitacolonna2, P. Di Carlo3, F. Cipollone1, F. Santilli1 | 1Department of Medicine and Aging Sciences, Center for Advanced Studies and Technology (CAST), University of Chieti, Chieti, Italy, University General Medicine Division, Medical Department, SS. Annunziata Hospital, Chieti, Italy; 2Department of Medicine and Aging, School of Medicine and Health Sciences, G. d'Annunzio University, Chieti, Italy; 3Department of Innovative Technologies in Medicine & Dentistry, "G. d'Annunzio" University of Chieti-Pescara, Chieti, Italy
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CO43 | Early platelet dysfunction in sepsis: an ICU pilot study S. Sorrentino1, C. Gori2, L. D’Innocenzo1, M. De Siati1, Mg. Bocci3, E. De Candia1 | 1Unit of Haemostasis and Thrombosis Diseases, Fondazione Policlinico Universitario A. Gemelli, IRCCS, Roma; 2UOC Shock & Trauma, Azienda Ospedaliera San Camillo Forlanini, Roma; 3National Institute for Infectious Diseases, Lazzaro Spallanzani, IRCCS, Roma, Italy
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PO01 | MELANOMA-DERIVED EXTRACELLULAR VESICLES DRIVE VON WILLEBRAND FACTOR–DEPENDENT THROMBOSIS AND METASTASIS Y. Wang1|2, X. Liu1, T. Downar3, A. Topuz4, A. Bauer1, J. Kött1|5, K. Nekipelov6, S. Brenna7, G. Bendas6, B. Puig7, S. Schneider1, D. Fedosov4, C. Gorzelanny1 | 1Department of Dermatology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; 2Mildred Scheel Cancer Career Center HaTriCS4, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; 3Experimental Dermatology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany; 4Institute for Advanced Simulation (IAS-2), Forschungszentrum Jülich, Jülich, Germany; 5Fleur Hiege Center for Skin Cancer Research, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; 6Pharmaceutical Institute, University of Bonn, Bonn, Germany; 7Neurology Department, Experimental Research in Stroke and Inflammation (ERSI), University Medical Center Hamburg-Eppendorf, Hamburg, Germany
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CO072 | PERSISTENT ENDOTHELIAL THROMBOINFLAMMATORY PHENOTYPE IN PATENT FORAMEN OVALE: EVIDENCE FROM PATIENT-DERIVED ENDOTHELIAL COLONY-FORMING CELLS M. Conti1, D. Trabattoni1, F. Vieceli Dalla Sega2, F. Fortini2, A. Becchetti1, P. Della Valle1, M. Brambilla1, M. Chiesa1, C. Pericleous3, A. Randi3, E. Tremoli2, M. Camera1|4 | 1Centro Cardiologico Monzino IRCCS, Milano, Italy; 2Maria Cecilia Hospital, GVM Care & Research, Cotignola, Italy; 3Imperial College London, London, United Kingdom; 4Università degli Studi di Milano, Department of Pharmaceutical Sciences, Milano, Italy
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PO016 | TOLL-LIKE RECEPTOR 4-MEDIATED ENDOTHELIAL DYSFUNCTION VIA NOX2 ACTIVATION IN COVID-19 C. Nocella1|2, V. Castellani2, L. Loffredo1, V. Cammisotto1, S. Bartimoccia1, P. Pignatelli1, R. Carnevale3|4, F. Violi1 | 1Dip di Scienze Mediche e Cardiovascolari, Sapienza Università di Roma, Italy; 2Fondazione Cenci Bolognetti, Istituto Pasteur Italia, Italy; 3IRCCS Neuromed, Italy; 4Dip di Scienze e Biotecnologie Medico-Chirurgiche, Sapienza Università di Roma, Italy
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