Thrombophilia work-up and clinical outcomes in Indian patients with unprovoked venous and arterial thrombosis aged 18-50 years | BTVB Bioequivalence of von Willebrand factor-containing concentrates: implications for von Willebrand disease | BTVB Cardiovascular risk in hormone replacement therapy | BTVB Direct oral anticoagulants: does one dose fit all? Why, when and how testing | BTVB Cardiovascular risk profile evolution over 15 years: CV-PREVITAL vs Moli-sani Study | BTVB Launch of National Registry for Congenital Hematological Disorders in Palestine: Haemo-PAL | BTVB
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Bleeding, Thrombosis and Vascular Biology

Editor-in-Chief: Giovanni de Gaetano, Italy | eISSN: 2785-5309

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  • The landscape of rare coagulation factor deficiency management in Italy: a national hemophilia center survey

    Silvia Linari, Renato Marino, Marzia Leotta, Antonio Coppola, Patrizia Di Gregorio, Augusto Bramante Federici, Flora Peyvandi, Cristina Santoro, Ezio Zanon, Rita Carlotta Santoro
    05-11-2025
    https://doi.org/10.4081/btvb.2025.369
    1017
    PDF: 131
    HTML: 37
    Appendix: 60
  • The key to fibrinolysis and thrombolysis

    Roger Lijnen, Désiré Collen
    09-09-2025
    https://doi.org/10.4081/btvb.2025.368
    1495
    PDF: 254
    HTML: 123
  • Diagnostic and management practices for inherited fibrinogen disorders: a nationwide survey of Italian Hemophilia Treatment Centers

    Renato Marino, Silvia Linari, Marzia Leotta, Antonio Coppola, Chiara Biasoli, Maria Elisa Mancuso, Flora Peyvandi, Cristina Santoro, Ezio Zanon, Rita Carlotta Santoro
    02-12-2025
    https://doi.org/10.4081/btvb.2025.372
    424
    PDF: 60
    HTML: 39
    Supplementary: 19
    Appendix: 34
  • Bioequivalence of von Willebrand factor-containing concentrates: implications for the choice in patients with von Willebrand disease. A position paper from the Italian Association of Hemophilia Centers

    Ezio Zanon, Giancarlo Castaman, Augusto Bramante Federici, Maria Elisa Mancuso, Gianfranco Pasut, Alberto Tosetto, Angiola Rocino, Rita Carlotta Santoro
    26-01-2026
    https://doi.org/10.4081/btvb.2026.415
    758
    PDF: 239
    HTML: 58
  • CO19 | Hypercoagulability in wild-type transthyretin amyloidosis: evidence from whole blood thromboelastometry A. Napolitano1, L. Spiezia1, C. Samà1, A. Benetti1, G. Sinigiani2, L. De Michieli2, A. Cipriani2, P. Simioni1 | 1First Chair of Internal Medicine, Department of Medicine, University Hospital of Padua; 2Department of Cardiothoracic and Vascular Sciences & Public Health, University Hospital of Padua, Italy

    22-10-2025
    https://doi.org/10.4081/btvb.2025.223
    438
    PDF: 0
  • PO33 | Whole blood hypercoagulable profiles in patients with rheumatoid arthritis L. Spiezia1, A. Giollo2, C. Samà1, A. Benetti1, L. Di Luozzo2, M. Salvato2, A. Doria2, P. Simioni1 | 1First Chair of Internal Medicine, Thrombotic and Hemorrhagic Diseases Unit, Department of Medicine, University Hospital of Padova; 2Rheumatology Unit, Department of Medicine, University Hospital of Padova, Italy

    22-10-2025
    https://doi.org/10.4081/btvb.2025.296
    476
    PDF: 0
  • Anticoagulation in obese patients: challenges and strategies

    Alice Lipari, Esmeralda Capristo, Antonietta Ferretti, Erica De Candia
    18-09-2025
    https://doi.org/10.4081/btvb.2025.174
    1824
    PDF: 261
    HTML: 195
    XML: 77
  • CO37 | Assessment of clotting factor activity and sterility in thawed fresh frozen plasma supplied to helicopter emergency medical services for prehospital transfusion D. Romeo1, M. Marchetti1,2, M. Testa1, A. Motta1, P. Gomez-Rosas1, G. Ravasio1, F. Daminelli3, L. Barcella1, A. Falanga1,2 | 1Immunohematology and Transfusion Medicine Department, Hospital Papa Giovanni XXIII, Bergamo; 2School of Medicine and Surgery, University Milano Bicocca, Milan; 3Anesthesia and Resuscitation Department, Hospital Papa Giovanni XXIII, Bergamo, Italy

    22-10-2025
    https://doi.org/10.4081/btvb.2025.244
    514
    PDF: 0
  • Thrombin generation assay in COVID-19 patients shows a hypocoagulable pattern

    Giovanni L. Tiscia, Donatella Colaizzo, Antonio De Laurenzo, Filomena Cappucci, Lucia Fischetti, Elena Chinni, Mario Mastroianno, Giovanni Favuzzi, Massimo Carella, Elvira Grandone
    22-10-2024
    https://doi.org/10.4081/btvb.2024.145
    2300
    PDF: 404
    Supplementary: 222
  • PO68 | Whole blood hypercoagulable profiles in a patient with markedly elevated lipoprotein(A) plasma levels and thrombotic complications: a case report C. Portinari, M. Biolo, A. Napolitano, L. Spiezia, A. Colpo, S. Zambon, A. Zambon, P. Simioni | Department of Medicine, Padova University Hospital, Padova, Italy

    22-10-2025
    https://doi.org/10.4081/btvb.2025.337
    498
    PDF: 0
  • PO69 | Whole blood thrombin generation hypercoagulable profile in a patient with hemolytic crisis due to paroxysmal nocturnal hemoglobinuria: a case report A. Napolitano, L. Spiezia, C. Bulato, E. Campello, P. Simioni | First Chair of Internal Medicine, Department of Medicine, University-Hospital of Padua Medical School, Padua, Italy

    22-10-2025
    https://doi.org/10.4081/btvb.2025.338
    540
    PDF: 0
  • CO21 | Viscoelastic testing in inherited bleeding disorders: a cross-sectional comparison between viscoelastic coagulation monitoring and rotational thromboelastometry C. Simion, C. Samà, C. Bulato, G. Gottardi, D. Regazzo, E. Campello, P. Simioni | Department of Medicine – DIMED, University of Padua, Italy

    22-10-2025
    https://doi.org/10.4081/btvb.2025.227
    470
    PDF: 0
  • PO71 | How the presence of paraproteins can interfere in coagulation tests: case report M. Gagliardi, L. Capone, A. Ciampa | Centro Emostasi, AORN Moscati, Avellino, Italy

    22-10-2025
    https://doi.org/10.4081/btvb.2025.340
    511
    PDF: 0
  • PO26 | Non-canonical coagulation platelets function: monocyte-platelet interaction a bridge between inflammation and coagulation A. Benetti1, A. Galbiati1, M. Cola2, L. Calandrino2, C. Samà1, D. Regazzo1, S. Ferrari1, C.M. Radu1, A. Cattelan2, P. Simioni1 | 1Department of Medicine - DIMED; 2Infectious and Tropical Diseases Unit, Padua University Hospital, Padua, Italy

    22-10-2025
    https://doi.org/10.4081/btvb.2025.287
    475
    PDF: 0
  • CO15 | Longitudinal coagulation profiling of individuals undergoing gender-affirming hormone therapy: the hyper-gender study A. Napolitano, E. Campello, A. Scala, C. Simion, C. Bulato, S. Gavasso, C. Samà, A. Benetti, S. Toffanin, G. Faggian, R. Scafa, A. Garolla, P. Simioni | First Chair of Internal Medicine, Department of Medicine, University Hospital of Padua; Unit of Andrology and Reproductive Medicine, Department of Medicine, University Hospital of Padua, Italy

    22-10-2025
    https://doi.org/10.4081/btvb.2025.219
    504
    PDF: 0
  • The small numbers of medicine and the big numbers of artificial intelligence: a curated-data approach to appropriateness in laboratory medicine and coagulation

    Anna Mazzetto, Alessandro Camerotto
    15-04-2026
    https://doi.org/10.4081/btvb.2026.460
    0
    PDF: 0
  • PO65 | Utilization of emicizumab in acquired hemophilia A: a case report C. Caputo, P. Conca, I.L. Calcaterra, E. Cimino, M. Romeo, M. Aversano, E. Franco, C. De Luca, G. D’errico, L. Jr Valletta, M. Di Minno, A. Tufano | Department of Clinical Medicine and Surgery, Federico II University, Naples, Italy

    22-10-2025
    https://doi.org/10.4081/btvb.2025.334
    466
    PDF: 0
  • PO75 | Prophylaxis with RFXIII: a clinical case in a pediatric patient with congenital FXIII deficiency and delayed diagnosis M.L. Tramontano, M. Coppola, S. Coppola, M. Schiavulli | UOSD Centro Regionale Pediatrico Malattie della Coagulazione. Santobono Pausilipon Children Hospital, AORN, Napoli, Italy

    22-10-2025
    https://doi.org/10.4081/btvb.2025.344
    468
    PDF: 0
  • PO58 | Gender differences in primary haemostasis A. Becchetti2, M. Brambilla2, M. Conti2, D. Trabattoni2, E. Tremoli3, M. Camera1,2 | 1Department of Pharmaceutical Sciences, Università degli Studi di Milano; 2Centro Cardiologico Monzino IRCCS, Milan; 3Maria Cecilia Hospital, Cotignola (RA), Italy

    22-10-2025
    https://doi.org/10.4081/btvb.2025.327
    501
    PDF: 0
  • CO52 | The impact of KRAS mutations on the risk of recurrent venous thromboembolism in patients with cancer-associated thrombosis and gastrointestinal neoplasms B. Cosmi1,2, S. Cavara2, M. Soldati2, L. Borgese2, M. Sartori2 | 1Angiology and Blood Coagulation Unit, Department of Medical and Surgical Sciences, University of Bologna; 2Angiology and Blood Coagulation Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Italy

    22-10-2025
    https://doi.org/10.4081/btvb.2025.262
    460
    PDF: 0
  • CO14 | Inflammation and fibrinolysis biomarkers as predictors of cancer risk in healthy subjects: results from the hypercan study C. Ticozzi1, S. Bolognini1,2, P. Gomez-Rosas1,3, L. Russo1,2, Cj. Tartari1,2, F. Schieppati1,2, G. Sampietro4, L. Barcella1, M. Marchetti1,2, A. Falanga1,2 | 1Immunohematology and Transfusion Medicine, Hospital Papa Giovanni XXIII, Bergamo, Italy; 2School of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy; 3Maastricht University Medical Center, Cardiovascular Research Institute Maastricht, Maastricht, The Netherlands; 4Unit of Epidemiology and Statistics, ATS Bergamo, Italy

    22-10-2025
    https://doi.org/10.4081/btvb.2025.218
    490
    PDF: 0
  • Launch of a National Registry for Congenital Hematological Disorders in Palestine: the Haemo-PAL Initiative

    Fabio Candura, Emanuela Marchesini, Gian Luca Forni, Alessandro Gringeri, Ilaria Gentilini, Mirko Tricoli, Osama Najjar, Luciana Teofili
    15-01-2026
    https://doi.org/10.4081/btvb.2026.417
    778
    PDF: 164
  • PO74 | Combined therapeutic approaches in a patient with hereditary hemorrhagic telangiectasia (HHT) and cardiovascular comorbidities M. Romeo, E. Cimino, P. Conca, I.L. Calcaterra, G. Iannuzzo, C. Caputo, M. Aversano, E. Franc, S. Donnarumma, C. De Luca, M.N.D. Di Minno, A. Tufano | Department of Clinical Medicine and Surgery, Federico II University, Naples, Italy

    22-10-2025
    https://doi.org/10.4081/btvb.2025.343
    576
    PDF: 0
  • PO78 | Acquired hemophilia A as a paraneoplastic syndrome: two cases report on a rare coexistence M. Gagliardi, L. Capone, A. Ciampa | Centro Emostasi, AORN Moscati, Avellino, Italy

    22-10-2025
    https://doi.org/10.4081/btvb.2025.347
    472
    PDF: 0
  • A re-appraisal of thrombogenesis in COVID-19, seen as a multiple "Complex system"

    Sergio Coccheri
    24-10-2022
    https://doi.org/10.4081/btvb.2022.48
    2025
    PDF: 346
  • PO25 | Baseline thrombin generation test does not predict thrombotic events in acute leukemia: a monocentric prospective study M. Biglietto, R. Mormile, M.L. Bisegna, A. Laganà, A. L. Faccini, A. Papa, E. Baldacci, C. Santoro, M.S. De Propris, A. Chistolini | Hematology, Department of Translational and Precision Medicine Sapienza University of Roma, Italy

    22-10-2025
    https://doi.org/10.4081/btvb.2025.286
    501
    PDF: 0
  • CS01 | Elucidating the evil relationship of metabolic dysfunction–associated fatty liver disease with cardiovascular comorbidities: the complex interplay among hypercoagulability, inflammation and liver fibrosis G. Gagliardi, E. Campello, A. Napolitano, B. Stocco, C. Di Gesù, G. Gobbo, I. Condonato, M. Allegra, G. Camporese, P. Scarinzi, R. Pesavento, F. Bilora, C. Bulato, A. Benetti, C. Samà, C. Portinari, G. Antonello, C. Goffi, L. Di Daniel, A. Zambon, L. Fabris, P. Simioni | First Chair of Internal Medicine, Department of Medicine, University-Hospital of Padua Medical School, Padua, Italy

    22-10-2025
    https://doi.org/10.4081/btvb.2025.196
    640
    PDF: 0
  • PO01 | Diagnosis of inherited platelet function disorders by platelet aggregometry using a fully automated coagulation analyzer E. Falcinelli1, A.M. Mezzasoma1, L. Bury1, R. Martini1, I. Tano1, A. Rechner2, P. Gresele1 | 1Department of Medicine, Section of Internal and Cardiovascular Medicine, University of Perugia, Italy; 2Sysmex Europe, Germany

    22-10-2025
    https://doi.org/10.4081/btvb.2025.311
    479
    PDF: 0
  • PO39 | Bleeding events in Von Willebrand disease type 1 yearly treatable with desmopressin A. Gringeri1,2, P.M. Mannucci3, M. Gringeri4, G. Castaman5, F. Peyvandi3,6 | 1Fondazione Charta, Milan; 2Centro di Sanità Solidale, Lucca; 3Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Angelo Bianchi Bonomi Hemophilia and Thrombosis Center and Fondazione Luigi Villa, Milan; 4Department of Medical Biotechnologies and Translational Medicine, Postgraduate School of Clinical Pharmacology and Toxicology, University of Milan; 5Centre for Bleeding Disorders and Coagulation, Careggi University Hospital, Firenze; 6Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Italy

    22-10-2025
    https://doi.org/10.4081/btvb.2025.302
    491
    PDF: 0
  • CO32 | Major surgery in patients with severe hemophilia A without inhibitors receiving prophylaxis with fitusiran E. Zanon, C. Simion, A. Napolitano, L. Spiezia, P. Simioni | Haemophilia Center, First Chair of Internal Medicine, Department of Medicine, University-Hospital of Padua Medical School, Padua, Italy

    22-10-2025
    https://doi.org/10.4081/btvb.2025.239
    410
    PDF: 0
  • The changing landscape of treatment for acquired hemophilia A

    Massimo Franchini, Daniele Focosi
    30-01-2025
    https://doi.org/10.4081/btvb.2025.157
    1794
    PDF: 451
  • CO06 | Recurrences of catheter associated upper extremity deep vein thrombosis in cancer: a two year prospective study with enoxaparin M. Sartori, A. Trentini, S. Cavara, L. Borgese, M. Soldati, B. Cosmi | Angiology and Blood Coagulation Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Italy

    22-10-2025
    https://doi.org/10.4081/btvb.2025.210
    517
    PDF: 0
  • Management of anticoagulation in atrial fibrillation patients in Italy: insight from the Atrial Fibrillation-Survey on Anticoagulated Patients Register (AF-START)

    Daniela Poli, Walter Ageno, Emilia Antonucci, Salvatore Bradamante, Eugenio Bucherini, Paolo Chiarugi, Antonio Chistolini, Benilde Cosmi, Anna Falanga, Antonio Insana, Domenico Lione, Rosa Maria Lombardi, Giuseppe Malcangi, Rossella Marcucci, Giuliana Martini, Lucilla Masciocco, Carmelo Paparo, Daniele Pastori, Simona Pedrini, Vittorio Pengo, Pasquale Pignatelli, Andrea Toma, Sophie Testa, Gualtiero Palareti
    27-06-2023
    https://doi.org/10.4081/btvb.2023.84
    1788
    PDF: 501
    Supplementary File: 226
  • CS06 | Patient specific iPSCs-derived sinusoidal endothelial cells for phenotypic correction of haemophilia A A. Benetti1, C.M. Radu1, C. Samà1, M. Trevisan2, C. Simion1, E. Campello1, P. Simioni1 | 1Department of Medicine - DIMED, Padua University Hospital; 2Department of Molecular Medicine, University of Padua, Italy

    22-10-2025
    https://doi.org/10.4081/btvb.2025.203
    546
    PDF: 0
  • PO22 | Early detection and management of PICC-related thrombosis in oncohematologic patients through serial ultrasound monitoring: a prospective observational study S. Laurenti, M. Schneeberger, G. Rosati, A. Pozzi, M. Padrini, R. Vacchelli, A. Morotti | University of Turin, AUO San Luigi Gonzaga, Orbassano (TO), Italy

    22-10-2025
    https://doi.org/10.4081/btvb.2025.282
    461
    PDF: 0
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Vol. 5 No. 1 (2026)
A lifetime in biomedical research: an interview with Silvio Garattini
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10 March 2026

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Bleeding, Thrombosis and Vascular Biology

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