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Bleeding, Thrombosis and Vascular Biology

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  • Persistence of functional anti-PF4 antibodies and neutrophil activation in vaccine-induced immune thrombotic thrombocytopenia

    Eleonora Petito, Anna Maria Mezzasoma, Emanuela Falcinelli, Chiara Conti, Erica De Candia, Raimondo De Cristofaro, Silvia Sorrentino, Gian Marco Podda, Mariangela Scavone, Anna Falanga, Marina Marchetti, Luca Barcella, Stefania Basili, Lucia Stefanini, Andrea Boccatonda, Laura Contino, Patrizia Sciancalepore, Igor Florio, Egidio Imbalzano, Rossella Marcucci, Angela Rogolino, Patrizia Noris, Marta Panella, Rita Santoro, Maria Costanza Turi, Gaetano Vaudo, Rosa Curcio, Paolo Gresele
    18-11-2025
    https://doi.org/10.4081/btvb.2025.400
    680
    PDF: 116
    HTML: 67
  • Cancer complicated by thrombosis and thrombocytopenia: still a therapeutic dilemma

    Yishi Tan, Marc Carrier, Nicola Curry, Michael Desborough, Kathryn Musgrave, Marie Scully, Tzu-Fei Wang, Mari Thomas, Simon J. Stanworth
    16-05-2024
    https://doi.org/10.4081/btvb.2024.115
    1258
    PDF: 844
  • Recent advances in classic heparin-induced thrombocytopenia (HIT), autoimmune HIT, spontaneous HIT, and vaccine-induced immune thrombotic thrombocytopenia

    Bianca Clerici, Mariangela Scavone, Gian Marco Podda
    20-06-2024
    https://doi.org/10.4081/btvb.2024.127
    2606
    PDF: 710
  • Anticoagulation challenges in patients with hematological malignancy-associated thrombosis and severe thrombocytopenia

    Emilie Chalayer, Géraldine Poenou, Corinne Frere
    16-04-2026
    https://doi.org/10.4081/btvb.2026.429
    104
    PDF: 62
  • Long-term persistence of high anti-PF4 antibodies titer in a challenging case of AZD1222 vaccine-induced thrombotic thrombocytopenia

    Luca Barcella, Chiara Ambaglio, Paolo Gritti, Francesca Schieppati, Varusca Brusegan, Eleonora Sanga, Marina Marchetti, Luca Lorini, Anna Falanga
    28-06-2023
    https://doi.org/10.4081/btvb.2023.72
    1083
    PDF: 361
  • PO61 | ACTN1-related thrombocytopenia and severe hyperhomocysteinemia: a case report A. Pozzi, G. Rosati, M. Padrini, S. Laurenti, G. Ferrari, R.M. Medici, C. Barale, I. Russo, A. Morotti | University of Turin, San Luigi Hospital, Orbassano (TO), Italy

    22-10-2025
    https://doi.org/10.4081/btvb.2025.330
    457
    PDF: 0
  • Vaccine-induced immune thrombotic thrombocytopenia following ChAdOx1 nCoV-19 vaccine: report of two cases

    Rita Carlotta Santoro, Roberto Minici, Marzia Leotta, Mariapia Falbo, Lucia Concetta Elia, Francesca Leo, Antonella Ierardi, Alessandra Strangio, Simona Prejanò
    23-05-2022
    https://doi.org/10.4081/btvb.2022.23
    4296
    PDF: 0
  • PO95 | Idiopathic thrombocytopenic purpura in tuberculosis M. Shani | Università di Medicina Tirana, Albania

    22-10-2025
    https://doi.org/10.4081/btvb.2025.365
    535
    PDF: 0
  • PO80 | Heparin-induced thrombocytopenia: a monocentric experience with danaparoid L. D’Innocenzo, S. Sorrentino, M. De Siati, A. Ferretti, E. De Candia | Unit of Haemostasis and Thrombosis Diseases, Fondazione Policlinico Universitario A. Gemelli, IRCCS, Roma, Italy

    22-10-2025
    https://doi.org/10.4081/btvb.2025.349
    573
    PDF: 0
  • CO44 | First interlaboratory validation workshop of immunofluorescence microscopy on the peripheral blood smear for recognizing patients with inherited platelet disorders C. Zaninetti1, L. Bury2, V. Bozzi3, A. Zamora-Cánovas4, K. Althaus5, G. Uzun5, S. Brown6, A. Norman6, D. Faille7, A. Stepanian8, C. Freyer1, L. Kager9, T. Bakchoul5, A. Pecci3, P. Gresele2, T. Thiele1, J. Rivera4, A. Greinacher1 | 1Institut für Immunologie und Transfusionsmedizin, Universitätsmedizin Greifswald, Germany; 2Department of Medicine, Section of Internal and Cardiovascular Medicine, University of Perugia, Italy; 3Department of Internal Medicine, University of Pavia, Italy; General Medicine 1, IRCCS Policlinico San Matteo Foundation, Pavia, Italy; 4Servicio de Hematología, Hospital Universitario Morales Meseguer, Centro Regional de Hemodonacio´n, Universidad de Murcia, Spain; 5Institute for Clinical and Experimental Transfusion Medicine, University Hospital of Tuebingen, Germany; Center for Clinical Transfusion Medicine, Tuebingen, Germany; 6Centre for Children’s Health and Research CCHR, South Brisbane, Australia; 7Laboratoire d’Hématologie, Assistance Publique Hôpitaux de Paris, Hôpital Bichat-Claude-Bernard, Paris, France; 8AP-HP, Service d’Hématologie Biologique, Hôpital Lariboisière, Paris Cité University, Paris, France; 9St. Anna Kinderspital, Universitätsklinik für Kinder- und Jugendheilkunde der Medizinischen Universität Wien, Austria

    22-10-2025
    https://doi.org/10.4081/btvb.2025.250
    476
    PDF: 0
  • CO43 | Early platelet dysfunction in sepsis: an ICU pilot study S. Sorrentino1, C. Gori2, L. D’Innocenzo1, M. De Siati1, Mg. Bocci3, E. De Candia1 | 1Unit of Haemostasis and Thrombosis Diseases, Fondazione Policlinico Universitario A. Gemelli, IRCCS, Roma; 2UOC Shock & Trauma, Azienda Ospedaliera San Camillo Forlanini, Roma; 3National Institute for Infectious Diseases, Lazzaro Spallanzani, IRCCS, Roma, Italy

    22-10-2025
    https://doi.org/10.4081/btvb.2025.249
    525
    PDF: 0
  • “Living under the sword of Damocles”: a psychological support project for patients with immune thrombocytopenia and their caregivers

    Giuseppe Auteri, Laura Ricci, Nicola Vianelli, Barbara Lovrencic
    13-03-2025
    https://doi.org/10.4081/btvb.2025.161
    848
    PDF: 286
    Appendix A: 95
    Appendix B: 120
  • PO79 | Trying to hit the hit in the shadow of renal failure: a complex case managed with danaparoid S. Chessa1,2, M. Anedda2, M.V. Cherchi2, M. Vacca1,2, M. Caboni2, J. Pilia2, A.M. Bussu2, M. Mantega2, G. Costanzo1, D. Firinu1, S. Del Giacco1, A. Mameli3, D. Barcellona3 | 1Department of Medical Science and Public Health, University of Cagliari; 2Internal Medicine, ASL Sulcis, PO Sirai, Carbonia; 3Department of Medical Sciences and Public Health, Hemostasis and Thrombosis Unit, University of Cagliari and AOU of Cagliari, Italy

    22-10-2025
    https://doi.org/10.4081/btvb.2025.348
    553
    PDF: 0
  • Safety of COVID-19 mRNA vaccination in patients with history of acquired hemophilia A: a case series

    Luca Puccetti, Vincenzo Sammartano, Federico Caroni, Margherita Malchiodi, Paola Calzoni, Eleonora Franceschini, Lucrezia Galasso, Monica Bocchia
    17-10-2022
    https://doi.org/10.4081/btvb.2022.40
    2877
    PDF: 353
  • 29th National Conference of the Italian Society for the Study of Hemostasis and Thrombosis, 2025

    Guest Editor: Valerio De Stefano
    22-10-2025
    https://doi.org/10.4081/btvb.2025.408
    719
  • PO34 | A negative oncologic follow up doesn’t always really mean no cancer: two case report of cancer-associated thrombotic microangiopathy E. Cosi, A. Bertomoro, G. Bogoni, I. Bertozzi, I. Cortella, P. Simioni | Clinica Medica ORI, Azienda Ospedale-Università Padova, DIDAS, Italy

    22-10-2025
    https://doi.org/10.4081/btvb.2025.297
    484
    PDF: 0
  • PO92 | Challenging management of portal vein thrombosis in a cirrhotic patient on hormone therapy after breast cancer L. Jr Valletta, C. De Luca, M. Aversano, C. Caputo, E. Cimino, P. Conca, A. Tufano, M.D. Di Minno | AOU Federico II Napoli, Italy

    22-10-2025
    https://doi.org/10.4081/btvb.2025.362
    477
    PDF: 0
  • CS08 | A combination of two rapid immunoassays improves HIT diagnosis G. Ciarrocca Taranta1, A. Rogolino2, A. Bertelli1, A. Sorrentino1, M. Di Gioia2, F. Cesari2, B. Giusti1,2, E. Sticchi1,2, M. Berteotti1,2, A.M. Gori1,2, R. Marcucci1,2 | 1Department of Experimental and Clinical Medicine, University of Firenze; 2Atherothrombotic Disease Unit, Careggi University Hospital, Firenze, Italy

    22-10-2025
    https://doi.org/10.4081/btvb.2025.205
    583
    PDF: 0
  • PO63 | Atypical venous thrombosis in young patient with systemic lupus erythematosus and high-risk APL profile: provoked or not? E. Marrone, A. Parisi, G. Di Monda, F. Gallucci, D. Morelli, C. Romano, U. Malgeri, D. D’Auria, P. Morella | Internal Medicine Unit 3, Cardarelli Hospital, Naples, Italy

    22-10-2025
    https://doi.org/10.4081/btvb.2025.332
    486
    PDF: 0
  • CO50 | Diagnostic accuracy of the heparin-induced multiple electrode aggregometry (HIMEA) functional test for heparin-induced thrombocytopenia M. Bovara1, M. Sebastiani2, Am. Gori3,4, A. Rogolino3,4, A. Bertelli3,4, G. Ciarrocca Taranta3,4, R. Marcucci3,4, M. Sartori5, B. Cosmi5, M. Silingardi6, A. M. Pizzini6, A. Marrocchi1, R. Mancini1 | 1Laboratorio Unico Metropolitano Ospedale Maggiore, AUSL Bologna; 2IRCCS Istituto delle Scienze Neurologiche, Bologna; 3Centro Malattie Aterotrombotiche Azienda Ospedaliera Universitaria Careggi, Firenze; 4Dipartimento di Medicina Sperimentale e Clinica, Università di Firenze; 5U.O. di Angiologia e Malattie della Coagulazione dell’Azienda Ospedaliero Universitaria Policlinico S. Orsola-Malpighi, Bologna; 6Medicina Interna Ospedale Maggiore, Bologna, Italy

    22-10-2025
    https://doi.org/10.4081/btvb.2025.260
    500
    PDF: 0
  • Anticoagulation in obese patients: challenges and strategies

    Alice Lipari, Esmeralda Capristo, Antonietta Ferretti, Erica De Candia
    18-09-2025
    https://doi.org/10.4081/btvb.2025.174
    1874
    PDF: 283
    HTML: 218
    XML: 91
  • OC08 | A SILK-BASED 3D BONE MARROW MODEL FOR CHEMOTHERAPY-INDUCED THROMBOCYTOPENIA C.A. Di Buduo, M. Migliavacca, A. Malara, A. Balduini | Department of Molecular Medicine, University of Pavia, Italy

    Società Italiana di Emostasi e Trombosi
    16-04-2026
    https://doi.org/10.4081/btvb.2026.491
    121
    PDF: 30
  • CO17 | Clinical relevance of isolated anti-phosphatidylserine/ prothrombin antibody positivity A. Hoxha1, P. Žigon2,3, L. Katja2,3, S. Čučnik2,4, Ž. Rotar2,5, S. Gavasso1, P. Zerbinati1, G. Gobbo1, P. Simioni1 | 1University of Padua, Internal Medicine Unit, Thrombotic and Hemorrhagic Centre, Department of Medicine-DIMED, Padua, Italy; 2University Medical Centre Ljubljana, Department of Rheumatology, Ljubljana, Slovenia; 3University of Primorska, Faculty of Mathematics, Natural Sciences and Information Technologies, Koper, Slovenia; 4University of Ljubljana, Faculty of Pharmacy, Ljubljana, Slovenia; 5University of Ljubljana, Faculty of Medicine, Ljubljana, Slovenia

    22-10-2025
    https://doi.org/10.4081/btvb.2025.221
    521
    PDF: 0
  • Preface to the 13th International Conference on Thrombosis and Hemostasis Issues in Cancer, 2026

    Anna Falanga, Benjamin Brenner, Alok A. Khorana
    16-04-2026
    https://doi.org/10.4081/btvb.2026.479
    163
    PDF: 106
  • Venous thromboembolism treatment in patients with cancer: reflections on an evolving landscape

    Agnes Y.Y. Lee
    29-02-2024
    https://doi.org/10.4081/btvb.2024.111
    1962
    PDF: 1017
  • PO64 | A silent hemorrhage in the immuno-thrombotic chaos of antiphospholipid syndrome G. Autiero, S.A. Malerba, A. Malaguti, M. Dalla Vestra, F. Presotto | Medicina Generale, Ospedale dell’Angelo, Mestre-Venezia, Italy

    22-10-2025
    https://doi.org/10.4081/btvb.2025.333
    543
    PDF: 0
  • PO82 | Retrospective application of the TH2 score in a multicenter cohort of ITP patients: a reliable predictive tool or a score in need of refinement? C. Giubbilei1, M. Defina2, S. Rosati3, M. Rocco3, A. Votto4, F. Simonetti5, F. Paoletti6, V. Carrai1 | 1Hematology Unit, AOU Careggi; 2Hematology unit AOU Senese; 3Hematology Unit Azienda Sanitaria Toscana Centro; 4Hematology Unit, AOU Pisana; 5Hematology Unit, Ospedale Versilia; 6Hematology Unit, Azienda Sanitaria Nord Ovest, Italy

    22-10-2025
    https://doi.org/10.4081/btvb.2025.351
    473
    PDF: 0
  • PO03 | Enlarged platelets with reduced GP IB/IX can indicate disorders other than Bernard-Soulier syndrome C. Zaninetti1, A. Marín-Quilez2, S. Semenowitsch1, A. Sánchez-Fuentes2, A. Zamora-Cánovas2, P. Gómez-González2, E. Birgitte Leinøe3, N. Fernández-Mosteirin4, T. Murciano5,6, C. Freyer1, T. Thiele1, J. Rivera2,7, A. Greinacher1 | 1Universitätsmedizin Greifswald, Institut Für Transfusionsmedizin, Greifswald, Germany; 2Universidad De Murcia, Servicio De Hematología, Hospital Universitario Morales Meseguer, Centro Regional De Hemodonacion, Imib-Pascual Parrilla, Ciberer-U765, Murcia, Spain; 3Rigshospitalet University Hospital, Department of Haematology and Department of Genomic Medicine, Copenhagen, Denmark; 4Hospital Universitario Miguel Servet, Servicio De Hematología, Zaragoza, Spain; 5Hospital Universitario Vall D’Hebron, Servicio De Oncología y Hematología Pediatricas; 6Vall D’Hebron Institut De Recerca, Barcelona, Spain; 7Grupo Español De Alteraciones Plaquetarias Congénitas, Murcia, Spain

    22-10-2025
    https://doi.org/10.4081/btvb.2025.265
    460
    PDF: 0
  • PO41 | VENOUS THROMBOEMBOLISM IN PERIPHERAL BLOOD STEM CELL COLLECTION. A SINGLE CENTER EXPERIENCE P. Holly1, J. Hudecek1, J. Chudej1, L. Valekova1, I. Plamenova1, E. Flochova1, R. Simonova1, J. Sokol1, J. Stasko1, M. Pietrzykova1|2, E. Vescecikova2 | 1Department of Hematology and Transfusion Medicine, University Hospital in Martin, Martin, Slovakia; 2National Transfusion Service, Martin, Slovakia

    Società Italiana di Emostasi e Trombosi
    16-04-2026
    https://doi.org/10.4081/btvb.2026.535
    125
    PDF: 25
  • How to manage antithrombotic treatments in thrombocytopenic patients with cancer. Comments on the European Haematology Association guidelines

    Anna Falanga, Hugo Ten Cate, Bianca Rocca
    27-01-2023
    https://doi.org/10.4081/btvb.2023.60
    1128
    PDF: 447
  • PO62 | Management of anticoagulation during extracorporeal circulation in a patient with APS T. Marrazzo1, C. Marra2, A. Caiazzo2, I. Mattucci2, L. Verniero3, N. Galdieri3, M.P. Ursi4, R. Albisinni5 | 1UOC Medicina Interna e dei Trapianti, Ospedale Monaldi Azienda dei Colli, Napoli; 2UOSD di Cardiochirurgia dei Trapianti, Ospedale Monaldi Azienda dei Colli, Napoli; 3UOSD Terapia Intensiva di CCH Ospedale Monaldi Azienda dei Colli, Napoli; 4UOC MECAU Ospedale CTO Azienda dei Colli, Napoli; 5UOC CCH generale Ospedale Monaldi Azienda dei Colli, Napoli, Italy

    22-10-2025
    https://doi.org/10.4081/btvb.2025.331
    495
    PDF: 0
  • PO23 | IMMUNE THROMBOTIC THROMBOCYTOPENIC PURPURA RELATED TO DELAYED IMMUNE CHECKPOINT INHIBITORS TOXICITY: A CASE REPORT E. Galimberti1, F. Schieppati1, C. Ambaglio1, M. Marchetti1, L. Barcella1, A. Falanga1|2 | 1Immunohematology and Transfusion Medicine Unit, ASST Papa Giovanni XXIII, Bergamo, Italy; 2School of Medicine and Surgery, University of Milan-Bicocca, Milano, Italy

    Società Italiana di Emostasi e Trombosi
    16-04-2026
    https://doi.org/10.4081/btvb.2026.518
    124
    PDF: 26
  • Venous thromboembolism and mortality in patients with hematological malignancies

    Kristen M. Sanfilippo, Tzu-Fei Wang
    16-05-2024
    https://doi.org/10.4081/btvb.2024.119
    1316
    PDF: 700
  • PO75 | Prophylaxis with RFXIII: a clinical case in a pediatric patient with congenital FXIII deficiency and delayed diagnosis M.L. Tramontano, M. Coppola, S. Coppola, M. Schiavulli | UOSD Centro Regionale Pediatrico Malattie della Coagulazione. Santobono Pausilipon Children Hospital, AORN, Napoli, Italy

    22-10-2025
    https://doi.org/10.4081/btvb.2025.344
    499
    PDF: 0
  • PO60 | Asymptomatic PNH clone in acquired aplasia (AA) E. Marrone1, U. Valentino1, C. Mastrobuoni1, A. Abate1, A. Magliocca1, F. Cinque1, R. Buono1, M. Annunziata2, A. Picardi3, P. Morella1 | 1UOC Medicina 3, 2UOC Ematologia, 3UOC Ematologia, e Trapianto, AORN A. Cardarelli, Napoli, Italy

    22-10-2025
    https://doi.org/10.4081/btvb.2025.329
    455
    PDF: 0
  • OC05 | TIME TO START OF ANTICOAGULANT THERAPY AND SURVIVAL OUTCOMES IN CANCER PATIENTS WITH PULMONARY EMBOLISM K. Bria, B. Gage, M. Bealsey, K. Sanfilippo | Washington University in St. Louis School of Medicine, St. Louis, MO, USA

    Società Italiana di Emostasi e Trombosi
    16-04-2026
    https://doi.org/10.4081/btvb.2026.489
    135
    PDF: 39
  • Factor XI inhibitors: a new option for the prevention and treatment of cancer-associated thrombosis

    Marcello Di Nisio, Matteo Candeloro, Nicola Potere, Ettore Porreca, Jeffrey I. Weitz
    16-05-2024
    https://doi.org/10.4081/btvb.2024.118
    1681
    PDF: 952
  • PO69 | Whole blood thrombin generation hypercoagulable profile in a patient with hemolytic crisis due to paroxysmal nocturnal hemoglobinuria: a case report A. Napolitano, L. Spiezia, C. Bulato, E. Campello, P. Simioni | First Chair of Internal Medicine, Department of Medicine, University-Hospital of Padua Medical School, Padua, Italy

    22-10-2025
    https://doi.org/10.4081/btvb.2025.338
    568
    PDF: 0
  • CO40 | The co-inheritance of two ITGB3 variants exerting additive detrimental effects on platelets leads to variant Glanzmann thrombasthenia N. Arndt1, E. Falcinelli1, A. Zamora-Cánovas2, A. Sánchez Fuentes2, A. Marín-Quilez2, I. Tano1, M.D.M. Nieto-Hernández3, J.M. Bastida4, J. Rivera2, P. Gresele1, L. Bury1 | 1Department of Medicine and Surgery, Section of Internal and Cardiovascular Medicine, University of Perugia, Italy; 2Servicio de Hematología y Oncología Médica, Hospital Universitario Morales Meseguer, Centro Regional de Hemodonación, Universidad de Murcia, IMIB-Pascual Parrilla, ISCIII-CIBERER, Murcia, Spain; 3Servicio de Hematología, Hospital Universitario de Jaen, Spain; 4Departamento de Hematología, Complejo Asistencial Universitario de Salamanca “CAUSA”, Instituto de Investigación Biomédica de Salamanca “IBSAL”, Centro de Investigación del Cáncer, IBMCC-CSIC, Universidad de Salamanca “USAL”, Salamanca, Spain

    22-10-2025
    https://doi.org/10.4081/btvb.2025.247
    498
    PDF: 0
  • Bleeding and thrombosis in patients receiving chimeric antigen receptor T-cell therapy

    Dana Lee, Pedro Luiz Lage Bodour Danielian, Avi Leader
    16-04-2026
    https://doi.org/10.4081/btvb.2026.461
    112
    PDF: 67
  • PO66 | Viscoelastic tests in disseminated intravascular coagulation associated with aortic aneurysm A. M. Pizzini1, C. Biasoli2, M. Bovara3, E. Gesuete1, A. Fusco1, C. Fantoni1, P. Pedrazzi2, R. Mancini3, M. Silingardi1 | 1Ambulatorio Emostasi & Trombosi, Dipartimento Medico, Ospedale Maggiore AUSL Bologna; 2SSI Presa in Carico delle Malattie Emorragiche e Tromboemboliche della Romagna; 3Laboratorio Unico Metropolitano AUSL Bologna, Italy

    22-10-2025
    https://doi.org/10.4081/btvb.2025.335
    532
    PDF: 0
  • PO23 | Plasmic score applicability for the diagnosis of thrombotic microangiopathy associated with acquired ADAMTS13 deficiency in emergency settings at the hub laboratory of AUSL Romagna: state of the art and future prospects M. Olivieri1, M. Rosetti1, A. Clementoni1, V. Marinucci1, M. Monterosso1, E. Massari1, V. Polli1, M. Zauli1, V. Sambri2 | 1Clinical Pathology Unit; 2Unit of Microbiology, Area Hub Laboratory, Cesena, Italy

    22-10-2025
    https://doi.org/10.4081/btvb.2025.284
    521
    PDF: 0
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Bleeding, Thrombosis and Vascular Biology

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