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CO107 | PREGNANCY IN A YOUNG WOMAN WITH SEVERE THROMBOCYTOPENIA ASSOCIATED WITH GNE GENE MUTATION S. Bonafini1, A. Meneguzzi1, A. Savoia2, S. Uccella3, V. Tamborrino3, S. Cesaro3, E. Bonetti3, A. Giuffrida4, P. Minuz1, C. Fava1 | 1Dip. Medicina, Azienda Ospedaliera Universitaria Integrata Verona, Italy; 2Dip di Ingegneria per la Medicina di innovazione, Università di Verona, Italy; 3Dip. Materno-Infantile, Azienda Ospedaliera Universitaria Integrata Verona, Italy; 4Dip. Medicina trasfusionale, Azienda Ospedaliera Universitaria Integrata Verona, Italy
45PDF: 15 -
PO093 | HOW LONG IS TOO LONG? A CASE OF SEVERE PERSISTENT THROMBOCYTOPENIA B. Clerici1|2, C. Ghali2, M. Scavone2, A. Fioretti2, M. Perego1, C. Mondini1|2, E. Fiorini1, L. Catarini1, C. Pescia3, S. Caberlon1, U. Gianelli2|3, G.M. Podda1|2 | 1S.C. Medicina Generale SP, Ospedale San Paolo, ASST Santi Paolo e Carlo, Milano, Italy; 2Dipartimento di Scienze della Salute (DISS), Università degli Studi di Milano, Milano, Italy; 3S.C. Anatomia Patologica, Ospedale San Paolo, ASST Santi Paolo e Carlo, Milano, Italy
30PDF: 14 -
PO036 | EVALUATION OF BREAST MILK AS A POTENTIAL MEDIATOR FOR THE TRANSFER OF MATERNAL ANTI-PLATELET ALLOANTIBODIES IN FETAL AND NEONATAL ALLOIMMUNE THROMBOCYTOPENIA D. Dragonetti1, C. Autilio1, S. Pesce2, A. Amendola3, A.M. Calabrese1, V. Martinelli1, P. Dolce1, M.C. Cardillo1, I. Potenza1, C. Roselli1, M. Pizzuti3, V. Pafundi1 | 1CEDIA Analysis Laboratory, San Carlo Regional Hospital, Potenza, Italy; 2Neonatology Unit, Maternal and Child Health Department, San Carlo Regional Hospital, Potenza, Italy; 3Hematology Unit, San Carlo Regional Hospital, Potenza, Italy
31PDF: 11 -
PO148 | ANALYTICAL DISCREPANCY IN PLATELET COUNTING REVEALING MYH9-RD: A CASE REPORT M. De Girolamo, A. Marrocchi, F. Vitone, M. Scapaticci, M. Bovara, T. Papillo, R. Mancini | Laboratorio Unico Metropolitano, Bologna, Italy
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PO61 | ACTN1-related thrombocytopenia and severe hyperhomocysteinemia: a case report A. Pozzi, G. Rosati, M. Padrini, S. Laurenti, G. Ferrari, R.M. Medici, C. Barale, I. Russo, A. Morotti | University of Turin, San Luigi Hospital, Orbassano (TO), Italy
578PDF: 22 -
PO026 | AUTOSOMAL DOMINANT ITGA2B AND ITGB3 VARIANTS EXPAND THE PHENOTYPIC SPECTRUM OF ΑIIBΒ3-RELATED PLATELET DISORDERS S. Ferrari, D. Regazzo, L. Onorati, A. Galbiati, L. Spiezia, A. Bertomoro, P. Simioni | Department of Medicine, University of Padova, Italy
34PDF: 15 -
PO062 | AN AUTOMATED LABORATORY ALERT ALGORITHM FOR EARLY IDENTIFICATION OF THROMBOTIC THROMBOCYTOPENIC PURPURA IN THE EMERGENCY SETTING M. Bovara1, P. Conte1, M. Sebastiani2, A. Bartolini1, M. Scapaticci1, T. Papillo1, A. Marrocchi1, A.M. Pizzini3, M. Silingardi3, F. Palandri4, R. Mancini1 | 1Laboratorio Unico Metropolitano Ospedale Maggiore, Bologna, Italy; 2IRCCS Istituto delle Scienze Neurologiche, Bologna, Italy; 3Medicina Interna Ospedale Maggiore, Bologna, Italy; 4IRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia Seràgnoli, Bologna, Italy
28PDF: 14 -
PO95 | Idiopathic thrombocytopenic purpura in tuberculosis M. Shani | Università di Medicina Tirana, Albania
654PDF: 20 -
PO80 | Heparin-induced thrombocytopenia: a monocentric experience with danaparoid L. D’Innocenzo, S. Sorrentino, M. De Siati, A. Ferretti, E. De Candia | Unit of Haemostasis and Thrombosis Diseases, Fondazione Policlinico Universitario A. Gemelli, IRCCS, Roma, Italy
708PDF: 16 -
CO44 | First interlaboratory validation workshop of immunofluorescence microscopy on the peripheral blood smear for recognizing patients with inherited platelet disorders C. Zaninetti1, L. Bury2, V. Bozzi3, A. Zamora-Cánovas4, K. Althaus5, G. Uzun5, S. Brown6, A. Norman6, D. Faille7, A. Stepanian8, C. Freyer1, L. Kager9, T. Bakchoul5, A. Pecci3, P. Gresele2, T. Thiele1, J. Rivera4, A. Greinacher1 | 1Institut für Immunologie und Transfusionsmedizin, Universitätsmedizin Greifswald, Germany; 2Department of Medicine, Section of Internal and Cardiovascular Medicine, University of Perugia, Italy; 3Department of Internal Medicine, University of Pavia, Italy; General Medicine 1, IRCCS Policlinico San Matteo Foundation, Pavia, Italy; 4Servicio de Hematología, Hospital Universitario Morales Meseguer, Centro Regional de Hemodonacio´n, Universidad de Murcia, Spain; 5Institute for Clinical and Experimental Transfusion Medicine, University Hospital of Tuebingen, Germany; Center for Clinical Transfusion Medicine, Tuebingen, Germany; 6Centre for Children’s Health and Research CCHR, South Brisbane, Australia; 7Laboratoire d’Hématologie, Assistance Publique Hôpitaux de Paris, Hôpital Bichat-Claude-Bernard, Paris, France; 8AP-HP, Service d’Hématologie Biologique, Hôpital Lariboisière, Paris Cité University, Paris, France; 9St. Anna Kinderspital, Universitätsklinik für Kinder- und Jugendheilkunde der Medizinischen Universität Wien, Austria
603PDF: 24 -
PO064 | CONGENITAL THROMBOTIC THROMBOCYTOPENIC PURPURA: HOW TO MANAGE? - A CASE FROM REAL WORLD N. Galli1, S. Giuliano2, S. Grasso3, B. Montaruli4, D. Cilloni1, G. Giuffrida3, P. Sivera4 | 1Department of Clinical and Biological Sciences, University of Turin, Italy; 2Department of Medical Sciences, University of Turin, Italy; 3AOU Policlinico “G. Rodolico San Marco”, Catania, Italy; 4Haematology and Cellular Therapies Unit, A. O. Ordine Mauriziano di Torino, Italy
32PDF: 14 -
CO43 | Early platelet dysfunction in sepsis: an ICU pilot study S. Sorrentino1, C. Gori2, L. D’Innocenzo1, M. De Siati1, Mg. Bocci3, E. De Candia1 | 1Unit of Haemostasis and Thrombosis Diseases, Fondazione Policlinico Universitario A. Gemelli, IRCCS, Roma; 2UOC Shock & Trauma, Azienda Ospedaliera San Camillo Forlanini, Roma; 3National Institute for Infectious Diseases, Lazzaro Spallanzani, IRCCS, Roma, Italy
662PDF: 21 -
PO072 | DIAGNOSTIC CHALLENGES IN THROMBOTIC MICROANGIOPATHY: A CASE OF ATYPICAL HEMOLYTIC UREMIC SYNDROME M. Moretti1, R. Gervasi2, E. Rossini2, G.F. Romiti1, P. Carfagna2, S. Basili1, P. Battisti2 | 1Azienda Ospedaliero-Universitaria Policlinico Umberto I, Roma, Italy; 2Azienda Ospedaliera San Giovanni Addolorata, Roma, Italy
34PDF: 15 -
CO-65 | COVID-19-ASSOCIATED HYPERCOAGULABILITY IN TYPE 2B VON WILLEBRAND DISEASE: INSIGHTS FROM GLOBAL HEMOSTATIC ASSAYS I. Condonato, C. Simion, E. Zanon, P. Simioni | Hemophilia Center, University Hospital of Padua, Italy
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CO091 | DOWNREGULATION OF MARKERS OF PLATELET ACTIVATION, PLATELET TURNOVER, AND PLATELET DESIALYLATION IN GOOD RESPONDERS TO FIRST-LINE TREATMENT(S) FOR IMMUNE THROMBOCYTOPENIA B. Clerici1|2, C. Ghali2, M. Scavone2, A. Fioretti2, E.G. Bossi2, S. Birocchi1, E. Tarasconi1|2, G. D'Avanzo1, M. Carpenedo3, S. Caberlon2, G.M. Podda1|2 | 1.S.C. Medicina Generale SP, Ospedale San Paolo, ASST Santi Paolo e Carlo, Milano, Italy; 2Dipartimento di Scienze della Salute (DISS), Università degli Studi di Milano, Italy; 3S.S. Ematologia Non Oncologica, ASST Grande Ospedale Metropolitano Niguarda, Milano, Italy. B. Clerici and C. Ghali contributed as co-first authors
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“Living under the sword of Damocles”: a psychological support project for patients with immune thrombocytopenia and their caregivers
1002PDF: 373Appendix A: 140Appendix B: 143 -
PO79 | Trying to hit the hit in the shadow of renal failure: a complex case managed with danaparoid S. Chessa1,2, M. Anedda2, M.V. Cherchi2, M. Vacca1,2, M. Caboni2, J. Pilia2, A.M. Bussu2, M. Mantega2, G. Costanzo1, D. Firinu1, S. Del Giacco1, A. Mameli3, D. Barcellona3 | 1Department of Medical Science and Public Health, University of Cagliari; 2Internal Medicine, ASL Sulcis, PO Sirai, Carbonia; 3Department of Medical Sciences and Public Health, Hemostasis and Thrombosis Unit, University of Cagliari and AOU of Cagliari, Italy
670PDF: 15 -
PO109 | A RARE CASE OF ANEMIA AND THROMBOCYTOPENIA E. Cosi, A. Bertomoro, I. Bertozzi, G. Bogoni, M. Zerbinati, A. Galbiati, G. Antonello, D. Lovison, P. Simioni | Department of Medicine, University of Padua, Italy
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PO095 | HEPARIN-INDUCED THROMBOCYTOPENIA PRESENTING AS A CIRCUIT-TRIGGERED PULMONARY SYNDROME IN HEMODIALYSIS: A CASE REPORT S.P. Colapietra, M. Gino | Osp. Molinette, Torino, Italy
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CO093 | PROGNOSTIC ROLE OF ANTIPLATELET ANTIBODY TESTING IN IMMUNE THROMBOCYTOPENIA G. Maraziti, C. Schiavone, A. Fiaccadori, A. Mezzasoma, C. Becattini | Internal and Emergency Medicine - Stroke Unit, S. Maria della Misericordia Hospital – University of Perugia, Perugia, Italy
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PO058 | IMMUNOMODULATORY EFFECTS OF FOSTAMATINIB IN A PATIENT WITH EVANS SYNDROME, TRIPLE-POSITIVE ANTIPHOSPHOLIPID ANTIBODIES AND RELATED COAGULATION ABNORMALITIES S. Bergonzi1|2|4, G. Murante1|2|4, M. Capetta1|2|4, F. Valeri1|2, C. Dainese1|2, A. Valpreda3|4, R. Pastorino3|4, F. Bocchi3|4, B. Bruno2|4, A. Borchiellini1|2 | 1Regional Centre for Hemorrhagic and Thrombotic Diseases; 2Division of Hematology; 3Central Laboratory Baldi and Riberi, AOU Città della Salute e della Scienza, Università di Torino, Italy; 4Department of Molecular Biotechnology and Health Sciences, University of Turin, Italy
34PDF: 17 -
PO125 | ROMIPLOSTIM FOR CHEMOTHERAPY-INDUCED THROMBOCYTOPENIA IN ADVANCED SOLID TUMORS: A SINGLE-CENTER EXPERIENCE G. Giustini1, A. Baffioni1, C. Giubbilei1, A.M. Vannucchi2, V. Carrai3 | 1SOD Ematologia, Università degli studi di Firenze, Italy; 2Center for Research and Innovation of Myeloproliferative Neoplasms, SOD Ematologia, AOU Careggi, Università degli studi di Firenze, Italy; 3SOD Ematologia, Dipartimento di Oncologia, AOU Careggi, Firenze, Italy
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PO34 | A negative oncologic follow up doesn’t always really mean no cancer: two case report of cancer-associated thrombotic microangiopathy E. Cosi, A. Bertomoro, G. Bogoni, I. Bertozzi, I. Cortella, P. Simioni | Clinica Medica ORI, Azienda Ospedale-Università Padova, DIDAS, Italy
607PDF: 28 -
PO071 | WHEN SJÖGREN’S DISEASE MIMICS TTP A. Castoldi, R. Rossio, F. Peyvandi | Medicina generale Osp. Maggiore Policlinico, Milano, Italy
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PO092 | HEPARIN-INDUCED THROMBOCYTOPENIA IN A PATIENT WITH GUILLAIN-BARRÉ SYNDROME: A POSSIBLE LINK WITH IMMUNE DYSREGULATION S. Bernardi1, F. Cei2, R. Lavecchia3, L. Chiarugi4, R. Tarquini5 | 1Università degli Studi di Firenze, Italy; 2Osp. S. Giuseppe Empoli, Italy
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PO92 | Challenging management of portal vein thrombosis in a cirrhotic patient on hormone therapy after breast cancer L. Jr Valletta, C. De Luca, M. Aversano, C. Caputo, E. Cimino, P. Conca, A. Tufano, M.D. Di Minno | AOU Federico II Napoli, Italy
575PDF: 22 -
PO091 | RESPONSE AND CARDIOVASCULAR SAFETY OF FOSTAMATINIB IN CHRONIC IMMUNE THROMBOCYTOPENIA: A REAL WORLD ANALYSIS C. Giubbilei, G. Giustini, A. Baffioni, V. Carrai | SOD Ematologia, Azienda Universitaria Ospedaliera Careggi, Firenze, Italy
26PDF: 13 -
CS08 | A combination of two rapid immunoassays improves HIT diagnosis G. Ciarrocca Taranta1, A. Rogolino2, A. Bertelli1, A. Sorrentino1, M. Di Gioia2, F. Cesari2, B. Giusti1,2, E. Sticchi1,2, M. Berteotti1,2, A.M. Gori1,2, R. Marcucci1,2 | 1Department of Experimental and Clinical Medicine, University of Firenze; 2Atherothrombotic Disease Unit, Careggi University Hospital, Firenze, Italy
714PDF: 20 -
PO157 | DIAGNOSTIC CHALLENGES IN PREGNANCY-TRIGGERED IMMUNE-MEDIATED THROMBOTIC THROMBOCYTOPENIC PURPURA: A CASE FOR EARLY AND ACCURATE IDENTIFICATION M. Siepi1, G. Rescigno2 | 1UOC Patologia Clinica, AORN Santobono-Pausilipon, Napoli, Italy; 2UOC Patologia Clinica, AOU San Giovanni di Dio Ruggi d'Aragona, Salerno, Italy
50PDF: 14 -
CO096 | WHEN THE BODY SAYS ‘NO’: CHRONIC RELATIONAL STRESS AND IMMUNE THROMBOCYTOPENIA—TOWARD AN INTEGRATED PSYCHONEUROIMMUNOLOGICAL MODEL G. Auteri1, L. Ricci2, B. Lovrencic3, A. Cuneo4, V. De Stefano5 | 1Azienda Ospedaliero-Universitaria di Ferrara, Italy; 2Presidente dell’Associazione DOCEAT; 3Presidente dell’Associazione AIPIT; 4Università di Ferrara, Italy; 5Ospedale Policlinico Gemelli di Roma, Italy
40PDF: 13 -
PO63 | Atypical venous thrombosis in young patient with systemic lupus erythematosus and high-risk APL profile: provoked or not? E. Marrone, A. Parisi, G. Di Monda, F. Gallucci, D. Morelli, C. Romano, U. Malgeri, D. D’Auria, P. Morella | Internal Medicine Unit 3, Cardarelli Hospital, Naples, Italy
617PDF: 26 -
CO50 | Diagnostic accuracy of the heparin-induced multiple electrode aggregometry (HIMEA) functional test for heparin-induced thrombocytopenia M. Bovara1, M. Sebastiani2, Am. Gori3,4, A. Rogolino3,4, A. Bertelli3,4, G. Ciarrocca Taranta3,4, R. Marcucci3,4, M. Sartori5, B. Cosmi5, M. Silingardi6, A. M. Pizzini6, A. Marrocchi1, R. Mancini1 | 1Laboratorio Unico Metropolitano Ospedale Maggiore, AUSL Bologna; 2IRCCS Istituto delle Scienze Neurologiche, Bologna; 3Centro Malattie Aterotrombotiche Azienda Ospedaliera Universitaria Careggi, Firenze; 4Dipartimento di Medicina Sperimentale e Clinica, Università di Firenze; 5U.O. di Angiologia e Malattie della Coagulazione dell’Azienda Ospedaliero Universitaria Policlinico S. Orsola-Malpighi, Bologna; 6Medicina Interna Ospedale Maggiore, Bologna, Italy
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PO065 | PSEUDO-THROMBOTIC THROMBOCYTOPENIC PURPURA DUE TO VITAMIN B12: A SYSTEMATIC REVIEW L. Panepinto, M. Merlo, S.A. Alhamed, S. Moruzzi, L. Delfino, S. Suardi, L. Marzano, E. Malloggi, G.L. Bonisoli, G. Malfer, F. Presa, F. Pizzolo, S. Friso, N. Martinelli | Department of Medicine, Unit of Internal Medicine B, University of Verona, Verona, Italy
31PDF: 15 -
CO095 | IMMATURE PLATELET FRACTION PREDICTS CLINICAL INSTABILITY IN CHRONIC IMMUNE THROMBOCYTOPENIA: PRELIMINARY RESULTS FROM THE PLATE-RET STUDY F. Boggio1|2, J.A. Giannotta1, M. Abbattista1, M. Clerici1, S. La Marca1, L. Padovan1|2, A. Truma1, A.C. Migliorini3, S. Torricelli3, A. Lecchi1|2, A. Artoni1 | 1Centro Emofilia e Trombosi A. Bianchi Bonomi, IRCCS Fondazione Ca' Granda Ospedale Maggiore Policlinico di Milano, Italy; 2Dip. di Fisiopatologia Medico-Chirurgica e dei Trapianti, Università degli Studi di Milano, Italy; 3Settore di Ematologia, Lab. Analisi, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico di Milano, Italy
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PO087 | BEYOND POSITIVITY: THE HIERARCHICAL ROLE OF IMMUNOASSAYS IN HEPARIN INDUCED THROMBOCYTOPENIA G. Murante1|2|3, S. Bergonzi1|2|3, M. Capetta1|2|3, F. Valeri1|2, C. Dainese1|2, A. Valpreda4, R. Pastorino1|3, F. Bocchi1|3, A. Porreca5, B. Bruno2|3, A. Borchiellini1|2 | 1Regional Centre for Hemorrhagic and Thrombotic Diseases, AOU Città della Salute e della Scienza di Torino, Italy; 2Division of Hematology, AOU Città della Salute e della Scienza, Università di Torino, Italy; 3Dep. of Molecular Biotechnology and Health Sciences, University of Turin, Italy; 4Central Lab. Baldi and Riberi, AOU Città della Salute e della Scienza di Torino, Italy; 5Dep. of Human Sciences and Quality of Life Promotion, Clinical and Molecular Epidemiology, IRCCS San Raffaele Roma, Italy
31PDF: 14 -
CO007 | TPO-RECEPTOR AGONISTS AS AN INDEPENDENT RISK FACTOR FOR VENOUS THROMBOTIC EVENT IN IMMUNE THROMBOCYTOPENIA PATIENTS WITH PERSISTENT ANTIPHOSPHOLIPID ANTIBODIES POSITIVITY M. Biglietto, B. Mandelli, S. Sorella, S. Ligia, C. Andriola, R. Mormile, E. Baldacci, A. Chistolini, S. Truglia, C. Santoro | Sapienza, University of Rome, Italy
132PDF: 12 -
Anticoagulation in obese patients: challenges and strategies
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PO132 | POST KIDNEY TRANSPLANT PRESENTATION OF ACQUIRED THROMBOTIC THROMBOCYTOPENIC PURPURA: A CASE OF PRE-EXISTING ADAMTS13 INHIBITORS G. Murante1|2|5, S. Bergonzi1|2|5, M. Capetta1|2|5, F. Valeri1|2, C. Dainese1|2, A. Valpreda4, R. Pastorino1|5, F. Bocchi1|5, L. Biancone3, E. Gallo3, B. Bruno2|5, A. Borchiellini1|2 | 1Regional Centre for Hemorrhagic and Thrombotic Diseases; 2Division of Hematology; 3Nephrology Dialysis and Transplant U; 4Central Lab. Baldi and Riberi, AOU Città della Salute e della Scienza di Torino, Italy; 5Dep. of Molecular Biotechnology and Health Sciences, University of Turin, Italy
32PDF: 16 -
CO094 | ASSESSMENT OF THE MINIMAL EFFECTIVE DOSE OF AVATROMBOPAG IN IMMUNE THROMBOCYTOPENIA: A SINGLE-CENTER REAL-WORLD STUDY A. Baffioni1, C. Giubbilei1, G. Giustini1, A.M. Vannucchi2, V. Carrai3 | 1SOD Ematologia, Università degli studi di Firenze, Italy; 2Center for Innovation and Research in Myeloproliferative Neoplasms, SOD Ematologia, Azienda Ospedaliera Universitaria Careggi, Università degli studi di Firenze, Italy; 3SOD Ematologia, Dipartimento di Oncologia, Azienda Ospedaliera Universitaria Careggi, Firenze, Italy
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OC08 | A SILK-BASED 3D BONE MARROW MODEL FOR CHEMOTHERAPY-INDUCED THROMBOCYTOPENIA C.A. Di Buduo, M. Migliavacca, A. Malara, A. Balduini | Department of Molecular Medicine, University of Pavia, Italy
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CO17 | Clinical relevance of isolated anti-phosphatidylserine/ prothrombin antibody positivity A. Hoxha1, P. Žigon2,3, L. Katja2,3, S. Čučnik2,4, Ž. Rotar2,5, S. Gavasso1, P. Zerbinati1, G. Gobbo1, P. Simioni1 | 1University of Padua, Internal Medicine Unit, Thrombotic and Hemorrhagic Centre, Department of Medicine-DIMED, Padua, Italy; 2University Medical Centre Ljubljana, Department of Rheumatology, Ljubljana, Slovenia; 3University of Primorska, Faculty of Mathematics, Natural Sciences and Information Technologies, Koper, Slovenia; 4University of Ljubljana, Faculty of Pharmacy, Ljubljana, Slovenia; 5University of Ljubljana, Faculty of Medicine, Ljubljana, Slovenia
647PDF: 22 -
PO119 | BARTONELLA HENSELAE INFECTION ASSOCIATED WITH A MULTISYSTEMIC THROMBO-INFLAMMATORY SYNDROME IN AN IMMUNOCOMPETENT ADULT G. Gobbo1|2, M. Zacchia1|2, F. Nalesso1|3, M. Fedrigo1|4, S. Da Pozzo5, L. Frison7, F. Vianello1|6, A. Angelini1|4, P. Simioni1|2, A. Hoxha1|2 | 1Department of Medicine - DIMED, University of Padua, Italy; 2Internal Medicine Unit, Thrombotic and Bleeding Disorder Center; 3Nephrology Unit; 4Pathology Unit; 5Radiology Unit; 6Hematology Unit, University-Hospital of Padua, Italy; 7Hematology Unit, Ospedale dell’Angelo, Mestre, Italy
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PO162 | A RARE CASE OF PLATELET DISORDER MIMICKING HEMOPHILIA A M. Shani, T. Goxhaj | Mother Theresa University Hospital, Università Nostra Signora Dell Buon Consiglio, Tirana, Albania
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CO101 | PLATELET ACTIVATION AND THROMBOGENICITY IN ANTI-PHOSPHOLIPID ANTIBODY-POSITIVE SUBJECTS: AN INTEGRATED TGA AND T-TAS ANALYSIS G. Rosati1, A. Pozzi1, C. Barale1, M. Padrini1, R.M. Medici1, G. Ferrari1, E. Mordohovich1, M. Tamietti1, A. Barinotti2, M. Radin2, M. Geminiani1, M. De Gobbi1, I. Russo1, A. Morotti1 | 1Dip. Scienze Cliniche e Biologiche, Torino, Italy; 2Osp. San Giovanni Bosco, Torino, Italy
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PO64 | A silent hemorrhage in the immuno-thrombotic chaos of antiphospholipid syndrome G. Autiero, S.A. Malerba, A. Malaguti, M. Dalla Vestra, F. Presotto | Medicina Generale, Ospedale dell’Angelo, Mestre-Venezia, Italy
666PDF: 19 -
PO82 | Retrospective application of the TH2 score in a multicenter cohort of ITP patients: a reliable predictive tool or a score in need of refinement? C. Giubbilei1, M. Defina2, S. Rosati3, M. Rocco3, A. Votto4, F. Simonetti5, F. Paoletti6, V. Carrai1 | 1Hematology Unit, AOU Careggi; 2Hematology unit AOU Senese; 3Hematology Unit Azienda Sanitaria Toscana Centro; 4Hematology Unit, AOU Pisana; 5Hematology Unit, Ospedale Versilia; 6Hematology Unit, Azienda Sanitaria Nord Ovest, Italy
576PDF: 20 -
PO114 | A CASE OF ACQUIRED HEMOPHILIA AFTER TAVI AND CORONARY ANGIOPLASTY IN PATIENT WITH ATRIAL FIBRILLATION AND MULTIPLES CARDIOVASCULAR RISK FACTORS – THE ART AND SCIENCE OF THERAPEUTIC CONFLICT M.M. Poggi1, C. Tamburini2, M. Littera2, M. Mazzetti2 | 1SOC Medicina 1, Nuovo Ospedale Prato, Prato, Italy; 2SOD Medicina Interna Interdisciplinare, Azienda Ospedaliera Universitaria Careggi, Firenze, Italy
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CO032 | VENOUS THROMBOEMBOLISM IN ACUTE IMMUNE MEDIATED THROMBOTIC THROMBOCYTOPENIC PURPURA, A SINGLE-CENTER RETROSPECTIVE COHORT STUDY M. Zerbinati, E. Cosi, I. Bertozzi, G. Bogoni, A. Bertomoro, A. Galbiati, I. Cortella, L. Gianesello, D. Regazzo, S. Ferrari, P. Simioni | Department of Medicine, University of Padova, Italy
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PO03 | Enlarged platelets with reduced GP IB/IX can indicate disorders other than Bernard-Soulier syndrome C. Zaninetti1, A. Marín-Quilez2, S. Semenowitsch1, A. Sánchez-Fuentes2, A. Zamora-Cánovas2, P. Gómez-González2, E. Birgitte Leinøe3, N. Fernández-Mosteirin4, T. Murciano5,6, C. Freyer1, T. Thiele1, J. Rivera2,7, A. Greinacher1 | 1Universitätsmedizin Greifswald, Institut Für Transfusionsmedizin, Greifswald, Germany; 2Universidad De Murcia, Servicio De Hematología, Hospital Universitario Morales Meseguer, Centro Regional De Hemodonacion, Imib-Pascual Parrilla, Ciberer-U765, Murcia, Spain; 3Rigshospitalet University Hospital, Department of Haematology and Department of Genomic Medicine, Copenhagen, Denmark; 4Hospital Universitario Miguel Servet, Servicio De Hematología, Zaragoza, Spain; 5Hospital Universitario Vall D’Hebron, Servicio De Oncología y Hematología Pediatricas; 6Vall D’Hebron Institut De Recerca, Barcelona, Spain; 7Grupo Español De Alteraciones Plaquetarias Congénitas, Murcia, Spain
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PO068 | ANTIPHOSPHOLIPID ANTIBODIES IN PATIENTS WITH MULTIPLE SCLEROSIS AND MS-LIKE DISEASES: MS OR APS? M. Gagliardi, L. Capone, A. Ciampa | Centro Emostasi, AORN Moscati, Avellino, Italy
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PO089 | A RISK-ADAPTED, MULTIDISCIPLINARY CONSENSUS FOR ADULT ITP MANAGEMENT: BRIDGING GUIDELINES AND REAL-WORLD PRACTICE A. Votto1, E. Pacini2, G. Giustini3, I. Rina1, S. Galimberti1 | 1Department of Clinical and Experimental Medicine, University of Pisa, Italy; 2Hematology Unit, University of Siena, Azienda Ospedaliera Universitaria Senese, Italy; 3Hematology Unit, AOU Careggi, Firenze, Italy
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PO41 | VENOUS THROMBOEMBOLISM IN PERIPHERAL BLOOD STEM CELL COLLECTION. A SINGLE CENTER EXPERIENCE P. Holly1, J. Hudecek1, J. Chudej1, L. Valekova1, I. Plamenova1, E. Flochova1, R. Simonova1, J. Sokol1, J. Stasko1, M. Pietrzykova1|2, E. Vescecikova2 | 1Department of Hematology and Transfusion Medicine, University Hospital in Martin, Martin, Slovakia; 2National Transfusion Service, Martin, Slovakia
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CS07 | Endothelial dysfunction and impaired angiogenesis in Hermansky-Pudlak syndrome (HPS) type 1: studies with endothelial colony forming cells F. Tondi1, G. Purgatorio1, C. Sgromo2, E. Giglio1, E. Petito1, E. Falcinelli1, G. Guglielmini1, A. Follenzi2, P. Gresele1, L. Bury1*, C. Olgasi3* | *Shared senior authorship; 1Department of Medicine and Surgery, Section of Internal and Cardiovascular Medicine, University of Perugia; 2Department of Health Sciences, School of Medicine, University of Piemonte Orientale, Novara; 3Department of Translational Medicine, School of Medicine, University of Piemonte Orientale, Novara, Italy
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PO033 | PLATELET COUNT AND PERIPROCEDURAL MAJOR BLEEDING IN CIRRHOTIC PATIENTS UNDERGOING INVASIVE PROCEDURES: INDIVIDUAL PATIENT DATA META-ANALYSIS E. Tarasconi1|2, E. Pontisso1, M. Manzoni1, S. Birocchi1, B. Clerici1, E.G. Giannini3, A. Iacobellis4, Shalimar5, P. Ponzo6, F. Giuliante7, A. Lauterio8, L. Massicotte9, N. Cocero10, V. Ronca11, G.M. Podda1|2 | 1S.C. Medicina Generale II, Ospedale San Paolo Polo Universitario, ASST Santi Paolo e Carlo, Università degli Studi di Milano, Italy; 2Dipartimento di Scienze della Salute (DISS), Università degli Studi di Milano, Italy; 3Gastroenterology Unit, Department of Internal Medicine, University of Genoa, Italy; 4Department of Gastroenterology and Endoscopy, Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy; 5Department of Gastroenterology and Human Nutrition Unit, All India Institute of Medical Sciences, New Delhi, India; 6Division of Gastroenterology and Hepatology, Città della Salute e della Scienza Hospital, University of Torino, Italy; 7Hepatobiliary Surgery Unit, Foundation and Teaching Hospital Sacred Heart IRCCS A. Gemelli, Catholic University of the Sacred Heart, Roma, Italy; 8General Surgery and Abdominal Organ Transplantation, ASST Grande Ospedale Metropolitano Milano Niguarda School of Medicine and Surgery, University of Milan-Bicocca, Milano, Italy; 9Department of Anesthesiology, Centre Hôspitalier de l’Université de Montréal- Hôpital Saint-Luc, Montreal, Canada; 10Senior Consultant, Oral Surgery Section of the Dental School of the University of Torino at the Azienda Ospedaliera Città della Salute e della Scienza of Torino, Italy; 11IRCCS Humanitas Research Hospital, Department of Gastroenterology, Division of Internal Medicine and Hepatology, Milano, Italy. E. Tarasconi and E. Pontisso contributed as co-first authors
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PO111 | A RARE CASE OF ACUTE PROMYELOCYTIC LEUKAEMIA PRESENTING WITH A PURELY THROMBOTIC DISSEMINATED INTRAVASCULAR COAGULATION PHENOTYPE L. Colavolpe, M. Provisione, L. Appio, S. Tupputi, N. Mumoli | ASST Valle Olona, Busto Arsizio, VA, Italy
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CO031 | PREEMPTIVE RITUXIMAB IN ADAMTS13 RELAPSE DURING CLINICAL REMISSION OF IMMUNE THROMBOTIC THROMBOCYTOPENIC PURPURA: A MULTICENTER ITALIAN STUDY A. Dedola1|2, G. Carli3, C. Sartor1, B. Scappini4, B. Cambò5, G. Marchesini3, A. Dizdari6, S. Pozzi7, P. Bernuzzi8, A. Merli9, C. Lucarelli4, F. Salvatore1|2, D. Cavallina1|2, N. Severi1|2, F. Branzanti2, F. Lanza6, A. Lucchesi10, F. Palandri1 | 1IRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia “Seràgnoli”, Bologna, Italy; 2Dipartimento di Scienze Mediche e Chirurgiche, Università di Bologna, Bologna, Italy; 3Hematology Unit, Ospedale San Bortolo, ULSS8 Berica, Vicenza, Italy; 4Hematology Department, Azienda Ospedaliero-Universitaria Careggi, Firenze, Italy; 5U.O.C. Ematologia e Centro Trapianti Midollo Osseo, Azienda Ospedaliero-Universitaria di Parma, Parma, Italy; 6AUSL Romagna, Ospedale di Ravenna, Ravenna, Italy; 7Hematology Unit, Azienda USL-IRCSS di Reggio Emilia, Reggio Emilia, Italy; 8Hematology Unit, Department of Onco-Hematology, Guglielmo da Saliceto Hospital, Piacenza, Italy; 9U. O. C. Ematologia Infermi Rimini AUSL Romagna, Rimini, Italy; 10IRCCS Istituto Romagnolo per lo Studio dei Tumori IRST 'Dino Amadori', Meldola, Italy
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PO62 | Management of anticoagulation during extracorporeal circulation in a patient with APS T. Marrazzo1, C. Marra2, A. Caiazzo2, I. Mattucci2, L. Verniero3, N. Galdieri3, M.P. Ursi4, R. Albisinni5 | 1UOC Medicina Interna e dei Trapianti, Ospedale Monaldi Azienda dei Colli, Napoli; 2UOSD di Cardiochirurgia dei Trapianti, Ospedale Monaldi Azienda dei Colli, Napoli; 3UOSD Terapia Intensiva di CCH Ospedale Monaldi Azienda dei Colli, Napoli; 4UOC MECAU Ospedale CTO Azienda dei Colli, Napoli; 5UOC CCH generale Ospedale Monaldi Azienda dei Colli, Napoli, Italy
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PO23 | IMMUNE THROMBOTIC THROMBOCYTOPENIC PURPURA RELATED TO DELAYED IMMUNE CHECKPOINT INHIBITORS TOXICITY: A CASE REPORT E. Galimberti1, F. Schieppati1, C. Ambaglio1, M. Marchetti1, L. Barcella1, A. Falanga1|2 | 1Immunohematology and Transfusion Medicine Unit, ASST Papa Giovanni XXIII, Bergamo, Italy; 2School of Medicine and Surgery, University of Milan-Bicocca, Milano, Italy
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PO028 | SUSTAINED RESPONSE OFF TREATMENT IN ITP PATIENTS TREATED WITH TPO-RA: A SINGLE-CENTER EXPERIENCE A. Baffioni1, C. Giubbilei1, G. Giustini1, A.M. Vannucchi2, V. Carrai3 | 1SOD Ematologia, Università degli studi di Firenze, Italy; 2Center for Innovation and Research in Myeloproliferative Neoplasms, SOD Ematologia, Azienda Ospedaliera Universitaria Careggi, Università degli studi di Firenze, Italy; 3SOD Ematologia, Dipartimento di Oncologia, Azienda Ospedaliera Universitaria Careggi. Firenze, Italy
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PO073 | ANALYTICAL VARIABILITY IN FIBRINOGEN TESTING REVEALING FIBRINOGEN LONGMONT: A CASE REPORT A. Paradiso1, S. Cmet2, E. Fontanini2 | 1Dep. of Medicine, University of Udine, Udine, Italy; 2Dep. of Laboratory Medicine, Institute of Clinical Pathology, Azienda Ospedaliera Universitaria Friuli Centrale, Udine, Italy
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PO75 | Prophylaxis with RFXIII: a clinical case in a pediatric patient with congenital FXIII deficiency and delayed diagnosis M.L. Tramontano, M. Coppola, S. Coppola, M. Schiavulli | UOSD Centro Regionale Pediatrico Malattie della Coagulazione. Santobono Pausilipon Children Hospital, AORN, Napoli, Italy
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CO006 | PREVALENCE OF GASTROINTESTINAL BLEEDING IN GLANZMANN THROMBASTHENIA PATIENTS: RESULTS OF A WORLDWIDE SURVEY E. Falcinelli1, L. Bury1, S. Morais2, M. de Oliveira2, M. Kannan3, M. Faranoush4, D. Desprez5, V. Jean-Baptiste6, C. Santoro7, C. Falaise8, P. Saultier8, M. Fiore9, C. Albayrak10, A. Sánchez11, J.M. Bastida12, A. Artoni13, G. Castaman14, K. Gomez15, R. Schutgens16, L. Spiezia17, M. Sridharan18, N. Butta19, P. Buur van Kooten Niekerk20, E. Leinøe21, B. Guillet22, C. Panagiotis23, S. Crivelli24, E. De Candia25, M. Lewandowska26, P. De Bonis27, G. Kenet28, F. Heubel-Moenen29, J. Payne30, L. Banov31, L. Puccetti32, M. Olivieri33, M. Chitlur34, M. Lambert35, A. Pecci36, D. Martínez-Carballeira37, E. Zetterberg38, J. Curnow39, M. Napolitano40, A. Morotti41, R.C. Santoro42, R. Johann43, S. Saulyte Trakymiene44, A. Falanga45, C. Casas46, E. Zanon47, J. Moppet48, N.M. Popa-Fotea49, P. Gresele1 | 1Department of Medicine and Surgery, Section of Internal and Cardiovascular Medicine, University of Perugia, Italy; 2Centro Hospitalar Universitário de Santo António, Portugal; 3Blood and Vascular Biology Research Lab, Department of Biotechnology, Central University of Tamil Nadu, India; 4Iranian Hemophilia and Thrombophilia Association, MAHTA, Iran; 5CRC MHC Hopital Universaitire de Strasbourg, France; 6CHRU de Tours, University Hospital of Tours, France; 7UOC Ematologia, Azienda Ospedaliero Universitaria Policlinico Umberto I, Roma, Italy; 8AP-HM Timone, Marseille, France; 9CHU Bordeaux, France; 10Mayıs University Medical Faculty Pediatric Hematology and Oncology Dept, Türkiye; 11Hospital Universitario Morales Meseguer – Centro Regional de Hemodonación, Murcia, Spain; 12Complejo Asistencial Universitario De Salamanca, Spain; 13Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milano, Italy; 14Azienda Ospedaliera Universitaria Careggi Florence, Italy; 15Royal Free Hospital, London, UK; 16Center for Benign Haematology, Thrombosis and Haemostasis, Van Creveldkliniek, UMC Utrecht, The Netherlands; 17University of Padova, Italy; 18Mayo Clinic, Rochester, USA; 19Hospital Universitario La Paz-IdiPAZ, Madrid, Spain; 20Aarhus University Hospital, Denmark; 21Department of Hematology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark; 22University Hospital of Rennes, France; 23Blood unit and National Reference Center for Congenital Bleeding Disorders, ''Laiko'' General Hospital, Greece; 24Ospedale L. Sacco e Polo Universitario, Milano, Italy; 25Università Cattolica del Sacro Cuore-Roma, Fondazione Policlinico Universitario A. Gemelli IRCCS, Italy; 26Indiana Hemophilia and Thrombosis Center Innovative Hematology, USA; 27IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy; 28Sheba Medical Center, Israel; 29Department of Hematology Internal Medicine, Maastricht University Medical Center and Hemophilia Treatment Center Nijmegen Eindhoven Maastricht and CARIM, Maastricht University, Maastricht, Netherlands; 30Sheffield Children’s NHS foundation Trust, UK; 31Hemostasis and Thrombosis Unit, Gaslini Children’s Hospital, Italy; 32University Teaching Hospital of Siena, Italy; 33Pediatric Thrombosis and Hemostasis Unit, Dr. von Hauner Childreńs Hospital, LMU Munich, Munich, Germany; 34Children's Hospital of Michigan, USA; 35Children’s Hospital of Philadelphia, USA; 36IRCCS Policlinico San Matteo Foundation and University of Pavia, Italy; 37Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Spain; 38Department of Hematology, Coagulation Unit, Skane University hospital, Sweden; 39Westmead Hospital, Sydney, Australia; 40PROMISE Department, University of Palermo, Italy; 41AOU San Luigi Gonzaga Hospital, University of Turin, Italy; 42Hemostasis and Thrombosis, Az. Osp. Univ. Dulbecco, Catanzaro, Italy; 43Hospital Center of Le Mans, France; 44Vilnius University Hospital Santaros Klinikos, Lithuania; 45ASST Papa Giovanni XXIII, Bergamo, Italy; 46Hospital San José, Bogotà, Colombia; 47Haemophilia Center-General Medicine, Padova University Hospital, Padova, Italy; 48University Hospitals Bristol NHS Foundation Trust, UK; 49University of Medicine and Pharmacy “Carol Davila”, Bucharest, Romania
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PO129 | CLINICAL BENEFIT OF RECOMBINANT ADAMTS13 IN CTTP ASSOCIATED WITH HOMOZYGOUS PD173G MUTATION AND UNDETECTABLE ACTIVITY M. Sacco1, S. Lancellotti1, M. Basso1, R. De Cristofaro1|2 | 1Servizio Malattie Emorragiche e Trombotiche, Fondazione Policlinico Universitario Gemelli IRCCS, Roma, Italy; 2Dipartimento di Medicina e Chirurgia Traslazionale, Università Cattolica S. Cuore, Roma, Italy
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PO60 | Asymptomatic PNH clone in acquired aplasia (AA) E. Marrone1, U. Valentino1, C. Mastrobuoni1, A. Abate1, A. Magliocca1, F. Cinque1, R. Buono1, M. Annunziata2, A. Picardi3, P. Morella1 | 1UOC Medicina 3, 2UOC Ematologia, 3UOC Ematologia, e Trapianto, AORN A. Cardarelli, Napoli, Italy
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OC05 | TIME TO START OF ANTICOAGULANT THERAPY AND SURVIVAL OUTCOMES IN CANCER PATIENTS WITH PULMONARY EMBOLISM K. Bria, B. Gage, M. Bealsey, K. Sanfilippo | Washington University in St. Louis School of Medicine, St. Louis, MO, USA
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CO108 | MECHANOCHEMICAL REPROGRAMMING OF VWF–GPIB INTERACTIONS UNCOUPLES AFFINITY FROM AVIDITY AND LINKS THROMBOCYTOPENIA TO ANGIODYSPLASIA IN TYPE 2B VON WILLEBRAND DISEASE A. Ferretti1, M. Sacco1, S. Lancellotti1, P. Concolino2, A. Minucci2, R. De Cristofaro1|3 | 1Center for Hemorrhagic and Thrombotic Diseases; 2Molecular and Genomic Diagnostics Unit, Fondazione Policl.nico Univ. Gemelli IRCCS, Roma, Italy; 3Department of Translational Medicine and Surgery, Catholic University of the Sacred Heart, Roma, Italy
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PO69 | Whole blood thrombin generation hypercoagulable profile in a patient with hemolytic crisis due to paroxysmal nocturnal hemoglobinuria: a case report A. Napolitano, L. Spiezia, C. Bulato, E. Campello, P. Simioni | First Chair of Internal Medicine, Department of Medicine, University-Hospital of Padua Medical School, Padua, Italy
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CO-85 | ACQUIRED HEMOPHILIA A IN LIVER CIRRHOSIS: BALANCING HEMOSTASIS BETWEEN HIGH HEMORRHAGIC AND THROMBOTIC RISKS N. Portesi, G. Martini | ASST Spedali Civili di Brescia, Italy
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CO40 | The co-inheritance of two ITGB3 variants exerting additive detrimental effects on platelets leads to variant Glanzmann thrombasthenia N. Arndt1, E. Falcinelli1, A. Zamora-Cánovas2, A. Sánchez Fuentes2, A. Marín-Quilez2, I. Tano1, M.D.M. Nieto-Hernández3, J.M. Bastida4, J. Rivera2, P. Gresele1, L. Bury1 | 1Department of Medicine and Surgery, Section of Internal and Cardiovascular Medicine, University of Perugia, Italy; 2Servicio de Hematología y Oncología Médica, Hospital Universitario Morales Meseguer, Centro Regional de Hemodonación, Universidad de Murcia, IMIB-Pascual Parrilla, ISCIII-CIBERER, Murcia, Spain; 3Servicio de Hematología, Hospital Universitario de Jaen, Spain; 4Departamento de Hematología, Complejo Asistencial Universitario de Salamanca “CAUSA”, Instituto de Investigación Biomédica de Salamanca “IBSAL”, Centro de Investigación del Cáncer, IBMCC-CSIC, Universidad de Salamanca “USAL”, Salamanca, Spain
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CO092 | FOSTAMATINIB IN CHRONIC IMMUNE THROMBOCYTOPENIA: A REAL-WORLD MONOCENTRIC EXPERIENCE M. Biglietto, S. Sorella, S. Ligia, S. Santostefano, R. Celia, R. Mormile, E. Baldacci, A. Chistolini, C. Santoro | Sapienza University of Roma, Italy
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Inherited platelet function disorders: a comprehensive narrative review focusing on diagnostic and management aspects
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PO66 | Viscoelastic tests in disseminated intravascular coagulation associated with aortic aneurysm A. M. Pizzini1, C. Biasoli2, M. Bovara3, E. Gesuete1, A. Fusco1, C. Fantoni1, P. Pedrazzi2, R. Mancini3, M. Silingardi1 | 1Ambulatorio Emostasi & Trombosi, Dipartimento Medico, Ospedale Maggiore AUSL Bologna; 2SSI Presa in Carico delle Malattie Emorragiche e Tromboemboliche della Romagna; 3Laboratorio Unico Metropolitano AUSL Bologna, Italy
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PO041 | VARIABLE CLINICAL RESPONSE TO RECOMBINANT PORCINE FVIII IN ACQUIRED HAEMOPHILIA A: A TWO CASE EXPERIENCE WITH LABORATORY SUPPORTED MONITORING AM. Pizzini1, M. Bovara2, M. Sebastiani2, A. Fusco1, C. Fantoni1, M. Silingardi1, R. Mancini2, A. Coppola3 | 1Ambulatorio Emostasi & Trombosi, Dipartimento Medico - Ospedale Maggiore Bologna, Italy; 2Laboratorio Unico Metropolitano - Ospedale Maggiore Bologna, Italy; 3SDD Centro Hub Emofilia e MEC, Azienda Ospedaliero-Universitaria di Parma, Italy
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PO23 | Plasmic score applicability for the diagnosis of thrombotic microangiopathy associated with acquired ADAMTS13 deficiency in emergency settings at the hub laboratory of AUSL Romagna: state of the art and future prospects M. Olivieri1, M. Rosetti1, A. Clementoni1, V. Marinucci1, M. Monterosso1, E. Massari1, V. Polli1, M. Zauli1, V. Sambri2 | 1Clinical Pathology Unit; 2Unit of Microbiology, Area Hub Laboratory, Cesena, Italy
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PO069 | PERIOPERATIVE CHALLENGES IN ACQUIRED THROMBOTIC THROMBOCYTOPENIC PURPURA DURING CAPLACIZUMAB TREATMENT J. Agnelli Giacchello1, P. Sciancalepore1, N.F. Trincheri2, L. Contino1, M. Ladetto3, R.M. Santi1 | 1SSD Emostasi e trombosi e malattie rare; 2SC Laboratorio Analisi; 3SCDU Ematologia, AOU SS. Antonio e Biagio e Cesare Arrigo, Alessandria, Italy
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