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  The landscape of rare coagulation factor deficiency management in Italy: a national hemophilia center survey

  Silvia Linari, Renato Marino, Marzia Leotta, Antonio Coppola, Patrizia Di Gregorio, Augusto Bramante Federici, Flora Peyvandi, Cristina Santoro, Ezio Zanon, Rita Carlotta Santoro

  05-11-2025

  https://doi.org/10.4081/btvb.2025.369

  961

  PDF: 124

  HTML: 37

  Appendix: 56

• PO86 | Emicizumab in patients with moderate hemophilia A and severe bleeding phenotype: single-center real-world experience A.L. Faccini, M. Biglietto, S. Sorella, E. Crisanti, M. Antonacci, R. Mormile, R. Ciciani, E. Baldacci, C. Santoro, S. Ligia | Hematology, Department of Translational and Precision Medicine Sapienza University of Roma, Italy

  22-10-2025

  https://doi.org/10.4081/btvb.2025.355

  601

  PDF: 0

• PO02 | Pregnancy and delivery in women with hemophilia and carriers are still challenging: a ten years analysis from The Italian Association of Hemophilia Centers (AICE) M. Napolitano¹, M. Mattana², C. Cammarata¹, M. Leotta³, S. Linari⁴, M.E. Mancuso⁵, G. F. Rivolta⁶, C. Santoro⁷, L. Valdrè⁸, R.C. Santoro³, S. Siragusa¹ | ¹Department of Health Promotion, Mother and Child Care, Internal Medicine and Med, Palermo; University of Palermo, Italy; ²Department of Precision Medicine in Medical, Surgical and Critical Care “Me. Pre. Cc”, University of Palermo; ³Hemostasis and Thrombosis Unit, Azienda Ospedaliera Universitaria Dulbecco, Catanzaro; ⁴Center for Bleeding Disorders, Careggi University Hospital, Firenze; ⁵Center for Thrombosis and Hemorrhagic Diseases, IRCCS Humanitas Research Hospital, Rozzano, Milan; ⁶Regional Reference Center for the Treatment of Congenital Hemorrhagic Diseases, Parma University Hospital, Parma; ⁷Hematology, University Hospital Policlinico Umberto I, Roma; ⁸Inherited Bleeding Disorders Unit, IRCCS AOUBO, Bologna, Italy

  22-10-2025

  https://doi.org/10.4081/btvb.2025.312

  522

  PDF: 0

• PO83 | A case of deep vein thrombosis in a patient with systemic mastocytosis M. Leotta, A. Ierardi, A. Strangio, R C. Santoro | UO Emofilia, Emostasi e Trombosi, AOU R Dulbecco, Catanzaro

  22-10-2025

  https://doi.org/10.4081/btvb.2025.352

  582

  PDF: 0

• PO44 | Emicizumab in acquired haemophilia A M. Leotta, A. Strangio, A. Ierardi, S. Prejanò, R C. Santoro | Hemostasis and Thrombosis Unit, Department Hemato-Oncology, Azienda Ospedaliero-Universitaria Renato; Dulbecco, Catanzaro, Italy

  22-10-2025

  https://doi.org/10.4081/btvb.2025.307

  461

  PDF: 0

• PO67 | Pancreatic cancer in a 71-year-old severe hemophilia A patient with inhibitors and sustained zero bleeding during emicizumab prophylaxis M. Biglietto, A.L. Faccini, S. Sorella, E. Crisanti, M. Antonacci, A. Taglietti, M. Gherardini, A. Tirnetta, S. Ligia, R. Mormile, R. Ciciani, E. Baldacci, C. Santoro | Hematology, Department of Translational and Precision Medicine Sapienza University of Roma, Italy

  22-10-2025

  https://doi.org/10.4081/btvb.2025.336

  490

  PDF: 0

• PO42 | Acquired Von Willebrad syndrome in patients with myeloproliferative syndrome: literature review and single-center experience A. Strangio, M. Leotta, A. Ierardi, R C. Santoro | UO Emofilia, Emostasi e Trombosi, AOU R Dulbecco, Catanzaro, Italy

  22-10-2025

  https://doi.org/10.4081/btvb.2025.305

  404

  PDF: 0

• PO53 | Effectiveness and safety of DOACS in patients with renal transplantation A. Ierardi, A. Strangio, M. Leotta, R C. Santoro | UO Emofilia, Emostasi e Trombosi, AOU Renato Dulbecco, Catanzaro, Italy

  22-10-2025

  https://doi.org/10.4081/btvb.2025.322

  449

  PDF: 0
• 

  Diagnostic and management practices for inherited fibrinogen disorders: a nationwide survey of Italian Hemophilia Treatment Centers

  Renato Marino, Silvia Linari, Marzia Leotta, Antonio Coppola, Chiara Biasoli, Maria Elisa Mancuso, Flora Peyvandi, Cristina Santoro, Ezio Zanon, Rita Carlotta Santoro

  02-12-2025

  https://doi.org/10.4081/btvb.2025.372

  412

  PDF: 59

  HTML: 36

  Supplementary: 19

  Appendix: 31

• PO25 | Baseline thrombin generation test does not predict thrombotic events in acute leukemia: a monocentric prospective study M. Biglietto, R. Mormile, M.L. Bisegna, A. Laganà, A. L. Faccini, A. Papa, E. Baldacci, C. Santoro, M.S. De Propris, A. Chistolini | Hematology, Department of Translational and Precision Medicine Sapienza University of Roma, Italy

  22-10-2025

  https://doi.org/10.4081/btvb.2025.286

  480

  PDF: 0

• PO49 | Use of emicizumab in two patients with acquired hemophilia A: a new therapeutic approach S. Sorella, J. Micozzi, E. Baldacci, M. Biglietto, R. Mormile, A. Chistolini, R. Ciciani, L. Torrieri, N. Zhdanovskaya, M. Lorenzon, A. Delli Paoli, S. Ligia, C. Santoro | Hematology, Department of Translational and Precision Medicine, Policlinico Umberto I, Sapienza University of Roma, Italy

  22-10-2025

  https://doi.org/10.4081/btvb.2025.318

  478

  PDF: 0

• PO47 | Hemophilia A and antithrombin deficiency: a case of natural hemostatic rebalancing L. Torrieri, S. Ligia, E. Baldacci, R. Mormile, S. Sorella, R. Ciciani, M. Biglietto, N. Zhdanovskaya, A. Delli Paoli, A. Tirnetta, M. Lorenzon, C. Santoro | Hematology, Department of Translational and Precision Medicine, Policlinico Umberto I, Sapienza University of Roma, Italy

  22-10-2025

  https://doi.org/10.4081/btvb.2025.316

  461

  PDF: 0

• PO19 | Joint health status in patients with moderate hemophilia A: a cross-sectional multi-center study I.L. Calcaterra¹, F. Picasso², F. Valeri³, E. Baldacci⁴, M. Napolitano⁵, C. Guerrino¹, E. Zanon⁶, C. Santoro⁴, S. Siragusa⁷, C. Martinoli², M. Di Minno¹ | ¹Department of Clinical Medicine and Surgery, Regional Reference Centre for Coagulation Disorders, Federico II University, Naples; ²Department of Health Sciences “DISSAL”, Università di Genova; ³Regional Centre for Hemorrhagic and Thrombotic Diseases, AOU Città della Salute e della Scienza, Turin; ⁴Haematology, Department of Translational and Precision Medicine, Sapienza University, Roma; ⁵Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, University of Palermo and Haematology Unit and Rare Disorders Hospital “V. Cervello”, Palermo; ⁶Haemophilia Centre, General Medicine, Padua University Hospital, Padua; ⁷Department PROMISE, University of Palermo, Italy

  22-10-2025

  https://doi.org/10.4081/btvb.2025.279

  430

  PDF: 0
• 

  Diagnostic challenges in current laboratory practice at Italian Hemophilia Centers: findings from a nationwide survey

  Tiziano Martini, Alessandra Valpreda, Marina Marchetti, Alberto Catalano, Laura Contino, Raimondo De Cristofaro, Augusto Bramante Federici, Ilaria Quaglia, Rossana Rossi, Rita Carlotta Santoro, Armando Tripodi, Angelo Claudio Molinari

  12-03-2026

  https://doi.org/10.4081/btvb.2026.431

  74

  PDF: 26

  Supplementary: 6

• PO13 | Monitoring of anti-factor XA activity levels in patients treated with direct oral anticoagulants and concomitant tyrosine kinase inhibitors agents: a monocentric experience E. Santacroce^1,2, C. Santoro¹, E. Baldacci¹, S. Ligia¹, R. Mormile¹, M. Biglietto¹, M. Totaro¹, F. R. Mauro¹, M. Breccia¹, A. Chistolini¹ | ¹Department of Translational and Precision Medicine, Haematology, Sapienza University of Roma; ²Department of Clinical and Molecular Medicine, Sapienza University of Roma, Italy

  22-10-2025

  https://doi.org/10.4081/btvb.2025.313

  472

  PDF: 0
• 

  Comparison among three different bleeding scores and the thrombin generation assay to assess the different hemorrhagic phenotypes in patients with FVII deficiency

  Samantha Pasca, Cristina Santoro, Chiara Ambaglio, Marisanta Napolitano, Marta Milan, Letizia Natali, Silvia Nannizzi, Filippo Mori, Paolo Simioni, Ezio Zanon

  23-05-2022

  https://doi.org/10.4081/btvb.2022.12

  5365

  PDF: 406

• PO05 | Intensive FVIII replacement in haemophilia patients with hypertrophic synovium: a randomized study I.L. Calcaterra¹, E. Baldacci², R. Marino³, F. Valeri⁴, R.C. Santoro⁵, G. Pasta⁶, C. Martinoli⁷, M. Di Minno¹ | ¹Department of Clinical Medicine and Surgery, Federico II University, Naples; ²Haematology, University Hospital Policlinico Umberto I, Roma; ³Haemophilia Center and thrombosis, Policlinico, Bari; ⁴Regional Centre for Haemorrhagic and Thrombotic Diseases, AOU Città Della Salute e Della Scienza; Turin; ⁵Centre for Hemorrhagic and Thrombotic Disorders, Pugliese Ciaccio Hospital, Catanzaro; ⁶Fondazione IRCCS San Matteo Hospital, Pavia; ⁷Department of Health Science DISSAL, University of Genoa, Unit of Radiology and IRCCS San Martino Hospital, Genoa, Italy

  22-10-2025

  https://doi.org/10.4081/btvb.2025.267

  453

  PDF: 0
• 

  Hemophilia-free mind: a call to action

  Tiziano Martini, Chiara Gorio, Cristina Dainese, Rita Carlotta Santoro, Giancarlo Castaman

  10-03-2026

  https://doi.org/10.4081/btvb.2026.465

  144

  PDF: 63

• CO34 | Evaluation of emicizumab concentration and thrombin generation in a cohort of severe hemophilia A patients with and without inhibitor A. Taglietti¹, S. Ligia¹, F. Paoletti¹, R. Mormile¹, E. Baldacci², A. Chistolini¹, C. Santoro^1,2 | ¹Hematology, Department of Translational and Precision Medicine, Sapienza University of Roma; ²Hematology, Azienda Ospedaliera Universitaria Policlinico Umberto I, Roma, Italy

  22-10-2025

  https://doi.org/10.4081/btvb.2025.241

  483

  PDF: 0
• 

  Pharmacokinetics of extended half-life albumin-fused factor IX and heterogeneous F9 variants in hemophilia B: a retrospective cohort study

  Barbara Lunghi, Massimo Morfini, Silvia Linari, Dario Balestra, Alessio Branchini, Lisa Pieri, Donata Belvini, Laura Banov, Cristina Santoro, Giancarlo Castaman, Francesco Bernardi

  02-03-2026

  https://doi.org/10.4081/btvb.2026.413

  124

  PDF: 56

  Supplementary: 41

• CO27 | Intracerebral hemorrhage in hemophilia A and B: a 10-year prospective multicenter study in Italy (2012–2022) E. Zanon¹, A. Napolitano¹, A. Porreca², F. Demartis³, A. Coppola⁴, C. Santoro⁵, I. Cantori⁶, A. C. Molinari⁷, C. Biasioli⁸, M. Luciani⁹, G. Sottilotta¹⁰, B. Pollio¹¹, A. Borchiellini¹², A. Tosetto¹³, P. Flora¹⁴, P. Simioni¹ | ¹Haemophilia Center, First Chair of Internal Medicine, Department of Medicine, University-Hospital of Padua Medical School, Padua; ²Department of Human Sciences and Promotion of the Quality of Life, Unit of Clinical and Molecular Epidemiology IRCCS San Raffaele Roma Open University, Roma; Unit of Clinical and Molecular Epidemiology IRCCS San Raffaele, Roma; ³Centre for Bleeding Disorders, Careggi University Hospital of Firenze; ⁴Azienda Ospedaliero Universitaria di Parma; ⁵Hematology Division, Umberto I University Hospital of Roma; ⁶Haemophilia Center, Department of Transfusion Medicine, Hospital of Macerata; ⁷IRCCS Istituto Giannina Gaslini, Genova; ⁸Haemophilia and Transfusion Centre, Bufalini Hospital, Cesena; ⁹Children’s Hospital Bambino Gesù, Roma; ¹⁰Haemophilia Center, Department of Onco-Hematology and Radioterapy, Hospital of Reggio Calabria; ¹¹Haemophilia Pediatric Center, Transfusion Medicine, City of Health and Science of Turin; ¹²City of Health and Science of Turin; ¹³Hemorrhagic and Thrombotic Diseases Unit, S. Bortolo Hospital of Vicenza; ¹⁴RCCS Foundation Ca’ Granda Maggiore Policlinico Hospital, Milan, Italy

  22-10-2025

  https://doi.org/10.4081/btvb.2025.233

  504

  PDF: 0
• 

  Bioequivalence of von Willebrand factor-containing concentrates: implications for the choice in patients with von Willebrand disease. A position paper from the Italian Association of Hemophilia Centers

  Ezio Zanon, Giancarlo Castaman, Augusto Bramante Federici, Maria Elisa Mancuso, Gianfranco Pasut, Alberto Tosetto, Angiola Rocino, Rita Carlotta Santoro

  26-01-2026

  https://doi.org/10.4081/btvb.2026.415

  733

  PDF: 231

  HTML: 58
• 

  The evolving landscape of gene therapy for congenital severe hemophilia: a 2024 state of the art

  Giovanni Di Minno, Gaia Spadarella, Ilenia Lorenza Calcaterra, Giancarlo Castaman, Paolo Simioni, Raimondo De Cristofaro, Cristina Santoro, Flora Peyvandi, Matteo Di Minno

  04-09-2024

  https://doi.org/10.4081/btvb.2024.144

  1552

  PDF: 290

  SUPPLEMENTARY MATERIAL: 145
• 

  Addressing some challenges of congenital fibrinogen disorders in 2023 and beyond

  Cristina Santoro, Alessandro Casini

  03-08-2023

  https://doi.org/10.4081/btvb.2023.75

  1522

  PDF: 441
• 

  Persistence of functional anti-PF4 antibodies and neutrophil activation in vaccine-induced immune thrombotic thrombocytopenia

  Eleonora Petito, Anna Maria Mezzasoma, Emanuela Falcinelli, Chiara Conti, Erica De Candia, Raimondo De Cristofaro, Silvia Sorrentino, Gian Marco Podda, Mariangela Scavone, Anna Falanga, Marina Marchetti, Luca Barcella, Stefania Basili, Lucia Stefanini, Andrea Boccatonda, Laura Contino, Patrizia Sciancalepore, Igor Florio, Egidio Imbalzano, Rossella Marcucci, Angela Rogolino, Patrizia Noris, Marta Panella, Rita Santoro, Maria Costanza Turi, Gaetano Vaudo, Rosa Curcio, Paolo Gresele

  18-11-2025

  https://doi.org/10.4081/btvb.2025.400

  608

  PDF: 93

  HTML: 60

• PO24 | Emicizumab prophylaxis and bleeding outcomes: a single center clinical experience A. Taglietti¹, S. Ligia¹, F. Paoletti¹, R. Mormile¹, E. Baldacci², A. Chistolini¹, C. Santoro^1,2 | ¹Hematology, Department of Translational and Precision Medicine, Sapienza University of Roma; ²Hematology, Azienda Ospedaliera Universitaria Policlinico Umberto I, Roma, Italy

  22-10-2025

  https://doi.org/10.4081/btvb.2025.285

  464

  PDF: 0
• 

  Vaccine-induced immune thrombotic thrombocytopenia following ChAdOx1 nCoV-19 vaccine: report of two cases

  Rita Carlotta Santoro, Roberto Minici, Marzia Leotta, Mariapia Falbo, Lucia Concetta Elia, Francesca Leo, Antonella Ierardi, Alessandra Strangio, Simona Prejanò

  23-05-2022

  https://doi.org/10.4081/btvb.2022.23

  4216

  PDF: 0