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• CO43 | Early platelet dysfunction in sepsis: an ICU pilot study S. Sorrentino¹, C. Gori², L. D’Innocenzo¹, M. De Siati¹, Mg. Bocci³, E. De Candia¹ | ¹Unit of Haemostasis and Thrombosis Diseases, Fondazione Policlinico Universitario A. Gemelli, IRCCS, Roma; ²UOC Shock & Trauma, Azienda Ospedaliera San Camillo Forlanini, Roma; ³National Institute for Infectious Diseases, Lazzaro Spallanzani, IRCCS, Roma, Italy

  22-10-2025

  https://doi.org/10.4081/btvb.2025.249

  397

  PDF: 0

• PO09 | Comparison of different aggregometry methods for evaluation of platelet function in patients with myeloproliferative neoplasms C. Fortino, I. Bertozzi, D. Regazzo, L. Gianesello, G. Nuozzi, F. Sartorello, V. Azzaro, G. Saggiorato, A. Bertomoro, P. Simioni | First Medical Clinic, Department of Medicine – DIMED, Università degli Studi di Padova, Italy

  22-10-2025

  https://doi.org/10.4081/btvb.2025.271

  349

  PDF: 0

• PO01 | Diagnosis of inherited platelet function disorders by platelet aggregometry using a fully automated coagulation analyzer E. Falcinelli¹, A.M. Mezzasoma¹, L. Bury¹, R. Martini¹, I. Tano¹, A. Rechner², P. Gresele¹ | ¹Department of Medicine, Section of Internal and Cardiovascular Medicine, University of Perugia, Italy; ²Sysmex Europe, Germany

  22-10-2025

  https://doi.org/10.4081/btvb.2025.311

  410

  PDF: 0

• PO52 | Comprehensive assessment of variables affecting spontaneous platelet aggregation C. Ghali¹, A. Fioretti¹, M. Scavone¹, E. Bossi¹, B. Clerici¹, S. Birocchi¹, E. Popov², M. Centola³, G.M. Podda¹, M. Cattaneo⁴ | ¹Divisione di Medicina Generale II, ASST Santi Paolo e Carlo, DISS, Università degli Studi di Milano, Italy; ²National Medical Research Center of Cardiology, Ministry of Health of the Russian Federation, Moscow; ³Division of Cardiology, Pio XI Hospital, ASST Brianza, Desio, Italy; ⁴Fondazione Arianna Anticoagulazione, Bologna, Italy

  22-10-2025

  https://doi.org/10.4081/btvb.2025.321

  388

  PDF: 0

• CO25 | Thromboinflammation and ros accumulation in individuals with high lipoprotein(a) levels M. Frezza¹, P.G.M. Simeone¹, M. Alfonsetti¹, R. Liani¹, M. Cellini¹, P. Del Boccio², M.C. Cufaro³, O. Iuliani⁴, A. Quaglietta⁴, F. Cipollone¹, F. Santilli¹ | ¹Department of Medicine and Ageing Sciences, Center for Advanced Studies and Technology “CAST”, University of Chieti; ²Department of Pharmacy, Center for Advanced Studies and Technology “CAST”, Chieti; ³Department of Innovative Technologies in Medicine and Dentistry, Center for Advanced Studies and Technology “CAST”, Chieti; ⁴Department of Haematolgy and Oncology, Center of Transfusion Medicine, Pescara General Hospital, Pescara. Italy

  22-10-2025

  https://doi.org/10.4081/btvb.2025.231

  424

  PDF: 0

• PO58 | Gender differences in primary haemostasis A. Becchetti², M. Brambilla², M. Conti², D. Trabattoni², E. Tremoli³, M. Camera^1,2 | ¹Department of Pharmaceutical Sciences, Università degli Studi di Milano; ²Centro Cardiologico Monzino IRCCS, Milan; ³Maria Cecilia Hospital, Cotignola (RA), Italy

  22-10-2025

  https://doi.org/10.4081/btvb.2025.327

  427

  PDF: 0

• CO40 | The co-inheritance of two ITGB3 variants exerting additive detrimental effects on platelets leads to variant Glanzmann thrombasthenia N. Arndt¹, E. Falcinelli¹, A. Zamora-Cánovas², A. Sánchez Fuentes², A. Marín-Quilez², I. Tano¹, M.D.M. Nieto-Hernández³, J.M. Bastida⁴, J. Rivera², P. Gresele¹, L. Bury¹ | ¹Department of Medicine and Surgery, Section of Internal and Cardiovascular Medicine, University of Perugia, Italy; ²Servicio de Hematología y Oncología Médica, Hospital Universitario Morales Meseguer, Centro Regional de Hemodonación, Universidad de Murcia, IMIB-Pascual Parrilla, ISCIII-CIBERER, Murcia, Spain; ³Servicio de Hematología, Hospital Universitario de Jaen, Spain; ⁴Departamento de Hematología, Complejo Asistencial Universitario de Salamanca “CAUSA”, Instituto de Investigación Biomédica de Salamanca “IBSAL”, Centro de Investigación del Cáncer, IBMCC-CSIC, Universidad de Salamanca “USAL”, Salamanca, Spain

  22-10-2025

  https://doi.org/10.4081/btvb.2025.247

  403

  PDF: 0

• PO03 | Enlarged platelets with reduced GP IB/IX can indicate disorders other than Bernard-Soulier syndrome C. Zaninetti¹, A. Marín-Quilez², S. Semenowitsch¹, A. Sánchez-Fuentes², A. Zamora-Cánovas², P. Gómez-González², E. Birgitte Leinøe³, N. Fernández-Mosteirin⁴, T. Murciano^5,6, C. Freyer¹, T. Thiele¹, J. Rivera^2,7, A. Greinacher¹ | ¹Universitätsmedizin Greifswald, Institut Für Transfusionsmedizin, Greifswald, Germany; ²Universidad De Murcia, Servicio De Hematología, Hospital Universitario Morales Meseguer, Centro Regional De Hemodonacion, Imib-Pascual Parrilla, Ciberer-U765, Murcia, Spain; ³Rigshospitalet University Hospital, Department of Haematology and Department of Genomic Medicine, Copenhagen, Denmark; ⁴Hospital Universitario Miguel Servet, Servicio De Hematología, Zaragoza, Spain; ⁵Hospital Universitario Vall D’Hebron, Servicio De Oncología y Hematología Pediatricas; ⁶Vall D’Hebron Institut De Recerca, Barcelona, Spain; ⁷Grupo Español De Alteraciones Plaquetarias Congénitas, Murcia, Spain

  22-10-2025

  https://doi.org/10.4081/btvb.2025.265

  386

  PDF: 0

• CO46 | Comparison of reticulated platelet procoagulant role in liver cirrhosis vs. fibrosis S. Toffanin¹, E. Campello¹, A. Zanetto², G. Gagliardi¹, A. Napolitano¹, E. Stocco¹, G. Gobbo¹, E. Pinto², C. M. Radu¹, M. Senzolo², L. Fabris¹, P. Simioni¹ | ¹First Chair of Internal Medicine, Department of Medicine, University-Hospital of Padua Medical School, Padova; ²Department of Surgery Oncology and Gastroenterology, Gastroenterology and Multivisceral Transplant Unit, Padova University Hospital, Padova, Italy

  22-10-2025

  https://doi.org/10.4081/btvb.2025.256

  389

  PDF: 0

• CO45 | Role of urinary 11-dehydro-thromboxane B2 as a predictor of preeclampsia in pregnant high-risk women on low-dose aspirin treatment P.G.M. Simeone¹, R. Liani¹, M. Alfonsetti¹, A. Ricci¹, V. Cianci¹, S. Zeeba², M. Molino³, S. Palma², R. Malizia⁴, M. Luongo⁴, A. Di Castelnuovo⁵, F. Cipollone¹, F. D’antonio⁶, F. Ricci², G. Renda², F. Santilli¹ | ¹Department of Medicine and Aging Sciences, Center for Advanced Studies and Technology, University of Chieti; ²Department of Neuroscience, Imaging and Clinical Sciences, G D’Annunzio University of Chieti-Pescara, Chieti; University Cardiology Division, Heart Department, Policlinico SS Annunziata, Chieti; ³Clinical Pathology of Chieti University Hospital; ⁴Immunotransfusion Service, Clinical Haematology of Chieti University Hospital, Chieti; ⁵Mediterranea Cardiocentro, Napoli; ⁶Centre for Fetal Care and High-Risk Pregnancy, Department of Obstetrics and Gynecology, University of Chieti, Italy

  22-10-2025

  https://doi.org/10.4081/btvb.2025.251

  403

  PDF: 0

• PO79 | Trying to hit the hit in the shadow of renal failure: a complex case managed with danaparoid S. Chessa^1,2, M. Anedda², M.V. Cherchi², M. Vacca^1,2, M. Caboni², J. Pilia², A.M. Bussu², M. Mantega², G. Costanzo¹, D. Firinu¹, S. Del Giacco¹, A. Mameli³, D. Barcellona³ | ¹Department of Medical Science and Public Health, University of Cagliari; ²Internal Medicine, ASL Sulcis, PO Sirai, Carbonia; ³Department of Medical Sciences and Public Health, Hemostasis and Thrombosis Unit, University of Cagliari and AOU of Cagliari, Italy

  22-10-2025

  https://doi.org/10.4081/btvb.2025.348

  436

  PDF: 0

• PO26 | Non-canonical coagulation platelets function: monocyte-platelet interaction a bridge between inflammation and coagulation A. Benetti¹, A. Galbiati¹, M. Cola², L. Calandrino², C. Samà¹, D. Regazzo¹, S. Ferrari¹, C.M. Radu¹, A. Cattelan², P. Simioni¹ | ¹Department of Medicine - DIMED; ²Infectious and Tropical Diseases Unit, Padua University Hospital, Padua, Italy

  22-10-2025

  https://doi.org/10.4081/btvb.2025.287

  386

  PDF: 0

• PO61 | ACTN1-related thrombocytopenia and severe hyperhomocysteinemia: a case report A. Pozzi, G. Rosati, M. Padrini, S. Laurenti, G. Ferrari, R.M. Medici, C. Barale, I. Russo, A. Morotti | University of Turin, San Luigi Hospital, Orbassano (TO), Italy

  22-10-2025

  https://doi.org/10.4081/btvb.2025.330

  387

  PDF: 0

• PO06 | Extracellular vesicles profiles in patients with porto-sinusoidal vascular disease S. Toffanin¹, E. Campello¹, A. Zanetto², C. M. Radu¹, E. Pinto², K. Fernande², C. Bulato¹, B. Serena¹, L. Spiezia¹, P. Burra², M. Senzolo², P. Simioni¹ | ¹First Chair of Internal Medicine, Department of Medicine, University Hospital of Padua Medical School, Padua; ²Department of Surgery Oncology and Gastroenterology, Gastroenterology and Multivisceral Transplant Unit, University Hospital of Padua, Italy

  22-10-2025

  https://doi.org/10.4081/btvb.2025.268

  375

  PDF: 0

• CO44 | First interlaboratory validation workshop of immunofluorescence microscopy on the peripheral blood smear for recognizing patients with inherited platelet disorders C. Zaninetti¹, L. Bury², V. Bozzi³, A. Zamora-Cánovas⁴, K. Althaus⁵, G. Uzun⁵, S. Brown⁶, A. Norman⁶, D. Faille⁷, A. Stepanian⁸, C. Freyer¹, L. Kager⁹, T. Bakchoul⁵, A. Pecci³, P. Gresele², T. Thiele¹, J. Rivera⁴, A. Greinacher¹ | ¹Institut für Immunologie und Transfusionsmedizin, Universitätsmedizin Greifswald, Germany; ²Department of Medicine, Section of Internal and Cardiovascular Medicine, University of Perugia, Italy; ³Department of Internal Medicine, University of Pavia, Italy; General Medicine 1, IRCCS Policlinico San Matteo Foundation, Pavia, Italy; ⁴Servicio de Hematología, Hospital Universitario Morales Meseguer, Centro Regional de Hemodonacio´n, Universidad de Murcia, Spain; ⁵Institute for Clinical and Experimental Transfusion Medicine, University Hospital of Tuebingen, Germany; Center for Clinical Transfusion Medicine, Tuebingen, Germany; ⁶Centre for Children’s Health and Research CCHR, South Brisbane, Australia; ⁷Laboratoire d’Hématologie, Assistance Publique Hôpitaux de Paris, Hôpital Bichat-Claude-Bernard, Paris, France; ⁸AP-HP, Service d’Hématologie Biologique, Hôpital Lariboisière, Paris Cité University, Paris, France; ⁹St. Anna Kinderspital, Universitätsklinik für Kinder- und Jugendheilkunde der Medizinischen Universität Wien, Austria

  22-10-2025

  https://doi.org/10.4081/btvb.2025.250

  372

  PDF: 0

• PO32 | Effect of the sodium-glucose co-transporter-2 (SGLT2) inhibitors on platelet activation and lipid peroxidation: results of a pilot study P.G.M. Simeone¹, R. Liani¹, M. Alfonsetti¹, B. Cancelli¹, M. Frezza¹, G. Raggiunti¹, S. Zeeba², F. Cipollone¹, G. Renda², F. Santilli¹ | ¹Department of Medicine and Aging Sciences, Center for Advanced Studies and Technology, University of Chieti; ²Department of Neuroscience, Imaging and Clinical Sciences, G. D’Annunzio University of Chieti-Pescara; ³University Cardiology Division, Heart Department, Policlinico SS Annunziata, Chieti, Italy

  22-10-2025

  https://doi.org/10.4081/btvb.2025.293

  387

  PDF: 0

• PO46 | Intravitreal treatment with faricimab in patients with age-related macular degeneration M. Alfonsetti¹, R. Liani¹, P.G.M. Simeone¹, M. Frezza¹, A. Ricci³, S. Lattanzio¹, R. D’Aloisio², L. Toto², F. Santilli¹ | ¹Department of Medicine and Aging, Center for Advanced Studies and Technology “CAST”; ²Ophthalmology Clinic, Department of Medicine and Aging; ³Department of Pharmacy, University “G. d’Annunzio” of Chieti Pescara, Chieti, Italy

  22-10-2025

  https://doi.org/10.4081/btvb.2025.315

  322

  PDF: 0

• PO82 | Retrospective application of the TH2 score in a multicenter cohort of ITP patients: a reliable predictive tool or a score in need of refinement? C. Giubbilei¹, M. Defina², S. Rosati³, M. Rocco³, A. Votto⁴, F. Simonetti⁵, F. Paoletti⁶, V. Carrai¹ | ¹Hematology Unit, AOU Careggi; ²Hematology unit AOU Senese; ³Hematology Unit Azienda Sanitaria Toscana Centro; ⁴Hematology Unit, AOU Pisana; ⁵Hematology Unit, Ospedale Versilia; ⁶Hematology Unit, Azienda Sanitaria Nord Ovest, Italy

  22-10-2025

  https://doi.org/10.4081/btvb.2025.351

  400

  PDF: 0

• CO50 | Diagnostic accuracy of the heparin-induced multiple electrode aggregometry (HIMEA) functional test for heparin-induced thrombocytopenia M. Bovara¹, M. Sebastiani², Am. Gori^3,4, A. Rogolino^3,4, A. Bertelli^3,4, G. Ciarrocca Taranta^3,4, R. Marcucci^3,4, M. Sartori⁵, B. Cosmi⁵, M. Silingardi⁶, A. M. Pizzini⁶, A. Marrocchi¹, R. Mancini¹ | ¹Laboratorio Unico Metropolitano Ospedale Maggiore, AUSL Bologna; ²IRCCS Istituto delle Scienze Neurologiche, Bologna; ³Centro Malattie Aterotrombotiche Azienda Ospedaliera Universitaria Careggi, Firenze; ⁴Dipartimento di Medicina Sperimentale e Clinica, Università di Firenze; ⁵U.O. di Angiologia e Malattie della Coagulazione dell’Azienda Ospedaliero Universitaria Policlinico S. Orsola-Malpighi, Bologna; ⁶Medicina Interna Ospedale Maggiore, Bologna, Italy

  22-10-2025

  https://doi.org/10.4081/btvb.2025.260

  368

  PDF: 0

• CO15 | Longitudinal coagulation profiling of individuals undergoing gender-affirming hormone therapy: the hyper-gender study A. Napolitano, E. Campello, A. Scala, C. Simion, C. Bulato, S. Gavasso, C. Samà, A. Benetti, S. Toffanin, G. Faggian, R. Scafa, A. Garolla, P. Simioni | First Chair of Internal Medicine, Department of Medicine, University Hospital of Padua; Unit of Andrology and Reproductive Medicine, Department of Medicine, University Hospital of Padua, Italy

  22-10-2025

  https://doi.org/10.4081/btvb.2025.219

  414

  PDF: 0

• CO02 | Hepatic fibrosis as predictor of cancer-associated thrombosis in patients with intrahepatic cholangiocarcinoma Y. Frion-Herrera^1,2, C. Venturin^1,3, M. Cadamuro⁴, J. Gasparello⁵, C.M. Radu¹, M. Fassan⁵, C. Mescoli⁶, U. Cillo⁷, E. Gringeri⁷, G. Zanus⁸, L. Fabris^1,3, P. Simioni¹ | ¹Clinical Medicine and Thrombotic and Haemorrhagic Disease Unit, and Haemophilia Center, Padua University-Hospital, Department of Medicine [DIMED], University of Padua, Italy; ²Department of Biology [DiBio], University of Padua, Italy; ³Department of Internal Medicine, Digestive Disease Section, Liver Center, Yale University, New Haven, CT, USA; ⁴School of Medicine and Surgery, University of Milan-Bicocca, Milan, Italy; ⁵Department of Pathology Ca’ Foncello Hospital, ULSS2 Marca Trevigiana, Italy; ⁶Pathology Unit, Padua University-Hospital, Padua, Italy; ⁷Hepatobiliary Surgery and Liver Transplantation Unit, Padua University-Hospital, Department of Surgery, Oncology and Gastroenterology [DISCOG], University of Padua, Italy; ⁸General Surgery Unit, Ca’ Foncello Hospital, ULSS2 Marca Trevigiana, Department of Surgery, Oncology and Gastroenterology [DISCOG], University of Padua, Italy

  22-10-2025

  https://doi.org/10.4081/btvb.2025.207

  517

  PDF: 0

• CO24 | Extracellular vesicles profiles in patients with wild-type transthyretin amyloidosis S. Toffanin¹, L. Spiezia¹, C.M. Radu¹, A. Napolitano¹, A. Benetti¹, C. Samà¹, E. Campello¹, L. De Michieli², G. Sinigiani², A. Cipriani², P. Simioni¹ | ¹First Chair of Internal Medicine, Department of Medicine, University-Hospital of Padua Medical School, Padua; ²Department of Cardiac, Thoracic and Vascular Sciences and Public Health, University of Padua, Italy

  22-10-2025

  https://doi.org/10.4081/btvb.2025.230

  425

  PDF: 0

• CO42 | Oxidative stress may contribute to enhanced thrombopoiesis through miR-150: implications for aspirin response R. Liani¹, P.G.M. Simeone¹, M. Alfonsetti¹, M. Frezza¹, R. Tripaldi¹, S. Ciotti¹, M. Luongo², F. Cipollone¹, L. Vanella³, F. Santilli¹ | ¹Department of Medicine and Aging, and Center for Advanced Studies and Technology “CAST”, G. d’Annunzio University of Chieti-Pescara, Chieti; ²Immunotransfusion Service, Clinical Haematology of Chieti University Hospital, Chieti; ³Department of Drug Sciences, University of Catania, Italy

  22-10-2025

  https://doi.org/10.4081/btvb.2025.248

  372

  PDF: 0

• PO25 | Baseline thrombin generation test does not predict thrombotic events in acute leukemia: a monocentric prospective study M. Biglietto, R. Mormile, M.L. Bisegna, A. Laganà, A. L. Faccini, A. Papa, E. Baldacci, C. Santoro, M.S. De Propris, A. Chistolini | Hematology, Department of Translational and Precision Medicine Sapienza University of Roma, Italy

  22-10-2025

  https://doi.org/10.4081/btvb.2025.286

  414

  PDF: 0

• PO42 | Acquired Von Willebrad syndrome in patients with myeloproliferative syndrome: literature review and single-center experience A. Strangio, M. Leotta, A. Ierardi, R C. Santoro | UO Emofilia, Emostasi e Trombosi, AOU R Dulbecco, Catanzaro, Italy

  22-10-2025

  https://doi.org/10.4081/btvb.2025.305

  349

  PDF: 0

• CS08 | A combination of two rapid immunoassays improves HIT diagnosis G. Ciarrocca Taranta¹, A. Rogolino², A. Bertelli¹, A. Sorrentino¹, M. Di Gioia², F. Cesari², B. Giusti^1,2, E. Sticchi^1,2, M. Berteotti^1,2, A.M. Gori^1,2, R. Marcucci^1,2 | ¹Department of Experimental and Clinical Medicine, University of Firenze; ²Atherothrombotic Disease Unit, Careggi University Hospital, Firenze, Italy

  22-10-2025

  https://doi.org/10.4081/btvb.2025.205

  469

  PDF: 0

• PO11 | Neutrophil cathepsin G and risk of cardiovascular events in patients with diabetes mellitus V. Cammisotto¹, F. Baratta², S. Bartimoccia³, D. Pastori¹, N. Cocomello⁴, V. Castellani⁵, C. Nocella¹, R. Carnevale³, G. Desideri¹, F. Violi¹, P. Pignatelli¹ | ¹Department of Clinical, Internal Medicine, Anesthesiological and Cardiovascular Sciences, Sapienza University of Roma; ²Geriatric Unit, Department of Internal Medicine and Medical Specialties, AOU Policlinico Umberto I, Roma; ³Department of Medical-Surgical Sciences and Biotechnologies, Sapienza University of Roma; ⁴Department of Anatomical Sciences, Histological, Legal Medical and Locomotor, Sapienza University of Roma; ⁵Department of Experimental Medicine, Sapienza University of Roma, Italy

  22-10-2025

  https://doi.org/10.4081/btvb.2025.273

  400

  PDF: 0

• PO33 | Whole blood hypercoagulable profiles in patients with rheumatoid arthritis L. Spiezia¹, A. Giollo², C. Samà¹, A. Benetti¹, L. Di Luozzo², M. Salvato², A. Doria², P. Simioni¹ | ¹First Chair of Internal Medicine, Thrombotic and Hemorrhagic Diseases Unit, Department of Medicine, University Hospital of Padova; ²Rheumatology Unit, Department of Medicine, University Hospital of Padova, Italy

  22-10-2025

  https://doi.org/10.4081/btvb.2025.296

  402

  PDF: 0

• PO78 | Acquired hemophilia A as a paraneoplastic syndrome: two cases report on a rare coexistence M. Gagliardi, L. Capone, A. Ciampa | Centro Emostasi, AORN Moscati, Avellino, Italy

  22-10-2025

  https://doi.org/10.4081/btvb.2025.347

  395

  PDF: 0

• PO51 | Thrombocythemia associated with a non-canonical JAK2 mutation: a case report G. Rosati, A. Pozzi, M. Padrini, S. Laurenti, G. Ferrari, R.M. Medici, C. Barale, I. Russo, A. Morotti | University of Turin, AUO San Luigi Gonzaga, Orbassano (TO), Italy

  22-10-2025

  https://doi.org/10.4081/btvb.2025.320

  468

  PDF: 0

• PO08 | Efficacy and safety of thromboprophylaxis in hospitalized hematological patients: a monocenter retrospective study S. Cordella^1,2, V. Coluccio³, M. Luppi¹, M. Marietta¹ |  ¹Department of Medical and Surgical Sciences, Section of Hematology. University of Modena and Reggio Emilia, Azienda Ospedaliero-Universitaria di Modena; ²Clinical and Experimental Medicine PhD Programme, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena; ³Department of Hematology, Unità Sanitaria Locale di Modena, Italy 

  22-10-2025

  https://doi.org/10.4081/btvb.2025.270

  368

  PDF: 0

• PO63 | Atypical venous thrombosis in young patient with systemic lupus erythematosus and high-risk APL profile: provoked or not? E. Marrone, A. Parisi, G. Di Monda, F. Gallucci, D. Morelli, C. Romano, U. Malgeri, D. D’Auria, P. Morella | Internal Medicine Unit 3, Cardarelli Hospital, Naples, Italy

  22-10-2025

  https://doi.org/10.4081/btvb.2025.332

  386

  PDF: 0

• CO27 | Intracerebral hemorrhage in hemophilia A and B: a 10-year prospective multicenter study in Italy (2012–2022) E. Zanon¹, A. Napolitano¹, A. Porreca², F. Demartis³, A. Coppola⁴, C. Santoro⁵, I. Cantori⁶, A. C. Molinari⁷, C. Biasioli⁸, M. Luciani⁹, G. Sottilotta¹⁰, B. Pollio¹¹, A. Borchiellini¹², A. Tosetto¹³, P. Flora¹⁴, P. Simioni¹ | ¹Haemophilia Center, First Chair of Internal Medicine, Department of Medicine, University-Hospital of Padua Medical School, Padua; ²Department of Human Sciences and Promotion of the Quality of Life, Unit of Clinical and Molecular Epidemiology IRCCS San Raffaele Roma Open University, Roma; Unit of Clinical and Molecular Epidemiology IRCCS San Raffaele, Roma; ³Centre for Bleeding Disorders, Careggi University Hospital of Firenze; ⁴Azienda Ospedaliero Universitaria di Parma; ⁵Hematology Division, Umberto I University Hospital of Roma; ⁶Haemophilia Center, Department of Transfusion Medicine, Hospital of Macerata; ⁷IRCCS Istituto Giannina Gaslini, Genova; ⁸Haemophilia and Transfusion Centre, Bufalini Hospital, Cesena; ⁹Children’s Hospital Bambino Gesù, Roma; ¹⁰Haemophilia Center, Department of Onco-Hematology and Radioterapy, Hospital of Reggio Calabria; ¹¹Haemophilia Pediatric Center, Transfusion Medicine, City of Health and Science of Turin; ¹²City of Health and Science of Turin; ¹³Hemorrhagic and Thrombotic Diseases Unit, S. Bortolo Hospital of Vicenza; ¹⁴RCCS Foundation Ca’ Granda Maggiore Policlinico Hospital, Milan, Italy

  22-10-2025

  https://doi.org/10.4081/btvb.2025.233

  441

  PDF: 0

• CO41 | Failure in assisted reproductive techniques: insights from the first registry E. Grandone^1,3,4, C. Lodigiani², D. Colaizzo³, M. Passaretti², J. Khizroeva⁴, A. De Laurenzo³, P. Totaro⁵, E. Bucherini⁶, D. Baldini⁷, V. Bitsadze⁴, A. Makatsarya⁴, M. Mastroianno³, G. Piazza⁸, M. Othman⁹, M. Margaglione¹ | ¹University of Foggia, Italy; ²Humanitas University, Rozzano, Italy; ³IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy; ⁴First Sechenov University, Russia; ⁵Santa Maria Hospital, Bari, Italy; ⁶Angiologia, Faenza, Italy; ⁷Momo Fertilife, Bisceglie, Italy; ⁸Brigham Women Hospital, USA; ⁹Queen’s University, Kingston, Canada

  22-10-2025

  https://doi.org/10.4081/btvb.2025.310

  374

  PDF: 0

• CO52 | The impact of KRAS mutations on the risk of recurrent venous thromboembolism in patients with cancer-associated thrombosis and gastrointestinal neoplasms B. Cosmi^1,2, S. Cavara², M. Soldati², L. Borgese², M. Sartori² | ¹Angiology and Blood Coagulation Unit, Department of Medical and Surgical Sciences, University of Bologna; ²Angiology and Blood Coagulation Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Italy

  22-10-2025

  https://doi.org/10.4081/btvb.2025.262

  400

  PDF: 0

• PO22 | Early detection and management of PICC-related thrombosis in oncohematologic patients through serial ultrasound monitoring: a prospective observational study S. Laurenti, M. Schneeberger, G. Rosati, A. Pozzi, M. Padrini, R. Vacchelli, A. Morotti | University of Turin, AUO San Luigi Gonzaga, Orbassano (TO), Italy

  22-10-2025

  https://doi.org/10.4081/btvb.2025.282

  408

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• PO80 | Heparin-induced thrombocytopenia: a monocentric experience with danaparoid L. D’Innocenzo, S. Sorrentino, M. De Siati, A. Ferretti, E. De Candia | Unit of Haemostasis and Thrombosis Diseases, Fondazione Policlinico Universitario A. Gemelli, IRCCS, Roma, Italy

  22-10-2025

  https://doi.org/10.4081/btvb.2025.349

  458

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• CO51 | Novel biomarkers of neurological damage in acute immune-mediated thrombotic thrombocytopenic purpura A. Truma^1,2, I. Mancini¹, F. Verde^2,3, J. A. Giannotta¹, A. Artoni¹, B. Ferrari¹, P. Agosti^1,2, M. Gagliardi¹, A. Ratti^3,4, N. Ticozzi^2,3, F. Peyvandi^1,2 | ¹Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Milan; ²Università degli Studi di Milano, Department of Pathophysiology and Transplantation, Milan; ³Department of Neurology and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, Milan; ⁴Università degli Studi di Milano, Department of Medical Biotechnology and Translational Medicine, Milan, Italy

  22-10-2025

  https://doi.org/10.4081/btvb.2025.261

  388

  PDF: 0

• CO22 | Assessment of coagulation profiles in septic patients using viscoelastic coagulation monitoring and rotational thromboelastometry in an internal medicine setting G. Gottardi, C. Simion, D. Regazzo, C. Samà, G.P. Arcidiacono, L. Gianesello, E. Campello, P. Simioni | Department of Medicine – DIMED, University of Padua, Italy

  22-10-2025

  https://doi.org/10.4081/btvb.2025.228

  379

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• CS07 | Endothelial dysfunction and impaired angiogenesis in Hermansky-Pudlak syndrome (HPS) type 1: studies with endothelial colony forming cells F. Tondi¹, G. Purgatorio¹, C. Sgromo², E. Giglio¹, E. Petito¹, E. Falcinelli¹, G. Guglielmini¹, A. Follenzi², P. Gresele¹, L. Bury^1*, C. Olgasi^3* | ^*Shared senior authorship; ¹Department of Medicine and Surgery, Section of Internal and Cardiovascular Medicine, University of Perugia; ²Department of Health Sciences, School of Medicine, University of Piemonte Orientale, Novara; ³Department of Translational Medicine, School of Medicine, University of Piemonte Orientale, Novara, Italy

  16-09-2025

  https://doi.org/10.4081/btvb.2025.204

  225

• PO96 | Patient management with arteriovenous thrombotic manifestation and hemorrhagic complications M. Aversano, E. Cimino, L. Jr Valletta, C. Caputo, M. Romeo, M.D. Di Minno, A. Tufano, I.L. Calcaterra, C. De Luca, R. Russo, G. D’errico, P. Conca | Università degli Studi Federico II, Napoli, Italy

  22-10-2025

  https://doi.org/10.4081/btvb.2025.366

  427

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• CO49 | The burden of cerebral small vessel disease in ITTP patients from acute phase to remission A. Truma^1,2, F. M. Lo Russo¹, G. Conte^1,2, I. Mancini¹, M. Abbattista¹, J. A. Giannotta¹, A. Artoni¹, B. Ferrari¹, P. Agosti^1,2, F. M. Triulzi^1,2, F. Peyvandi^1,2 | ¹Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Milan; ²Università degli Studi di Milano, Department of Pathophysiology and Transplantation, Milan, Italy

  22-10-2025

  https://doi.org/10.4081/btvb.2025.259

  388

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• CO20 | Coagulation alterations as prognostic indicators in septic patients L. Baratti¹, S. N. Pasturenzi¹, P. Onorato², W. Ageno³, F. Cortellaro², M.P. Donadini^2,4 | ¹Scuola di Medicina, Università degli Studi dell’Insubria, Varese; ²Pronto Soccorso e Medicina d’Urgenza, Ospedale di Circolo, Varese; ³Dipartimento di Medicina, Università degli Studi di Padova; ⁴Dipartimento di Medicina e Chirurgia, Università degli Studi dell’Insubria, Varese, Italy

  22-10-2025

  https://doi.org/10.4081/btvb.2025.226

  426

  PDF: 0

• PO68 | Whole blood hypercoagulable profiles in a patient with markedly elevated lipoprotein(A) plasma levels and thrombotic complications: a case report C. Portinari, M. Biolo, A. Napolitano, L. Spiezia, A. Colpo, S. Zambon, A. Zambon, P. Simioni | Department of Medicine, Padova University Hospital, Padova, Italy

  22-10-2025

  https://doi.org/10.4081/btvb.2025.337

  423

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• PO28 | Long term effectiveness and safety of venous thromboembolism with fondaparinux: data from the start registry I.M. Palumbo¹, E. Valeriani^1,2, A. Pannunzio¹, S. Marucci³, D. Menichelli¹, D. Pastori^3,4, P. Pignatelli³ | ¹Department of General Surgery and Surgical Specialty, Sapienza University of Roma; ²Department of Infectious Disease, Azienda Ospedaliero-Universitaria Policlinico Umberto I, Roma; ³Department of Clinical Internal, Anaesthesiologic and Cardiovascular Sciences, Sapienza University of Roma, Roma; ⁴IRCCS NeuRomad, Pozzilli, Italy

  22-10-2025

  https://doi.org/10.4081/btvb.2025.289

  411

  PDF: 0

• PO95 | Idiopathic thrombocytopenic purpura in tuberculosis M. Shani | Università di Medicina Tirana, Albania

  22-10-2025

  https://doi.org/10.4081/btvb.2025.365

  451

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• CO48 | Gynecological involvement in females with congenital plasminogen deficiency type 1 C. Dalla Porta^1,2, M.T. Sartori¹, G. Saggiorato¹, I. Cortella¹, S.A. Malerba^1,3, P. Simioni¹ | ¹First Medical Clinic, Department of Medicine - DIMED, Università degli Studi di Padova; ²Department of Medicine, Casa di Cura Villa Maria, Padova; ³Medicina Generale, Ospedale dell’Angelo, Mestre, Italy

  22-10-2025

  https://doi.org/10.4081/btvb.2025.258

  363

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• CO16 | The predictive value of high-sensitivity C-reactive protein for assessing thrombosis risk in non-small cell lung cancer P. Gomez-Rosas^1,2, M. Marchetti^1,3, L. Russo¹, C.J. Tartari¹, S. Bolognini¹, C. Ticozzi¹, F. Schieppati¹, A. D’Alessio⁴, R. Labianca⁵, A. Falanga^1,3 All on behalf of the Hypercan Investigators | ¹Hospital Papa Giovanni XXIII, Bergamo, Italy; ²Cardiovascular Research Institute Maastricht, CARIM, Maastricht University, Maastricht, the Netherlands; ³School of Medicine and Surgery, University of Milan Bicocca, Italy; ⁴University Vita-Salute San Raffaele, Milan, Italy; ⁵Fondazione ARTET Onlus, Bergamo, Italy

  22-10-2025

  https://doi.org/10.4081/btvb.2025.220

  419

  PDF: 0

• PO66 | Viscoelastic tests in disseminated intravascular coagulation associated with aortic aneurysm A. M. Pizzini¹, C. Biasoli², M. Bovara³, E. Gesuete¹, A. Fusco¹, C. Fantoni¹, P. Pedrazzi², R. Mancini³, M. Silingardi¹ | ¹Ambulatorio Emostasi & Trombosi, Dipartimento Medico, Ospedale Maggiore AUSL Bologna; ²SSI Presa in Carico delle Malattie Emorragiche e Tromboemboliche della Romagna; ³Laboratorio Unico Metropolitano AUSL Bologna, Italy

  22-10-2025

  https://doi.org/10.4081/btvb.2025.335

  407

  PDF: 0

• PO84 | Beyond the scores: unmasking a silent pulmonary embolism in essential thrombocythemia N. Battino | ASL Sulcis Iglesiente PO CTO, Italy

  22-10-2025

  https://doi.org/10.4081/btvb.2025.353

  435

  PDF: 0

• CO47 | Genetic characterization of the KIV2 LPA polymorphism in subjects with bicuspid aortic valve with different clinical complications R. Orsi¹, G. Barbieri¹, E. Sticchi^1,2, A. Kura¹, L. Squillantini¹, P. Cantini¹, A. Rogolino², M. Berteotti^1,2, S. Nistri³, P. Stefàno⁴, R. Marcucci^1,2, B. Giusti^1,2 | ¹Department of Experimental and Clinical Medicine, University of Firenze; ²Centre for Atherothrombotic Diseases, AOU Careggi, Firenze; ³Cardiology, CMSR Veneto Medica, Altavilla Vicentina; ⁴Cardiac Surgery, AOU-Careggi, Firenze, Italy

  22-10-2025

  https://doi.org/10.4081/btvb.2025.257

  364

  PDF: 0