Thrombophilia work-up and clinical outcomes in Indian patients with unprovoked venous and arterial thrombosis aged 18-50 years | BTVB Bioequivalence of von Willebrand factor-containing concentrates: implications for von Willebrand disease | BTVB Cardiovascular risk in hormone replacement therapy | BTVB Direct oral anticoagulants: does one dose fit all? Why, when and how testing | BTVB Cardiovascular risk profile evolution over 15 years: CV-PREVITAL vs Moli-sani Study | BTVB Launch of National Registry for Congenital Hematological Disorders in Palestine: Haemo-PAL | BTVB
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Bleeding, Thrombosis and Vascular Biology

Editor-in-Chief: Giovanni de Gaetano, Italy | eISSN: 2785-5309

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  • Anticoagulation in obese patients: challenges and strategies

    Alice Lipari, Esmeralda Capristo, Antonietta Ferretti, Erica De Candia
    18-09-2025
    https://doi.org/10.4081/btvb.2025.174
    1790
    PDF: 249
    HTML: 181
    XML: 73
  • Platelet distribution width is associated with cardiovascular mortality in an adult general population

    Benedetta Izzi, Simona Costanzo, Alessandro Gialluisi, Amalia De Curtis, Sara Magnacca, Teresa Panzera, Augusto Di Castelnuovo, Maria Benedetta Donati, Chiara Cerletti, Marc F. Hoylaerts, Giovanni de Gaetano, Licia Iacoviello, *on behalf of the Moli-sani Study Investigators
    27-09-2023
    https://doi.org/10.4081/btvb.2023.83
    2715
    PDF: 394
    Supplementary Material: 90
  • Still unmet problems with low molecular weight heparin prophylaxis of venous thromboembolism. An Italian survey

    Stefania Cavazza, Gualtiero Palareti*
    03-10-2025
    https://doi.org/10.4081/btvb.2025.177
    1260
    PDF: 207
    HTML: 86
    Supplementary: 57
  • Plasma fibrinogen levels and all-cause and cause-specific mortality in an Italian adult population: results from the Moli-sani study

    Roberta Parisi, Simona Costanzo, Romy de Laat-Kremers, Augusto Di Castelnuovo, Amalia De Curtis, Teresa Panzera, Mariarosaria Persichillo, Chiara Cerletti, Giovanni de Gaetano, Maria Benedetta Donati, Licia Iacoviello, Bas de Laat , for the Moli-sani Study Investigators
    27-01-2023
    https://doi.org/10.4081/btvb.2023.46
    2059
    PDF: 522
    APPENDIX: 170
  • The night of randomized clinical trials where all patients are black: a need to estimate variability in treatment effects

    Giovanni de Gaetano, Chiara Cerletti, Licia Iacoviello, Maria Benedetta Donati
    22-03-2022
    https://doi.org/10.4081/btvb.2022.24
    2109
    PDF: 327
  • PO89 | Apixaban for secondary prevention of venous thromboembolism in hemodialysis patients: pharmacokinetic profile and safety outcomes S. Guglielmo1, E. De Bon2, L. Scarano1, R. Fabris1, E. Pierobon3, S. Barbar2 | 1Internal Medicine, Department of Medicine; 2Thrombotic and Hemorrhagic Disorders Unit, Department of Medicine; 3Nephrology and Dialysis Unit, Azienda ULSS 6 Euganea, Cittadella and Camposampiero, Padua, Italy

    22-10-2025
    https://doi.org/10.4081/btvb.2025.359
    557
    PDF: 0
  • CO01 | Statin therapy for the prevention of venous thromboembolism in cancer patients: a systematic review and meta-analysis F. Catalani, R. Del Giorno, R. Canevascini, W. Ageno, L. Gabutti, G. Prouse, L. Giovannacci | Ospedale Regionale di Bellinzona, Switzerland.

    22-10-2025
    https://doi.org/10.4081/btvb.2025.199
    518
    PDF: 0
  • Reducing the risks of nuclear war - The role of health professionals

    Kamran Abbasi, Parveen Ali, Virginia Barbour, Kirsten Bibbins-Domingo, Marcel G.M. Olde Rikkert, Andy Haines, Ira Helfand, Richard Horton, Bob Mash, Arun Mitra, Carlos Monteiro, Elena N. Naumova, Eric J. Rubin, Tilman Ruff, Peush Sahni, James Tumwine, Paul Yonga, Chris Zielinski
    21-08-2023
    https://doi.org/10.4081/btvb.2023.94
    1224
    PDF: 294
  • When a feminist platelet went to the convention of prostaglandins and thromboxanes

    Giovanni de Gaetano
    04-11-2025
    https://doi.org/10.4081/btvb.2025.412
    1032
    PDF: 103
    HTML: 62
    Italian version: 59
  • It’s definitely time to consider diet in its ultra-processing form as a major risk factor for thrombotic vascular disorders

    Marialaura Bonaccio, Licia Iacoviello, Maria Benedetta Donati
    03-08-2023
    https://doi.org/10.4081/btvb.2023.91
    1457
    PDF: 375
  • New perspectives for prevention of the post-thrombotic syndrome

    Paolo Prandoni
    22-03-2022
    https://doi.org/10.4081/btvb.2022.20
    2057
    PDF: 544
  • On the impact of generative artificial intelligence on peer review

    Giovanni de Gaetano, Chiara Cerletti, Augusto Di Castelnuovo
    03-03-2025
    https://doi.org/10.4081/btvb.2025.176
    1044
    PDF: 333
  • Bioequivalence of von Willebrand factor-containing concentrates: implications for the choice in patients with von Willebrand disease. A position paper from the Italian Association of Hemophilia Centers

    Ezio Zanon, Giancarlo Castaman, Augusto Bramante Federici, Maria Elisa Mancuso, Gianfranco Pasut, Alberto Tosetto, Angiola Rocino, Rita Carlotta Santoro
    26-01-2026
    https://doi.org/10.4081/btvb.2026.415
    723
    PDF: 225
    HTML: 57
  • Unveiling the “common soil” of cardiovascular disease and cancer

    Licia Iacoviello, Maria Benedetta Donati
    24-02-2025
    https://doi.org/10.4081/btvb.2025.167
    1272
    PDF: 341
  • Cardiovascular risk profile evolution over 15 years: comparison between CV-PREVITAL Trial and Moli-sani Study participants

    Augusto Di Castelnuovo, Mariarosaria Persichillo
    15-01-2026
    https://doi.org/10.4081/btvb.2026.416
    776
    PDF: 187
  • Pleiotropic effects of anti-thrombotic therapies: have direct oral anticoagulants any anti-inflammatory effect?

    Anna Maria Gori, Eleonora Camilleri, Alessia Bertelli, Angela Rogolino, Francesca Cesari, Elena Lotti, Tommaso Capobianco, Walther Iannotti, Betti Giusti , Rossella Marcucci
    14-12-2022
    https://doi.org/10.4081/btvb.2022.50
    1493
    PDF: 442
  • Blood platelets, prostaglandins and aspirin: a historical and personal rereading

    Giovanni de Gaetano, Chiara Cerletti
    13-03-2024
    https://doi.org/10.4081/btvb.2024.121
    1786
    PDF: 301
  • The evolution of hemostasis genetics: from monogenic disorders to complex traits. A historical perspective

    Augusto Di Castelnuovo
    01-07-2025
    https://doi.org/10.4081/btvb.2025.184
    1241
    PDF: 235
  • Medicine at the crossroads of science, compassion and ethical responsibility

    Maria Benedetta Donati
    12-12-2025
    https://doi.org/10.4081/btvb.2025.423
    452
    PDF: 39
    HTML: 29
  • In this issue

    Giovanni de Gaetano, Chiara Cerletti
    18-03-2026
    https://doi.org/10.4081/btvb.2026.472
    45
    PDF: 14
  • A lifetime in biomedical research: an interview with Silvio Garattini

    Americo Bonanni
    12-03-2026
    https://doi.org/10.4081/btvb.2026.466
    47
    PDF: 15
  • Risk of recurrent venous thromboembolism in cancer patients after discontinuation of anticoagulant therapy

    Gary E. Raskob
    16-05-2024
    https://doi.org/10.4081/btvb.2024.124
    1265
    PDF: 680
  • SISET50: trajectories of hemostasis and thrombosis in Italy 1970-2020

    Giovanni de Gaetano, Maria Benedetta Donati, Americo Bonanni
    17-01-2025
    https://doi.org/10.4081/btvb.2025.170
    1330
    PDF: 282
  • The changing landscape of treatment for acquired hemophilia A

    Massimo Franchini, Daniele Focosi
    30-01-2025
    https://doi.org/10.4081/btvb.2025.157
    1737
    PDF: 436
  • Executive summary of the SISET position paper on the management of antithrombotic therapy in left ventricular thrombus

    Emanuele Valeriani, Arianna Pannunzio, Danilo Menichelli, Domenico Prisco, Walter Ageno, Daniele Pastori, Pasquale Pignatelli
    16-12-2025
    https://doi.org/10.4081/btvb.2025.401
    228
    PDF: 50
    HTML: 17
  • PO18 | Does muscle mass matter? Appendicular lean mass as a determinant of anti-XA activity in elderly patientes B.M. Zanforlini1, V. Bernardi1, E. Campello2, E.M. Bicego1, C. Curreri1, A. Vaticano1, C. Sartori1, L. Manfron1, A. Perencin1, P. Rollo1, A. Baruffol1, L. Ruoso1, C. Simion2, C. Bulato2, P. Berto2, P. Simioni2, G. Sergi1 | 1Department of Medicine, Geriatrics Section, University of Padova; 2Haemorrhagic and Thrombotic Diseases Unit, Department of Medicine DIMED, Padova University Hospital, Padova, Italy

    22-10-2025
    https://doi.org/10.4081/btvb.2025.278
    449
    PDF: 0
  • Author's Reply. Da la scheggia rotta usciva insieme parole e sangue: an unusual case of bleeding and the metaphor of a clinical trial

    Giovanni de Gaetano
    05-12-2024
    https://doi.org/10.4081/btvb.2024.163
    861
    PDF: 179
  • PO88 | Bacterial lysate “lantigen B” induces proliferation of B and NK cells and the release of related cytokines M. Alfonsetti1, R. Liani1, P. Di Mattia3, M. Tredicine4, F. Papa3, Q. Niu5, M. Di Gioacchino2, F. Santilli1,3 | 1Department of Medicine and Aging, Center for Advanced Studies and Technology, University of Chieti, Italy; 2Institute for Clinical Immunotherapy and Advanced Biological Treatments, Pescara, Italy; 3Specialization School of Allergy and Clinical Immunology, G. d’Annunzio University, Chieti, Italy; 4Department of Medical, Oral, and Biotechnology Science, University G. d’Annunzio, Chieti-Pescara, Chieti, Italy; 5Department of Occupational Health, School of Public Health, Shanxi Medical University, Taiyuan, Shanxi, China

    22-10-2025
    https://doi.org/10.4081/btvb.2025.358
    548
    PDF: 0
  • Moving beyond p-value

    Augusto Di Castelnuovo, Licia Iacoviello
    15-04-2022
    https://doi.org/10.4081/btvb.2022.30
    2327
    PDF: 527
  • CO28 | Cognitive, adaptive abilities and behavioral symptoms in children and adolescents with hemophilia: a pilot study R. Vallone1, M. Luciani2, A. Smigliani2, M. F. Mansueto3, S. Vicari1,4, D. Menghini1 | 1Child and Adolescent Neuropsychiatry Unit, Bambino Gesù Children’s Hospital, IRCCS, Roma; 2OncoHematology Unit, Bambino Gesù Children’s Hospital, IRCCS, Roma; 3Department of Oncology U.O. Hematology AUO Policlinico, Paolo Giaccone, Palermo; 4Department of Life Science and Public Health, Università Cattolica del Sacro Cuore, Roma, Italy

    22-10-2025
    https://doi.org/10.4081/btvb.2025.234
    484
    PDF: 0
  • Da la scheggia rotta usciva insieme parole e sangue: an unusual case of bleeding and the metaphor of a clinical trial

    Giovanni de Gaetano
    29-10-2024
    https://doi.org/10.4081/btvb.2024.156
    1823
    PDF: 346
    Appendix: 250
  • PO82 | Retrospective application of the TH2 score in a multicenter cohort of ITP patients: a reliable predictive tool or a score in need of refinement? C. Giubbilei1, M. Defina2, S. Rosati3, M. Rocco3, A. Votto4, F. Simonetti5, F. Paoletti6, V. Carrai1 | 1Hematology Unit, AOU Careggi; 2Hematology unit AOU Senese; 3Hematology Unit Azienda Sanitaria Toscana Centro; 4Hematology Unit, AOU Pisana; 5Hematology Unit, Ospedale Versilia; 6Hematology Unit, Azienda Sanitaria Nord Ovest, Italy

    22-10-2025
    https://doi.org/10.4081/btvb.2025.351
    429
    PDF: 0
  • Comment on "Apixaban vs. aspirin for stroke prevention in people with subclinical atrial fibrillation and a history of stroke or transient ischemic attack: subgroup analysis of the ARTESiA randomized controlled trial"

    Vittorio Pengo
    01-07-2025
    https://doi.org/10.4081/btvb.2025.179
    859
    PDF: 228
  • CO27 | Intracerebral hemorrhage in hemophilia A and B: a 10-year prospective multicenter study in Italy (2012–2022) E. Zanon1, A. Napolitano1, A. Porreca2, F. Demartis3, A. Coppola4, C. Santoro5, I. Cantori6, A. C. Molinari7, C. Biasioli8, M. Luciani9, G. Sottilotta10, B. Pollio11, A. Borchiellini12, A. Tosetto13, P. Flora14, P. Simioni1 | 1Haemophilia Center, First Chair of Internal Medicine, Department of Medicine, University-Hospital of Padua Medical School, Padua; 2Department of Human Sciences and Promotion of the Quality of Life, Unit of Clinical and Molecular Epidemiology IRCCS San Raffaele Roma Open University, Roma; Unit of Clinical and Molecular Epidemiology IRCCS San Raffaele, Roma; 3Centre for Bleeding Disorders, Careggi University Hospital of Firenze; 4Azienda Ospedaliero Universitaria di Parma; 5Hematology Division, Umberto I University Hospital of Roma; 6Haemophilia Center, Department of Transfusion Medicine, Hospital of Macerata; 7IRCCS Istituto Giannina Gaslini, Genova; 8Haemophilia and Transfusion Centre, Bufalini Hospital, Cesena; 9Children’s Hospital Bambino Gesù, Roma; 10Haemophilia Center, Department of Onco-Hematology and Radioterapy, Hospital of Reggio Calabria; 11Haemophilia Pediatric Center, Transfusion Medicine, City of Health and Science of Turin; 12City of Health and Science of Turin; 13Hemorrhagic and Thrombotic Diseases Unit, S. Bortolo Hospital of Vicenza; 14RCCS Foundation Ca’ Granda Maggiore Policlinico Hospital, Milan, Italy

    22-10-2025
    https://doi.org/10.4081/btvb.2025.233
    483
    PDF: 0
  • Ankle brachial index for the diagnosis of asymptomatic lower extremity peripheral arterial disease

    Francesco Cicconi
    05-07-2024
    https://doi.org/10.4081/btvb.2024.128
    2180
    PDF: 501
  • CO05 | Long-term management of upper extremity catheter-related thrombosis in female patients with cancer: a retrospective cohort study Chiara Cavallaro1,2, Paolo Santini1,2, Laura Leoni3, Carolina Mosoni1,2, Silvia D’Ambrosio1,2, Francesco Mancinetti1,2, Nicola Coletta1,2, Michela Iorio1,2, Angelo Porfidia1,2, Alessandro D’Errico1,2, Rosa Talerico1,2, Roberto Pola1,2 | 1Department of Aging, Orthopedic, and Rheumatologic Sciences, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome; 2Università Cattolica del Sacro Cuore, Rome; 3Vita-Salute University, San Raffaele Hospital IRCCS, Milan, Italy

    22-10-2025
    https://doi.org/10.4081/btvb.2025.309
    491
    PDF: 0
  • CO25 | Thromboinflammation and ros accumulation in individuals with high lipoprotein(a) levels M. Frezza1, P.G.M. Simeone1, M. Alfonsetti1, R. Liani1, M. Cellini1, P. Del Boccio2, M.C. Cufaro3, O. Iuliani4, A. Quaglietta4, F. Cipollone1, F. Santilli1 | 1Department of Medicine and Ageing Sciences, Center for Advanced Studies and Technology “CAST”, University of Chieti; 2Department of Pharmacy, Center for Advanced Studies and Technology “CAST”, Chieti; 3Department of Innovative Technologies in Medicine and Dentistry, Center for Advanced Studies and Technology “CAST”, Chieti; 4Department of Haematolgy and Oncology, Center of Transfusion Medicine, Pescara General Hospital, Pescara. Italy

    22-10-2025
    https://doi.org/10.4081/btvb.2025.231
    450
    PDF: 0
  • PO42 | Acquired Von Willebrad syndrome in patients with myeloproliferative syndrome: literature review and single-center experience A. Strangio, M. Leotta, A. Ierardi, R C. Santoro | UO Emofilia, Emostasi e Trombosi, AOU R Dulbecco, Catanzaro, Italy

    22-10-2025
    https://doi.org/10.4081/btvb.2025.305
    388
    PDF: 0
  • Inflammation, platelets and diabetes

    Francesca Santilli, Paola Simeone, Rossella Liani
    12-06-2023
    https://doi.org/10.4081/btvb.2023.77
    1036
    PDF: 392
  • CO11 | Oral anticoagulation with vitamin K antagonists in early childhood: a single centre-experience B. Borsellino1,2, B. Pollio1, I. Ricca1, R. Albiani1, T. Martini1 | 1Haemophilia Centre, Immune-Haematology and Transfusion Medicine, University Hospital “Città della Salute e della Scienza”, Torino; 2Department of Biomedicine and Prevention, PhD in Immunology, Molecular Medicine and Applied Biotechnology, University of Roma Tor Vergata, Roma, Italy

    22-10-2025
    https://doi.org/10.4081/btvb.2025.215
    520
    PDF: 0
  • Factor XI inhibitors: a new option for the prevention and treatment of cancer-associated thrombosis

    Marcello Di Nisio, Matteo Candeloro, Nicola Potere, Ettore Porreca, Jeffrey I. Weitz
    16-05-2024
    https://doi.org/10.4081/btvb.2024.118
    1524
    PDF: 750
  • PO41 | Comparison of the haemorrhagic phenotype between female and male patients affected by autosomal inherited bleeding disorders in a single-centre cohort B. Borsellino1,3, C. Zuccotti2, L. Guarnera3,4, C. Biasoli5, P. Pedrazzi5, T. Martini1 | 1Haemophilia Centre, Immune-Haematology and Transfusion Medicine, University Hospital “Città della Salute e della Scienza”, Turin, Italy; 2Department of Clinical Pathology, Bufalini Hospital, Cesena, Italy; 3Department of Biomedicine and Prevention, PhD in Immunology, Molecular Medicine and Applied Biotechnology, University of Roma Tor Vergata, Roma, Italy; 4Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, USA; 5Haemophilia and Transfusion Centre, Bufalini Hospital, Cesena, Italy

    22-10-2025
    https://doi.org/10.4081/btvb.2025.304
    434
    PDF: 0
  • 29th National Conference of the Italian Society for the Study of Hemostasis and Thrombosis, 2025

    Guest Editor: Valerio De Stefano
    22-10-2025
    https://doi.org/10.4081/btvb.2025.408
    662
  • CS05 | Joint ultrasound follow-up in pediatric patients with haemophilia: a 12-year prospective single-center experience B. Borsellino1,2, B. Pollio1, C. Martinoli3, T. Martini1, R. Albiani1, I. Ricca1 | 1Haemophilia Centre, Immune-Haematology and Transfusion Medicine, University Hospital “Città della Salute e della Scienza”, Turin; 2Department of Biomedicine and Prevention, PhD in Immunology, Molecular Medicine and Applied Biotechnology, University of Roma Tor Vergata, Roma; 3Department of Health Science DISSAL, University of Genoa, Unit of Radiology and IRCCS San Martino Hospital, Genoa, Italy

    22-10-2025
    https://doi.org/10.4081/btvb.2025.202
    477
    PDF: 0
  • Venous thromboembolism treatment in patients with cancer: reflections on an evolving landscape

    Agnes Y.Y. Lee
    29-02-2024
    https://doi.org/10.4081/btvb.2024.111
    1807
    PDF: 704
  • PO40 | Management of paediatric patients affected by mild factor VII deficiency undergoing surgery B. Borsellino1,2, B. Pollio1, I. Ricca1, R. Albiani1, T. Martini1 | 1Haemophilia Centre, Immune-Haematology and Transfusion Medicine, University Hospital “Città della Salute e della Scienza”, Turin; 2Department of Biomedicine and Prevention, PhD in Immunology, Molecular Medicine and Applied Biotechnology, University of Roma Tor Vergata, Roma, Italy

    22-10-2025
    https://doi.org/10.4081/btvb.2025.303
    411
    PDF: 0
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Vol. 5 No. 1 (2026)
In this issue
Giovanni de Gaetano et al.
18 March 2026
Vol. 5 No. 1 (2026)
A lifetime in biomedical research: an interview with Silvio Garattini
Americo Bonanni
12 March 2026
Vol. 5 No. 1 (2026)
Diagnostic challenges in current laboratory practice at Italian Hemophilia Centers: findings from a nationwide survey
Tiziano Martini et al.
12 March 2026
Vol. 5 No. 1 (2026)
Hemophilia-free mind: a call to action
Tiziano Martini et al.
10 March 2026

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Bleeding, Thrombosis and Vascular Biology

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