Thrombophilia work-up and clinical outcomes in Indian patients with unprovoked venous and arterial thrombosis aged 18-50 years

Harimadhavan, Monisha; Ram, Bharath; G, Karthick R; Shetty, Devi Prasad; Prabhu, Shilpa; S, Nataraj K; Nayak, Akshatha; Damodar, Sharat; Zanon, Ezio; Castaman, Giancarlo; Federici, Augusto Bramante; Mancuso, Maria Elisa; Pasut, Gianfranco; Tosetto, Alberto; Rocino, Angiola; Santoro, Rita Carlotta; Barcellona, Doris; Tripodi, Armando; Di Castelnuovo, Augusto; Persichillo, Mariarosaria; Candura, Fabio; Marchesini, Emanuela; Forni, Gian Luca; Gringeri, Alessandro; Gentilini, Ilaria; Tricoli, Mirko; Najjar, Osama; Teofili, Luciana

doi:10.4081/btvb..193

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CO-36 | PLATELETS MATTER: THROMBIN GENERATION IN PLATELET‐RICH-PLASMA VS. PLATELET‐POOR‐PLASMA UNDER NON-REPLACEMENT THERAPIES IN HEMOPHILIA F. Bocchi^1|2, R. Pastorino^1|2, G. Murante^1|2|3, S. Bergonzi^1|2|3, M. Capetta^1|2|3, F. Valeri^2|3, C. Dainese^2|3, A. Valpreda⁴, B. Bruno^1|3, A. Borchiellini^2|3 | ¹Department of Molecular Biotechnology and Health Sciences, University of Turin, Italy; ²Regional Centre for Thrombotic and Hemorrhagic Diseases, AOU Città della salute e della Scienza di Torino, Italy; ³Division of Hematology, AOU Città della Salute e della Scienza, University of Turin, Italy; ⁴Central Lab Baldi and Riberi, AOU Città della salute e della Scienza di Torino, Italy

Francesca Bocchi

14-10-2026

https://doi.org/10.4081/btvb.2026.646

24

PDF: 13
Thrombin generation assay in COVID-19 patients shows a hypocoagulable pattern

Giovanni L. Tiscia, Donatella Colaizzo, Antonio De Laurenzo, Filomena Cappucci, Lucia Fischetti, Elena Chinni, Mario Mastroianno, Giovanni Favuzzi, Massimo Carella, Elvira Grandone

22-10-2024

https://doi.org/10.4081/btvb.2024.145

2496

PDF: 502

Supplementary: 263
The landscape of rare coagulation factor deficiency management in Italy: a national hemophilia center survey

Silvia Linari, Renato Marino, Marzia Leotta, Antonio Coppola, Patrizia Di Gregorio, Augusto Bramante Federici, Flora Peyvandi, Cristina Santoro, Ezio Zanon, Rita Carlotta Santoro

05-11-2025

https://doi.org/10.4081/btvb.2025.369

1349

PDF: 217

HTML: 133

Appendix: 119
CO-69 | IN VITRO CORRECTION OF SEVERE FACTOR V DEFICIENCY USING A NOVEL PLASMA-DERIVED FACTOR V CONCENTRATE: A WHOLE BLOOD THROMBIN GENERATION STUDY C. Bulato¹, E. Campello¹, L. Spiezia¹, B. Serena¹, S. Toffanin¹, C. Simion¹, A. Caricasole², M. Sotgiu², A. Salvatore², F. Pierantoni², T.M. Hackeng^3|4, H.M.H. Spronk^3|4, P. Simioni¹ | ¹First Chair of Internal Medicine, Thrombotic and Haemorrhagic Diseases Unit and Haemophilia Centre, Department of Medicine, Padova University Hospital, Padova, Italy; ²Kedrion SpA, Barga Lucca, Italy; ³Coagulation Profile B.V., Maastricht, Netherland; ⁴Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, Netherland

Cristiana Bulato

14-10-2026

https://doi.org/10.4081/btvb.2026.679

23

PDF: 9
Comparison among three different bleeding scores and the thrombin generation assay to assess the different hemorrhagic phenotypes in patients with FVII deficiency

Samantha Pasca, Cristina Santoro, Chiara Ambaglio, Marisanta Napolitano, Marta Milan, Letizia Natali, Silvia Nannizzi, Filippo Mori, Paolo Simioni, Ezio Zanon

23-05-2022

https://doi.org/10.4081/btvb.2022.12

5641

PDF: 533
CO-28 | SYNERGISTIC EFFECT OF RECOMBINANT FACTOR INFUSION ON THROMBIN GENERATION IN HEMOPHILIA PATIENTS UNDER EMICIZUMAB OR CONCIZUMAB PROPHYLAXIS F. Bocchi^1|2, R. Pastorino^1|2, G. Murante^1|2|3, S. Bergonzi^1|2|3, M. Capetta^1|2|3, F. Valeri^2|3, C. Dainese^2|3, A. Valpreda⁴, B. Bruno^1|3, A. Borchiellini^2|3 | ¹Department of Molecular Biotechnology and Health Sciences, University of Turin, Italy; ²Regional Centre for Thrombotic and Hemorrhagic Diseases, AOU Città della salute e della Scienza di Torino, Italy; ³Division of Hematology, AOU Città della Salute e della Scienza, University of Turin, Italy; ⁴Central Lab Baldi and Riberi, AOU Città della salute e della Scienza di Torino, Italy

Francesca Bocchi

14-10-2026

https://doi.org/10.4081/btvb.2026.638

26

PDF: 17
CO-43 | VALIDATION OF THROMBIN GENERATION MEASUREMENT IN PLATELET-RICH PLASMA: EVOLUTION IN THE ST GENESIA^® SYSTEM F. Bocchi^1|2, R. Pastorino^1|2, G. Murante^1|2|3, S. Bergonzi^1|2|3, M. Capetta^1|2|3, F. Valeri^2|3, C. Dainese^2|3, A. Valpreda⁴, B. Bruno^1|3, A. Borchiellini^2|3 | ¹Department of Molecular Biotechnology and Health Sciences, University of Turin, Italy; ²Regional Centre for Thrombotic and Hemorrhagic Diseases, AOU Città della salute e della Scienza di Torino, Italy; ³Division of Hematology, AOU Città della Salute e della Scienza, University of Turin, Italy; ⁴Central Lab Baldi and Riberi, AOU Città della salute e della Scienza di Torino, Italy

Francesca Bocchi

14-10-2026

https://doi.org/10.4081/btvb.2026.653

18

PDF: 12
PO02 | SYNERGISTIC INTERACTION OF ENDOTHELIAL AND CANCER CELLS IN THE FORMATION AND STRUCTURE OF THE FIBRIN CLOT SHIELDS M.A. Baghdadi^1|2, E. Mbemba¹, P. Las Casa¹, P. Van Dreden^1|3, N. Saleem^1|4, J. Fareed⁴, P. Kempaiah⁴, M. Sabbah¹, G. Gerotziafas^1|4 | ¹Sorbonne University, INSERM UMR_S_938, CRSA, Research Department "Cancer, Vessels, Biology and Therapeutics" (CaVITE), Research Group "Cancer-Angiogenesis-Thrombosis and Haemostasis," Thrombosis Center, University Institute of Cancerology (UIC), Saint Antoine University Hospital Assistance Publique Hôpitaux de Paris (AP-HP) Paris France; ²Research Center, King Faisal Specialist Hospital and Research Center, Jeddah, Saudi Arabia; ³Diagnostica Stago, clinical research, Gennevilliers, France; ⁴Center of Translational Research and Education, Department of Pathology and Laboratory Medicine, Loyola University Stritch School of Medicine, Maywood, Ill., USA

ICTHIC 2026

16-04-2026

https://doi.org/10.4081/btvb.2026.498

453

PDF: 99
PO58 | Gender differences in primary haemostasis A. Becchetti², M. Brambilla², M. Conti², D. Trabattoni², E. Tremoli³, M. Camera^1,2 | ¹Department of Pharmaceutical Sciences, Università degli Studi di Milano; ²Centro Cardiologico Monzino IRCCS, Milan; ³Maria Cecilia Hospital, Cotignola (RA), Italy

22-10-2025

https://doi.org/10.4081/btvb.2025.327

641

PDF: 12
Cancer-associated thrombosis: limitations of conventional models and advances with endothelial cell-based microfluidics incorporating thrombin generation

Dongyue Fan, Araci M.R. Rondon, Henri H. Versteeg

16-04-2026

https://doi.org/10.4081/btvb.2026.438

811

PDF: 145
CO34 | Evaluation of emicizumab concentration and thrombin generation in a cohort of severe hemophilia A patients with and without inhibitor A. Taglietti¹, S. Ligia¹, F. Paoletti¹, R. Mormile¹, E. Baldacci², A. Chistolini¹, C. Santoro^1,2 | ¹Hematology, Department of Translational and Precision Medicine, Sapienza University of Roma; ²Hematology, Azienda Ospedaliera Universitaria Policlinico Umberto I, Roma, Italy

22-10-2025

https://doi.org/10.4081/btvb.2025.241

669

PDF: 12
PO47 | Hemophilia A and antithrombin deficiency: a case of natural hemostatic rebalancing L. Torrieri, S. Ligia, E. Baldacci, R. Mormile, S. Sorella, R. Ciciani, M. Biglietto, N. Zhdanovskaya, A. Delli Paoli, A. Tirnetta, M. Lorenzon, C. Santoro | Hematology, Department of Translational and Precision Medicine, Policlinico Umberto I, Sapienza University of Roma, Italy

22-10-2025

https://doi.org/10.4081/btvb.2025.316

623

PDF: 12
PO25 | Baseline thrombin generation test does not predict thrombotic events in acute leukemia: a monocentric prospective study M. Biglietto, R. Mormile, M.L. Bisegna, A. Laganà, A. L. Faccini, A. Papa, E. Baldacci, C. Santoro, M.S. De Propris, A. Chistolini | Hematology, Department of Translational and Precision Medicine Sapienza University of Roma, Italy

22-10-2025

https://doi.org/10.4081/btvb.2025.286

647

PDF: 12
PO04 | FIBRIN CLOT SHIELDS PROMOTE CLONAL SELECTION IN CANCER CELLS: PROCOAGULANT ACTIVITY AND SURVIVAL OF CLOT-EMBEDDED CELLS. A NOVEL TUMOR MICROENVIRONMENT MODEL M.A. Baghdadi^1|2, E. Mbemba¹, P. Las Casa¹, P. Van Dreden^1|3, N. Saleem^1|4, J. Fareed⁴, P. Kempaiah⁴, M. Sabbah¹, G. Gerotziafas^1|4 | ¹Sorbonne University, INSERM UMR_S_938, CRSA, Research Department "Cancer, Vessels, Biology and Therapeutics" (CaVITE), Research Group "Cancer-Angiogenesis-Thrombosis and Haemostasis," Thrombosis Center, University Institute of Cancerology, Saint Antoine University Hospital Assistance Publique Hôpitaux de Paris (AP-HP) Paris, France; ²Research Center, King Faisal Specialist Hospital and Research Center, Jeddah, Saudi Arabia; ³Diagnostica Stago, Gennevilliers, France; ⁴Center of Translational Research and Education, Department of Pathology and Laboratory Medicine, Loyola University Stritch School of Medicine, Maywood, Ill., USA

ICTHIC 2026

16-04-2026

https://doi.org/10.4081/btvb.2026.500

467

PDF: 94

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Thrombin generation assay in COVID-19 patients shows a hypocoagulable pattern

The landscape of rare coagulation factor deficiency management in Italy: a national hemophilia center survey

Comparison among three different bleeding scores and the thrombin generation assay to assess the different hemorrhagic phenotypes in patients with FVII deficiency

Cancer-associated thrombosis: limitations of conventional models and advances with endothelial cell-based microfluidics incorporating thrombin generation

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Thrombin generation assay in COVID-19 patients shows a hypocoagulable pattern

The landscape of rare coagulation factor deficiency management in Italy: a national hemophilia center survey

Comparison among three different bleeding scores and the thrombin generation assay to assess the different hemorrhagic phenotypes in patients with FVII deficiency

PO58 | Gender differences in primary haemostasis A. Becchetti2, M. Brambilla2, M. Conti2, D. Trabattoni2, E. Tremoli3, M. Camera1,2 | 1Department of Pharmaceutical Sciences, Università degli Studi di Milano; 2Centro Cardiologico Monzino IRCCS, Milan; 3Maria Cecilia Hospital, Cotignola (RA), Italy

Cancer-associated thrombosis: limitations of conventional models and advances with endothelial cell-based microfluidics incorporating thrombin generation

authors

reviewers

indexing

Keywords