Thrombophilia work-up and clinical outcomes in Indian patients with unprovoked venous and arterial thrombosis aged 18-50 years | BTVB Bioequivalence of von Willebrand factor-containing concentrates: implications for von Willebrand disease | BTVB Cardiovascular risk in hormone replacement therapy | BTVB Direct oral anticoagulants: does one dose fit all? Why, when and how testing | BTVB Cardiovascular risk profile evolution over 15 years: CV-PREVITAL vs Moli-sani Study | BTVB Launch of National Registry for Congenital Hematological Disorders in Palestine: Haemo-PAL | BTVB
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Bleeding, Thrombosis and Vascular Biology

Editor-in-Chief: Giovanni de Gaetano, Italy | eISSN: 2785-5309

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  • A commitment to global collaboration, welcoming international participation and advancing science for the benefit of patients

    Pantep Angchaisuksiri, Wolfram Ruf, Jeffrey Weitz, Sam Schulman, Guy A. Young
    01-07-2025
    https://doi.org/10.4081/btvb.2025.188
    1430
    PDF: 243
    HTML: 31
  • Medicine at the crossroads of science, compassion and ethical responsibility

    Maria Benedetta Donati
    12-12-2025
    https://doi.org/10.4081/btvb.2025.423
    487
    PDF: 48
    HTML: 30
  • Designing comprehensive and impactful implementation strategies for cancer-associated thrombosis prevention

    Karlyn A. Martin
    16-04-2026
    https://doi.org/10.4081/btvb.2026.454
    13
    PDF: 5
  • The metaphor of Ukrainian science "bleeding"

    Gaetano Torlone
    04-04-2023
    https://doi.org/10.4081/btvb.2023.73
    607
    PDF: 293
  • A message of science, peace and gratitude

    Giovanni de Gaetano, Chiara Cerletti
    02-12-2025
    https://doi.org/10.4081/btvb.2025.420
    432
    PDF: 45
  • Stroke in women: anticoagulation in a complicated puzzle

    Francesco Marongiu, Elvira Grandone, Silvia Marongiu, Antonella Mameli, Doris Barcellona
    26-08-2024
    https://doi.org/10.4081/btvb.2024.137
    1496
    PDF: 361
  • Cancer complicated by thrombosis and thrombocytopenia: still a therapeutic dilemma

    Yishi Tan, Marc Carrier, Nicola Curry, Michael Desborough, Kathryn Musgrave, Marie Scully, Tzu-Fei Wang, Mari Thomas, Simon J. Stanworth
    16-05-2024
    https://doi.org/10.4081/btvb.2024.115
    1209
    PDF: 709
  • Comments on “Low-dose aspirin for preventing intrauterine growth restriction and pre-eclampsia in sickle cell pregnancy in Nigeria (PIPSICKLE): a randomised controlled trial”

    Sistiana Aiello, Ariela Benigni, Giuseppe Remuzzi
    10-03-2026
    https://doi.org/10.4081/btvb.2026.463
    165
    PDF: 63
  • Hemostasis and the kidney: an unforeseen initial opportunity to create a small research group that grew into an institute

    Carlamaria Zoja, Ariela Benigni, Giuseppe Remuzzi
    30-06-2025
    https://doi.org/10.4081/btvb.2025.190
    590
    PDF: 140
    Supplementary: 44
  • PO61 | RISK FACTORS FOR INTRACRANIAL HEMORRHAGE: AN UMBRELLA REVIEW TO INFORM MACHINE LEARNING PREDICTION MODELS IN GLIOMA PATIENTS RECEIVING ANTICOAGULATION T.A. Adeyemo, S. Greenley, F. Ware, W. Jones, A. Maraveyas, F. Haque | 1Centre of Excellence for Data Science, Artificial Intelligence and Modelling DAIM, Faculty of Science and Engineering, University of Hull, UK; 2Hull York Medical School, Hull, UK; 3Academic Library Services, University of Hull, UK; 4NHS Humber Health Partnership, Hull, UK

    Società Italiana di Emostasi e Trombosi
    16-04-2026
    https://doi.org/10.4081/btvb.2026.552
    14
    PDF: 3
  • Automated identification of cancer-associated thrombosis events via natural language processing: a systematic review of the literature

    Aidan Boyne, Emily Zhou, Ang Li
    16-04-2026
    https://doi.org/10.4081/btvb.2026.437
    14
    PDF: 4
    Appendix_Search Terms: 2
  • CO27 | Intracerebral hemorrhage in hemophilia A and B: a 10-year prospective multicenter study in Italy (2012–2022) E. Zanon1, A. Napolitano1, A. Porreca2, F. Demartis3, A. Coppola4, C. Santoro5, I. Cantori6, A. C. Molinari7, C. Biasioli8, M. Luciani9, G. Sottilotta10, B. Pollio11, A. Borchiellini12, A. Tosetto13, P. Flora14, P. Simioni1 | 1Haemophilia Center, First Chair of Internal Medicine, Department of Medicine, University-Hospital of Padua Medical School, Padua; 2Department of Human Sciences and Promotion of the Quality of Life, Unit of Clinical and Molecular Epidemiology IRCCS San Raffaele Roma Open University, Roma; Unit of Clinical and Molecular Epidemiology IRCCS San Raffaele, Roma; 3Centre for Bleeding Disorders, Careggi University Hospital of Firenze; 4Azienda Ospedaliero Universitaria di Parma; 5Hematology Division, Umberto I University Hospital of Roma; 6Haemophilia Center, Department of Transfusion Medicine, Hospital of Macerata; 7IRCCS Istituto Giannina Gaslini, Genova; 8Haemophilia and Transfusion Centre, Bufalini Hospital, Cesena; 9Children’s Hospital Bambino Gesù, Roma; 10Haemophilia Center, Department of Onco-Hematology and Radioterapy, Hospital of Reggio Calabria; 11Haemophilia Pediatric Center, Transfusion Medicine, City of Health and Science of Turin; 12City of Health and Science of Turin; 13Hemorrhagic and Thrombotic Diseases Unit, S. Bortolo Hospital of Vicenza; 14RCCS Foundation Ca’ Granda Maggiore Policlinico Hospital, Milan, Italy

    22-10-2025
    https://doi.org/10.4081/btvb.2025.233
    524
    PDF: 0
  • PO09 | CANCER MORTALITY AFTER INCIDENT VENOUS THROMBOEMBOLISM C. Langholm1, N.H. Eide1, K. Hveem2|3|4, N. Van Es5|6, V.M. Morelli1|7, S.K. Braekkan1|7, J.B. Hansen1|7 | 1Thrombosis Research Group, Department of Clinical Medicine, UiT – The Arctic University of Norway, Tromsø, Norway; 2HUNT Research Centre, Department of Public Health and General Practice, Norwegian University of Science and Technology, Levanger, Norway; 3HUNT Center for Molecular and Clinical Epidemiology, Department of Public Health and Nursing, Norwegian University of Science and Technology, Trondheim, Norway; 4Department of Research, St. Olav University Hospital, Trondheim, Norway; 5Department of Vascular Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands; 6Amsterdam Cardiovascular Sciences Pulmonary Hypertension and Thrombosis Amsterdam, the Netherlands; 7Thrombosis Research Center, Department of Internal Medicine, University Hospital of North Norway, Tromsø, Norway

    Società Italiana di Emostasi e Trombosi
    16-04-2026
    https://doi.org/10.4081/btvb.2026.505
    8
    PDF: 2
  • Science and scientists under attack

    Valerio De Stefano
    23-05-2023
    https://doi.org/10.4081/btvb.2023.80
    614
    PDF: 276
  • The small numbers of medicine and the big numbers of artificial intelligence: a curated-data approach to appropriateness in laboratory medicine and coagulation

    Anna Mazzetto, Alessandro Camerotto
    15-04-2026
    https://doi.org/10.4081/btvb.2026.460
    19
    PDF: 9
  • A contribution from Umberto Veronesi Foundation

    Chiara Tonelli
    04-04-2023
    https://doi.org/10.4081/btvb.2023.74
    536
    PDF: 283
  • PO05 | Intensive FVIII replacement in haemophilia patients with hypertrophic synovium: a randomized study I.L. Calcaterra1, E. Baldacci2, R. Marino3, F. Valeri4, R.C. Santoro5, G. Pasta6, C. Martinoli7, M. Di Minno1 | 1Department of Clinical Medicine and Surgery, Federico II University, Naples; 2Haematology, University Hospital Policlinico Umberto I, Roma; 3Haemophilia Center and thrombosis, Policlinico, Bari; 4Regional Centre for Haemorrhagic and Thrombotic Diseases, AOU Città Della Salute e Della Scienza; Turin; 5Centre for Hemorrhagic and Thrombotic Disorders, Pugliese Ciaccio Hospital, Catanzaro; 6Fondazione IRCCS San Matteo Hospital, Pavia; 7Department of Health Science DISSAL, University of Genoa, Unit of Radiology and IRCCS San Martino Hospital, Genoa, Italy

    22-10-2025
    https://doi.org/10.4081/btvb.2025.267
    461
    PDF: 0
  • PO62 | CLINICAL AND MOLECULAR DIAGNOSTIC CHALLENGES IN MYELOPROLIFERATIVE NEOPLASMS WITH LOW JAK2V617F ALLELIC BURDEN E. Morsia, D. Lame, M. Pianelli, G. Gramazio, R. Ceccarelli, I. Battilà, S. Rupoli, A. Poloni | Department of Clinical and Molecular Science, Università Politecnica delle Marche, Ancona, Italy

    Società Italiana di Emostasi e Trombosi
    16-04-2026
    https://doi.org/10.4081/btvb.2026.553
    10
    PDF: 4
  • Thromboprophylaxis in primary brain cancer

    Eva N. Hamulyák, Barbara A. Hutten, Nick van Es
    16-04-2026
    https://doi.org/10.4081/btvb.2026.455
    31
    PDF: 3
  • CO28 | Cognitive, adaptive abilities and behavioral symptoms in children and adolescents with hemophilia: a pilot study R. Vallone1, M. Luciani2, A. Smigliani2, M. F. Mansueto3, S. Vicari1,4, D. Menghini1 | 1Child and Adolescent Neuropsychiatry Unit, Bambino Gesù Children’s Hospital, IRCCS, Roma; 2OncoHematology Unit, Bambino Gesù Children’s Hospital, IRCCS, Roma; 3Department of Oncology U.O. Hematology AUO Policlinico, Paolo Giaccone, Palermo; 4Department of Life Science and Public Health, Università Cattolica del Sacro Cuore, Roma, Italy

    22-10-2025
    https://doi.org/10.4081/btvb.2025.234
    521
    PDF: 0
  • Science in Ukraine is “bleeding”

    Giovanni de Gaetano
    14-03-2023
    https://doi.org/10.4081/btvb.2023.69
    1050
    PDF: 298
  • Still unmet problems with low molecular weight heparin prophylaxis of venous thromboembolism. An Italian survey

    Stefania Cavazza, Gualtiero Palareti*
    03-10-2025
    https://doi.org/10.4081/btvb.2025.177
    1292
    PDF: 217
    HTML: 86
    Supplementary: 60
  • PO57 | A NOVEL RISK ASSESSMENT MODEL FOR CANCER DETECTION WITHIN ONE YEAR AFTER INCIDENT VENOUS THROMBOEMBOLISM C. Antoun1, J. Hansen1|3, S. Brækkan1|3, C. Langholm1, N. Eide1, V. Morelli1|3, K. Hveem2 | 1Department of Clinical Medicine, UiT The Arctic University of Norway, Tromsø; 2HUNT Center for Molecular and Clinical Epidemiology, Norwegian University of Science and Technology, Trondheim; 3Thrombosis Research Center, Division of Internal Medicine, University Hospital of North Norway, Tromsø, Norway

    Società Italiana di Emostasi e Trombosi
    16-04-2026
    https://doi.org/10.4081/btvb.2026.549
    8
    PDF: 1
  • PO88 | Bacterial lysate “lantigen B” induces proliferation of B and NK cells and the release of related cytokines M. Alfonsetti1, R. Liani1, P. Di Mattia3, M. Tredicine4, F. Papa3, Q. Niu5, M. Di Gioacchino2, F. Santilli1,3 | 1Department of Medicine and Aging, Center for Advanced Studies and Technology, University of Chieti, Italy; 2Institute for Clinical Immunotherapy and Advanced Biological Treatments, Pescara, Italy; 3Specialization School of Allergy and Clinical Immunology, G. d’Annunzio University, Chieti, Italy; 4Department of Medical, Oral, and Biotechnology Science, University G. d’Annunzio, Chieti-Pescara, Chieti, Italy; 5Department of Occupational Health, School of Public Health, Shanxi Medical University, Taiyuan, Shanxi, China

    22-10-2025
    https://doi.org/10.4081/btvb.2025.358
    582
    PDF: 0
  • Trends and updates on the epidemiology of cancer-associated thrombosis: a systematic review

    Ang Li, Emily Zhou
    16-05-2024
    https://doi.org/10.4081/btvb.2024.108
    1443
    PDF: 563
  • A lifetime in biomedical research: an interview with Silvio Garattini

    Americo Bonanni
    12-03-2026
    https://doi.org/10.4081/btvb.2026.466
    138
    PDF: 35
  • CS05 | Joint ultrasound follow-up in pediatric patients with haemophilia: a 12-year prospective single-center experience B. Borsellino1,2, B. Pollio1, C. Martinoli3, T. Martini1, R. Albiani1, I. Ricca1 | 1Haemophilia Centre, Immune-Haematology and Transfusion Medicine, University Hospital “Città della Salute e della Scienza”, Turin; 2Department of Biomedicine and Prevention, PhD in Immunology, Molecular Medicine and Applied Biotechnology, University of Roma Tor Vergata, Roma; 3Department of Health Science DISSAL, University of Genoa, Unit of Radiology and IRCCS San Martino Hospital, Genoa, Italy

    22-10-2025
    https://doi.org/10.4081/btvb.2025.202
    503
    PDF: 0
  • PO16 | EPIDEMIOLOGY, CLINICAL CHARACTERISTICS, AND OUTCOMES OF PROVOKED AND UNPROVOKED PULMONARY EMBOLISM IN A MULTICULTURAL ISRAELI POPULATION R. Farah1, N.L. Bragazzi2|3|4, H.İ. Ceylan5, Ł. Szarpak6|7|8|9, W. Mahajni1, N. Ashqar1, A. M. Fioretti10, R. Khamisy-Farah11 | 1Internal Medicine B Department, Ziv Medical Center, Azrieli Faculty of Medicine, Bar-Ilan University, Galilee, Safed, Israel; 2Laboratory for Industrial and Applied Mathematics, Department of Mathematics and Statistics, York University, Toronto, Canada; 3Postgraduate School of Public Health, Department of Health Sciences, University of Genoa, Italy; 4UNESCO Chair, Health Anthropology, Biosphere and Healing Systems, University of Genoa, Italy; 5Physical Education and Sports Teaching Department, Faculty of Sports Sciences, Atatürk University, Erzurum, Turkey; 6Department of Clinical Research and Development, LUXMED Group, Warsaw, Poland; 7Institute of Medical Science, Collegium Medicum, The John Paul II Catholic University of Lublin, Lublin, Poland; 8The World Academic Council of Emergency Medicine, Sarasota, FL, USA; 9Henry JN Taub Department of Emergency Medicine, Baylor College of Medicine, Houston, TX, USA; 10Cardio-Oncology Unit, IRCCS Istituto Tumori “Giovanni Paolo II”, Bari, Italy; 11Clalit Health Service, Azrieli Faculty of Medicine, Bar-Ilan University, Galilee, Safed, Israel

    Società Italiana di Emostasi e Trombosi
    16-04-2026
    https://doi.org/10.4081/btvb.2026.511
    9
    PDF: 2
  • PO79 | Trying to hit the hit in the shadow of renal failure: a complex case managed with danaparoid S. Chessa1,2, M. Anedda2, M.V. Cherchi2, M. Vacca1,2, M. Caboni2, J. Pilia2, A.M. Bussu2, M. Mantega2, G. Costanzo1, D. Firinu1, S. Del Giacco1, A. Mameli3, D. Barcellona3 | 1Department of Medical Science and Public Health, University of Cagliari; 2Internal Medicine, ASL Sulcis, PO Sirai, Carbonia; 3Department of Medical Sciences and Public Health, Hemostasis and Thrombosis Unit, University of Cagliari and AOU of Cagliari, Italy

    22-10-2025
    https://doi.org/10.4081/btvb.2025.348
    528
    PDF: 0
  • Reducing the risks of nuclear war - The role of health professionals

    Kamran Abbasi, Parveen Ali, Virginia Barbour, Kirsten Bibbins-Domingo, Marcel G.M. Olde Rikkert, Andy Haines, Ira Helfand, Richard Horton, Bob Mash, Arun Mitra, Carlos Monteiro, Elena N. Naumova, Eric J. Rubin, Tilman Ruff, Peush Sahni, James Tumwine, Paul Yonga, Chris Zielinski
    21-08-2023
    https://doi.org/10.4081/btvb.2023.94
    1245
    PDF: 327
  • CS02 | Functional and structural impairments of the cerebral microcirculation in a mouse model of hemophilia A G. Venturin1, C. Olgasi2, C. Borsotti1, P.E. Di Simone1, E. Spicuglia1 A. Cucci1, C. Sgromo1, A. Follenzi2,3 | 1Department of Health Science, Università del Piemonte Orientale, Novara; 2Department of Translational Medicine, Università del Piemonte Orientale, Novara; 3Department of Attività Integrate Ricerca Innovazione, Azienda Ospedaliero-Universitaria SS. Antonio e Biagio e C. Arrigo, Alessandria, Italy

    22-10-2025
    https://doi.org/10.4081/btvb.2025.197
    589
    PDF: 0
  • PO56 | Safety of anticoagulant treatment in patients with splanchnic vein thrombosis and history of portal hypertension-related bleeding R. Talerico1, S. Pellegrino1, A. Plessier2, F.R. Ponziani3, A. Porfidia1, F. Landi1, A. Gasbarrini3, R. Pola1, F. Santopaolo3 | 1Department of Geriatric, Orthopedic, and Rheumatologic Sciences, Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica del Sacro Cuore, Roma, Italy; 2Université de Paris, AP-HP, C, DMU DIGEST, Centre de Référence des Maladies Vasculaires du Foie, FILFOIE, ERN RARE-LIVE. Centre de recherche sur l’inflammation, Inserm, Paris, France; 3Department of Medical and Surgical Sciences, Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica del Sacro Cuore, Roma, Italy

    22-10-2025
    https://doi.org/10.4081/btvb.2025.325
    457
    PDF: 0
  • Cardiovascular risk in hormone replacement therapy

    Doris Barcellona
    09-02-2026
    https://doi.org/10.4081/btvb.2026.411
    1161
    PDF: 234
  • Preface to the 13th International Conference on Thrombosis and Hemostasis Issues in Cancer, 2026

    Anna Falanga, Benjamin Brenner, Alok A. Khorana
    16-04-2026
    https://doi.org/10.4081/btvb.2026.479
    25
    PDF: 14
  • PO15 | Venous thromboembolism risk associated with midline catheters and peripherally inserted central catheters: a systematic review and meta-analysis D. Santagata1, F. Subri1, F. Dentali1,2, M.P. Donadini1, I. Giarretta2 | 1Department of Medicine and Surgery, Research Center on Thromboembolic Disorders and Antithrombotic Therapies, University of Insubria, Varese and Como; 2Department of Internal Medicine, Ospedale di Circolo and Fondazione Macchi, Varese, Italy

    22-10-2025
    https://doi.org/10.4081/btvb.2025.276
    435
    PDF: 0
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Vol. 5 No. 1 (2026)
A lifetime in biomedical research: an interview with Silvio Garattini
Americo Bonanni
12 March 2026
Vol. 5 No. 1 (2026)
Hemophilia-free mind: a call to action
Tiziano Martini et al.
10 March 2026
Vol. 5 No. 1 (2026)
Comments on “Low-dose aspirin for preventing intrauterine growth restriction and pre-eclampsia in sickle cell pregnancy in Nigeria (PIPSICKLE): a...
Sistiana Aiello et al.
10 March 2026

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Bleeding, Thrombosis and Vascular Biology

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