Commentaries
Vol. 5 No. 1 (2026)
Comments on “Low-dose aspirin for preventing intrauterine growth restriction and pre-eclampsia in sickle cell pregnancy in Nigeria (PIPSICKLE): a randomised controlled trial”
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All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Published: 10 March 2026
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In the early 1970s, aspirin (acetylsalicylic acid) was shown to inhibit platelet aggregation by irreversibly acetylating platelet cyclooxygenase (COX), thereby suppressing the synthesis of its pro-aggregating product thromboxane A₂ (TxA₂)...
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Citations
1. de Gaetano G, Cerletti C. Blood platelets, prostaglandins and aspirin: a historical and personal rereading. Bleeding Thromb Vasc Biol 2024;3:121. DOI: https://doi.org/10.4081/btvb.2024.121
2. Patrignani P, Filabozzi P, Patrono C. Selective cumulative inhibition of platelet thromboxane production by low-dose aspirin in healthy subjects. J Clin Invest 1982;69:1366-72. DOI: https://doi.org/10.1172/JCI110576
3. FitzGerald GA, Oates JA, Hawiger J, et al. Endogenous biosynthesis of prostacyclin and thromboxane and platelet function during chronic administration of aspirin in man. J Clin Invest 1983;71:676-88. DOI: https://doi.org/10.1172/JCI110814
4. No authors listed. Randomised trial of intravenous streptokinase, oral aspirin, both, or neither among 17,187 cases of suspected acute myocardial infarction: ISIS-2. ISIS-2 (Second International Study of Infarct Survival) Collaborative Group. Lancet 1988;2:349-60. DOI: https://doi.org/10.1016/S0140-6736(88)92833-4
5. de Gaetano G, Collaborative Group of the Primary Prevention Project. Low-dose aspirin and vitamin E in people at cardiovascular risk: a randomised trial in general practice. Lancet 2001;357:89-95. DOI: https://doi.org/10.1016/S0140-6736(00)03539-X
6. de Gaetano G, Livio M, Donati MB, Remuzzi G. Platelet and vascular prostaglandins in uraemia, thrombotic microangiopathy and pre-eclampsia. Philos Trans R Soc Lond B Biol Sci 1981;294:339-42. DOI: https://doi.org/10.1098/rstb.1981.0110
7. Remuzzi G, Marchesi D, Zoja C, et al. Reduced umbilical and placental vascular prostacyclin in severe pre-eclampsia. Prostaglandins 1980;20:105-10. DOI: https://doi.org/10.1016/0090-6980(80)90010-6
8. Remuzzi G, Zoja C, Marchesi D, et al. Plasmatic regulation of vascular prostacyclin in pregnancy. Br Med J 1981;282:542-4. DOI: https://doi.org/10.1136/bmj.282.6263.512
9. Remuzzi G, Marchesi D, Mecca G, et al. Reduction of fetal vascular prostacyclin activity in pre-eclampsia. Lancet 1980;2:310. DOI: https://doi.org/10.1016/S0140-6736(80)90249-4
10. Benigni A, Gregorini G, Frusca T, et al. Effect of low-dose aspirin on fetal and maternal generation of thromboxane by platelets in women at risk for pregnancy-induced hypertension. N Engl J Med 1989;321:357-62. DOI: https://doi.org/10.1056/NEJM198908103210604
11. World Health Organization. WHO recommendations on antiplatelet agents for the prevention of pre-eclampsia. 2021. Available from: https://www.who.int/publications/i/item/9789240037540
12. Henderson JT, Vesco KK, Senger CA, Thomas RG, Redmond N. Aspirin use to prevent preeclampsia and related morbidity and mortality: updated evidence report and systematic review for the US Preventive Services Task Force. JAMA 2021;326:1192-206. DOI: https://doi.org/10.1001/jama.2021.8551
13. Oteng-Ntim E, Pavord S, Howard R, et al. Management of sickle cell disease in pregnancy. A British Society for Haematology guideline. Br J Haematol 2021;194:980-95. DOI: https://doi.org/10.1111/bjh.17671
14. American College of Obstetricians and Gynecologists. Hemoglobinopathies in pregnancy. 2022. Available from: https://www.acog.org/clinical/clinical-guidance/practice-advisory/articles/2022/08/hemoglobinopathies-in-pregnancy
15. World Health Organization. WHO recommendations on the management of sickle cell disease during pregnancy, child birth and the interpregnancy period. 2025. Available from: https://www.who.int/publications/i/item/9789240109124
16. Afolabi BB, Babah OA, Oshodi YA, et al. Low-dose aspirin for preventing intrauterine growth restriction and pre-eclampsia in sickle cell pregnancy in Nigeria (PIPSICKLE): a randomised controlled trial. Lancet Glob Health 2026;14:e386-94.
17. Pecker LH, Lanzkron SM. Low-dose aspirin for preventing intrauterine growth restriction and pre-eclampsia in sickle cell pregnancy. Lancet Glob Health. 2026;14:e314. DOI: https://doi.org/10.1016/S2214-109X(25)00482-6
18. No authors listed. ACOG Committee Opinion No. 743: low dose aspirin use during pregnancy. Obstet Gynecol 2018;132:e44-52. DOI: https://doi.org/10.1097/AOG.0000000000002708
19. Greenberg J, Ohene-Frempong K, Halus J, et al. Trial of low doses of aspirin as prophylaxis in sickle cell disease. J Pediatr 1983;102:781-84. DOI: https://doi.org/10.1016/S0022-3476(83)80258-3
20. Swarray-Deen A, Asare EV, Brew RA, et al. Sustainability of low maternal mortality in pregnant women with SCD in a low-resource setting. Blood Adv 2022;6:1977-80. DOI: https://doi.org/10.1182/bloodadvances.2021005942
How to Cite
1.
Aiello S, Benigni A, Remuzzi G. Comments on “Low-dose aspirin for preventing intrauterine growth restriction and pre-eclampsia in sickle cell pregnancy in Nigeria (PIPSICKLE): a randomised controlled trial”. Bleeding Thromb Vasc Biol [Internet]. 2026 Mar. 10 [cited 2026 Apr. 21];5(1). Available from: https://www.btvb.org/btvb/article/view/463
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