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Bleeding, Thrombosis and Vascular Biology

Editor-in-Chief: Giovanni de Gaetano, Italy | eISSN: 2785-5309

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  • The landscape of rare coagulation factor deficiency management in Italy: a national hemophilia center survey

    Silvia Linari, Renato Marino, Marzia Leotta, Antonio Coppola, Patrizia Di Gregorio, Augusto Bramante Federici, Flora Peyvandi, Cristina Santoro, Ezio Zanon, Rita Carlotta Santoro
    05-11-2025
    https://doi.org/10.4081/btvb.2025.369
    1347
    PDF: 217
    HTML: 133
    Appendix: 119
  • Lupus anticoagulant: a never-ending story. New insights from anti-prothrombin antibodies

    Vittorio Pengo
    28-08-2026
    https://doi.org/10.4081/btvb.2026.469
    320
    PDF: 197
  • PO12 | IMPACT OF INHERITED THROMBOPHILIA ON CANCER-ASSOCIATED THROMBOSIS: A SYSTEMATIC REVIEW AND META-ANALYSIS E. Campello1, G. Furlan1, A. Boccatonda2, A. Napolitano1, C. Simion1, P. Simioni1 | 1Internal Medicine 1 and Thrombotic and Hemorrhagic Diseases Unit, Department of Medicine, University of Padova, Italy; 2Diagnostic and Therapeutic Interventional Ultrasound Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlinico Sant'Orsola-Malpighi, Bologna, Italy

    ICTHIC 2026
    16-04-2026
    https://doi.org/10.4081/btvb.2026.508
    461
    PDF: 105
  • The key to fibrinolysis and thrombolysis

    Roger Lijnen, Désiré Collen
    09-09-2025
    https://doi.org/10.4081/btvb.2025.368
    1686
    PDF: 521
    HTML: 261
  • CO09 | Long term effectiveness and safety of direct oral anticoagulants in patients with factor V Leiden and/or prothrombin gene mutation and venous thromboembolism: a single centre, retrospective cohort study I.M. Palumbo1, E. Valeriani1,2, A. Pannunzio1, S. Marucci3, D. Menichelli1, D. Pastori3,4, P. Pignatelli3 | 1Department of General Surgery and Surgical Specialty, Sapienza University of Roma; 2Department of Infectious Disease, Azienda Ospedaliero-Universitaria Policlinico Umberto I, Roma; 3Department of Clinical Internal, Anaesthesiologic and Cardiovascular Sciences, Sapienza University of Roma; 4IRCCS Neuromed, Pozzilli, Italy

    22-10-2025
    https://doi.org/10.4081/btvb.2025.213
    749
    PDF: 24
  • Diagnostic and management practices for inherited fibrinogen disorders: a nationwide survey of Italian Hemophilia Treatment Centers

    Renato Marino, Silvia Linari, Marzia Leotta, Antonio Coppola, Chiara Biasoli, Maria Elisa Mancuso, Flora Peyvandi, Cristina Santoro, Ezio Zanon, Rita Carlotta Santoro
    02-12-2025
    https://doi.org/10.4081/btvb.2025.372
    912
    PDF: 119
    HTML: 121
    Supplementary: 78
    Appendix: 79
  • CO17 | Clinical relevance of isolated anti-phosphatidylserine/ prothrombin antibody positivity A. Hoxha1, P. Žigon2,3, L. Katja2,3, S. Čučnik2,4, Ž. Rotar2,5, S. Gavasso1, P. Zerbinati1, G. Gobbo1, P. Simioni1 | 1University of Padua, Internal Medicine Unit, Thrombotic and Hemorrhagic Centre, Department of Medicine-DIMED, Padua, Italy; 2University Medical Centre Ljubljana, Department of Rheumatology, Ljubljana, Slovenia; 3University of Primorska, Faculty of Mathematics, Natural Sciences and Information Technologies, Koper, Slovenia; 4University of Ljubljana, Faculty of Pharmacy, Ljubljana, Slovenia; 5University of Ljubljana, Faculty of Medicine, Ljubljana, Slovenia

    22-10-2025
    https://doi.org/10.4081/btvb.2025.221
    635
    PDF: 13
  • PO37 | Single centre experience on anticoagulation in carriers of non-mild inherited thrombophilia: direct oral anticoagulants (DOAC) efficacy and safety M. D’uva1,2, G. La Barba1, G. Montanaro1, M. Di Ianni1,2, P. Ranalli1,2 | 1Hematology Unit, S. Spirito Hospital, Pescara; 2Department of Medicine and Aging Sciences, D’Annunzio University, Chieti, Italy

    22-10-2025
    https://doi.org/10.4081/btvb.2025.300
    643
    PDF: 21
  • CO-86 | A RARE CASE OF ACQUIRED HEMOPHILIA A ASSOCIATED WITH MYELOPROLIFERATIVE NEOPLASM A. Ierardi, A. Strangio, M. Leotta, R.C. Santoro | Hemophilia, Hemostasis and Thrombosis Unit, Azienda Ospedaliero Universitaria Renato Dulbecco, Catanzaro, Italy

    Antonella Ierardi
    14-10-2026
    https://doi.org/10.4081/btvb.2026.696
    27
    PDF: 11
  • Evaluation of Coaguchek® Pro II coagulation testing device performance to assess direct oral anticoagulant action. The DOAC-CHECK study

    Cristina Legnani, Michela Cini, Sophie Testa, Alberto Tosetto, Claudia Dellanoce, Stefania Bellesso, Giuseppe Carli, Ilaria Nichele, Laura Lissandrini, Serena Zorzi, Emilia Antonucci, Gualtiero Palareti
    01-12-2022
    https://doi.org/10.4081/btvb.2022.37
    2261
    PDF: 461
  • PO66 | Viscoelastic tests in disseminated intravascular coagulation associated with aortic aneurysm A. M. Pizzini1, C. Biasoli2, M. Bovara3, E. Gesuete1, A. Fusco1, C. Fantoni1, P. Pedrazzi2, R. Mancini3, M. Silingardi1 | 1Ambulatorio Emostasi & Trombosi, Dipartimento Medico, Ospedale Maggiore AUSL Bologna; 2SSI Presa in Carico delle Malattie Emorragiche e Tromboemboliche della Romagna; 3Laboratorio Unico Metropolitano AUSL Bologna, Italy

    22-10-2025
    https://doi.org/10.4081/btvb.2025.335
    640
    PDF: 17
  • CO11 | Oral anticoagulation with vitamin K antagonists in early childhood: a single centre-experience B. Borsellino1,2, B. Pollio1, I. Ricca1, R. Albiani1, T. Martini1 | 1Haemophilia Centre, Immune-Haematology and Transfusion Medicine, University Hospital “Città della Salute e della Scienza”, Torino; 2Department of Biomedicine and Prevention, PhD in Immunology, Molecular Medicine and Applied Biotechnology, University of Roma Tor Vergata, Roma, Italy

    22-10-2025
    https://doi.org/10.4081/btvb.2025.215
    704
    PDF: 23
  • PO42 | DIFFERENTIAL EXPRESSION OF HEMOSTATIC BIOMARKERS ACROSS CANCER TYPE AND DISEASE STAGE: A PROSPECTIVE ANALYSIS OF 4,292 PATIENTS FROM THE HYPERCAN STUDY P. Gómez-Rosas1|2|, D. Romeo1, S. Bolognini1, C. Ticozzi1, F. Schieppati1, A. D’Alessio4, R. Labianca4, A. Falanga1|5|6, M. Marchetti1|5|6 | 1Hospital Papa Giovanni XXIII, Bergamo, Italy; 2Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, the Netherlands; 3Hospital de Oncologia, Unidad Medica de Alta Especialidad (UMAE), Centro Medico Nacional Siglo XXI, Instituto Mexicano del Seguro Social (IMSS), Mexico City, Mexico; 4Fondazione ARTET Onlus, Bergamo, Italy; 5ERN EuroBloodNet; 6School of Medicine and Surgery, University of Milan Bicocca, Italy; *On Behalf Of The Hypercan Investigators

    ICTHIC 2026
    16-04-2026
    https://doi.org/10.4081/btvb.2026.536
    490
    PDF: 110
  • PO10 | Clinical and laboratory features of long-Covid syndrome: a cross-sectional study of 1,337 Covid-19 survivors C. Ambaglio1, S. V. Benatti2, C. J. Tartari1,3, L. Russo1,3, S. Bolognini1,3, C. Ticozzi1, F. Schieppati1, V. Brusegan1, S. Venturelli2, L. Barcella1, M. Rizzi2, M. Marchetti1,3, A. Falanga1,3 | 1Department of Immunohematology and Transfusion Medicine, Papa Giovanni XXIII Hospital, Bergamo; 2Division of Infectious Diseases, Papa Giovanni XXIII Hospital, Bergamo; 3Department of Medicine and Surgery, University of Milan Bicocca, Monza, Italy

    22-10-2025
    https://doi.org/10.4081/btvb.2025.272
    648
    PDF: 18
  • CO-85 | ACQUIRED HEMOPHILIA A IN LIVER CIRRHOSIS: BALANCING HEMOSTASIS BETWEEN HIGH HEMORRHAGIC AND THROMBOTIC RISKS N. Portesi, G. Martini | ASST Spedali Civili di Brescia, Italy

    Nicola Portesi
    14-10-2026
    https://doi.org/10.4081/btvb.2026.695
    22
    PDF: 15
  • PO63 | Atypical venous thrombosis in young patient with systemic lupus erythematosus and high-risk APL profile: provoked or not? E. Marrone, A. Parisi, G. Di Monda, F. Gallucci, D. Morelli, C. Romano, U. Malgeri, D. D’Auria, P. Morella | Internal Medicine Unit 3, Cardarelli Hospital, Naples, Italy

    22-10-2025
    https://doi.org/10.4081/btvb.2025.332
    599
    PDF: 22
  • CO35 | Bleeding phenotype characterization in patients with congenital bleeding disorders: a multigenic approach using next generation sequencing to identify coagulation-modulating variants C. Simion, L. Gianesello, C. Bulato, A. Benetti, E. Campello, A. Giannella, G. Ceolotto, E. Zanon, L. Spiezia, P. Simioni | Department of Medicine – DIMED, University of Padua, Italy

    22-10-2025
    https://doi.org/10.4081/btvb.2025.242
    537
    PDF: 27
  • CO-83 | ACQUIRED FACTOR V DEFICIENCY IN A HIGH-THROMBOTIC-RISK PATIENT: DIAGNOSTIC DILEMMA AND SUCCESSFUL MANAGEMENT G. Gazzelli1, L. Banov1, Y. Azzanelli1, C. Vernarecci1, F. Marotta1, F. Giacopelli1, E. Cenni2, V. Agostini2, A.C. Molinari1 | 1IRCCS Istituto Giannina Gaslini, Italy; 2IRCSS AOM S. Martino, Genova, Italy

    Angelo Claudio Molinari
    14-10-2026
    https://doi.org/10.4081/btvb.2026.693
    32
    PDF: 18
  • PO49 | Use of emicizumab in two patients with acquired hemophilia A: a new therapeutic approach S. Sorella, J. Micozzi, E. Baldacci, M. Biglietto, R. Mormile, A. Chistolini, R. Ciciani, L. Torrieri, N. Zhdanovskaya, M. Lorenzon, A. Delli Paoli, S. Ligia, C. Santoro | Hematology, Department of Translational and Precision Medicine, Policlinico Umberto I, Sapienza University of Roma, Italy

    22-10-2025
    https://doi.org/10.4081/btvb.2025.318
    657
    PDF: 23
  • The changing landscape of treatment for acquired hemophilia A

    Massimo Franchini, Daniele Focosi
    30-01-2025
    https://doi.org/10.4081/btvb.2025.157
    2057
    PDF: 544
  • CO32 | Major surgery in patients with severe hemophilia A without inhibitors receiving prophylaxis with fitusiran E. Zanon, C. Simion, A. Napolitano, L. Spiezia, P. Simioni | Haemophilia Center, First Chair of Internal Medicine, Department of Medicine, University-Hospital of Padua Medical School, Padua, Italy

    22-10-2025
    https://doi.org/10.4081/btvb.2025.239
    555
    PDF: 21
  • CO-73 | WHEN BLEEDING MIMICS THROMBOSIS: DIAGNOSTIC DELAY AND THROMBOTIC COMPLICATIONS IN ACQUIRED HEMOPHILIA A R. Tomasello1, M. Mattana1, S. Raso1, F. Schirò1, P. Polidori2, M.I. Di Lena3, F. La Gattuta4, M. Napolitano1 | 1Ematologia e malattie rare, PO Cervello di Palermo, Italy; 2Farmacia ospedaliera, PO Cervello di Palermo, Italy; 3Direzione medica, PO Cervello di Palermo, Italy; 4Radiologia interventistica, PO Villa Sofia di Palermo, Italy

    Riccardo Tomasello
    14-10-2026
    https://doi.org/10.4081/btvb.2026.683
    28
    PDF: 8
  • PO45 | Routine prophylaxis with PD-FX concentrate in severe inherited FX deficiency: a case report S. Linari, L. Pieri, M. Attanasio, F. Salvianti, M. Coppo, E. Grisanti, F. Demartis, R. Fjerza, G. Castaman | Centre for Bleeding Disorders and Coagulation, Azienda Ospedaliera Universitaria Careggi, Firenze, Italy

    22-10-2025
    https://doi.org/10.4081/btvb.2025.308
    618
    PDF: 20
  • Influence of emicizumab on protein C-mediated clotting regulation

    Federica Mancazzo, Antonia Vitulli, Lavinia Dirienzo, Concetta T. Ammollo, Fabrizio Semeraro, Mario Colucci
    25-10-2023
    https://doi.org/10.4081/btvb.2023.89
    2647
    PDF: 439
    Supplementary Material: 136
  • CO19 | Hypercoagulability in wild-type transthyretin amyloidosis: evidence from whole blood thromboelastometry A. Napolitano1, L. Spiezia1, C. Samà1, A. Benetti1, G. Sinigiani2, L. De Michieli2, A. Cipriani2, P. Simioni1 | 1First Chair of Internal Medicine, Department of Medicine, University Hospital of Padua; 2Department of Cardiothoracic and Vascular Sciences & Public Health, University Hospital of Padua, Italy

    22-10-2025
    https://doi.org/10.4081/btvb.2025.223
    591
    PDF: 10
  • CO-57 | NXT007 PROPHYLAXIS IN PEOPLE WITH HEMOPHILIA A WITH OR WITHOUT FACTOR VIII INHIBITORS: COMBINED ANALYSIS OF TWO PHASE I/II MULTIPLE-ASCENDING-DOSE STUDIES M.E. Mancuso1|2, M. Shima3, J.M. Staber4, Y.C. Chen5, F.J. López-Jaime6, M.C. Shen7, G. Ventriglia8, M. Takeyama9, C. Schmitt8, Y.S. Park10, A. Kiialainen8, N. Mizuno11, M. Niggli8, T. Miyake11, D. Matino12, T. Saito11, V. Jiménez-Yuste13, R. Kobayashi11, D. Hart14, K. Nogami15 | 1Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milano, Italy; 2Center for Thrombosis and Hemorrhagic Diseases, IRCCS Humanitas Research Hospital, Rozzano, Milano, Italy; 3Thrombosis and Hemostasis Research Center, Nara Medical University, Kashihara, Nara, Japan; 4Stead Family Department of Pediatrics, Carver College of Medicine, University of Iowa, Iowa City, USA; 5Hemophilia Care and Research Center, Tri-Service General Hospital, National Defense Medical University, Taipei, Taiwan; 6Servicio de Hematología, Hospital Universitario Regional de Málaga / Instituto de Investigación Biomédica de Málaga (IBIMA), Málaga, Spain; 7Department of Internal Medicine, Changhua Christian Hospital, Changhua, Taiwan; 8F. Hoffmann-La Roche Ltd, Basel, Switzerland; 9Division of Hemophilia, National Hospital Organization, Osaka National Hospital, Osaka, Japan; 10Department of Pediatrics, Kyung Hee University Hospital at Gangdong, Seoul, South Korea; 11Chugai Pharmaceutical Co., Ltd, Tokyo, Japan; 12McMaster University, Hamilton, Ontario, Canada; 13La Paz University Hospital-IdiPAZ, Autónoma University, Madrid, Spain; 14Roche Products Ltd, Welwyn Garden City, UK; 15Department of Pediatrics, Nara Medical University, Kashihara, Nara, Japan

    Maria Elisa Mancuso
    14-10-2026
    https://doi.org/10.4081/btvb.2026.667
    23
    PDF: 14
  • PO44 | Emicizumab in acquired haemophilia A M. Leotta, A. Strangio, A. Ierardi, S. Prejanò, R C. Santoro | Hemostasis and Thrombosis Unit, Department Hemato-Oncology, Azienda Ospedaliero-Universitaria Renato; Dulbecco, Catanzaro, Italy

    22-10-2025
    https://doi.org/10.4081/btvb.2025.307
    619
    PDF: 19
  • A case of acquired factor XIII deficiency secondary to plasmablastic lymphoma

    Vincenzo Sammartano, Adele Santoni, Elisabetta Zappone, Paola Calzoni, Daniela Fineschi, Eleonora Franceschini, Federico Caroni, Anna Sicuranza, Monica Bocchia, Luca Puccetti
    09-03-2023
    https://doi.org/10.4081/btvb.2023.53
    1426
    PDF: 561
  • Expanding the genetic landscape of hereditary thrombophilia: classical defects, novel variants, and genomic perspectives. A narrative review

    Chiara Simion, Elena Campello, Walter Ageno, Paolo Simioni
    28-08-2026
    https://doi.org/10.4081/btvb.2026.427
    1206
    PDF: 153
    SUPPLEMENTARY FILES: 109
  • Safety of COVID-19 mRNA vaccination in patients with history of acquired hemophilia A: a case series

    Luca Puccetti, Vincenzo Sammartano, Federico Caroni, Margherita Malchiodi, Paola Calzoni, Eleonora Franceschini, Lucrezia Galasso, Monica Bocchia
    17-10-2022
    https://doi.org/10.4081/btvb.2022.40
    3050
    PDF: 431
  • PO77 | The clinical awareness of mixing test interpretation in the era of complex reporting algorithm: do we forget the origins? A. Fassina, L. De Valentin, S. Luzi, R. Turrini, A. Antico, L. Zardo | Laboratorio Analisi Castelfranco Veneto, ULSS Marca Trevigiana, Italy

    22-10-2025
    https://doi.org/10.4081/btvb.2025.346
    625
    PDF: 16
  • CO16 | The predictive value of high-sensitivity C-reactive protein for assessing thrombosis risk in non-small cell lung cancer P. Gomez-Rosas1,2, M. Marchetti1,3, L. Russo1, C.J. Tartari1, S. Bolognini1, C. Ticozzi1, F. Schieppati1, A. D’Alessio4, R. Labianca5, A. Falanga1,3 All on behalf of the Hypercan Investigators | 1Hospital Papa Giovanni XXIII, Bergamo, Italy; 2Cardiovascular Research Institute Maastricht, CARIM, Maastricht University, Maastricht, the Netherlands; 3School of Medicine and Surgery, University of Milan Bicocca, Italy; 4University Vita-Salute San Raffaele, Milan, Italy; 5Fondazione ARTET Onlus, Bergamo, Italy

    22-10-2025
    https://doi.org/10.4081/btvb.2025.220
    630
    PDF: 14
  • PO27 | B-cell lymphoproliferative disorder and acquired coagulopathy: an insidious link C. Caputo, P. Conca, I.L. Calcaterra, E. Cimino, M. Romeo, M. Aversano, E. Franco, C. De Luca, R. Russo, C. Fierarossa, M.N.D. Di Minno, A. Tufano | Department of Clinical Medicine and Surgery, Federico II University, Naples, Italy

    22-10-2025
    https://doi.org/10.4081/btvb.2025.288
    615
    PDF: 15
1 - 33 of 33 items

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Bleeding, Thrombosis and Vascular Biology

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