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  The key to fibrinolysis and thrombolysis

  Roger Lijnen, Désiré Collen

  09-09-2025

  https://doi.org/10.4081/btvb.2025.368

  1700

  PDF: 527

  HTML: 263

• CO113 | AN OBSERVATIONAL STUDY ON THE EFFECT OF HEMODIALYSIS MEMBRANES ON ENDOGENOUS THROMBIN POTENTIAL IN END-STAGE RENAL DISEASE PATIENTS Z. Saeed^1|4, O. Ndrecka², V. Sirolli², M. Bonomini², P. Lanuti^1|3, S. Gallina⁴, G. Rend^1|4 | ¹Center for Advanced Studies and Technology, G. d’Annunzio University of Chieti-Pescara, Chieti, Italy; ²Nephrology and Dialysis Unit, Department of Medicine, G. d’Annunzio University of Chieti-Pescara, SS. Annunziata Hospital, Chieti, Italy; ³Department of Medicine and Aging Sciences, G. d’Annunzio University of Chieti-Pescara, Chieti, Italy; ⁴Department of Neuroscience, Imaging and Clinical Sciences, G. d’Annunzio University of Chieti-Pescara, Chieti, Italy

  Zeeba Saeed

  26-10-2026

  https://doi.org/10.4081/btvb.2026.815

  23

  PDF: 7

• PO021 | PLATELETS MATTER: THROMBIN GENERATION IN PLATELET‐RICH PLASMA VERSUS PLATELET-POOR-PLASMA UNDER NON-REPLACEMENT THERAPIES IN HAEMOPHILIA F. Bocchi^1|2, R. Pastorino^1|2, G. Murante^1|2|3, S. Bergonzi^1|2|3, M. Capetta^1|2|3, F. Valeri^2|3, C. Dainese^2|3, A. Valpreda⁴, B. Bruno^1|3, A. Borchiellini^2|3 | ¹Department of Molecular Biotechnology and Health Sciences, University of Turin, Torino, Italy; ²Regional Centre for Thrombotic and Hemorrhagic Diseases; ³Division of Hematology; ⁴Central Lab Baldi and Riberi, AOU Città della salute e della Scienza di Torino, Torino, Italy

  Francesca Bocchi

  26-10-2026

  https://doi.org/10.4081/btvb.2026.837

  21

  PDF: 10

• CO083 | IN VITRO CORRECTION OF SEVERE FACTOR V DEFICIENCY USING A NOVEL PLASMA-DERIVED FV CONCENTRATE: A WHOLE BLOOD THROMBIN GENERATION STUDY C. Bulato¹, L. Spiezia¹, E. Campello¹, B. Serena¹, S. Toffanin¹, C. Simion¹, A. Caricasole², M. Sotgiu², A. Salvatore², F. Pierantoni², T.M. Hackeng^3|4, H.M.H. Spronk^3|4, P. Simioni¹ | ¹Thrombotic and Hemorrhagic Diseases Unit, General Internal Medicine, Department of Medicine, Padova University Hospital, Italy; ²Kedrion SpA, Barga Lucca, Italy; ³Coagulation Profile B.V., Maastricht, the Netherlands; ⁴Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University, the Netherlands

  Cristiana Bulato

  26-10-2026

  https://doi.org/10.4081/btvb.2026.785

  20

  PDF: 10

• CO-36 | PLATELETS MATTER: THROMBIN GENERATION IN PLATELET‐RICH-PLASMA VS. PLATELET‐POOR‐PLASMA UNDER NON-REPLACEMENT THERAPIES IN HEMOPHILIA F. Bocchi^1|2, R. Pastorino^1|2, G. Murante^1|2|3, S. Bergonzi^1|2|3, M. Capetta^1|2|3, F. Valeri^2|3, C. Dainese^2|3, A. Valpreda⁴, B. Bruno^1|3, A. Borchiellini^2|3 | ¹Department of Molecular Biotechnology and Health Sciences, University of Turin, Italy; ²Regional Centre for Thrombotic and Hemorrhagic Diseases, AOU Città della salute e della Scienza di Torino, Italy; ³Division of Hematology, AOU Città della Salute e della Scienza, University of Turin, Italy; ⁴Central Lab Baldi and Riberi, AOU Città della salute e della Scienza di Torino, Italy

  Francesca Bocchi

  14-10-2026

  https://doi.org/10.4081/btvb.2026.646

  47

  PDF: 14

• PO117 | LONGITUDINAL THROMBIN GENERATION PROFILING IN A PATIENT WITH SEVERE HEMOPHILIA A DURING ANTITHROMBIN-LOWERING THERAPY, CANCER, AND MAJOR SURGERY C. Simion, C. Bulato, E. Campello, E. Zanon, B. Serena, S. Toffanin, P. Simioni | Department of Medicine, University of Padova, Italy

  Chiara Simion

  26-10-2026

  https://doi.org/10.4081/btvb.2026.933

  21

  PDF: 7

• CO-42 | LONGITUDINAL THROMBIN GENERATION PROFILING IN A PATIENT WITH SEVERE HEMOPHILIA A DURING ANTITHROMBIN-LOWERING THERAPY, CANCER, AND MAJOR SURGERY C. Simion^1|2, C. Bulato¹, E. Campello^1|2, E. Zanon^1|2, B. Serena¹, S. Toffanin¹, P. Simioni^1|2 | ¹First Chair of Internal Medicine and Thrombotic and Haemorrhagic Diseases Unit, Department of Medicine, Padova University Hospital, Italy; ²Hemophilia Center, Padova University Hospital, Italy

  Chiara Simion

  14-10-2026

  https://doi.org/10.4081/btvb.2026.652

  42

  PDF: 10
• 

  Thrombin generation assay in COVID-19 patients shows a hypocoagulable pattern

  Giovanni L. Tiscia, Donatella Colaizzo, Antonio De Laurenzo, Filomena Cappucci, Lucia Fischetti, Elena Chinni, Mario Mastroianno, Giovanni Favuzzi, Massimo Carella, Elvira Grandone

  22-10-2024

  https://doi.org/10.4081/btvb.2024.145

  2510

  PDF: 507

  Supplementary: 264

• CO-69 | IN VITRO CORRECTION OF SEVERE FACTOR V DEFICIENCY USING A NOVEL PLASMA-DERIVED FACTOR V CONCENTRATE: A WHOLE BLOOD THROMBIN GENERATION STUDY C. Bulato¹, E. Campello¹, L. Spiezia¹, B. Serena¹, S. Toffanin¹, C. Simion¹, A. Caricasole², M. Sotgiu², A. Salvatore², F. Pierantoni², T.M. Hackeng^3|4, H.M.H. Spronk^3|4, P. Simioni¹ | ¹First Chair of Internal Medicine, Thrombotic and Haemorrhagic Diseases Unit and Haemophilia Centre, Department of Medicine, Padova University Hospital, Padova, Italy; ²Kedrion SpA, Barga Lucca, Italy; ³Coagulation Profile B.V., Maastricht, Netherland; ⁴Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, Netherland

  Cristiana Bulato

  14-10-2026

  https://doi.org/10.4081/btvb.2026.679

  40

  PDF: 12

• PO051 | ENDOGENOUS THROMBIN POTENTIAL RATIO AS A PREDICTOR OF BIRTHWEIGHT PERCENTILE IN PREGNANCY G. Tiscia¹, F. Cappucci¹, A. de Laurenzo¹, M.P. Palumbo¹, D. Colaizzo¹, E. Grandone^1|2 | ¹IRCCS Casa Sollievo della Sofferenza, Italy; ²Università degli Studi di Foggia, Italy

  Elvira Grandone

  26-10-2026

  https://doi.org/10.4081/btvb.2026.867

  22

  PDF: 10

• PO049 | WHOLE-BLOOD THROMBIN GENERATION ASSAY REVEALS HYPERCOAGULABLE STATE IN SICKLE CELL DISEASE IN STEADY STATE AND CORRELATES WITH CLINICAL EVENTS A. Bravin¹, E. Campello¹, A. Bertomoro¹, C. Bulato¹, B. Serena¹, S. Toffanin¹, G. Bogoni¹, F. Lucente¹, M.P. Boaro², G. Reggiani², R. Colombatti², P. Simioni¹ | ¹Department of Medicine, University of Padova, Italy; ²Pediatric Hematology-Oncology and Bone Marrow Transplant Unit, Department of Woman's and Child's Health, Padova University Hospital, Italy

  Angela Bravin

  26-10-2026

  https://doi.org/10.4081/btvb.2026.865

  22

  PDF: 7

• PO69 | Whole blood thrombin generation hypercoagulable profile in a patient with hemolytic crisis due to paroxysmal nocturnal hemoglobinuria: a case report A. Napolitano, L. Spiezia, C. Bulato, E. Campello, P. Simioni | First Chair of Internal Medicine, Department of Medicine, University-Hospital of Padua Medical School, Padua, Italy

  22-10-2025

  https://doi.org/10.4081/btvb.2025.338

  704

  PDF: 18
• 

  Bioequivalence of von Willebrand factor-containing concentrates: implications for the choice in patients with von Willebrand disease. A position paper from the Italian Association of Hemophilia Centers

  Ezio Zanon, Giancarlo Castaman, Augusto Bramante Federici, Maria Elisa Mancuso, Gianfranco Pasut, Alberto Tosetto, Angiola Rocino, Rita Carlotta Santoro

  26-01-2026

  https://doi.org/10.4081/btvb.2026.415

  1307

  PDF: 347

  HTML: 165

• PO055 | THROMBIN GENERATION PROFILES IN PATIENTS WITH WILD-TYPE TRANSTHYRETIN AMYLOIDOSIS L. Spiezia¹, A. Napolitano¹, C. Bulato¹, S. Toffanin¹, A. Benetti¹, C. Samà¹, L. De Michieli², G. Sinigiani², A. Cipriani², P. Simioni¹ | ¹Dipartimento di Medicina, Azienda Osp. Università di Padova, Italy; ²Dipartimento di Scienze cardio toraco vascolari, Azienda Osp. Università di Padova, Italy

  Luca Spiezia

  26-10-2026

  https://doi.org/10.4081/btvb.2026.871

  22

  PDF: 7

• CO15 | Longitudinal coagulation profiling of individuals undergoing gender-affirming hormone therapy: the hyper-gender study A. Napolitano, E. Campello, A. Scala, C. Simion, C. Bulato, S. Gavasso, C. Samà, A. Benetti, S. Toffanin, G. Faggian, R. Scafa, A. Garolla, P. Simioni | First Chair of Internal Medicine, Department of Medicine, University Hospital of Padua; Unit of Andrology and Reproductive Medicine, Department of Medicine, University Hospital of Padua, Italy

  22-10-2025

  https://doi.org/10.4081/btvb.2025.219

  675

  PDF: 18

• CO073 | THROMBIN GENERATION PROFILE IN ELDERLY PATIENTS WITH ATRIAL FIBRILLATION: IMPACT OF ORAL ANTICOAGULANT TYPE M. Di Gioia¹, M. Berteotti^1|2, G. Ciarrocca Taranta², F. Alfano^1|2, F. Crudele¹, F. Cesari¹, A.M. Gori^1|2, A. Rogolino¹, B. Giusti^1|2, R. Marcucci^1|2 | ¹Atherothrombotic Diseases, Careggi University Hospital, Firenze, Italy; ²Dep. of Experimental and Clinical Medicine, University of Florence, Italy

  Michela Di Gioia

  26-10-2026

  https://doi.org/10.4081/btvb.2026.775

  26

  PDF: 9

• PO006 | FLOW-MEDIATED DILATION AND ECFC DERIVED ENDOTHELIAL DYSFUNCTION IN VENOUS THROMBOEMBOLISM C.M. Totè¹, M. Donadini^1|2, R. Ciceri^3|4, M. Bacci⁴, A. Cancellara^3|4, E. Romualdi¹, L. Guerrieri^3|4, F. Tumminello⁴, C. Lodigiani⁴, W. Ageno⁵, S. Della Bella^3|4, F. Calcaterra^3|4, D. Mavilio^3|4 | ¹ASST Sette Laghi, Varese, Italy; ²Università of Insubria, Varese, Italy; ³University of Milano, Milano, Italy; ⁴IRCCS Humanitas Research Hospital, Rozzano, Italy; ⁵Università of Padua, Padova, Italy

  Chiara Maria TotÈ

  26-10-2026

  https://doi.org/10.4081/btvb.2026.822

  23

  PDF: 9
• 

  Comparison among three different bleeding scores and the thrombin generation assay to assess the different hemorrhagic phenotypes in patients with FVII deficiency

  Samantha Pasca, Cristina Santoro, Chiara Ambaglio, Marisanta Napolitano, Marta Milan, Letizia Natali, Silvia Nannizzi, Filippo Mori, Paolo Simioni, Ezio Zanon

  23-05-2022

  https://doi.org/10.4081/btvb.2022.12

  5660

  PDF: 546
• 

  Platelets versus monocytes as cellular sources of blood-borne tissue factor: a quantitative and functional comparison in healthy subjects and in patients with STEMI

  Marina Camera, Marta Brambilla, Alessia Becchetti, Patrizia Della Valle, Nicola Cosentino, Jeness Campodonico, Gian Carlo Marenzi, Daniela Trabattoni, Peter L.A. Giesen, Vincenzo Toschi, Elena Tremoli

  12-10-2026

  https://doi.org/10.4081/btvb.2026.584

  425

  PDF: 48

  SUPPLEMENTARY FILES: 24

• CO086 | CLINICAL AND GENETIC CHARACTERIZATION OF A NEW FAMILY CARRYING THE “FACTOR VIII PADUA” F8 DUPLICATION E. Campello, C. Simion, F. Sartorello, D. Regazzo, C. Bulato, B. Serena, S. Toffanin, L. Spiezia, P. Simioni | Department of Medicine, University of Padova, Italy

  Elena Campello

  26-10-2026

  https://doi.org/10.4081/btvb.2026.788

  28

  PDF: 10

• PO47 | Hemophilia A and antithrombin deficiency: a case of natural hemostatic rebalancing L. Torrieri, S. Ligia, E. Baldacci, R. Mormile, S. Sorella, R. Ciciani, M. Biglietto, N. Zhdanovskaya, A. Delli Paoli, A. Tirnetta, M. Lorenzon, C. Santoro | Hematology, Department of Translational and Precision Medicine, Policlinico Umberto I, Sapienza University of Roma, Italy

  22-10-2025

  https://doi.org/10.4081/btvb.2025.316

  633

  PDF: 13

• PO122 | SUCCESSFUL MANAGEMENT OF THERAPEUTIC ANTICOAGULATION FOR PROVOKED VENOUS THROMBOEMBOLISM IN A PATIENT WITH FACTOR VII DEFICIENCY AND SEPTIC SHOCK S. Birocchi¹, F.M. Monda¹, B. Clerici^1|2, M. Scavone², R. Cabiddu¹, E. Pontisso¹, C. Ortelli¹, M.L.G. Perego¹, E. Fiorini¹, L. Catarini¹, A. Bortoli¹, M. Manzoni¹, F.M. Casanova¹, A. Tripodi^2|3, F. Peyvandi^2|3, G.M. Podda^1|2 | ¹S.C. Medicina Generale 2, Ospedale San Paolo, ASST Santi Paolo e Carlo, Milano, Italy; ²Dipartimento di Scienze della Salute, Università degli Studi di Milano, Italy; ³Centro di riferimento emofilia e trombosi "Emilio Bianchi"; ⁴S. Birocchi and F.M. Monda contributed equally as co-first authors

  Simone Birocchi

  26-10-2026

  https://doi.org/10.4081/btvb.2026.938

  31

  PDF: 6
• 

  The clinical usefulness of measuring thrombin generation

  Coenraad H. Hemker

  06-03-2023

  https://doi.org/10.4081/btvb.2023.62

  1428

  PDF: 606

• CO34 | Evaluation of emicizumab concentration and thrombin generation in a cohort of severe hemophilia A patients with and without inhibitor A. Taglietti¹, S. Ligia¹, F. Paoletti¹, R. Mormile¹, E. Baldacci², A. Chistolini¹, C. Santoro^1,2 | ¹Hematology, Department of Translational and Precision Medicine, Sapienza University of Roma; ²Hematology, Azienda Ospedaliera Universitaria Policlinico Umberto I, Roma, Italy

  22-10-2025

  https://doi.org/10.4081/btvb.2025.241

  676

  PDF: 12

• CO070 | PLASMIN GENERATION AND ITS INTERPLAY WITH COAGULATION AND FIBRINOLYSIS IN ATRIAL FIBRILLATION: IMPACT OF ANTICOAGULANT THERAPY G. Ciarrocca Taranta¹, F. Alfano¹, M. Di Gioia², M. Berteotti^1|2, E. Lotti², F. Cesari², A. Rogolino², F.A. Barbuto¹, A. M Gori^1|2, E. Sticchi^1|2, B. Giusti^1|2, R. Marcucci^1|2 | ¹Dep of Experimental and Clinical Medicine, University of Florence, Italy; ²Atherothrombotic Diseases, Careggi University Hospital, Firenze, Italy

  Giulia Ciarrocca Taranta

  26-10-2026

  https://doi.org/10.4081/btvb.2026.772

  31

  PDF: 7