Thrombophilia work-up and clinical outcomes in Indian patients with unprovoked venous and arterial thrombosis aged 18-50 years | BTVB Bioequivalence of von Willebrand factor-containing concentrates: implications for von Willebrand disease | BTVB Cardiovascular risk in hormone replacement therapy | BTVB Direct oral anticoagulants: does one dose fit all? Why, when and how testing | BTVB Cardiovascular risk profile evolution over 15 years: CV-PREVITAL vs Moli-sani Study | BTVB Launch of National Registry for Congenital Hematological Disorders in Palestine: Haemo-PAL | BTVB
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Bleeding, Thrombosis and Vascular Biology

Editor-in-Chief: Giovanni de Gaetano, Italy | eISSN: 2785-5309

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  • Gene therapy for hemophilia B

    Pier Mannuccio Mannucci
    12-12-2025
    https://doi.org/10.4081/btvb.2025.425
    570
    PDF: 49
    HTML: 36
  • Is non-alcoholic fatty liver disease a prothrombotic risk factor?

    Niccolò Bitto, Vincenzo La Mura, Anna Ludovica Fracanzani, Armando Tripodi
    19-05-2023
    https://doi.org/10.4081/btvb.2023.81
    983
    PDF: 436
  • Diagnostic and management practices for inherited fibrinogen disorders: a nationwide survey of Italian Hemophilia Treatment Centers

    Renato Marino, Silvia Linari, Marzia Leotta, Antonio Coppola, Chiara Biasoli, Maria Elisa Mancuso, Flora Peyvandi, Cristina Santoro, Ezio Zanon, Rita Carlotta Santoro
    02-12-2025
    https://doi.org/10.4081/btvb.2025.372
    475
    PDF: 74
    HTML: 57
    Supplementary: 32
    Appendix: 49
  • Persistence of functional anti-PF4 antibodies and neutrophil activation in vaccine-induced immune thrombotic thrombocytopenia

    Eleonora Petito, Anna Maria Mezzasoma, Emanuela Falcinelli, Chiara Conti, Erica De Candia, Raimondo De Cristofaro, Silvia Sorrentino, Gian Marco Podda, Mariangela Scavone, Anna Falanga, Marina Marchetti, Luca Barcella, Stefania Basili, Lucia Stefanini, Andrea Boccatonda, Laura Contino, Patrizia Sciancalepore, Igor Florio, Egidio Imbalzano, Rossella Marcucci, Angela Rogolino, Patrizia Noris, Marta Panella, Rita Santoro, Maria Costanza Turi, Gaetano Vaudo, Rosa Curcio, Paolo Gresele
    18-11-2025
    https://doi.org/10.4081/btvb.2025.400
    704
    PDF: 119
    HTML: 84
  • The landscape of rare coagulation factor deficiency management in Italy: a national hemophilia center survey

    Silvia Linari, Renato Marino, Marzia Leotta, Antonio Coppola, Patrizia Di Gregorio, Augusto Bramante Federici, Flora Peyvandi, Cristina Santoro, Ezio Zanon, Rita Carlotta Santoro
    05-11-2025
    https://doi.org/10.4081/btvb.2025.369
    1111
    PDF: 154
    HTML: 46
    Appendix: 83
  • CO51 | Novel biomarkers of neurological damage in acute immune-mediated thrombotic thrombocytopenic purpura A. Truma1,2, I. Mancini1, F. Verde2,3, J. A. Giannotta1, A. Artoni1, B. Ferrari1, P. Agosti1,2, M. Gagliardi1, A. Ratti3,4, N. Ticozzi2,3, F. Peyvandi1,2 | 1Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Milan; 2Università degli Studi di Milano, Department of Pathophysiology and Transplantation, Milan; 3Department of Neurology and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, Milan; 4Università degli Studi di Milano, Department of Medical Biotechnology and Translational Medicine, Milan, Italy

    22-10-2025
    https://doi.org/10.4081/btvb.2025.261
    477
    PDF: 0
  • Diagnostic challenges in current laboratory practice at Italian Hemophilia Centers: findings from a nationwide survey

    Tiziano Martini, Alessandra Valpreda, Marina Marchetti, Alberto Catalano, Laura Contino, Raimondo De Cristofaro, Augusto Bramante Federici, Ilaria Quaglia, Rossana Rossi, Rita Carlotta Santoro, Armando Tripodi, Angelo Claudio Molinari
    12-03-2026
    https://doi.org/10.4081/btvb.2026.431
    197
    PDF: 53
    Supplementary: 13
  • PO39 | Bleeding events in Von Willebrand disease type 1 yearly treatable with desmopressin A. Gringeri1,2, P.M. Mannucci3, M. Gringeri4, G. Castaman5, F. Peyvandi3,6 | 1Fondazione Charta, Milan; 2Centro di Sanità Solidale, Lucca; 3Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Angelo Bianchi Bonomi Hemophilia and Thrombosis Center and Fondazione Luigi Villa, Milan; 4Department of Medical Biotechnologies and Translational Medicine, Postgraduate School of Clinical Pharmacology and Toxicology, University of Milan; 5Centre for Bleeding Disorders and Coagulation, Careggi University Hospital, Firenze; 6Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Italy

    22-10-2025
    https://doi.org/10.4081/btvb.2025.302
    525
    PDF: 0
  • Attitude to clinical research among health professionals affiliated with the Italian Federation of Centers for the Diagnosis of Thrombotic Disorders and the Surveillance of the Antithrombotic Therapies (FCSA)

    Daniela Poli, Riccardo Tartaglia, Doris Barcellona , Paolo Bucciarelli , Antonio Ciampa, Elvira Grandone, Giuseppe Malcangi, Giuseppe Rescigno, Vincenzo Toschi, Sophie Testa, Alessandro Squizzato
    21-03-2023
    https://doi.org/10.4081/btvb.2023.59
    1078
    PDF: 331
  • CO49 | The burden of cerebral small vessel disease in ITTP patients from acute phase to remission A. Truma1,2, F. M. Lo Russo1, G. Conte1,2, I. Mancini1, M. Abbattista1, J. A. Giannotta1, A. Artoni1, B. Ferrari1, P. Agosti1,2, F. M. Triulzi1,2, F. Peyvandi1,2 | 1Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Milan; 2Università degli Studi di Milano, Department of Pathophysiology and Transplantation, Milan, Italy

    22-10-2025
    https://doi.org/10.4081/btvb.2025.259
    504
    PDF: 0
  • Direct oral anticoagulants: does one dose fit all? Why, when and how testing

    Armando Tripodi
    15-01-2026
    https://doi.org/10.4081/btvb.2026.418
    1178
    PDF: 236
  • CO05 | Long-term management of upper extremity catheter-related thrombosis in female patients with cancer: a retrospective cohort study Chiara Cavallaro1,2, Paolo Santini1,2, Laura Leoni3, Carolina Mosoni1,2, Silvia D’Ambrosio1,2, Francesco Mancinetti1,2, Nicola Coletta1,2, Michela Iorio1,2, Angelo Porfidia1,2, Alessandro D’Errico1,2, Rosa Talerico1,2, Roberto Pola1,2 | 1Department of Aging, Orthopedic, and Rheumatologic Sciences, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome; 2Università Cattolica del Sacro Cuore, Rome; 3Vita-Salute University, San Raffaele Hospital IRCCS, Milan, Italy

    22-10-2025
    https://doi.org/10.4081/btvb.2025.309
    563
    PDF: 0
  • CO38 | Management of pregnancy, delivery, and postpartum in Italian carriers and women with hemophilia A and B S. Linari1, B. Pollio2, A. Ferretti3, M. Napolitano4, E. Grandone5, S. Siboni6, Ab. Aru7, E. Bertoni8, C. Biasoli9, I. Cantori10, P. Di Gregorio11, G. Lassandro12, G. Sottilotta13, A. Strangio14, Mr. Villa15, A. Rocino16, G. Castaman1 | 1Center for Bleeding Disorders and Coagulation, Careggi University Hospital, Firenze; 2Regional Reference Center for Inherited Bleeding and Thrombotic Disorders, Transfusion Medicine, Regina Margherita Children Hospital, Turin; 3Center for Hemorrhagic and Thrombotic Diseases, IRCCS A. Gemelli University Hospital Foundation, Roma; 4Department of Health Promotion, Maternal-Childhood, Internal Medicine of Excellence G. D’Alessandro, University of Palermo; 5Thrombosis and Hemostasis Unit, Fondazione IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo; 6Angelo Bianchi Bonomi Hemophilia and Thrombosis Center and Fondazione Luigi Villa, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan; 7Pediatric Onco-Hematology Center, Microcitemico Hospital Cagliari; 8Pediatric Oncohematology and Bone Marrow Transplant “BMT” Unit, Children’s Hospital, Spedali Civili, Brescia; 9Hemophilia and Transfusion Center, Bufalini Hospital, Cesena; 10Hemophilia Center, Department of Transfusion Medicine, Hospital of Macerata; 11Transfusion Medicine Department, SS. Annunziata Hospital, Chieti; 12B. Trambusti General and Specialised Pediatrics Unit, Giovanni XXIII Hospital, University of Bari; 13Hemophilia Center, Grande Ospedale Metropolitano, Reggio Calabria; 14Center for Hemorrhagic and Thrombotic Disorders, Pugliese Ciaccio Hospital, Catanzaro; 15Hemophilia and Thrombosis Center, Haematology Unit, Ospedale del Mare Hospital, Naples; 16Past President of the Italian Association of Hemophilia Centers, Italy

    22-10-2025
    https://doi.org/10.4081/btvb.2025.245
    485
    PDF: 0
  • Gene transfer in hemophilia A: not cogent yet

    Pier Mannuccio Mannucci
    20-04-2022
    https://doi.org/10.4081/btvb.2022.32
    2428
    PDF: 353
  • An ecological alliance against air pollution and cardiovascular disease

    Pier Mannuccio Mannucci
    22-03-2022
    https://doi.org/10.4081/btvb.2022.21
    2057
    PDF: 416
  • Pharmacokinetics of extended half-life albumin-fused factor IX and heterogeneous F9 variants in hemophilia B: a retrospective cohort study

    Barbara Lunghi, Massimo Morfini, Silvia Linari, Dario Balestra, Alessio Branchini, Lisa Pieri, Donata Belvini, Laura Banov, Cristina Santoro, Giancarlo Castaman, Francesco Bernardi
    02-03-2026
    https://doi.org/10.4081/btvb.2026.413
    249
    PDF: 82
    Supplementary: 59
  • Growing weapons to fight hemophilia

    Pier Mannuccio Mannucci
    23-02-2023
    https://doi.org/10.4081/btvb.2023.64
    1332
    PDF: 475
  • CO27 | Intracerebral hemorrhage in hemophilia A and B: a 10-year prospective multicenter study in Italy (2012–2022) E. Zanon1, A. Napolitano1, A. Porreca2, F. Demartis3, A. Coppola4, C. Santoro5, I. Cantori6, A. C. Molinari7, C. Biasioli8, M. Luciani9, G. Sottilotta10, B. Pollio11, A. Borchiellini12, A. Tosetto13, P. Flora14, P. Simioni1 | 1Haemophilia Center, First Chair of Internal Medicine, Department of Medicine, University-Hospital of Padua Medical School, Padua; 2Department of Human Sciences and Promotion of the Quality of Life, Unit of Clinical and Molecular Epidemiology IRCCS San Raffaele Roma Open University, Roma; Unit of Clinical and Molecular Epidemiology IRCCS San Raffaele, Roma; 3Centre for Bleeding Disorders, Careggi University Hospital of Firenze; 4Azienda Ospedaliero Universitaria di Parma; 5Hematology Division, Umberto I University Hospital of Roma; 6Haemophilia Center, Department of Transfusion Medicine, Hospital of Macerata; 7IRCCS Istituto Giannina Gaslini, Genova; 8Haemophilia and Transfusion Centre, Bufalini Hospital, Cesena; 9Children’s Hospital Bambino Gesù, Roma; 10Haemophilia Center, Department of Onco-Hematology and Radioterapy, Hospital of Reggio Calabria; 11Haemophilia Pediatric Center, Transfusion Medicine, City of Health and Science of Turin; 12City of Health and Science of Turin; 13Hemorrhagic and Thrombotic Diseases Unit, S. Bortolo Hospital of Vicenza; 14RCCS Foundation Ca’ Granda Maggiore Policlinico Hospital, Milan, Italy

    22-10-2025
    https://doi.org/10.4081/btvb.2025.233
    553
    PDF: 0
  • PO02 | Pregnancy and delivery in women with hemophilia and carriers are still challenging: a ten years analysis from The Italian Association of Hemophilia Centers (AICE) M. Napolitano1, M. Mattana2, C. Cammarata1, M. Leotta3, S. Linari4, M.E. Mancuso5, G. F. Rivolta6, C. Santoro7, L. Valdrè8, R.C. Santoro3, S. Siragusa1 | 1Department of Health Promotion, Mother and Child Care, Internal Medicine and Med, Palermo; University of Palermo, Italy; 2Department of Precision Medicine in Medical, Surgical and Critical Care “Me. Pre. Cc”, University of Palermo; 3Hemostasis and Thrombosis Unit, Azienda Ospedaliera Universitaria Dulbecco, Catanzaro; 4Center for Bleeding Disorders, Careggi University Hospital, Firenze; 5Center for Thrombosis and Hemorrhagic Diseases, IRCCS Humanitas Research Hospital, Rozzano, Milan; 6Regional Reference Center for the Treatment of Congenital Hemorrhagic Diseases, Parma University Hospital, Parma; 7Hematology, University Hospital Policlinico Umberto I, Roma; 8Inherited Bleeding Disorders Unit, IRCCS AOUBO, Bologna, Italy

    22-10-2025
    https://doi.org/10.4081/btvb.2025.312
    583
    PDF: 0
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Vol. 5 No. 2 (2026)
The small numbers of medicine and the big numbers of artificial intelligence: a curated-data approach to appropriateness in laboratory medicine and...
Anna Mazzetto et al.
15 April 2026
Vol. 5 No. 2 (2026)
Bleeding complications of oral anticoagulant therapy: from ISCOAT to the START Register
Francesco Marongiu
10 April 2026
Vol. 5 No. 2 (2026)
Neurovascular protective effects of nutritional interventions in ischemic brain injury
Geetika Mehta et al.
10 April 2026

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Bleeding, Thrombosis and Vascular Biology

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