Thrombophilia work-up and clinical outcomes in Indian patients with unprovoked venous and arterial thrombosis aged 18-50 years | BTVB Bioequivalence of von Willebrand factor-containing concentrates: implications for von Willebrand disease | BTVB Cardiovascular risk in hormone replacement therapy | BTVB Direct oral anticoagulants: does one dose fit all? Why, when and how testing | BTVB Cardiovascular risk profile evolution over 15 years: CV-PREVITAL vs Moli-sani Study | BTVB Launch of National Registry for Congenital Hematological Disorders in Palestine: Haemo-PAL | BTVB
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Bleeding, Thrombosis and Vascular Biology

Editor-in-Chief: Giovanni de Gaetano, Italy | eISSN: 2785-5309

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  • https://BioRender.com/zrlk3rh

    The subtle red line between combating and resolving inflammation in the cardiovascular disease, a “silent sniper”

    Ciarán Kennedy, Luke J. Conroy, Braden Millar, Monica de Gaetano
    30-06-2025
    https://doi.org/10.4081/btvb.2025.187
    1637
    PDF: 449
  • A lifetime in biomedical research: an interview with Silvio Garattini

    Americo Bonanni
    12-03-2026
    https://doi.org/10.4081/btvb.2026.466
    389
    PDF: 91
  • Diagnostic and management practices for inherited fibrinogen disorders: a nationwide survey of Italian Hemophilia Treatment Centers

    Renato Marino, Silvia Linari, Marzia Leotta, Antonio Coppola, Chiara Biasoli, Maria Elisa Mancuso, Flora Peyvandi, Cristina Santoro, Ezio Zanon, Rita Carlotta Santoro
    02-12-2025
    https://doi.org/10.4081/btvb.2025.372
    925
    PDF: 120
    HTML: 129
    Supplementary: 79
    Appendix: 80
  • In this issue

    Giovanni de Gaetano, Chiara Cerletti
    10-07-2026
    https://doi.org/10.4081/btvb.2026.578
    1195
    PDF: 67
  • Antithrombotic therapy in idiopathic infertility

    Fabio Tumminello, Silvia Cardi, Corrado Lodigiani, Maria Elisa Mancuso
    03-10-2024
    https://doi.org/10.4081/btvb.2024.126
    3542
    PDF: 1263
  • Next-generation biomarkers for cancer-associated thrombosis prediction: the role of non-genomic-omics

    Jose Manuel Soria, Joan Carles Souto, Andrés Muñoz
    16-04-2026
    https://doi.org/10.4081/btvb.2026.447
    601
    PDF: 155
  • CO23 | Markers of inflammation and hypofibrinolysis are associated with cognitive dysfunction and motor performances in atrial fibrillation patients on oral anticoagulant therapy: insights from the Strat-AF study F. Alfano1,2, F. Cesari1,2, A.M. Gori1,2, M. Berteotti1,2, E. Salvadori3, B. Giusti1,2, A. Bertelli1,2, F. Fratini4, A. Rogolino1,2, B. Formelli4,5, F. Pescini4,5, E. Fainardi6, E. Barucci4, G. Salti5, A. Cavaliere4, A. Ginestroni6, A. Poggesi4,5, R. Marcucci1,2 | 1Department of Experimental and Clinical Medicine, University of Firenze; 2Center for Atherothrombotic Diseases, Careggi University Hospital, Firenze; 3Department of Biomedical and Clinical Sciences, University of Milan; 4NEUROFARBA Department, Neuroscience Section, University of Firenze; 5Stroke Unit, Careggi University Hospital, Firenze; 6Neuroradiology Unit, Careggi University Hospital, Department of Experimental and Clinical Biomedical Sciences, University of Firenze, Italy

    22-10-2025
    https://doi.org/10.4081/btvb.2025.229
    732
    PDF: 26
  • Bioequivalence of von Willebrand factor-containing concentrates: implications for the choice in patients with von Willebrand disease. A position paper from the Italian Association of Hemophilia Centers

    Ezio Zanon, Giancarlo Castaman, Augusto Bramante Federici, Maria Elisa Mancuso, Gianfranco Pasut, Alberto Tosetto, Angiola Rocino, Rita Carlotta Santoro
    26-01-2026
    https://doi.org/10.4081/btvb.2026.415
    1307
    PDF: 347
    HTML: 165
  • Comparison among three different bleeding scores and the thrombin generation assay to assess the different hemorrhagic phenotypes in patients with FVII deficiency

    Samantha Pasca, Cristina Santoro, Chiara Ambaglio, Marisanta Napolitano, Marta Milan, Letizia Natali, Silvia Nannizzi, Filippo Mori, Paolo Simioni, Ezio Zanon
    23-05-2022
    https://doi.org/10.4081/btvb.2022.12
    5660
    PDF: 546
  • CO-19 | A CASE OF LOSS OF EFFICACY OF EMICIZUMAB AFTER 6 YEARS OF REGULAR USE M.R. Fasulo1, I. Quaglia1, A. Colombo1, C. Lodigiani1, M.E. Mancuso1|2 | 1Center for Thrombosis and Hemorrhagic Diseases, IRCCS Humanitas Research Hospital, Rozzano, Milano, Italy; 2Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milano, Italy

    Maria Rosaria Fasulo
    14-10-2026
    https://doi.org/10.4081/btvb.2026.629
    45
    PDF: 16
  • BEST-05 | LONG-TERM EMICIZUMAB PROPHYLAXIS IN PEOPLE WITH HEMOPHILIA A: REAL-WORLD EXPERIENCE ACROSS ALL AGES A. Colombo1, I. Quaglia1, M.R. Fasulo1, C. Lodigiani1, M.E. Mancuso1|2 | 1Center for Thrombosis and Hemorrhagic Diseases, IRCCS Humanitas Research Hospital, Rozzano, Milano, Italy; 2Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milano, Italy

    Arianna Colombo
    14-10-2026
    https://doi.org/10.4081/btvb.2026.605
    93
    PDF: 14
  • A commitment to global collaboration, welcoming international participation and advancing science for the benefit of patients

    Pantep Angchaisuksiri, Wolfram Ruf, Jeffrey Weitz, Sam Schulman, Guy A. Young
    01-07-2025
    https://doi.org/10.4081/btvb.2025.188
    1643
    PDF: 338
    HTML: 130
  • PO137 | SMAD3 VARIANTS IN LOEYS-DIETZ SYNDROME: RELATIONSHIP WITH NON-AORTIC CARDIOVASCULAR FEATURES E. Sticchi1, L. Squillantini1, P. Cantini1, S. Suraci1, F. Basso1, G. Barbieri1, A. Kura1, F. Gensini2, E. Fiorentini2, S. Nistri3, G. Pepe1, A.M. Gori1, M. Berteotti1, R. Marcucci1, B. Giusti1 | 1Atherothrombotic Diseases Center, Dpt. Experimental and Clinical Medicine, University of Florence - Careggi Hospital, Firenze, Italy; 2Dpt. Experimental and Clinical Biomedical Sciences 'Mario Serio', Medical Genetics Unit, University of Florence, Firenze, Italy; 3Cardiology Service CMSR Veneto Medica Altavilla Vicentina, Vicenza, Italy

    Elena Sticchi
    26-10-2026
    https://doi.org/10.4081/btvb.2026.953
    26
    PDF: 10
  • PO42 | Acquired Von Willebrad syndrome in patients with myeloproliferative syndrome: literature review and single-center experience A. Strangio, M. Leotta, A. Ierardi, R C. Santoro | UO Emofilia, Emostasi e Trombosi, AOU R Dulbecco, Catanzaro, Italy

    22-10-2025
    https://doi.org/10.4081/btvb.2025.305
    558
    PDF: 22
  • From rare to aware: confronting Lemierre syndrome

    Silvia Cardi, Filippo Catalani, Luca Valerio, Stefano Barco
    21-10-2024
    https://doi.org/10.4081/btvb.2024.147
    2682
    PDF: 597
  • CO102 | VARIABILITY IN ANTIPHOSPHOLIPID ANTIBODY TESTING AND TREATMENT STRATEGIES IN OBSTETRIC ANTIPHOSPHOLIPID SYNDROME: RESULTS FROM THE OAPS-CARE SURVEY, ON BEHALF OF THE EUROPEAN FORUM ON ANTIPHOSPHOLIPID ANTIBODIES A. Hoxha1|2, E. Esteve-Valverde3|4, G. Gobbo1|2, F. Miró-Mur4, M. Radin5, S. De Carolis6, C. Trilla7|8|9|10, A. Tincani11|12, R. Cervera13|14, J. Alijotas-Reig3|15|16 | 1Department of Medicine - DIMED, University of Padua, Padova, Italy; 2Internal Medicine Unit, Thrombosis and Bleeding Disorder, University Hospital of Padua, Padova, Italy; 3Systemic Autoimmune Diseases Unit. Department of Internal Medicine, Hospital Sant Camil, Consorci Sanitari Alt-Penedes-Garraf, Sant Pere de Ribas, Barcelona, Spain; 4Systemic Autoimmune Disease Research Unit. Vall d'Hebron Institut de Recerca (VHIR), Barcelona, Spain; 5Center of Research of Immunopathology and Rare Diseases - Coordinating Center of Piemonte and Valle d'Aosta Network for Rare Diseases, SCDU Nephrology and Dialysis, School of Specialization of Clinical Pathology, Department of Clinical and Biological Sciences, S. Giovanni Bosco Hospital, University of Turin, Torino, Italy; 6Fondazione Policlinico Universitario A. Gemelli IRCCS, Dipartimento di Scienze per la salute della Donna e del Bambino e di Sanità Pubblica, Roma, Italy; 7Hospital de la Santa Creu i Sant Pau, Barcelona, Spain; 8Universitat Autònoma de Barcelona, Barcelona, Spain; 9Spanish Network in Maternal, Neonatal, Child and Developmental Health Research (RICORS-SAMID, RD24/0013/0001), Instituto de Salud Carlos III, 28040 Madrid, Spain; 10Women and Perinatal Health Research Group, Institut de Recerca (IR SANT PAU), Sant Quintí 77-79, 08041 Barcelona, Spain; 11Rheumatology and Clinical Immunology Unit - ERN ReCONNET, ASST Spedali Civili, Brescia, Italy; 12Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy; 13Department of Autoimmune Diseases, Hospital Clínic, University of Barcelona, Barcelona, Catalonia, Spain; 14August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Catalonia, Spain; 15Department of Medicine. Universitat Autonoma de Barcelona, Barcelona, Spain; 16Systemic Autoimmune Disease Unit, Department of Internal Medicine, Vall d’Hebron University Hospital, Barcelona, Spain

    Ariela Hoxha
    26-10-2026
    https://doi.org/10.4081/btvb.2026.804
    25
    PDF: 7
  • PO08 | Efficacy and safety of thromboprophylaxis in hospitalized hematological patients: a monocenter retrospective study S. Cordella1,2, V. Coluccio3, M. Luppi1, M. Marietta1 |  1Department of Medical and Surgical Sciences, Section of Hematology. University of Modena and Reggio Emilia, Azienda Ospedaliero-Universitaria di Modena; 2Clinical and Experimental Medicine PhD Programme, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena; 3Department of Hematology, Unità Sanitaria Locale di Modena, Italy 

    22-10-2025
    https://doi.org/10.4081/btvb.2025.270
    576
    PDF: 15
  • To P or not to P. That is the wrong question. Suggestions on reporting uncertainty

    Augusto Di Castelnuovo, Giovanni de Gaetano
    10-06-2026
    https://doi.org/10.4081/btvb.2026.572
    2389
    PDF: 208
  • CO-68 | ACQUIRED FACTOR XIII DEFICIENCY ASSOCIATED WITH CROHN’S DISEASE: A CHALLENGING DIAGNOSTIC AND THERAPEUTIC CASE A. Colombo1, A. Dal Buono2|3, I. Quaglia1, C. Novembrino4, M.R. Fasulo1, C. Lodigiani1, M.E. Mancuso1|2 | 1Center for Thrombosis and Hemorrhagic Diseases, IRCCS Humanitas Research Hospital, Rozzano, Milano, Italy; 2Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milano, Italy; 3IBD Center, IRCCS Humanitas Research Hospital, Rozzano, Milano, Italy; 4Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico Angelo Bianchi Bonomi, Hemophilia and Thrombosis Center and Fondazione Luigi Villa, Milano, Italy

    Arianna Colombo
    14-10-2026
    https://doi.org/10.4081/btvb.2026.678
    45
    PDF: 12
  • CO46 | Comparison of reticulated platelet procoagulant role in liver cirrhosis vs. fibrosis S. Toffanin1, E. Campello1, A. Zanetto2, G. Gagliardi1, A. Napolitano1, E. Stocco1, G. Gobbo1, E. Pinto2, C. M. Radu1, M. Senzolo2, L. Fabris1, P. Simioni1 | 1First Chair of Internal Medicine, Department of Medicine, University-Hospital of Padua Medical School, Padova; 2Department of Surgery Oncology and Gastroenterology, Gastroenterology and Multivisceral Transplant Unit, Padova University Hospital, Padova, Italy

    22-10-2025
    https://doi.org/10.4081/btvb.2025.256
    595
    PDF: 18
  • Factor XI inhibitors: a new option for the prevention and treatment of cancer-associated thrombosis

    Marcello Di Nisio, Matteo Candeloro, Nicola Potere, Ettore Porreca, Jeffrey I. Weitz
    16-05-2024
    https://doi.org/10.4081/btvb.2024.118
    1907
    PDF: 1305
  • CO-57 | NXT007 PROPHYLAXIS IN PEOPLE WITH HEMOPHILIA A WITH OR WITHOUT FACTOR VIII INHIBITORS: COMBINED ANALYSIS OF TWO PHASE I/II MULTIPLE-ASCENDING-DOSE STUDIES M.E. Mancuso1|2, M. Shima3, J.M. Staber4, Y.C. Chen5, F.J. López-Jaime6, M.C. Shen7, G. Ventriglia8, M. Takeyama9, C. Schmitt8, Y.S. Park10, A. Kiialainen8, N. Mizuno11, M. Niggli8, T. Miyake11, D. Matino12, T. Saito11, V. Jiménez-Yuste13, R. Kobayashi11, D. Hart14, K. Nogami15 | 1Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milano, Italy; 2Center for Thrombosis and Hemorrhagic Diseases, IRCCS Humanitas Research Hospital, Rozzano, Milano, Italy; 3Thrombosis and Hemostasis Research Center, Nara Medical University, Kashihara, Nara, Japan; 4Stead Family Department of Pediatrics, Carver College of Medicine, University of Iowa, Iowa City, USA; 5Hemophilia Care and Research Center, Tri-Service General Hospital, National Defense Medical University, Taipei, Taiwan; 6Servicio de Hematología, Hospital Universitario Regional de Málaga / Instituto de Investigación Biomédica de Málaga (IBIMA), Málaga, Spain; 7Department of Internal Medicine, Changhua Christian Hospital, Changhua, Taiwan; 8F. Hoffmann-La Roche Ltd, Basel, Switzerland; 9Division of Hemophilia, National Hospital Organization, Osaka National Hospital, Osaka, Japan; 10Department of Pediatrics, Kyung Hee University Hospital at Gangdong, Seoul, South Korea; 11Chugai Pharmaceutical Co., Ltd, Tokyo, Japan; 12McMaster University, Hamilton, Ontario, Canada; 13La Paz University Hospital-IdiPAZ, Autónoma University, Madrid, Spain; 14Roche Products Ltd, Welwyn Garden City, UK; 15Department of Pediatrics, Nara Medical University, Kashihara, Nara, Japan

    Maria Elisa Mancuso
    14-10-2026
    https://doi.org/10.4081/btvb.2026.667
    46
    PDF: 17
  • Circulating albumin-to-fibrinogen ratio may be a risk indicator for venous thromboembolism: findings from a population-based prospective cohort study

    Setor K. Kunutsor, Sudhir Kurl, Ari Voutilainen, Jari Laukkanen
    14-07-2022
    https://doi.org/10.4081/btvb.2022.36
    1693
    PDF: 402
  • CO-54 | DECREASED BONE MINERAL DENSITY IN HEMOPHILIA IS NOT CORRELATED WITH INCREASED RISK OF FRACTURES M.R. Fasulo1, F. Carrone2, G. Mazziotti3|4, A. Colombo1, C. Lodigiani1, M.E. Mancuso1|4 | 1Center for Thrombosis and Hemorrhagic Diseases, IRCCS Humanitas Research Hospital, Rozzano, Milano, Italy; 2Endocrinology and Diabetology Unit, Humanitas Mater Domini, Castellanza, Varese, Italy; 3Endocrinology, Diabetology and Medical Andrology Unit, Metabolic Bone Diseases and Osteoporosis Section, IRCCS Humanitas Research Hospital, Rozzano, Milano, Italy; 4Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milano, Italy

    Maria Rosaria Fasulo
    14-10-2026
    https://doi.org/10.4081/btvb.2026.664
    38
    PDF: 16
  • CO07 | Real word management of anticoagulant therapy in brain metastasis: moving toward a multidisciplinary approach in complex cases E. Lotti1, C. Manneschi2, S. Fancelli2, F. Scolari1, F. Crudele1, D. Poli1, M. Berteotti1, D. Rossini3, S. Pillozzi2, L. Antonuzzo2,3, R. Marcucci1,3 | 1Disease Unit, Careggi University Hospital, Firenze; 2Oncology Unit, Careggi University Hospital, Firenze; <sup>3</sup>Department of Experimental and Clinical Biomedical Sciences, University of Firenze, Italy

    22-10-2025
    https://doi.org/10.4081/btvb.2025.211
    626
    PDF: 20
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Vol. 5 No. 4 (2026)
Platelets versus monocytes as cellular sources of blood-borne tissue factor: a quantitative and functional comparison in healthy subjects...
Marina Camera et al.
12 October 2026
Vol. 5 No. 4 (2026)
Von Willebrand Disease (VWD) 100 years after its first description: the research of Italian investigators for a better management of VWD patients
Augusto B. Federici et al.
9 October 2026
Vol. 5 No. 4 (2026)
The history of the TIMI, GISSI, and ISIS trials: the development of thrombolytic therapy in acute myocardial infarction
Aldo Pietro Maggioni et al.
13 October 2026
Vol. 5 No. 4 (2026)
Anticoagulant treatment in patients with internal jugular vein thrombosis: a case serie
Arianna Pannunzio et al.
14 October 2026

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Bleeding, Thrombosis and Vascular Biology

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