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• CO43 | Early platelet dysfunction in sepsis: an ICU pilot study S. Sorrentino¹, C. Gori², L. D’Innocenzo¹, M. De Siati¹, Mg. Bocci³, E. De Candia¹ | ¹Unit of Haemostasis and Thrombosis Diseases, Fondazione Policlinico Universitario A. Gemelli, IRCCS, Roma; ²UOC Shock & Trauma, Azienda Ospedaliera San Camillo Forlanini, Roma; ³National Institute for Infectious Diseases, Lazzaro Spallanzani, IRCCS, Roma, Italy

  15-07-2025

  https://doi.org/10.4081/btvb.2025.249

  0

• CO40 | The co-inheritance of two ITGB3 variants exerting additive detrimental effects on platelets leads to variant Glanzmann thrombasthenia N. Arndt¹, E. Falcinelli¹, A. Zamora-Canovas², A. Sánchez Fuentes², A. Marín-Quilez², I. Tano¹, M.D.M. Nieto-Hernández³, J.M. Bastida⁴, J. Rivera², P. Gresele¹, L. Bury¹ | ¹Department of Medicine and Surgery, Section of Internal and Cardiovascular Medicine, University of Perugia, Italy; ²Servicio de Hematología y Oncología Médica, Hospital Universitario Morales Meseguer, Centro Regional de Hemodonación, Universidad de Murcia, IMIB-Pascual Parrilla, ISCIII-CIBERER, Murcia, Spain; ³Servicio de Hematología, Hospital Universitario de Jaen, Spain; ⁴Departamento de Hematología, Complejo Asistencial Universitario de Salamanca “CAUSA”, Instituto de Investigación Biomédica de Salamanca “IBSAL”, Centro de Investigación del Cáncer, IBMCC-CSIC, Universidad de Salamanca “USAL”, Salamanca, Spain

  15-07-2025

  https://doi.org/10.4081/btvb.2025.247

  0

• CO46 | Comparison of reticulated platelet procoagulant role in liver cirrhosis vs. fibrosis S. Toffanin¹, E. Campello¹, A. Zanetto², G. Gagliardi¹, A. Napolitano¹, E. Stocco¹, G. Gobbo¹, E. Pinto², M.C. Radu¹, M. Senzolo², L. Fabris¹, P. Simioni¹ | ¹First Chair of Internal Medicine, Department of Medicine, University-Hospital of Padua Medical School, Padova; ²Department of Surgery Oncology and Gastroenterology, Gastroenterology and Multivisceral Transplant Unit, Padova University Hospital, Padova, Italy

  15-07-2025

  https://doi.org/10.4081/btvb.2025.256

  0

• CO45 | Role of urinary 11-dehydro-thromboxane B2 as a predictor of preeclampsia in pregnant high-risk women on low-dose aspirin treatment P. Simeone¹, R. Liani¹, M. Alfonsetti¹, A. Ricci¹, V. Cianci¹, S. Zeeba², M. Molino³, S. Palma², R. Malizia⁴, M. Luongo⁴, A. Di Castelnuovo⁵, F. Cipollone¹, F. D’antonio⁶, F. Ricci², G. Renda², F. Santilli¹ | ¹Department of Medicine and Aging Sciences, Center for Advanced Studies and Technology, University of Chieti; ²Department of Neuroscience, Imaging and Clinical Sciences, G D’Annunzio University of Chieti-Pescara, Chieti; University Cardiology Division, Heart Department, Policlinico SS Annunziata, Chieti; ³Clinical Pathology of Chieti University Hospital; ⁴Immunotransfusion Service, Clinical Haematology of Chieti University Hospital, Chieti; ⁵Mediterranea Cardiocentro, Napoli; ⁶Centre for Fetal Care and High-Risk Pregnancy, Department of Obstetrics and Gynecology, University of Chieti, Italy

  15-07-2025

  https://doi.org/10.4081/btvb.2025.251

  2

• CO44 | First interlaboratory validation workshop of immunofluorescence microscopy on the peripheral blood smear for recognizing patients with inherited platelet disorders C. Zaninetti¹, L. Bury², V. Bozzi³, A. Zamora-Cánovas⁴, K. Althaus⁵, G. Uzun⁵, S. Brown⁶, A. Norman⁶, D. Faille⁷, A. Stepanian⁸, C. Freyer¹, L. Kager⁹, T. Bakchoul⁵, A. Pecci³, P. Gresele², T. Thiele¹, J. Rivera⁴, A. Greinacher¹ | ¹Institut für Immunologie und Transfusionsmedizin, Universitätsmedizin Greifswald, Germany; ²Department of Medicine, Section of Internal and Cardiovascular Medicine, University of Perugia, Italy; ³Department of Internal Medicine, University of Pavia, Italy; General Medicine 1, IRCCS Policlinico San Matteo Foundation, Pavia, Italy; ⁴Servicio de Hematología, Hospital Universitario Morales Meseguer, Centro Regional de Hemodonacio´n, Universidad de Murcia, Spain; ⁵Institute for Clinical and Experimental Transfusion Medicine, University Hospital of Tuebingen, Germany; Center for Clinical Transfusion Medicine, Tuebingen, Germany; ⁶Centre for Children’s Health and Research CCHR, South Brisbane, Australia; ⁷Laboratoire d’Hématologie, Assistance Publique Hôpitaux de Paris, Hôpital Bichat-Claude-Bernard, Paris, France; ⁸AP-HP, Service d’Hématologie Biologique, Hôpital Lariboisière, Paris Cité University, Paris, France; ⁹St. Anna Kinderspital, Universitätsklinik für Kinder- und Jugendheilkunde der Medizinischen Universität Wien, Austria

  15-07-2025

  https://doi.org/10.4081/btvb.2025.250

  0

• CO47 | Genetic characterization of the KIV2 LPA polymorphism in subjects with bicuspid aortic valve with different clinical complications R. Orsi¹, G. Barbieri¹, E. Sticchi^1,2, A. Kura¹, L. Squillantini¹, P. Cantini¹, A. Rogolino², M. Berteotti^1,2, S. Nistri³, P. Stefàno⁴, R. Marcucci^1,2, B. Giusti^1,2 | ¹Department of Experimental and Clinical Medicine, University of Firenze; ²Centre for Atherothrombotic Diseases, AOU Careggi, Firenze; ³Cardiology, CMSR Veneto Medica, Altavilla Vicentina; ⁴Cardiac Surgery, AOU-Careggi, Firenze, Italy

  15-07-2025

  https://doi.org/10.4081/btvb.2025.257

  0

• CO50 | Diagnostic accuracy of the heparin-induced multiple electrode aggregometry (HIMEA) functional test for heparin-induced thrombocytopenia M. Bovara¹, M. Sebastiani², Am. Gori^3,4, A. Rogolino^3,4, A. Bertelli^3,4, G. Ciarrocca Taranta^3,4, R. Marcucci^3,4, M. Sartori⁵, B. Cosmi⁵, M. Silingardi⁶, A. Pizzini⁶, A. Marrocchi¹, R. Mancini¹ | ¹Laboratorio Unico Metropolitano Ospedale Maggiore, AUSL Bologna; ²IRCCS Istituto delle Scienze Neurologiche, Bologna; ³Centro Malattie Aterotrombotiche Azienda Ospedaliera Universitaria Careggi, Firenze; ⁴Dipartimento di Medicina Sperimentale e Clinica, Università di Firenze; ⁵U.O. di Angiologia e Malattie della Coagulazione dell’Azienda Ospedaliero Universitaria Policlinico S. Orsola-Malpighi, Bologna; ⁶Medicina Interna Ospedale Maggiore, Bologna, Italy

  15-07-2025

  https://doi.org/10.4081/btvb.2025.260

  0

• CO42 | Oxidative stress may contribute to enhanced thrombopoiesis through miR-150: implications for aspirin response R. Liani¹, P.G. Simeone¹, M. Alfonsetti¹, M. Frezza¹, R. Tripaldi¹, S. Ciotti¹, M. Luongo², F. Cipollone¹, L. Vanella³, F. Santilli¹ | ¹Department of Medicine and Aging, and Center for Advanced Studies and Technology “CAST”, G. d’Annunzio University of Chieti-Pescara, Chieti; ²Immunotransfusion Service, Clinical Haematology of Chieti University Hospital, Chieti; ³Department of Drug Sciences, University of Catania, Italy

  15-07-2025

  https://doi.org/10.4081/btvb.2025.248

  0

• CO51 | Novel biomarkers of neurological damage in acute immune-mediated thrombotic thrombocytopenic purpura A. Truma^1,2, I. Mancini¹, F. Verde^2,3, J. A. Giannotta¹, A. Artoni¹, B. Ferrari¹, P. Agosti^1,2, M. Gagliardi¹, A. Ratti^3,4, N. Ticozzi^2,3, F. Peyvandi^1,2 | ¹Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Milan; ²Università degli Studi di Milano, Department of Pathophysiology and Transplantation, Milan; ³Department of Neurology and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, Milan; ⁴Università degli Studi di Milano, Department of Medical Biotechnology and Translational Medicine, Milan, Italy

  15-07-2025

  https://doi.org/10.4081/btvb.2025.261

  0

• CO49 | The burden of cerebral small vessel disease in ITTP patients from acute phase to remission A. Truma^1,2, F. M. Lo Russo¹, G. Conte^1,2, I. Mancini¹, M. Abbattista¹, J. Giannotta¹, A. Artoni¹, B. Ferrari¹, P. Agosti^1,2, F. M. Triulzi^1,2, F. Peyvandi^1,2 | ¹Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Milan; ²Università degli Studi di Milano, Department of Pathophysiology and Transplantation, Milan, Italy

  15-07-2025

  https://doi.org/10.4081/btvb.2025.259

  0

• CO48 | Gynecological involvement in females with congenital plasminogen deficiency type 1 C. Dalla Porta^1,2, M.T. Sartori¹, G. Saggiorato¹, I. Cortella¹, S.A. Malerba^1,3, P. Simioni¹ | ¹First Medical Clinic, Department of Medicine - DIMED, Università degli Studi di Padova; ²Department of Medicine, Casa di Cura Villa Maria, Padova; ³Medicina Generale, Ospedale dell’Angelo, Mestre, Italy

  15-07-2025

  https://doi.org/10.4081/btvb.2025.258

  0

• CO52 | The impact of KRAS mutations on the risk of recurrent venous thromboembolism in patients with cancer-associated thrombosis and gastrointestinal neoplasms B. Cosmi^1,2, S. Cavara², M. Soldati², L. Borgese², M. Sartori² | ¹Angiology and Blood Coagulation Unit, Department of Medical and Surgical Sciences, University of Bologna; ²Angiology and Blood Coagulation Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Italy

  15-07-2025

  https://doi.org/10.4081/btvb.2025.262

  0