Mini-reviews
Vol. 2 No. 4 (2023)
Polycythemia vera and management of the thrombotic risk: an update
Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Published: 20 December 2023
2355
Views
355
Downloads
Authors
Polycythemia vera (PV) is a chronic Philadelphia-negative myeloproliferative neoplasm caused by JAK2 mutation and characterized predominantly by the overproduction of red blood cells. The current treatment strategies of PV are based on periodic phlebotomies aimed at preventing thrombotic events associated with increased hematocrit levels. Additional therapies to mitigate the thrombotic burden, which represents the most important predictor of reduced survival in PV patients, include cytoreductive therapies, low-dose aspirin, and systemic anticoagulation. This concise review summarizes the current knowledge on the management of the thrombotic risk in PV patients.
Downloads
Download data is not yet available.
Citations
Tefferi A, Barbui T. Polycythemia vera and essential thrombocythemia: 2021 update on diagnosis, risk-stratification and management. Am J Hematol 2024;98:1465-87. DOI: https://doi.org/10.1002/ajh.27002
Tefferi A, Vannucchi AM, Barbui T. Polycythemia vera: historical oversights, diagnostic details, and therapeutic views. Leukemia 2021;35:3339-351. DOI: https://doi.org/10.1038/s41375-021-01401-3
Guglielmelli P, Vannucchi AM. Current management strategies for polycythemia vera and essential thrombocythemia. Blood Rev 2020;42:100714. DOI: https://doi.org/10.1016/j.blre.2020.100714
Grunwald MR, Stein BL, Boccia RV, et al. Clinical and Disease Characteristics From REVEAL at Time of Enrollment (Baseline): Prospective Observational Study of Patients With Polycythemia Vera in the United States. Clin Lymphoma Myeloma Leuk. 2018;18:788-95. DOI: https://doi.org/10.1016/j.clml.2018.08.009
Szuber N, Mudireddy M, Nicolosi M, et al. 3023 Mayo Clinic patients with myeloproliferative neoplasms: risk-stratified comparison of survival and outcomes data among disease subgroups. Mayo Clin Proc. 2019;94:599-610. DOI: https://doi.org/10.1016/j.mayocp.2018.08.022
Carobbio A, Ferrari A, Masciulli A, Ghirardi A, Barosi G, Barbui T. Leukocytosis and thrombosis in essential thrombocythemia and polycythemia vera: a systematic review and meta-analysis. Blood Adv 2019;3:1729-37. DOI: https://doi.org/10.1182/bloodadvances.2019000211
Barbui T, Vannucchi AM, Finazzi G, et al. A reappraisal of the benefit-risk profile of hydroxyurea in polycythemia vera: A propensity-matched study. Am J Hematol 2017;92:1131-6. DOI: https://doi.org/10.1002/ajh.24851
Landolfi R, Marchioli R, Kutti J, et al.; European Collaboration on Low-Dose Aspirin in Polycythemia Vera Investigators. Efficacy and safety of low-dose aspirin in polycythemia vera. N Engl J Med 2004;350:114-24. DOI: https://doi.org/10.1056/NEJMoa035572
Marchioli R, Finazzi G, Landolfi R, Kutti J, Gisslinger H, Patrono C, et al. Vascular and neoplastic risk in a large cohort of patients with polycythemia vera. J Clin Oncol 2005;23:2224–32. DOI: https://doi.org/10.1200/JCO.2005.07.062
Mainoli B, Duarte GS, Costa J, Ferreira J, Caldeira D. Once- versus Twice-Daily Aspirin in Patients at High Risk of Thrombotic Events: Systematic Review and Meta-Analysis. Am J Cardiovasc Drugs 2021;21:63-71. DOI: https://doi.org/10.1007/s40256-020-00409-x
How to Cite
1.
Franchini M. Polycythemia vera and management of the thrombotic risk: an update. Bleeding Thromb Vascul Biol [Internet]. 2023 Dec. 20 [cited 2026 Jan. 21];2(4). Available from: https://www.btvb.org/btvb/article/view/102
Copyright (c) 2023 The Author(s)
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Similar Articles
- CO27 | Intracerebral hemorrhage in hemophilia A and B: a 10-year prospective multicenter study in Italy (2012–2022) , Bleeding, Thrombosis and Vascular Biology: Vol. 4 No. s1 (2025)
- Coenraad H. Hemker, The clinical usefulness of measuring thrombin generation , Bleeding, Thrombosis and Vascular Biology: Vol. 2 No. 1 (2023)
- PO95 | Idiopathic thrombocytopenic purpura in tuberculosis , Bleeding, Thrombosis and Vascular Biology: Vol. 4 No. s1 (2025)
- Luca Puccetti, Vincenzo Sammartano, Federico Caroni, Margherita Malchiodi, Paola Calzoni, Eleonora Franceschini, Lucrezia Galasso, Monica Bocchia, Safety of COVID-19 mRNA vaccination in patients with history of acquired hemophilia A: a case series , Bleeding, Thrombosis and Vascular Biology: Vol. 1 No. 3 (2022)
- CO18 | Relationship between gut permeability and PCSK9 in heterozygous familial hypercholesterolemia , Bleeding, Thrombosis and Vascular Biology: Vol. 4 No. s1 (2025)
- Ciarán Kennedy, Luke J. Conroy, Braden Millar, Monica de Gaetano, The subtle red line between combating and resolving inflammation in the cardiovascular disease, a “silent sniper” , Bleeding, Thrombosis and Vascular Biology: Vol. 4 No. 2 (2025)
- CO03 | Early discharge and home treatment of low-risk pulmonary embolism: a cohort study , Bleeding, Thrombosis and Vascular Biology: Vol. 4 No. s1 (2025)
- PO89 | Apixaban for secondary prevention of venous thromboembolism in hemodialysis patients: pharmacokinetic profile and safety outcomes , Bleeding, Thrombosis and Vascular Biology: Vol. 4 No. s1 (2025)
- CS07 | Endothelial dysfunction and impaired angiogenesis in Hermansky-Pudlak syndrome (HPS) type 1: studies with endothelial colony forming cells , Bleeding, Thrombosis and Vascular Biology: Special issues
- Pier Mannuccio Mannucci, Gene transfer in hemophilia A: not cogent yet , Bleeding, Thrombosis and Vascular Biology: Vol. 1 No. 1 (2022)
You may also start an advanced similarity search for this article.
Most read articles by the same author(s)
- Massimo Franchini, Daniele Focosi, The changing landscape of treatment for acquired hemophilia A , Bleeding, Thrombosis and Vascular Biology: Vol. 4 No. 1 (2025)
