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• CO25 | Thromboinflammation and ros accumulation in individuals with high lipoprotein(a) levels M. Frezza¹, P.G.M. Simeone¹, M. Alfonsetti¹, R. Liani¹, M. Cellini¹, P. Del Boccio², M.C. Cufaro³, O. Iuliani⁴, A. Quaglietta⁴, F. Cipollone¹, F. Santilli¹ | ¹Department of Medicine and Ageing Sciences, Center for Advanced Studies and Technology “CAST”, University of Chieti; ²Department of Pharmacy, Center for Advanced Studies and Technology “CAST”, Chieti; ³Department of Innovative Technologies in Medicine and Dentistry, Center for Advanced Studies and Technology “CAST”, Chieti; ⁴Department of Haematolgy and Oncology, Center of Transfusion Medicine, Pescara General Hospital, Pescara. Italy

  22-10-2025

  https://doi.org/10.4081/btvb.2025.231

  587

  PDF: 14

• CO42 | Oxidative stress may contribute to enhanced thrombopoiesis through miR-150: implications for aspirin response R. Liani¹, P.G.M. Simeone¹, M. Alfonsetti¹, M. Frezza¹, R. Tripaldi¹, S. Ciotti¹, M. Luongo², F. Cipollone¹, L. Vanella³, F. Santilli¹ | ¹Department of Medicine and Aging, and Center for Advanced Studies and Technology “CAST”, G. d’Annunzio University of Chieti-Pescara, Chieti; ²Immunotransfusion Service, Clinical Haematology of Chieti University Hospital, Chieti; ³Department of Drug Sciences, University of Catania, Italy

  22-10-2025

  https://doi.org/10.4081/btvb.2025.248

  582

  PDF: 16

• PO32 | Effect of the sodium-glucose co-transporter-2 (SGLT2) inhibitors on platelet activation and lipid peroxidation: results of a pilot study P.G.M. Simeone¹, R. Liani¹, M. Alfonsetti¹, B. Cancelli¹, M. Frezza¹, G. Raggiunti¹, S. Zeeba², F. Cipollone¹, G. Renda², F. Santilli¹ | ¹Department of Medicine and Aging Sciences, Center for Advanced Studies and Technology, University of Chieti; ²Department of Neuroscience, Imaging and Clinical Sciences, G. D’Annunzio University of Chieti-Pescara; ³University Cardiology Division, Heart Department, Policlinico SS Annunziata, Chieti, Italy

  22-10-2025

  https://doi.org/10.4081/btvb.2025.293

  615

  PDF: 19

• PO46 | Intravitreal treatment with faricimab in patients with age-related macular degeneration M. Alfonsetti¹, R. Liani¹, P.G.M. Simeone¹, M. Frezza¹, A. Ricci³, S. Lattanzio¹, R. D’Aloisio², L. Toto², F. Santilli¹ | ¹Department of Medicine and Aging, Center for Advanced Studies and Technology “CAST”; ²Ophthalmology Clinic, Department of Medicine and Aging; ³Department of Pharmacy, University “G. d’Annunzio” of Chieti Pescara, Chieti, Italy

  22-10-2025

  https://doi.org/10.4081/btvb.2025.315

  487

  PDF: 18

• CO077 | PLATELET MIR-144-5P REGULATES COX-1/2 EXPRESSION AND MODULATES ASPIRIN RESPONSE IN PATIENTS WITH CARDIOMETABOLIC RISK P. Simeone¹, R. Liani¹, V. Abbonante², M. Alfonsetti¹, M. Frezza¹, P. Lanuti¹, A. Recchiuti³, A. Balduini², F. Santilli¹ | ¹Department of Medicine and Aging, and Center for Advanced Studies and Technology (CAST), "G. d'Annunzio" University of Chieti-Pescara, Chieti, Italy; ²Department of Molecular Medicine, University of Pavia, Pavia, Italy; ³Department of Medical, Oral, and Biotechnological Science, Center for Advanced Studies and Technology (CAST), "G. d'Annunzio" University of Chieti-Pescara, Chieti, Italy

  Paola Giustina Maria Simeone

  26-10-2026

  https://doi.org/10.4081/btvb.2026.779

  37

  PDF: 13

• CO047 | OXIDATIVE STRESS–RELATED PLATELET HO-1 AND MICRO-RNA MODULATION IN PATIENTS WITH TYPE 2 DIABETES MELLITUS UNDER ASPIRIN THERAPY R . Liani¹, P.G. Simeone¹, M. Alfonsetti¹, M. Frezza¹, B. Di Marco¹, V. Sorrenti², A. Russo², C. Di Giacomo², M. Gulisano², M. Luongo³, F. Cipollone¹, T. Colangelo⁴, L. Vanella², F. Santilli¹ | ¹Dep. of Medicine and Aging Sciences, Center for Advanced Studies and Technology (CAST), University of Chieti, Italy; ²Dep. of Drug and Health Sciences, University of Catania, Italy; ³Immunotransfusion Service, Clinical Haematology of Chieti University Hospital, Italy; ⁴Dep. of Medical and Surgical Sciences, University of Foggia, Italy

  Rossella Liani

  26-10-2026

  https://doi.org/10.4081/btvb.2026.749

  45

  PDF: 21

• CO056 | URINARY MARKERS OF PLATELET ACTIVATION AND OXIDATIVE STRESS IN ATHEROSCLEROTIC CARDIOVASCULAR DISEASE IN TYPE 2 DIABETES M. Alfonsetti¹, P. Simeone¹, R. Liani¹, M. Frezza¹, B. Di Marco¹, A. Cipollone¹, D. D’ Ardes¹, T. Taverriti¹, C. Della Penna¹, L. Cantagallo¹, G. Ciferni¹, L. Del Rosso¹, M. Caporale¹, S. Brandolino², E. Vitacolonna², P. Di Carlo³, F. Cipollone¹, F. Santilli¹ | ¹Department of Medicine and Aging Sciences, Center for Advanced Studies and Technology (CAST), University of Chieti, Chieti, Italy, University General Medicine Division, Medical Department, SS. Annunziata Hospital, Chieti, Italy; ²Department of Medicine and Aging, School of Medicine and Health Sciences, G. d'Annunzio University, Chieti, Italy; ³Department of Innovative Technologies in Medicine & Dentistry, "G. d'Annunzio" University of Chieti-Pescara, Chieti, Italy

  Paola Giustina Maria Simeone

  26-10-2026

  https://doi.org/10.4081/btvb.2026.758

  44

  PDF: 13

• CO057 | THROMBOPOIETIN-PLATELET AXIS IN METABOLIC-ASSOCIATED STEATOTIC LIVER DISEASE M. Alfonsetti¹, P. Simeone¹, R. Liani¹, M. Frezza¹, B. Di Marco¹, A. Cipollone¹, C. Della Penna¹, L. Cantagallo¹, G. Ciferni¹, L. Del Rosso¹, M. Caporale¹, S. Brandolino², E. Vitacolonna², P. Di Carlo³, F. Cipollone¹, F. Santilli¹ | ¹Department of Medicine and Aging Sciences, Center for Advanced Studies and Technology (CAST), University of Chieti, Chieti, Italy, University General Medicine Division, Medical Department, SS. Annunziata Hospital, Chieti, Italy; ²Department of Medicine and Aging, School of Medicine and Health Sciences, G. d'Annunzio University, Chieti, Italy; ³Department of Innovative Technologies in Medicine & Dentistry, "G. d'Annunzio" University of Chieti-Pescara, Chieti, Italy

  Paola Giustina Maria Simeone

  26-10-2026

  https://doi.org/10.4081/btvb.2026.759

  43

  PDF: 14

• PO145 | KINETIC ASSESSMENT OF PLATELET REACTIVITY DURING DUAL ANTIPLATELET THERAPY IN ACUTE CORONARY SYNDROMES: PRELIMINARY RESULTS FROM AN ONGOING STUDY B. Di Marco^1|2, R. Liani¹, F. D’Ambrosio^1|2, M. Alfonsetti¹, P.G. Simeone¹, M. Frezza¹, S. Porro¹, M. Brambilla³, P. Lanuti¹, M. Camera³, F. Santilli¹ | ¹Department of Medicine and Aging Sciences, Center for Advanced Studies and Technology (CAST), University of Chieti, Chieti, Italy; ²ASL 2 Abruzzo, SS. Annunziata Hospital, Chieti, Italy; ³Unit of Cell and Molecular Biology in Cardiovascular Diseases, Centro Cardiologico Monzino IRCCS, Milano, Italy

  Beatrice Di Marco

  26-10-2026

  https://doi.org/10.4081/btvb.2026.961

  32

  PDF: 13