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  Bioequivalence of von Willebrand factor-containing concentrates: implications for the choice in patients with von Willebrand disease. A position paper from the Italian Association of Hemophilia Centers

  Ezio Zanon, Giancarlo Castaman, Augusto Bramante Federici, Maria Elisa Mancuso, Gianfranco Pasut, Alberto Tosetto, Angiola Rocino, Rita Carlotta Santoro

  26-01-2026

  https://doi.org/10.4081/btvb.2026.415

  1307

  PDF: 347

  HTML: 165

• CO-01 | BLEEDING EVENTS IN MILD HEMOPHILIA A AND VON WILLEBRAND DISEASE TYPE 1 YEARLY TREATABLE WITH DESMOPRESSIN IN ITALY A. Gringeri^1|2, P.M. Mannucci³, G.C. Castaman⁴, F. Peyvandi^3|5 | ¹Fondazione Charta, Milano, Italy; ²Centro di Sanità Solidale, Lucca, Italy; ³Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Angelo Bianchi Bonomi Hemophilia and Thrombosis Center and Fondazione Luigi Villa, Milano, Italy; ⁴Centre for Bleeding Disorders and Coagulation, Careggi University Hospital, Firenze, Italy; ⁵Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Italy

  Alessandro Gringeri

  14-10-2026

  https://doi.org/10.4081/btvb.2026.611

  81

  PDF: 14

• PO45 | Routine prophylaxis with PD-FX concentrate in severe inherited FX deficiency: a case report S. Linari, L. Pieri, M. Attanasio, F. Salvianti, M. Coppo, E. Grisanti, F. Demartis, R. Fjerza, G. Castaman | Centre for Bleeding Disorders and Coagulation, Azienda Ospedaliera Universitaria Careggi, Firenze, Italy

  22-10-2025

  https://doi.org/10.4081/btvb.2025.308

  625

  PDF: 20

• PO39 | Bleeding events in Von Willebrand disease type 1 yearly treatable with desmopressin A. Gringeri^1,2, P.M. Mannucci³, M. Gringeri⁴, G. Castaman⁵, F. Peyvandi^3,6 | ¹Fondazione Charta, Milan; ²Centro di Sanità Solidale, Lucca; ³Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Angelo Bianchi Bonomi Hemophilia and Thrombosis Center and Fondazione Luigi Villa, Milan; ⁴Department of Medical Biotechnologies and Translational Medicine, Postgraduate School of Clinical Pharmacology and Toxicology, University of Milan; ⁵Centre for Bleeding Disorders and Coagulation, Careggi University Hospital, Firenze; ⁶Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Italy

  22-10-2025

  https://doi.org/10.4081/btvb.2025.302

  645

  PDF: 23

• CO38 | Management of pregnancy, delivery, and postpartum in Italian carriers and women with hemophilia A and B S. Linari¹, B. Pollio², A. Ferretti³, M. Napolitano⁴, E. Grandone⁵, S. Siboni⁶, Ab. Aru⁷, E. Bertoni⁸, C. Biasoli⁹, I. Cantori¹⁰, P. Di Gregorio¹¹, G. Lassandro¹², G. Sottilotta¹³, A. Strangio¹⁴, Mr. Villa¹⁵, A. Rocino¹⁶, G. Castaman¹ | ¹Center for Bleeding Disorders and Coagulation, Careggi University Hospital, Firenze; ²Regional Reference Center for Inherited Bleeding and Thrombotic Disorders, Transfusion Medicine, Regina Margherita Children Hospital, Turin; ³Center for Hemorrhagic and Thrombotic Diseases, IRCCS A. Gemelli University Hospital Foundation, Roma; ⁴Department of Health Promotion, Maternal-Childhood, Internal Medicine of Excellence G. D’Alessandro, University of Palermo; ⁵Thrombosis and Hemostasis Unit, Fondazione IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo; ⁶Angelo Bianchi Bonomi Hemophilia and Thrombosis Center and Fondazione Luigi Villa, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan; ⁷Pediatric Onco-Hematology Center, Microcitemico Hospital Cagliari; ⁸Pediatric Oncohematology and Bone Marrow Transplant “BMT” Unit, Children’s Hospital, Spedali Civili, Brescia; ⁹Hemophilia and Transfusion Center, Bufalini Hospital, Cesena; ¹⁰Hemophilia Center, Department of Transfusion Medicine, Hospital of Macerata; ¹¹Transfusion Medicine Department, SS. Annunziata Hospital, Chieti; ¹²B. Trambusti General and Specialised Pediatrics Unit, Giovanni XXIII Hospital, University of Bari; ¹³Hemophilia Center, Grande Ospedale Metropolitano, Reggio Calabria; ¹⁴Center for Hemorrhagic and Thrombotic Disorders, Pugliese Ciaccio Hospital, Catanzaro; ¹⁵Hemophilia and Thrombosis Center, Haematology Unit, Ospedale del Mare Hospital, Naples; ¹⁶Past President of the Italian Association of Hemophilia Centers, Italy

  22-10-2025

  https://doi.org/10.4081/btvb.2025.245

  586

  PDF: 15
• 

  Hemophilia-free mind: a call to action

  Tiziano Martini, Chiara Gorio, Cristina Dainese, Rita Carlotta Santoro, Giancarlo Castaman

  10-03-2026

  https://doi.org/10.4081/btvb.2026.465

  549

  PDF: 127

• CO-64 | REAPPRAISAL OF DESMOPRESSIN FOR MANAGEMENT OF MILD/MODERATE VON WILLEBRAND DISEASE: RESULTS OF A RETROSPECTIVE ANALYSIS IN 127 ITALIAN PATIENTS SUGGEST FURTHER ORGANIZATION OF PROSPECTIVE OBSERVATIONAL STUDIES TO PREDICT DESMOPRESSIN FAILURE WITH IMMEDIATE VWF CONCENTRATES REQUIREMENT A.B. Federici¹, G. Castaman² | ¹Ematologia e Medicina Trasfusionale, Ospedale Luigi Sacco, Polo Didattico Università di Milano, Italy; ²Centro Emofilia e Malattie Emorragiche Regione Toscana, Ospedale Careggi, Firenze, Italy

  Augusto B Federici

  14-10-2026

  https://doi.org/10.4081/btvb.2026.674

  44

  PDF: 15
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  Impaired platelet function in Hermansky-Pudlak syndrome associated with novel mutations in HPS3, HPS6 and HPS8 genes

  Lisa Pieri, Silvia Linari, Francesca Salvianti, Monica Attanasio, Giancarlo Castaman

  27-11-2024

  https://doi.org/10.4081/btvb.2024.150

  1411

  PDF: 462
• 

  Von Willebrand Disease (VWD) 100 years after its first description: the research of Italian investigators for a better management of VWD patients

  Augusto B. Federici, Giancarlo Castaman, Paolo Gresele, Alberto Tosetto

  09-10-2026

  https://doi.org/10.4081/btvb.2026.580

  420

  PDF: 98
• 

  Pharmacokinetics of extended half-life albumin-fused factor IX and heterogeneous F9 variants in hemophilia B: a retrospective cohort study

  Barbara Lunghi, Massimo Morfini, Silvia Linari, Dario Balestra, Alessio Branchini, Lisa Pieri, Donata Belvini, Laura Banov, Cristina Santoro, Giancarlo Castaman, Francesco Bernardi

  02-03-2026

  https://doi.org/10.4081/btvb.2026.413

  456

  PDF: 129

  Supplementary: 96

• CO-07 | ITALIAN RESOURCE USE IN MILD HEMOPHILIA A AND TYPE 1 VON WILLEBRAND DISEASE A. Gringeri^1|2, G.C. Castaman³ | ¹Fondazione Charta, Milano, Italy; ²Centro di Sanità Solidale, Lucca, Italy; ³Centre for Bleeding Disorders and Coagulation, Careggi University Hospital, Firenze, Italy

  Alessandro Gringeri

  14-10-2026

  https://doi.org/10.4081/btvb.2026.617

  94

  PDF: 17
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  The evolving landscape of gene therapy for congenital severe hemophilia: a 2024 state of the art

  Giovanni Di Minno, Gaia Spadarella, Ilenia Lorenza Calcaterra, Giancarlo Castaman, Paolo Simioni, Raimondo De Cristofaro, Cristina Santoro, Flora Peyvandi, Matteo Di Minno

  04-09-2024

  https://doi.org/10.4081/btvb.2024.144

  2089

  PDF: 359

  SUPPLEMENTARY MATERIAL: 218

• PO043 | MULTICENTRE REAL‑WORLD EXPERIENCE OF EMICIZUMAB PROPHYLAXIS IN AN ITALIAN COHORT OF 49 CHILDREN WITH SEVERE HEMOPHILIA A - EMIPED STUDY L. Pieri¹, B. Pollio², P. Giordano³, G. Lassandro⁴, S. Linari¹, R. Pasquino¹, E. Piellucci¹, MC. Di Stefano¹, F. Demartis¹, R. Fjerza¹, G. Castaman¹ | ¹Center for Bleeding Disorders, Careggi University Hospital, Firenze, Italy; ²Center for Inherited Bleeding and Thrombotic Disorders, Transfusion Medicine, "Regina Margherita" Children Hospital, Torino, Italy; ³Department of Interdisciplinary of Medicine, University of Bari 'Aldo Moro', Bari, Italy; ⁴General and Specialised Pediatrics Unit, "Giovanni XXIII" Hospital, University of Bari, Bari, Italy

  Lisa Pieri

  26-10-2026

  https://doi.org/10.4081/btvb.2026.859

  27

  PDF: 8
• 

  Gene transfer in hemophilia B: a big step forward

  Giancarlo Castaman

  17-05-2023

  https://doi.org/10.4081/btvb.2023.70

  1436

  PDF: 659

• CO029 | REAL WORLD EVALUATION OF A NOVEL PATIENT CENTERED OUTCOME INDICATOR TO SUPPORT VALUE BASED HEALTHCARE DECISION-MAKING IN HEMOPHILIA A IN ITALY: THE HEMPROVE NON-INTERVENTIONAL STUDY G. Castaman¹, C. Santoro², E. Ferri Grazzi³, S. Bendinelli⁴, R. Perrone⁴, C. Lainez Diaz⁴, P.A. Cortesi⁵, M.N.D. Di Minno⁶ | ¹Dep. of Oncology, Centre for Bleeding Disorders and Coagulation, Careggi Univ. Hosp., Firenze, Italy; ²Hematology, Dep. of Translational and Precision Medicine, Sapienza University of Roma, Italy; ³FedEmo, Milano, Italy; ⁴Roche S.p.A. Italy, Monza, Italy; ⁵CESP, Univ. of Milano-Bicocca, Monza, Italy; ⁶Dep. of Clinical Medicine and Surgery, Regional Reference Center for Coagulation Disorders, Federico II Univ., Napoli, Italy

  Raffaella Perrone

  26-10-2026

  https://doi.org/10.4081/btvb.2026.731

  34

  PDF: 12

• BEST-04 | MAJOR ORTHOPEDIC SURGERY WITH EMICIZUMAB: A SERIES OF 22 PATIENTS (40 PROCEDURES) WITH A MID-TERM FOLLOW-UP G. Daniele¹, C. Carulli¹, S. Linari², L. Pieri², G. Castaman² | ¹Clinica Ortopedica, Azienda Ospedaliero-Universitaria Careggi, Università degli Studi di Firenze, Italy; ²Centro Malattie Emorragiche e della Coagulazione, Azienda Ospedaliero-Universitaria Careggi, Firenze, Italy

  Giovanna Daniele

  14-10-2026

  https://doi.org/10.4081/btvb.2026.604

  86

  PDF: 13

• CO006 | PREVALENCE OF GASTROINTESTINAL BLEEDING IN GLANZMANN THROMBASTHENIA PATIENTS: RESULTS OF A WORLDWIDE SURVEY E. Falcinelli¹, L. Bury¹, S. Morais², M. de Oliveira², M. Kannan³, M. Faranoush⁴, D. Desprez⁵, V. Jean-Baptiste⁶, C. Santoro⁷, C. Falaise⁸, P. Saultier⁸, M. Fiore⁹, C. Albayrak¹⁰, A. Sánchez¹¹, J.M. Bastida¹², A. Artoni¹³, G. Castaman¹⁴, K. Gomez¹⁵, R. Schutgens¹⁶, L. Spiezia¹⁷, M. Sridharan¹⁸, N. Butta¹⁹, P. Buur van Kooten Niekerk²⁰, E. Leinøe²¹, B. Guillet²², C. Panagiotis²³, S. Crivelli²⁴, E. De Candia²⁵, M. Lewandowska²⁶, P. De Bonis²⁷, G. Kenet²⁸, F. Heubel-Moenen²⁹, J. Payne³⁰, L. Banov³¹, L. Puccetti³², M. Olivieri³³, M. Chitlur³⁴, M. Lambert³⁵, A. Pecci³⁶, D. Martínez-Carballeira³⁷, E. Zetterberg³⁸, J. Curnow³⁹, M. Napolitano⁴⁰, A. Morotti⁴¹, R.C. Santoro⁴², R. Johann⁴³, S. Saulyte Trakymiene⁴⁴, A. Falanga⁴⁵, C. Casas⁴⁶, E. Zanon⁴⁷, J. Moppet⁴⁸, N.M. Popa-Fotea⁴⁹, P. Gresele¹ | ¹Department of Medicine and Surgery, Section of Internal and Cardiovascular Medicine, University of Perugia, Italy; ²Centro Hospitalar Universitário de Santo António, Portugal; ³Blood and Vascular Biology Research Lab, Department of Biotechnology, Central University of Tamil Nadu, India; ⁴Iranian Hemophilia and Thrombophilia Association, MAHTA, Iran; ⁵CRC MHC Hopital Universaitire de Strasbourg, France; ⁶CHRU de Tours, University Hospital of Tours, France; ⁷UOC Ematologia, Azienda Ospedaliero Universitaria Policlinico Umberto I, Roma, Italy; ⁸AP-HM Timone, Marseille, France; ⁹CHU Bordeaux, France; ¹⁰Mayıs University Medical Faculty Pediatric Hematology and Oncology Dept, Türkiye; ¹¹Hospital Universitario Morales Meseguer – Centro Regional de Hemodonación, Murcia, Spain; ¹²Complejo Asistencial Universitario De Salamanca, Spain; ¹³Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milano, Italy; ¹⁴Azienda Ospedaliera Universitaria Careggi Florence, Italy; ¹⁵Royal Free Hospital, London, UK; ¹⁶Center for Benign Haematology, Thrombosis and Haemostasis, Van Creveldkliniek, UMC Utrecht, The Netherlands; ¹⁷University of Padova, Italy; ¹⁸Mayo Clinic, Rochester, USA; ¹⁹Hospital Universitario La Paz-IdiPAZ, Madrid, Spain; ²⁰Aarhus University Hospital, Denmark; ²¹Department of Hematology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark; ²²University Hospital of Rennes, France; ²³Blood unit and National Reference Center for Congenital Bleeding Disorders, ''Laiko'' General Hospital, Greece; ²⁴Ospedale L. Sacco e Polo Universitario, Milano, Italy; ²⁵Università Cattolica del Sacro Cuore-Roma, Fondazione Policlinico Universitario A. Gemelli IRCCS, Italy; ²⁶Indiana Hemophilia and Thrombosis Center Innovative Hematology, USA; ²⁷IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy; ²⁸Sheba Medical Center, Israel; ²⁹Department of Hematology Internal Medicine, Maastricht University Medical Center and Hemophilia Treatment Center Nijmegen Eindhoven Maastricht and CARIM, Maastricht University, Maastricht, Netherlands; ³⁰Sheffield Children’s NHS foundation Trust, UK; ³¹Hemostasis and Thrombosis Unit, Gaslini Children’s Hospital, Italy; ³²University Teaching Hospital of Siena, Italy; ³³Pediatric Thrombosis and Hemostasis Unit, Dr. von Hauner Childreńs Hospital, LMU Munich, Munich, Germany; ³⁴Children's Hospital of Michigan, USA; ³⁵Children’s Hospital of Philadelphia, USA; ³⁶IRCCS Policlinico San Matteo Foundation and University of Pavia, Italy; ³⁷Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Spain; ³⁸Department of Hematology, Coagulation Unit, Skane University hospital, Sweden; ³⁹Westmead Hospital, Sydney, Australia; ⁴⁰PROMISE Department, University of Palermo, Italy; ⁴¹AOU San Luigi Gonzaga Hospital, University of Turin, Italy; ⁴²Hemostasis and Thrombosis, Az. Osp. Univ. Dulbecco, Catanzaro, Italy; ⁴³Hospital Center of Le Mans, France; ⁴⁴Vilnius University Hospital Santaros Klinikos, Lithuania; ⁴⁵ASST Papa Giovanni XXIII, Bergamo, Italy; ⁴⁶Hospital San José, Bogotà, Colombia; ⁴⁷Haemophilia Center-General Medicine, Padova University Hospital, Padova, Italy; ⁴⁸University Hospitals Bristol NHS Foundation Trust, UK; ⁴⁹University of Medicine and Pharmacy “Carol Davila”, Bucharest, Romania

  Loredana Bury

  26-10-2026

  https://doi.org/10.4081/btvb.2026.708

  39

  PDF: 11
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  Development of a shared decision-making tool for gene therapy in hemophilia A in Italy

  Giovanni Di Minno, Sarah Bigi, Serena Barello, Enrico Ferri Grazzi, Marco Follino, Maria Francesca Mansueto, Mariasanta Napolitano, Rita Carlotta Santoro, Giancarlo Castaman

  22-06-2026

  https://doi.org/10.4081/btvb.2026.426

  933

  PDF: 139

  SUPPLEMENTARY MATERIAL: 78

• CO-70 | CONGENITAL AFIBRINOGENEMIA: BLEEDING PHENOTYPE, THROMBOTIC COMPLICATIONS, AND LONG-TERM MANAGEMENT IN A MULTICENTER COHORT M. Biglietto^1|2, M. Presti¹, R.C. Santoro³, I. Nichele⁴, M. Napolitano⁵, S. Pasca⁶, A. Borchiellini⁷, B. Pollio⁸, E. Zanon⁹, G. Barillari¹⁰, A. Poz¹⁰, S. Sorella¹, S. Ligia¹, R. Mormile¹, E. Baldacci¹, G. Castaman¹¹, F. Peyvandi^12|13, C. Santoro¹ | ¹Hematology, Department of Translational and Precision Medicine, Sapienza University of Rome, Italy; ²Department of Molecular Biology, Sapienza University of Rome, Italy; ³Hemostasis and Thrombosis Unit, Azienda Ospedaliera Pugliese-Ciaccio, Catanzaro, Italy; ⁴Hematology Unit, Azienda ULSS 8 Berica - San Bortolo Hospital, Vicenza, Italy; ⁵Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, University of Palermo, Italy; ⁶Coagulation Diseases Center, Transfusion Medicine Department - Azienda Sanitaria Universitaria Integrata del Trentino, Trento, Italy; ⁷Centro di Riferimento Regionale Malattie Emorragiche e Trombotiche dell'Adulto, Divisione di Ematologia, Università Città della Salute e della Scienza di Torino, Italy; ⁸SIMT Immunohematology and Transfusion Medicine Service, Diagnostic Department, A.O. Città della Salute e della Scienza, Torino, Italy; ⁹Department of Medicine, Haemophilia Centre, University Hospital of Padua, Italy; ¹⁰Center for Hemorrhagic and Thrombotic Diseases, General and University Hospital S. Maria della Misericordia, Udine, Italy; ¹¹Centre for Bleeding Disorders and Coagulation, Careggi University Hospital, Firenze, Italy; ¹²IRCCS Fondazione Ca' Granda Ospedale Maggiore Policlinico, Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Milano, Italy; ¹³Università degli Studi di Milano, Department of Pathophysiology and Transplantation, Milano, Italy

  Mario Biglietto

  14-10-2026

  https://doi.org/10.4081/btvb.2026.680

  43

  PDF: 16
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  Efficacy, safety and surgical management with concizumab prophylaxis in three young patients affected by severe hemophilia with inhibitors

  Silvia Linari, Lisa Pieri, Raffaella Pasquino, Eleonora Piellucci, Monica Attanasio, Francesca Salvianti, Giancarlo Castaman

  11-05-2026

  https://doi.org/10.4081/btvb.2026.467

  1333

  PDF: 213

• CO-67 | CONGENITAL DYSFIBRINOGENEMIA: BLEEDING PHENOTYPE, THROMBOTIC COMPLICATIONS, AND LONG-TERM MANAGEMENT IN A MULTICENTER COHORT M. Biglietto^1|2, M. Presti¹, R.C. Santoro³, I. Nichele⁴, M. Napolitano⁵, S. Pasca⁶, A. Borchiellini⁷, B. Pollio⁸, E. Zanon⁹, G. Barillari¹⁰, A. Poz¹⁰, S. Sorella¹, S. Ligia¹, R. Mormile¹, E. Baldacci¹, G. Castaman¹¹, F. Peyvandi^12|13, C. Santoro¹ | ¹Hematology, Department of Translational and Precision Medicine, Sapienza University of Rome, Italy; ²Department of Molecular Biology, Sapienza University of Rome, Italy; ³Hemostasis and Thrombosis Unit, Azienda Ospedaliera Pugliese-Ciaccio, Catanzaro, Italy; ⁴Hematology Unit, Azienda ULSS 8 Berica - San Bortolo Hospital, Vicenza, Italy; ⁵Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, University of Palermo, Italy; ⁶Coagulation Diseases Center, Transfusion Medicine Department - Azienda Sanitaria Universitaria Integrata del Trentino, Trento, Italy; ⁷Centro di Riferimento Regionale Malattie Emorragiche e Trombotiche dell'Adulto, Divisione di Ematologia, Università Città della Salute e della Scienza di Torino, Italy; ⁸SIMT Immunohematology and Transfusion Medicine Service, Diagnostic Department, A.O. Città della Salute e della Scienza, Torino, Italy; ⁹Department of Medicine, Haemophilia Centre, University Hospital of Padua, Italy; ¹⁰Center for Hemorrhagic and Thrombotic Diseases, General and University Hospital S. Maria della Misericordia, Udine, Italy; ¹¹Centre for Bleeding Disorders and Coagulation, Careggi University Hospital, Firenze, Italy; ¹²IRCCS Fondazione Ca' Granda Ospedale Maggiore Policlinico, Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Milano, Italy; ¹³Università degli Studi di Milano, Department of Pathophysiology and Transplantation, Milano, Italy

  Mario Biglietto

  14-10-2026

  https://doi.org/10.4081/btvb.2026.677

  46

  PDF: 13
• 

  Comments on “Safe and effective anticoagulation use: case studies in anticoagulation stewardship”

  Marco Marietta, Giancarlo Castaman

  01-07-2025

  https://doi.org/10.4081/btvb.2025.180

  1929

  PDF: 552