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• CO-57 | NXT007 PROPHYLAXIS IN PEOPLE WITH HEMOPHILIA A WITH OR WITHOUT FACTOR VIII INHIBITORS: COMBINED ANALYSIS OF TWO PHASE I/II MULTIPLE-ASCENDING-DOSE STUDIES M.E. Mancuso^1|2, M. Shima³, J.M. Staber⁴, Y.C. Chen⁵, F.J. López-Jaime⁶, M.C. Shen⁷, G. Ventriglia⁸, M. Takeyama⁹, C. Schmitt⁸, Y.S. Park¹⁰, A. Kiialainen⁸, N. Mizuno¹¹, M. Niggli⁸, T. Miyake¹¹, D. Matino¹², T. Saito¹¹, V. Jiménez-Yuste¹³, R. Kobayashi¹¹, D. Hart¹⁴, K. Nogami¹⁵ | ¹Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milano, Italy; ²Center for Thrombosis and Hemorrhagic Diseases, IRCCS Humanitas Research Hospital, Rozzano, Milano, Italy; ³Thrombosis and Hemostasis Research Center, Nara Medical University, Kashihara, Nara, Japan; ⁴Stead Family Department of Pediatrics, Carver College of Medicine, University of Iowa, Iowa City, USA; ⁵Hemophilia Care and Research Center, Tri-Service General Hospital, National Defense Medical University, Taipei, Taiwan; ⁶Servicio de Hematología, Hospital Universitario Regional de Málaga / Instituto de Investigación Biomédica de Málaga (IBIMA), Málaga, Spain; ⁷Department of Internal Medicine, Changhua Christian Hospital, Changhua, Taiwan; ⁸F. Hoffmann-La Roche Ltd, Basel, Switzerland; ⁹Division of Hemophilia, National Hospital Organization, Osaka National Hospital, Osaka, Japan; ¹⁰Department of Pediatrics, Kyung Hee University Hospital at Gangdong, Seoul, South Korea; ¹¹Chugai Pharmaceutical Co., Ltd, Tokyo, Japan; ¹²McMaster University, Hamilton, Ontario, Canada; ¹³La Paz University Hospital-IdiPAZ, Autónoma University, Madrid, Spain; ¹⁴Roche Products Ltd, Welwyn Garden City, UK; ¹⁵Department of Pediatrics, Nara Medical University, Kashihara, Nara, Japan

  Maria Elisa Mancuso

  14-10-2026

  https://doi.org/10.4081/btvb.2026.667

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• BEST-09 | IMMUNOGENIC IMPLICATIONS OF TRANSLATIONAL READTHROUGH MODULATE THE ASSOCIATION OF F8 NONSENSE MUTATIONS WITH INHIBITORS IN HEMOPHILIA A D. Balestra¹, M.F. Testa¹, M. Pinotti¹, A. Branchini¹, M.E. Mancuso², F. Bernardi¹ | ¹Department of Life Sciences and Biotechnology and LTTA Center, University of Ferrara, Italy; ²IRCCS, Humanitas Research Hospital, Center for Thrombosis and Hemorrhagic diseases, Milano, Italy

  Dario Balestra

  14-10-2026

  https://doi.org/10.4081/btvb.2026.609

  6

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• CO-68 | ACQUIRED FACTOR XIII DEFICIENCY ASSOCIATED WITH CROHN’S DISEASE: A CHALLENGING DIAGNOSTIC AND THERAPEUTIC CASE A. Colombo¹, A. Dal Buono^2|3, I. Quaglia¹, C. Novembrino⁴, M.R. Fasulo¹, C. Lodigiani¹, M.E. Mancuso^1|2 | ¹Center for Thrombosis and Hemorrhagic Diseases, IRCCS Humanitas Research Hospital, Rozzano, Milano, Italy; ²Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milano, Italy; ³IBD Center, IRCCS Humanitas Research Hospital, Rozzano, Milano, Italy; ⁴Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico Angelo Bianchi Bonomi, Hemophilia and Thrombosis Center and Fondazione Luigi Villa, Milano, Italy

  Arianna Colombo

  14-10-2026

  https://doi.org/10.4081/btvb.2026.678

  7

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• CO-11 | MAPPING THE COMPETENCIES OF NURSES IN ITALIAN HEMOPHILIA CENTERS: CURRENT STATUS AND PERSPECTIVES FOR THE IDENTIFICATION OF NURSE-SENSITIVE OUTCOMES M.V. Puliga¹, A.C. Ferrini², C. Manzi³, D. Meneghini⁴, E. Tosi⁴, P. Berto⁵, M. Amelotti-Botta⁶, E. Quercio⁶, M.E. Mancuso⁷, R.C. Santoro⁸ | ¹SODc Malattie Emorragiche e della Coagulazione, AOU Careggi, Firenze, Italy; ²SSI Malattie Emorragiche e Tromboemboliche, Osp. Bufalini, Cesena, Italy; ³SSD Malattie Emorragiche Congenite, IRCCS Policlinico Sant'Orsola, Bologna, Italy; ⁴Centro Emofilia e UOC Medicina Trasfusionale, AOU Integrata, Verona, Italy; ⁵Centro Emofilia Hub, AO di Padova, Italy; ⁶SSD Emostasi e Coordinamento Malattie Rare, AO SS. Antonio e Biagio, Alessandria, Italy; ⁷UOC Centro Trombosi e Malattie Emorragiche, IRCCS Humanitas Research Hospital, Rozzano, Milano, Italy; ⁸UOD Emofilia, Emostasi e Trombosi, AOU Renato Dulbecco, Catanzaro, Italy

  Maria-Virginia Puliga

  14-10-2026

  https://doi.org/10.4081/btvb.2026.621

  6

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• CO-19 | A CASE OF LOSS OF EFFICACY OF EMICIZUMAB AFTER 6 YEARS OF REGULAR USE M.R. Fasulo¹, I. Quaglia¹, A. Colombo¹, C. Lodigiani¹, M.E. Mancuso^1|2 | ¹Center for Thrombosis and Hemorrhagic Diseases, IRCCS Humanitas Research Hospital, Rozzano, Milano, Italy; ²Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milano, Italy

  Maria Rosaria Fasulo

  14-10-2026

  https://doi.org/10.4081/btvb.2026.629

  7

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• CO-54 | DECREASED BONE MINERAL DENSITY IN HEMOPHILIA IS NOT CORRELATED WITH INCREASED RISK OF FRACTURES M.R. Fasulo¹, F. Carrone², G. Mazziotti^3|4, A. Colombo¹, C. Lodigiani¹, M.E. Mancuso^1|4 | ¹Center for Thrombosis and Hemorrhagic Diseases, IRCCS Humanitas Research Hospital, Rozzano, Milano, Italy; ²Endocrinology and Diabetology Unit, Humanitas Mater Domini, Castellanza, Varese, Italy; ³Endocrinology, Diabetology and Medical Andrology Unit, Metabolic Bone Diseases and Osteoporosis Section, IRCCS Humanitas Research Hospital, Rozzano, Milano, Italy; ⁴Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milano, Italy

  Maria Rosaria Fasulo

  14-10-2026

  https://doi.org/10.4081/btvb.2026.664

  1

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• BEST-05 | LONG-TERM EMICIZUMAB PROPHYLAXIS IN PEOPLE WITH HEMOPHILIA A: REAL-WORLD EXPERIENCE ACROSS ALL AGES A. Colombo¹, I. Quaglia¹, M.R. Fasulo¹, C. Lodigiani¹, M.E. Mancuso^1|2 | ¹Center for Thrombosis and Hemorrhagic Diseases, IRCCS Humanitas Research Hospital, Rozzano, Milano, Italy; ²Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milano, Italy

  Arianna Colombo

  14-10-2026

  https://doi.org/10.4081/btvb.2026.605

  5

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