Thrombophilia work-up and clinical outcomes in Indian patients with unprovoked venous and arterial thrombosis aged 18-50 years | BTVB Bioequivalence of von Willebrand factor-containing concentrates: implications for von Willebrand disease | BTVB Cardiovascular risk in hormone replacement therapy | BTVB Direct oral anticoagulants: does one dose fit all? Why, when and how testing | BTVB Cardiovascular risk profile evolution over 15 years: CV-PREVITAL vs Moli-sani Study | BTVB Launch of National Registry for Congenital Hematological Disorders in Palestine: Haemo-PAL | BTVB
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Bleeding, Thrombosis and Vascular Biology

Editor-in-Chief: Giovanni de Gaetano, Italy | eISSN: 2785-5309

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  • Anticoagulation in obese patients: challenges and strategies

    Alice Lipari, Esmeralda Capristo, Antonietta Ferretti, Erica De Candia
    18-09-2025
    https://doi.org/10.4081/btvb.2025.174
    2022
    PDF: 522
    HTML: 302
    XML: 185
  • Persistence of functional anti-PF4 antibodies and neutrophil activation in vaccine-induced immune thrombotic thrombocytopenia

    Eleonora Petito, Anna Maria Mezzasoma, Emanuela Falcinelli, Chiara Conti, Erica De Candia, Raimondo De Cristofaro, Silvia Sorrentino, Gian Marco Podda, Mariangela Scavone, Anna Falanga, Marina Marchetti, Luca Barcella, Stefania Basili, Lucia Stefanini, Andrea Boccatonda, Laura Contino, Patrizia Sciancalepore, Igor Florio, Egidio Imbalzano, Rossella Marcucci, Angela Rogolino, Patrizia Noris, Marta Panella, Rita Santoro, Maria Costanza Turi, Gaetano Vaudo, Rosa Curcio, Paolo Gresele
    18-11-2025
    https://doi.org/10.4081/btvb.2025.400
    948
    PDF: 170
    HTML: 201
  • The landscape of rare coagulation factor deficiency management in Italy: a national hemophilia center survey

    Silvia Linari, Renato Marino, Marzia Leotta, Antonio Coppola, Patrizia Di Gregorio, Augusto Bramante Federici, Flora Peyvandi, Cristina Santoro, Ezio Zanon, Rita Carlotta Santoro
    05-11-2025
    https://doi.org/10.4081/btvb.2025.369
    1343
    PDF: 216
    HTML: 133
    Appendix: 119
  • Bioequivalence of von Willebrand factor-containing concentrates: implications for the choice in patients with von Willebrand disease. A position paper from the Italian Association of Hemophilia Centers

    Ezio Zanon, Giancarlo Castaman, Augusto Bramante Federici, Maria Elisa Mancuso, Gianfranco Pasut, Alberto Tosetto, Angiola Rocino, Rita Carlotta Santoro
    26-01-2026
    https://doi.org/10.4081/btvb.2026.415
    1285
    PDF: 342
    HTML: 163
  • 2024 EACTS guidelines on perioperative medication in adult cardiac surgery: embracing precision medicine driven by strong evidence-based methodology

    Bianca Rocca, Emma Hansson, Milan Milojevic, Anders Jeppsson
    01-07-2025
    https://doi.org/10.4081/btvb.2025.178
    2304
    PDF: 878
  • Diagnostic and management practices for inherited fibrinogen disorders: a nationwide survey of Italian Hemophilia Treatment Centers

    Renato Marino, Silvia Linari, Marzia Leotta, Antonio Coppola, Chiara Biasoli, Maria Elisa Mancuso, Flora Peyvandi, Cristina Santoro, Ezio Zanon, Rita Carlotta Santoro
    02-12-2025
    https://doi.org/10.4081/btvb.2025.372
    909
    PDF: 118
    HTML: 121
    Supplementary: 78
    Appendix: 79
  • The evolving landscape of gene therapy for congenital severe hemophilia: a 2024 state of the art

    Giovanni Di Minno, Gaia Spadarella, Ilenia Lorenza Calcaterra, Giancarlo Castaman, Paolo Simioni, Raimondo De Cristofaro, Cristina Santoro, Flora Peyvandi, Matteo Di Minno
    04-09-2024
    https://doi.org/10.4081/btvb.2024.144
    2075
    PDF: 359
    SUPPLEMENTARY MATERIAL: 217
  • Expanding the genetic landscape of hereditary thrombophilia: classical defects, novel variants, and genomic perspectives. A narrative review

    Chiara Simion, Elena Campello, Walter Ageno, Paolo Simioni
    28-08-2026
    https://doi.org/10.4081/btvb.2026.427
    1205
    PDF: 153
    SUPPLEMENTARY FILES: 109
  • CO-14 | BEYOND BLEEDING: NARRATIVE MEDICINE AS A METHODOLOGICAL TOOL FOR INVESTIGATION AND CARE IN CONGENITAL BLEEDING DISORDERS V. Grippa1, S. Riva2, A. Gringeri3 | 1Centro Malattie Emorragiche Salerno, Italy; 2St. Mary's University, London, UK; 3Fondazione Charta, Milano, Centro di Solidarietà Solidale, Lucca, Italy

    Silvia Riva
    14-10-2026
    https://doi.org/10.4081/btvb.2026.624
    61
    PDF: 13
  • Executive summary of the SISET position paper on the management of antithrombotic therapy in left ventricular thrombus

    Emanuele Valeriani, Arianna Pannunzio, Danilo Menichelli, Domenico Prisco, Walter Ageno, Daniele Pastori, Pasquale Pignatelli
    16-12-2025
    https://doi.org/10.4081/btvb.2025.401
    456
    PDF: 132
    HTML: 110
  • Still unmet problems with low molecular weight heparin prophylaxis of venous thromboembolism. An Italian survey

    Stefania Cavazza, Gualtiero Palareti*
    03-10-2025
    https://doi.org/10.4081/btvb.2025.177
    1443
    PDF: 303
    HTML: 201
    Supplementary: 102
  • CO-70 | CONGENITAL AFIBRINOGENEMIA: BLEEDING PHENOTYPE, THROMBOTIC COMPLICATIONS, AND LONG-TERM MANAGEMENT IN A MULTICENTER COHORT M. Biglietto1|2, M. Presti1, R.C. Santoro3, I. Nichele4, M. Napolitano5, S. Pasca6, A. Borchiellini7, B. Pollio8, E. Zanon9, G. Barillari10, A. Poz10, S. Sorella1, S. Ligia1, R. Mormile1, E. Baldacci1, G. Castaman11, F. Peyvandi12|13, C. Santoro1 | 1Hematology, Department of Translational and Precision Medicine, Sapienza University of Rome, Italy; 2Department of Molecular Biology, Sapienza University of Rome, Italy; 3Hemostasis and Thrombosis Unit, Azienda Ospedaliera Pugliese-Ciaccio, Catanzaro, Italy; 4Hematology Unit, Azienda ULSS 8 Berica - San Bortolo Hospital, Vicenza, Italy; 5Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, University of Palermo, Italy; 6Coagulation Diseases Center, Transfusion Medicine Department - Azienda Sanitaria Universitaria Integrata del Trentino, Trento, Italy; 7Centro di Riferimento Regionale Malattie Emorragiche e Trombotiche dell'Adulto, Divisione di Ematologia, Università Città della Salute e della Scienza di Torino, Italy; 8SIMT Immunohematology and Transfusion Medicine Service, Diagnostic Department, A.O. Città della Salute e della Scienza, Torino, Italy; 9Department of Medicine, Haemophilia Centre, University Hospital of Padua, Italy; 10Center for Hemorrhagic and Thrombotic Diseases, General and University Hospital S. Maria della Misericordia, Udine, Italy; 11Centre for Bleeding Disorders and Coagulation, Careggi University Hospital, Firenze, Italy; 12IRCCS Fondazione Ca' Granda Ospedale Maggiore Policlinico, Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Milano, Italy; 13Università degli Studi di Milano, Department of Pathophysiology and Transplantation, Milano, Italy

    Mario Biglietto
    14-10-2026
    https://doi.org/10.4081/btvb.2026.680
    20
    PDF: 12
  • The therapeutic landscape of cancer-associated splanchnic vein thrombosis

    Alessia Abenante, Filippo Catalani, Walter Ageno
    16-04-2026
    https://doi.org/10.4081/btvb.2026.458
    306
    PDF: 149
  • Pharmacokinetic interactions between anticancer drugs and direct oral anticoagulants: clinical implications for safe anticoagulation

    Tzu-Fei Wang, Kristen M. Sanfilippo, Marc Carrier
    16-04-2026
    https://doi.org/10.4081/btvb.2026.434
    360
    PDF: 183
  • Antithrombotic therapy in retinal vein occlusion: many questions, few evidence-based answers

    Emanuele Valeriani, Paolo Gresele, Francesco Paciullo, Pasquale Pignatelli, Domenico Prisco
    19-10-2026
    https://doi.org/10.4081/btvb.2026.592
    209
    PDF: 15
  • Cancer-associated superficial vein thrombosis: clinical outcomes and management

    Adrian Joseph Michel Bailey, Owen Dan Luo, Phil Stephen Wells
    16-04-2026
    https://doi.org/10.4081/btvb.2026.446
    337
    PDF: 157
  • PO29 | CANADIAN INSIGHTS INTO THE MANAGEMENT OF BREAKTHROUGH THROMBOSIS S. Ramdani1, C. Séguin2 | 1Division of Hematology, Post-Graduate Medical Education Program, McGill University, Montreal; 2Division of Hematology, Department of Medicine, McGill University Health Center, Montreal, Canada

    ICTHIC 2026
    16-04-2026
    https://doi.org/10.4081/btvb.2026.524
    477
    PDF: 97
  • Risk of recurrent venous thromboembolism in cancer patients after discontinuation of anticoagulant therapy

    Gary E. Raskob
    16-05-2024
    https://doi.org/10.4081/btvb.2024.124
    1666
    PDF: 1237
  • CO-02 | NEONATAL GENOMIC SCREENING ENABLES PRE-SYMPTOMATIC DIAGNOSIS AND PREVENTIVE MANAGEMENT OF HEMOPHILIA B. Borsellino1, B. Pollio1, P. Quarello2|3, T. Martini1, C. Linari4, M. Carabotta5, C. Cagnazzo2, S. Minucci6, F. Fagioli2|3 | 1Paediatric Haemophilia Centre, Immune-Haematology and Transfusion Medicine, University Hospital "Città della Salute e della Scienza", Torino, Italy; 2Paediatric Onco-Hematology, Stem Cell Transplantation and Cellular Therapy Division, Regina Margherita Children’s Hospital, Torino, Italy; 3Department of Paediatric and Public Health Sciences, University of Turin, Italy; 4Department of Laboratory Medicine, Azienda Ospedaliera Universitaria Città della Salute e della Scienza, Torino, Italy; 5Department of Pediatrics, G. d'Annunzio University, Chieti, Italy; 6Italian Institute for Genomic Medicine, IRCCS, Candiolo, Italy

    Beatrice Borsellino
    14-10-2026
    https://doi.org/10.4081/btvb.2026.612
    68
    PDF: 12
  • CO-89 | FEMORAL FRACTURE SURGERY IN AN ELDERLY, FRAIL PATIENT WITH ACQUIRED HEMOPHILIA A RECEIVING EMICIZUMAB PROPHYLAXIS: A CASE REPORT C. Simion1|2, E. Zanon1|2, B. Stocco1|2, F. Sartorello1, C. Bulato1, G. Saggiorato1, P. Simioni1|2 | 1First Chair of Internal Medicine and Thrombotic and Haemorrhagic Diseases Unit, Department of Medicine, Padova University Hospital, Italy; 2Hemophilia Center, Padova University Hospital, Italy

    Chiara Simion
    14-10-2026
    https://doi.org/10.4081/btvb.2026.699
    24
    PDF: 15
  • The night of randomized clinical trials where all patients are black: a need to estimate variability in treatment effects

    Giovanni de Gaetano, Chiara Cerletti, Licia Iacoviello, Maria Benedetta Donati
    22-03-2022
    https://doi.org/10.4081/btvb.2022.24
    2435
    PDF: 435
  • PO89 | Apixaban for secondary prevention of venous thromboembolism in hemodialysis patients: pharmacokinetic profile and safety outcomes S. Guglielmo1, E. De Bon2, L. Scarano1, R. Fabris1, E. Pierobon3, S. Barbar2 | 1Internal Medicine, Department of Medicine; 2Thrombotic and Hemorrhagic Disorders Unit, Department of Medicine; 3Nephrology and Dialysis Unit, Azienda ULSS 6 Euganea, Cittadella and Camposampiero, Padua, Italy

    22-10-2025
    https://doi.org/10.4081/btvb.2025.359
    839
    PDF: 14
  • Anticoagulation during anti-angiogenic cancer therapy: balancing risks of thrombosis and bleeding

    Nikola Vladic, Florian Moik
    16-04-2026
    https://doi.org/10.4081/btvb.2026.452
    294
    PDF: 173
  • Venous thromboembolism prophylaxis in orthopedic surgery: a narrative review

    Sarah Gallitto, Thomas C. Varkey, Jacob Lahti
    13-12-2024
    https://doi.org/10.4081/btvb.2024.131
    3337
    PDF: 455
  • PO22 | LONG-TERM ANTICOAGULANT THERAPY AND REDUCTION OF OVARIAN CANCER RECURRENCE: CLINICAL EVIDENCE OF A POTENTIAL ANTITUMOUR EFFECT J. Khizroeva1, V. Bitsadze1, A. Vorobev1, A. Solopova1, M. Tretyakova1, N. Gashimova1, K. Grigoreva1, A. Khisamieva1, J. Gris1|2, I. Elalamy1|3|4, G. Gerotziafas1|3|4, A. Makatsariya1 | 1Department of Obstetrics, Gynecology and Perinatal Medicine, N. F. Filatov Clinical Institute of Children’s Health, I. M. Sechenov First Moscow State Medical University, Moscow, Russia; 2Faculty of Pharmaceutical and Biological Sciences, Montpellier University, France; 3Department Hematology and Thrombosis Center, Medicine Sorbonne University, Paris, France; 4Hospital Tenon, Paris, France

    ICTHIC 2026
    16-04-2026
    https://doi.org/10.4081/btvb.2026.517
    412
    PDF: 89
  • PO64 | MANAGEMENT OF BLEEDING RISK IN PATIENTS WITH HEPATOCELLULAR CARCINOMA RECEIVING SYSTEMIC THERAPY: A SURVEY OF CLINICAL PRACTICE T. Van Broeckhoven1|9, E. Van Gansewinkel5|10, J. De Bruijne2, F. Eskens3, D. De Groot4, K. Hermans5, N. Mohammad6, F. Van Vilsteren7, C. Verslype8, W. Moris9, M. Roest10, B. De Laat10 , J. De Vos-Geelen5, M. Kramer1|9 | 1Department of Gastroenterology and Hepatology, GROW – Research Institute for Oncology and Reproduction, Maastricht University Medical Center, Maastricht, The Netherlands; 2Department of Gastroenterology & Hepatology, Utrecht University, University Medical Center Utrecht, The Netherlands; 3Department of Medical Oncology, Erasmus Medical Centre, Rotterdam, the Netherlands; 4Department of Medical Oncology, University Medical Centre Groningen, University of Groningen, the Netherlands; 5Department of Internal Medicine, Division of Medical Oncology, GROW – Research Institute for Oncology & Reproduction, Maastricht University Medical Center, Maastricht, The Netherlands; 6Department of Medical Oncology, University Medical Centre Utrecht, Utrecht University, Utrecht, the Netherlands; 7Department of Gastroenterology and Hepatology, University Medical Centre Groningen, Groningen, The Netherlands; 8Digestive Oncology, University Hospitals Leuven, Belgium; 9Department of Gastroenterology and Hepatology, Maastricht University Medical Center, Maastricht, The Netherlands; 10Department of Functional Coagulation, Synapse Research Institute, Maastricht, The Netherlands, on behalf of the Dutch Hepatocellular & Cholangiocarcinoma Group

    ICTHIC 2026
    16-04-2026
    https://doi.org/10.4081/btvb.2026.554
    436
    PDF: 96
  • PO15 | Venous thromboembolism risk associated with midline catheters and peripherally inserted central catheters: a systematic review and meta-analysis D. Santagata1, F. Subri1, F. Dentali1,2, M.P. Donadini1, I. Giarretta2 | 1Department of Medicine and Surgery, Research Center on Thromboembolic Disorders and Antithrombotic Therapies, University of Insubria, Varese and Como; 2Department of Internal Medicine, Ospedale di Circolo and Fondazione Macchi, Varese, Italy

    22-10-2025
    https://doi.org/10.4081/btvb.2025.276
    567
    PDF: 17
  • CO11 | Oral anticoagulation with vitamin K antagonists in early childhood: a single centre-experience B. Borsellino1,2, B. Pollio1, I. Ricca1, R. Albiani1, T. Martini1 | 1Haemophilia Centre, Immune-Haematology and Transfusion Medicine, University Hospital “Città della Salute e della Scienza”, Torino; 2Department of Biomedicine and Prevention, PhD in Immunology, Molecular Medicine and Applied Biotechnology, University of Roma Tor Vergata, Roma, Italy

    22-10-2025
    https://doi.org/10.4081/btvb.2025.215
    704
    PDF: 23
  • Anticoagulation challenges in patients with hematological malignancy-associated thrombosis and severe thrombocytopenia

    Emilie Chalayer, Géraldine Poenou, Corinne Frere
    16-04-2026
    https://doi.org/10.4081/btvb.2026.429
    378
    PDF: 167
  • CO23 | Markers of inflammation and hypofibrinolysis are associated with cognitive dysfunction and motor performances in atrial fibrillation patients on oral anticoagulant therapy: insights from the Strat-AF study F. Alfano1,2, F. Cesari1,2, A.M. Gori1,2, M. Berteotti1,2, E. Salvadori3, B. Giusti1,2, A. Bertelli1,2, F. Fratini4, A. Rogolino1,2, B. Formelli4,5, F. Pescini4,5, E. Fainardi6, E. Barucci4, G. Salti5, A. Cavaliere4, A. Ginestroni6, A. Poggesi4,5, R. Marcucci1,2 | 1Department of Experimental and Clinical Medicine, University of Firenze; 2Center for Atherothrombotic Diseases, Careggi University Hospital, Firenze; 3Department of Biomedical and Clinical Sciences, University of Milan; 4NEUROFARBA Department, Neuroscience Section, University of Firenze; 5Stroke Unit, Careggi University Hospital, Firenze; 6Neuroradiology Unit, Careggi University Hospital, Department of Experimental and Clinical Biomedical Sciences, University of Firenze, Italy

    22-10-2025
    https://doi.org/10.4081/btvb.2025.229
    721
    PDF: 23
  • CO-06 | ENHANCING SHARED DECISION-MAKING IN INHERITED BLEEDING DISORDERS: A SINGLE-CENTER QUALITY IMPROVEMENT INITIATIVE C. Manzi, L. Piscitelli, E. Zacchi, V. Caldi, L. Valdrè | Inherited Bleeding Disorders Unit, IRCCS AOU, Bologna, Italy

    Chiara Manzi
    14-10-2026
    https://doi.org/10.4081/btvb.2026.616
    61
    PDF: 10
  • Attitude to clinical research among health professionals affiliated with the Italian Federation of Centers for the Diagnosis of Thrombotic Disorders and the Surveillance of the Antithrombotic Therapies (FCSA)

    Daniela Poli, Riccardo Tartaglia, Doris Barcellona , Paolo Bucciarelli , Antonio Ciampa, Elvira Grandone, Giuseppe Malcangi, Giuseppe Rescigno, Vincenzo Toschi, Sophie Testa, Alessandro Squizzato
    21-03-2023
    https://doi.org/10.4081/btvb.2023.59
    1295
    PDF: 385
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Vol. 5 No. 4 (2026)
Platelets versus monocytes as cellular sources of blood-borne tissue factor: a quantitative and functional comparison in healthy subjects...
Marina Camera et al.
12 October 2026
Vol. 5 No. 4 (2026)
Von Willebrand Disease (VWD) 100 years after its first description: the research of Italian investigators for a better management of VWD patients
Augusto B. Federici et al.
9 October 2026
Vol. 5 No. 4 (2026)
The history of the TIMI, GISSI, and ISIS trials: the development of thrombolytic therapy in acute myocardial infarction
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13 October 2026
Vol. 5 No. 4 (2026)
Anticoagulant treatment in patients with internal jugular vein thrombosis: a case serie
Arianna Pannunzio et al.
14 October 2026

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Bleeding, Thrombosis and Vascular Biology

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