Editorials
Vol. 2 No. 2 (2023)
Blood platelet heterogeneity at a glance: new insights into the relationship between platelet distribution width and neuropsychiatric disorders
Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Received: 27 February 2023
Accepted: 30 March 2023
Accepted: 30 March 2023
1269
Views
355
Downloads
Authors
Not available
Downloads
Download data is not yet available.
Citations
Lesyk G, Jurasz P. Advances in platelet subpopulation research. Front Cardiovasc Med 2019;6:138. DOI: https://doi.org/10.3389/fcvm.2019.00138
Borkataky S, Jain R, Gupta R, et al. Role of platelet volume indices in the differential diagnosis of thrombocytopenia: a simple and inexpensive method. Hematology 2009;14:182-6. DOI: https://doi.org/10.1179/102453309X426182
Handtke S, Thiele T. Large and small platelets - (when) do they differ? J Thromb Haemost 2020;18:1256-67. DOI: https://doi.org/10.1111/jth.14788
Vagdatli E, Gounari E, Lazaridou E, et al. Platelet distribution width: a simple, practical and specific marker of activation of coagulation. Hippokratia 2010;14:28-32.
Izzi B, Gialluisi A, Gianfagna F, et al. Platelet distribution width is associated with P-selectin dependent platelet function: results from the moli-family cohort study. Cells 2021;10:2737. DOI: https://doi.org/10.3390/cells10102737
Izzi B, Gianfagna F, Yang WY, et al. Variation of PEAR1 DNA methylation influences platelet and leukocyte function. Clin Epigenetics 2019;11:151. DOI: https://doi.org/10.1186/s13148-019-0744-8
Kar SP, Quiros PM, Gu M, et al. Genome-wide analyses of 200,453 individuals yield new insights into the causes and consequences of clonal hematopoiesis. Nat Genet 2022;54:1155-66. DOI: https://doi.org/10.1038/s41588-022-01121-z
Izzi B, Tirozzi A, Cerletti C, et al. Beyond haemostasis and thrombosis: platelets in depression and its co-morbidities. Int J Mol Sci 2020;21:8817. DOI: https://doi.org/10.3390/ijms21228817
Yang Y, Zhou Y, Nyholt DR, et al. The shared genetic landscape of blood cell traits and risk of neurological and psychiatric disorders. Cell Genom 2023;3:100249. DOI: https://doi.org/10.1016/j.xgen.2022.100249
Astle WJ, Elding H, Jiang T, et al. The allelic landscape of human blood cell trait variation and links to common complex disease. Cell 2016;167:1415-29.e19. DOI: https://doi.org/10.1016/j.cell.2016.10.042
Nalls MA, Blauwendraat C, Vallerga CL, et al. Identification of novel risk loci, causal insights, and heritable risk for Parkinson's disease: a meta-analysis of genome-wide association studies. Lancet Neurol 2019;18:1091-102. DOI: https://doi.org/10.1016/S1474-4422(19)30320-5
Gialluisi A, Izzi B, Di Castelnuovo A, et al. Revisiting the link between platelets and depression through genetic epidemiology: new insights from platelet distribution width. Haematologica 2020;105:e246-8. DOI: https://doi.org/10.3324/haematol.2019.222513
Tirozzi A, Izzi B, Noro F, et al. Assessing genetic overlap between platelet parameters and neurodegenerative disorders. Front Immunol 2020;11:02127. DOI: https://doi.org/10.3389/fimmu.2020.02127
Tirozzi A, Quiccione MS, Cerletti C, et al. A multi-trait association analysis of brain disorders and platelet traits identifies novel susceptibility loci for major depression, Alzheimer's and Parkinson's disease. Cells 2023;12:245. DOI: https://doi.org/10.3390/cells12020245
How to Cite
1.
Izzi B, Fuster JJ. Blood platelet heterogeneity at a glance: new insights into the relationship between platelet distribution width and neuropsychiatric disorders. Bleeding Thromb Vascul Biol [Internet]. 2023 May 3 [cited 2026 Jan. 20];2(2). Available from: https://www.btvb.org/btvb/article/view/65
Copyright (c) 2023 The Author(s)
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Similar Articles
- Boris Shenkman, Ivan Budnik, Yulia Einav, Interaction between adenosine diphosphate receptors and protein-kinase C isoforms in platelet adhesion under flow condition , Bleeding, Thrombosis and Vascular Biology: Vol. 2 No. 1 (2023)
- CO40 | The co-inheritance of two ITGB3 variants exerting additive detrimental effects on platelets leads to variant Glanzmann thrombasthenia , Bleeding, Thrombosis and Vascular Biology: Vol. 4 No. s1 (2025)
- Luca D'Ambrosio, Maurizio Forte, Giacomo Frati, Sebastiano Sciarretta, Role of platelet autophagy in cardiovascular diseases , Bleeding, Thrombosis and Vascular Biology: Vol. 3 No. 2 (2024)
- Francesco Cicconi, Ankle brachial index for the diagnosis of asymptomatic lower extremity peripheral arterial disease , Bleeding, Thrombosis and Vascular Biology: Vol. 3 No. 2 (2024)
- Fabio Candura, Emanuela Marchesini, Gian Luca Forni, Alessandro Gringeri, Ilaria Gentilini, Mirko Tricoli, Osama Najjar, Luciana Teofili, Launch of a National Registry for Congenital Hematological Disorders in Palestine: the Haemo-PAL Initiative , Bleeding, Thrombosis and Vascular Biology: Vol. 5 No. 1 (2026)
- Vincenzo Sammartano, Adele Santoni, Elisabetta Zappone, Paola Calzoni, Daniela Fineschi, Eleonora Franceschini, Federico Caroni, Anna Sicuranza, Monica Bocchia, Luca Puccetti, A case of acquired factor XIII deficiency secondary to plasmablastic lymphoma , Bleeding, Thrombosis and Vascular Biology: Vol. 2 No. 1 (2023)
- CS01 | Elucidating the evil relationship of metabolic dysfunction–associated fatty liver disease with cardiovascular comorbidities: the complex interplay among hypercoagulability, inflammation and liver fibrosis , Bleeding, Thrombosis and Vascular Biology: Vol. 4 No. s1 (2025)
- Mattia Galli, C. Michael Gibson, Dominick J. Angiolillo, Factor XI inhibitors in adjunct to antiplatelet therapy: the ultimate dual-pathway inhibition? , Bleeding, Thrombosis and Vascular Biology: Vol. 2 No. 3 (2023)
- Ciarán Kennedy, Luke J. Conroy, Braden Millar, Monica de Gaetano, The subtle red line between combating and resolving inflammation in the cardiovascular disease, a “silent sniper” , Bleeding, Thrombosis and Vascular Biology: Vol. 4 No. 2 (2025)
- Pantep Angchaisuksiri, Wolfram Ruf, Jeffrey Weitz, Sam Schulman, Guy A. Young, A commitment to global collaboration, welcoming international participation and advancing science for the benefit of patients , Bleeding, Thrombosis and Vascular Biology: Vol. 4 No. 2 (2025)
You may also start an advanced similarity search for this article.
Most read articles by the same author(s)
- Benedetta Izzi, Simona Costanzo, Alessandro Gialluisi, Amalia De Curtis, Sara Magnacca, Teresa Panzera, Augusto Di Castelnuovo, Maria Benedetta Donati, Chiara Cerletti, Marc F. Hoylaerts, Giovanni de Gaetano, Licia Iacoviello, *on behalf of the Moli-sani Study Investigators, Platelet distribution width is associated with cardiovascular mortality in an adult general population , Bleeding, Thrombosis and Vascular Biology: Vol. 2 No. 3 (2023)
