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• CO27 | Intracerebral hemorrhage in hemophilia A and B: a 10-year prospective multicenter study in Italy (2012–2022) E. Zanon¹, A. Napolitano¹, A. Porreca², F. Demartis³, A. Coppola⁴, C. Santoro⁵, I. Cantori⁶, A. C. Molinari⁷, C. Biasioli⁸, M. Luciani⁹, G. Sottilotta¹⁰, B. Pollio¹¹, A. Borchiellini¹², A. Tosetto¹³, P. Flora¹⁴, P. Simioni¹ | ¹Haemophilia Center, First Chair of Internal Medicine, Department of Medicine, University-Hospital of Padua Medical School, Padua; ²Department of Human Sciences and Promotion of the Quality of Life, Unit of Clinical and Molecular Epidemiology IRCCS San Raffaele Roma Open University, Roma; Unit of Clinical and Molecular Epidemiology IRCCS San Raffaele, Roma; ³Centre for Bleeding Disorders, Careggi University Hospital of Firenze; ⁴Azienda Ospedaliero Universitaria di Parma; ⁵Hematology Division, Umberto I University Hospital of Roma; ⁶Haemophilia Center, Department of Transfusion Medicine, Hospital of Macerata; ⁷IRCCS Istituto Giannina Gaslini, Genova; ⁸Haemophilia and Transfusion Centre, Bufalini Hospital, Cesena; ⁹Children’s Hospital Bambino Gesù, Roma; ¹⁰Haemophilia Center, Department of Onco-Hematology and Radioterapy, Hospital of Reggio Calabria; ¹¹Haemophilia Pediatric Center, Transfusion Medicine, City of Health and Science of Turin; ¹²City of Health and Science of Turin; ¹³Hemorrhagic and Thrombotic Diseases Unit, S. Bortolo Hospital of Vicenza; ¹⁴RCCS Foundation Ca’ Granda Maggiore Policlinico Hospital, Milan, Italy

  22-10-2025

  https://doi.org/10.4081/btvb.2025.233

  680

  PDF: 28

• PO07 | Liver transplant in a case of congenital afibrinogenemia G. Murante^1,2,3, S. Bergonzi^1,2,3, C. Sella^1,2,3, F. Valeri^1,2, C. Dainese^1,2, A. Valpreda⁴, R. Pastorino^1,3, R. Romagnoli⁵, D. Patrono⁵, D. Cussa⁵, S. Martini⁶, B. Bruno^2,3, A. Borchiellini^1,2 | ¹Regional Centre for Hemorrhagic and Thrombotic Diseases, AOU Città della Salute e della Scienza, Torino; ²Division of Hematology, AOU Città della Salute e della Scienza, University of Turin; ³Department of Molecular Biotechnology and Health Sciences, University of Turin; ⁴Central Laboratory Baldi and Riberi, AOU Città della Salute e della Scienza, Torino; ⁵General Surgery 2U - Liver Transplant Center, Molinette Hospital, AOU Città della Salute e della Scienza, Torino; ⁶SSD Hepatic insufficiency and Liver Transplant, AOU Città della Salute e della Scienza, Torino, Italy

  22-10-2025

  https://doi.org/10.4081/btvb.2025.269

  576

  PDF: 15

• CO-36 | PLATELETS MATTER: THROMBIN GENERATION IN PLATELET‐RICH-PLASMA VS. PLATELET‐POOR‐PLASMA UNDER NON-REPLACEMENT THERAPIES IN HEMOPHILIA F. Bocchi^1|2, R. Pastorino^1|2, G. Murante^1|2|3, S. Bergonzi^1|2|3, M. Capetta^1|2|3, F. Valeri^2|3, C. Dainese^2|3, A. Valpreda⁴, B. Bruno^1|3, A. Borchiellini^2|3 | ¹Department of Molecular Biotechnology and Health Sciences, University of Turin, Italy; ²Regional Centre for Thrombotic and Hemorrhagic Diseases, AOU Città della salute e della Scienza di Torino, Italy; ³Division of Hematology, AOU Città della Salute e della Scienza, University of Turin, Italy; ⁴Central Lab Baldi and Riberi, AOU Città della salute e della Scienza di Torino, Italy

  Francesca Bocchi

  14-10-2026

  https://doi.org/10.4081/btvb.2026.646

  22

  PDF: 5

• CO-23 | PERIOPERATIVE MANAGEMENT OF MILD-TO-MODERATE HEMOPHILIA: A COMPARATIVE STUDY OF EXTENDED HALF-LIFE VERSUS STANDARD HALF-LIFE CONCENTRATES ON CLINICAL OUTCOMES AND FACTOR CONSUMPTION M. Capetta^1|2|3, F. Valeri^1|2, C. Dainese^1|2, S. Bergonzi^1|2|3, G. Murante^1|2|3, A. Valpreda⁴, R. Pastorino^1|3, F. Bocchi^1|3, B. Bruno^2|3, A. Borchiellini^1|2 | ¹Regional Centre for Hemorrhagic and Thrombotic Diseases, AOU Città della Salute e della Scienza, Torino, Italy; ²Division of Hematology, AOU Città della Salute e della Scienza, University of Turin, Italy; ³Department of Molecular Biotechnology and Health Sciences, University of Turin, Italy; ⁴Central Laboratory Baldi and Riberi, AOU Città della Salute e della Scienza, University of Turin, Italy

  Matilde Capetta

  14-10-2026

  https://doi.org/10.4081/btvb.2026.633

  21

  PDF: 4

• CO-41 | COMPARISON OF COAGULATION AND CHROMOGENIC METHODS IN PHARMACOKINETICS WITH EXTENDED HALF-LIFE FACTOR VIII R. Pastorino^1|2, F. Bocchi^1|2, G. Murante^1|2|3, S. Bergonzi^1|2|3, M. Capetta^1|2|3, F. Valeri^2|3, C. Dainese^2|3, A. Valpreda⁴, B. Bruno^1|3, A. Borchiellini^2|3 | ¹Department of Molecular Biotechnology and Health Sciences, University of Turin, Italy; ²Regional Centre for Thrombotic and Hemorrhagic Diseases, AOU Città della salute e della Scienza di Torino, Italy; ³Division of Hematology, AOU Città della Salute e della Scienza, University of Turin, Italy; ⁴Central Lab Baldi and Riberi, AOU Città della salute e della Scienza di Torino, Italy

  Rebecca Pastorino

  14-10-2026

  https://doi.org/10.4081/btvb.2026.651

  16

  PDF: 4

• CO-70 | CONGENITAL AFIBRINOGENEMIA: BLEEDING PHENOTYPE, THROMBOTIC COMPLICATIONS, AND LONG-TERM MANAGEMENT IN A MULTICENTER COHORT M. Biglietto^1|2, M. Presti¹, R.C. Santoro³, I. Nichele⁴, M. Napolitano⁵, S. Pasca⁶, A. Borchiellini⁷, B. Pollio⁸, E. Zanon⁹, G. Barillari¹⁰, A. Poz¹⁰, S. Sorella¹, S. Ligia¹, R. Mormile¹, E. Baldacci¹, G. Castaman¹¹, F. Peyvandi^12|13, C. Santoro¹ | ¹Hematology, Department of Translational and Precision Medicine, Sapienza University of Rome, Italy; ²Department of Molecular Biology, Sapienza University of Rome, Italy; ³Hemostasis and Thrombosis Unit, Azienda Ospedaliera Pugliese-Ciaccio, Catanzaro, Italy; ⁴Hematology Unit, Azienda ULSS 8 Berica - San Bortolo Hospital, Vicenza, Italy; ⁵Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, University of Palermo, Italy; ⁶Coagulation Diseases Center, Transfusion Medicine Department - Azienda Sanitaria Universitaria Integrata del Trentino, Trento, Italy; ⁷Centro di Riferimento Regionale Malattie Emorragiche e Trombotiche dell'Adulto, Divisione di Ematologia, Università Città della Salute e della Scienza di Torino, Italy; ⁸SIMT Immunohematology and Transfusion Medicine Service, Diagnostic Department, A.O. Città della Salute e della Scienza, Torino, Italy; ⁹Department of Medicine, Haemophilia Centre, University Hospital of Padua, Italy; ¹⁰Center for Hemorrhagic and Thrombotic Diseases, General and University Hospital S. Maria della Misericordia, Udine, Italy; ¹¹Centre for Bleeding Disorders and Coagulation, Careggi University Hospital, Firenze, Italy; ¹²IRCCS Fondazione Ca' Granda Ospedale Maggiore Policlinico, Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Milano, Italy; ¹³Università degli Studi di Milano, Department of Pathophysiology and Transplantation, Milano, Italy

  Mario Biglietto

  14-10-2026

  https://doi.org/10.4081/btvb.2026.680

  17

  PDF: 4

• CO-88 | TRANSIENT IDIOPHATIC ACQUIRED VON WILLEBRAND DISEASE: A RARE, CHALLENGING CONDITION WITH A POSSIBLE RAPID AND FAVORABLE EVOLUTION G. Murante^1|2|3, S. Bergonzi^1|2|3, M. Capetta^1|2|3, F. Valeri^1|2, C. Dainese^1|2, A. Valpreda⁴, R. Pastorino^1|3, F. Bocchi^1|3, B. Bruno^2|3, A. Borchiellini^1|2 | ¹Regional Centre for Hemorrhagic and Thrombotic Diseases, AOU Città della Salute e della Scienza of Turin, Italy; ²Division of Hematology, AOU Città della Salute e della Scienza, University of Turin, Italy; ³Dep. of Molecular Biotechnology and Health Sciences, University of Turin, Italy; ⁴Central Lab. Baldi and Riberi, AOU Città della Salute e della Scienza of Turin, Italy

  Giovanni Murante

  14-10-2026

  https://doi.org/10.4081/btvb.2026.698

  18

  PDF: 5

• CO-43 | VALIDATION OF THROMBIN GENERATION MEASUREMENT IN PLATELET-RICH PLASMA: EVOLUTION IN THE ST GENESIA^® SYSTEM F. Bocchi^1|2, R. Pastorino^1|2, G. Murante^1|2|3, S. Bergonzi^1|2|3, M. Capetta^1|2|3, F. Valeri^2|3, C. Dainese^2|3, A. Valpreda⁴, B. Bruno^1|3, A. Borchiellini^2|3 | ¹Department of Molecular Biotechnology and Health Sciences, University of Turin, Italy; ²Regional Centre for Thrombotic and Hemorrhagic Diseases, AOU Città della salute e della Scienza di Torino, Italy; ³Division of Hematology, AOU Città della Salute e della Scienza, University of Turin, Italy; ⁴Central Lab Baldi and Riberi, AOU Città della salute e della Scienza di Torino, Italy

  Francesca Bocchi

  14-10-2026

  https://doi.org/10.4081/btvb.2026.653

  16

  PDF: 4

• CO-24 | BALANCING BLEEDING AND THROMBOSIS: SAFETY OF LOW-MOLECULAR-WEIGHT HEPARIN THROMBOPROPHYLAXIS IN PATIENTS WITH HEMOPHILIA UNDERGOING MAJOR SURGERY S. Bergonzi^1|2|3, G. Murante^1|2|3, M. Capetta^1|2|3, F. Valeri^1|2, C. Dainese^1|2, A. Valpreda^3|4, R. Pastorino^3|4, F. Bocchi^3|4, B. Bruno^2|3, A. Borchiellini^1|2 | ¹Regional Centre for Hemorrhagic and Thrombotic Diseases, AOU Città della Salute e della Scienza, Torino, Italy; ²Division of Hematology, AOU Città della Salute e della Scienza, University of Turin, Italy; ³Department of Molecular Biotechnology and Health Sciences, University of Turin, Italy; ⁴Central Laboratory Baldi and Riberi, AOU Città della Salute e della Scienza, University of Turin, Italy

  Sara Bergonzi

  14-10-2026

  https://doi.org/10.4081/btvb.2026.634

  21

  PDF: 4

• CO-45 | BRIDGING THE CLINICAL CHASM: GENETIC ANALYSIS AS A CONFIRMATORY TOOL IN MISMATCHED GLANZMANN THROMBASTHENIA R. Pastorino^1|3, F. Bocchi^1|3, A. Valpreda⁴, G. Murante^1|2|3, S. Bergonzi^1|2|3, M. Capetta^1|2|3, F. Valeri^1|2, C. Dainese^1|2, M. Gilestro⁵, D. Peruccio⁶, E. De Candia⁷, P. Concolino⁸, B. Bruno^2|3, A. Borchiellini^1|2 | ¹Regional Centre for Hemorrhagic and Thrombotic Diseases, AOU Città della Salute e della Scienza, Italy; ²Division of Hematology, AOU Città della Salute e della Scienza and University of Turin, Italy; ³Department of Molecular Biotechnology and Health Sciences, University of Turin, Italy; ⁴Central Laboratory Baldi and Riberi, AOU Città della Salute e della Scienza di Torino, Italy; ⁵AOU Citta' della Salute e della Scienza, PO Molinette, Anatomy and Pathological Histology 1 U, Department of Laboratory Medicine - Flow Cytometry Laboratory, Torino, Italy; ⁶AOU Citta' della Salute e della Scienza di Torino, Maternal-Infant and Trauma Transfusion Medicine, Regina Margherita Hospital, Department of Laboratory Medicine, Torino, Italy; ⁷Haemostasis and Thrombosis Unit, Fondazione Policlinico Universitario A.Gemelli, IRCCS, Department of Translational Medicine, Università Cattolica del Sacro Cuore, Roma, Italy; ⁸Fondazione Policlinico Universitario A. Gemelli, IRCCS, Department of Laboratory and Hematological Sciences, Unit of Clinical Chemistry, Biochemistry and Molecular Biology, UOSD of Molecular and Genomic Diagnostics, Roma, Italy

  Rebecca Pastorino

  14-10-2026

  https://doi.org/10.4081/btvb.2026.655

  16

  PDF: 2

• CO-25 | MILD HEMOPHILIA A AND JOINT HEALTH IN REAL LIFE: IS THAT AN EMERGING ISSUE? A SINGLE CENTER EXPERIENCE F. Valeri¹, G. Murante¹, C. Dainese¹, M. Capetta¹, S. Bergonzi¹, R. Pastorino¹, F. Bocchi¹, B. Bruno², A. Borchiellini¹ | ¹Regional Centre for Haemorrhagic and Thrombotic Disease, Hematology Division, AOU Città della Salute e della Scienza, Torino, Italy; ²Division of Hematology, AOU Città della Salute e della Scienza, Department of Molecular Biotechnology and Health sciences, University of Turin, Italy

  Federica Valeri

  14-10-2026

  https://doi.org/10.4081/btvb.2026.635

  20

  PDF: 4

• CO-46 | MILD HEMOPHILIA A AND JOINT HEALTH IN REAL LIFE: IS THAT AN EMERGING ISSUE? A SINGLE CENTER EXPERIENCE G. Murante^1|2|3, F. Valeri^1|2, S. Bergonzi^1|2|3, M. Capetta^1|2|3, C. Dainese^1|2, A. Valpreda⁴, R. Pastorino^1|3, F. Bocchi^1|3, B. Bruno^2|3, A. Borchiellini^1|2 | ¹Regional Centre for Hemorrhagic and Thrombotic Diseases, AOU Città della Salute e della Scienza of Turin, Italy; ²Division of Hematology, AOU Città della Salute e della Scienza, University of Turin, Italy; ³Dep. of Molecular Biotechnology and Health Sciences, University of Turin, Italy; ⁴Central Lab. Baldi and Riberi, AOU Città della Salute e della Scienza of Turin, Italy

  Giovanni Murante

  14-10-2026

  https://doi.org/10.4081/btvb.2026.656

  13

  PDF: 4

• CO-28 | SYNERGISTIC EFFECT OF RECOMBINANT FACTOR INFUSION ON THROMBIN GENERATION IN HEMOPHILIA PATIENTS UNDER EMICIZUMAB OR CONCIZUMAB PROPHYLAXIS F. Bocchi^1|2, R. Pastorino^1|2, G. Murante^1|2|3, S. Bergonzi^1|2|3, M. Capetta^1|2|3, F. Valeri^2|3, C. Dainese^2|3, A. Valpreda⁴, B. Bruno^1|3, A. Borchiellini^2|3 | ¹Department of Molecular Biotechnology and Health Sciences, University of Turin, Italy; ²Regional Centre for Thrombotic and Hemorrhagic Diseases, AOU Città della salute e della Scienza di Torino, Italy; ³Division of Hematology, AOU Città della Salute e della Scienza, University of Turin, Italy; ⁴Central Lab Baldi and Riberi, AOU Città della salute e della Scienza di Torino, Italy

  Francesca Bocchi

  14-10-2026

  https://doi.org/10.4081/btvb.2026.638

  20

  PDF: 6

• CO-17 | EMBODIED SELF-MANAGEMENT IN HEMOPHILIA: PSYCHOSOMATIC EFFECTS OF A SUPERVISED PHYSICAL ACTIVITY PROGRAM F. Valeri¹, M. Miniotti², M.G. Bailon², C. Dainese¹, B. Bruno³, P. Leombruni², A. Borchiellini¹ | ¹Regional Centre for Haemorrhagic and Thrombotic Disease, Hematology Division, AOU Città della Salute e della Scienza, Torino, Italy; ²Departement of Neurosciences Rita Levi Montalcini, University of Turin, Italy; ³Division of Hematology, AOU Città della Salute e della Scienza, Department of Molecular Biotechnology and Health sciences, University of Turin, Italy

  Federica Valeri

  14-10-2026

  https://doi.org/10.4081/btvb.2026.627

  16

  PDF: 5

• CO-67 | CONGENITAL DYSFIBRINOGENEMIA: BLEEDING PHENOTYPE, THROMBOTIC COMPLICATIONS, AND LONG-TERM MANAGEMENT IN A MULTICENTER COHORT M. Biglietto^1|2, M. Presti¹, R.C. Santoro³, I. Nichele⁴, M. Napolitano⁵, S. Pasca⁶, A. Borchiellini⁷, B. Pollio⁸, E. Zanon⁹, G. Barillari¹⁰, A. Poz¹⁰, S. Sorella¹, S. Ligia¹, R. Mormile¹, E. Baldacci¹, G. Castaman¹¹, F. Peyvandi^12|13, C. Santoro¹ | ¹Hematology, Department of Translational and Precision Medicine, Sapienza University of Rome, Italy; ²Department of Molecular Biology, Sapienza University of Rome, Italy; ³Hemostasis and Thrombosis Unit, Azienda Ospedaliera Pugliese-Ciaccio, Catanzaro, Italy; ⁴Hematology Unit, Azienda ULSS 8 Berica - San Bortolo Hospital, Vicenza, Italy; ⁵Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, University of Palermo, Italy; ⁶Coagulation Diseases Center, Transfusion Medicine Department - Azienda Sanitaria Universitaria Integrata del Trentino, Trento, Italy; ⁷Centro di Riferimento Regionale Malattie Emorragiche e Trombotiche dell'Adulto, Divisione di Ematologia, Università Città della Salute e della Scienza di Torino, Italy; ⁸SIMT Immunohematology and Transfusion Medicine Service, Diagnostic Department, A.O. Città della Salute e della Scienza, Torino, Italy; ⁹Department of Medicine, Haemophilia Centre, University Hospital of Padua, Italy; ¹⁰Center for Hemorrhagic and Thrombotic Diseases, General and University Hospital S. Maria della Misericordia, Udine, Italy; ¹¹Centre for Bleeding Disorders and Coagulation, Careggi University Hospital, Firenze, Italy; ¹²IRCCS Fondazione Ca' Granda Ospedale Maggiore Policlinico, Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Milano, Italy; ¹³Università degli Studi di Milano, Department of Pathophysiology and Transplantation, Milano, Italy

  Mario Biglietto

  14-10-2026

  https://doi.org/10.4081/btvb.2026.677

  22

  PDF: 4

• CO-22 | CLINICAL FEATURES IN PATIENTS WITH NON-SEVERE HEMOPHILIA A: THE DISCOVERY SCORE PROPOSAL FOR PROPHYLAXIS PRESCRIPTION M.N.D. Di Minno¹, E. Baldacci², C. Biasoli³, A. Borchiellini⁴, F. Daniele⁵, P. Di Gregorio⁶, C. Gorio⁷, G. Malcangi⁸, E. Marchesini⁹, I. Ricca¹⁰, R. Santoro¹¹, S. Siragusa¹², M.R. Villa¹³, E. Zanon¹⁴, A. Tagliaferri¹⁵, A. Coppola¹⁵ | ¹Hub Centre for Thrombotic and Hemorrhagic Disorders, Federico II University Hospital, Napoli, Italy; ²Haematology, University Hospital Policlinico Umberto I, Roma, Italy; ³Interdepartmental Simple Structure for the Management of Hemorrhagic and Thromboembolic Diseases, M. Bufalini Hospital, Cesena, Italy; ⁴Regional Centre for Hemorrhagic and Thrombotic Diseases, AOU Città della Salute e della Scienza, Torino, Italy; ⁵Haemostasis and Thrombosis Service, Ospedale Civile dell'Annunziata, Cosenza, Italy; ⁶Transfusion Medicine Department, "SS. Annunziata" Hospital, Chieti, Italy; ⁷Pediatric Onco-Hematology Unit, Children's Hospital, ASST-Spedali Civili, Brescia, Italy; ⁸Haemophilia and Thrombosis Center, University Hospital Policlinico-Giovanni XXIII, Bari, Italy; ⁹Hemophilia Centre, SC Vascular and Emergency Department, University of Perugia, Italy; ¹⁰Centro Emofilia, Città della Salute e della Scienza, Torino, Italy; ¹¹Hemostasis and Thrombosis Unit, Azienda Ospedaliero Universitaria Dulbecco, Catanzaro, Italy; ¹²Centro di Riferimento Regionale per le Emocoagulopatie Congenite, Palermo, Italy; ¹³Hematology Unit, Ospedale Santa Maria di Loreto, Napoli, Italy; ¹⁴Hemophilia and Thrombosis Center, University Hospital of Padua, Italy; ¹⁵Hemophilia and Thrombosis Center, Azienda Ospedaliera di Parma, Italy

  Matteo Di Minno

  14-10-2026

  https://doi.org/10.4081/btvb.2026.632

  21

  PDF: 5