Editorials
Vol. 2 No. 1 (2023)
The clinical usefulness of measuring thrombin generation
Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Received: 30 January 2023
Accepted: 7 February 2023
Accepted: 7 February 2023
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Citations
Hemker HC, Béguin S. Thrombin generation in plasma: its assessment via the endogenous thrombin potential. Thromb Haemos 1995;74:134-8. DOI: https://doi.org/10.1055/s-0038-1642666
Dargaud Y, Negrier C, Rusen L, et al. Individual thrombin generation and spontaneous bleeding rate during personalized prophylaxis with Nuwiq®(human‐cl rh FVIII) in previously treated patients with severe haemophilia A. Haemophilia 2018;24:619-27. DOI: https://doi.org/10.1111/hae.13493
Dargaud Y, Lienhart A, Janbain M, et al. Use of thrombin generation assay to personalize treatment of breakthrough bleeds in a patient with hemophilia and inhibitors receiving prophylaxis with emicizumab. Haematologica 2018;103:e181. DOI: https://doi.org/10.3324/haematol.2017.185330
Lebreton A, Sinegre T, Lecompte T, et al. Thrombin generation and cirrhosis: state of the art and perspectives. InSeminars in thrombosis and hemostasis 2020;46:693-703. DOI: https://doi.org/10.1055/s-0040-1715102
Bloemen S, Huskens D, Konings J, et al. Interindividual variability and normal ranges of whole blood and plasma thrombin generation. J Appl Lab Med 2017;2:150-64.
Winckers K, van Hylclama Vlieg A, Thomassen MCLGD, et al. Thrombin Generation and the risk of venous thrombosis: results from a large population-based case-control study. ISTH Toronto 2015.
Bloemen S, Huskens D, Konings J, et al. Interindividual variability and normal ranges of whole blood and plasma thrombin generation. J Appl Lab Med 2017;2:150-64. DOI: https://doi.org/10.1373/jalm.2017.023630
Hron G, Kollars M, Binder BR, et al. Identification of patients at low risk for recurrent venous thromboembolism by measuring thrombin generation. Jama 2006;296:397-402. DOI: https://doi.org/10.1001/jama.296.4.397
Al Dieri R, Peyvandi F, Santagostino E, et al. The thrombogram in rare inherited coagulation disorders: its relation to clinical bleeding. Thromb Haemos 2002;88:576-82. DOI: https://doi.org/10.1055/s-0037-1613258
Azar AJ, Cannegieter SC, Deckers JW, et al. Optimal intensity of oral anticoagulant therapy after myocardial infarction. J Ame Coll Cardiol 1996;27:1349-55. DOI: https://doi.org/10.1016/0735-1097(96)00020-4
Zwaveling S, Bloemen S, Castoldi E, et al. Response of thrombin generation to rivaroxaban in twin-families: influence of sex and contraceptives. Abstract 144150. ISTH congress. Montreal 2023.
Bloemen S, Hemker HC, Al Dieri R. Large inter-individual variation of the pharmacodynamic effect of anticoagulant drugs on thrombin generation. Haematologica. 2013 Apr;98:549. DOI: https://doi.org/10.3324/haematol.2012.073601
Eikelboom J, Merli G. Bleeding with direct oral anticoagulants vs warfarin: clinical experience. Ame J Med 2016;129:S33-40. DOI: https://doi.org/10.1016/j.amjmed.2016.06.003
Troy A, Anderson TS. National trends in use of and spending on oral anticoagulants among US Medicare beneficiaries from 2011 to 2019. InJAMA Health Forum 2021;2:e211693. DOI: https://doi.org/10.1001/jamahealthforum.2021.1693
Dyer O. Bayer and Janssen pay $775 m to settle Xarelto misinformation claims. BMJ 2019; 364:I1413. DOI: https://doi.org/10.1136/bmj.l1413
How to Cite
1.
Hemker CH. The clinical usefulness of measuring thrombin generation. Bleeding Thromb Vascul Biol [Internet]. 2023 Mar. 6 [cited 2025 Dec. 26];2(1). Available from: https://www.btvb.org/btvb/article/view/62
Copyright (c) 2023 The Author(s)
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
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