Original Articles
Vol. 1 No. 3 (2022)
Association between non-O blood type and early unexplained recurrent spontaneous abortion in women with and without inherited thrombophilia
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All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Received: 24 July 2022
Accepted: 25 October 2022
Accepted: 25 October 2022
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We retrospectively evaluated the prevalence of non-O blood type – the most frequently inherited prothrombotic factor – and inherited thrombophilia (IT) in a group of women with recurrent spontaneous abortion (RSA). All consecutive women with a history of early unexplained RSA who underwent a screening for IT between December 2008 and December 2021 were considered for enrolment. A group of healthy, age-matched women with ≥1 normal pregnancy and no adverse pregnancy outcomes acted as controls. Two hundred and seventeen women were enrolled. The adjusted odds ratio (aOR) of RSA in non-O vs. O blood type was 1.37 (95% CI, 1.04-2.78), and in women with vs. without IT was 1.26 (95% CI, 1.08-3.61); aOR of RSA in women with non-O blood type and IT was 2.52 (95% CI, 1.12-5.47). We observed a significant association between non-O blood group or IT and RSA. The concomitant presence of non-O blood group and IT further increases RSA risk.
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Citations
Robinson GA. Pregnancy loss. Best Pract Res Clin Obstet Gynaecol 2014;28:169-78. DOI: https://doi.org/10.1016/j.bpobgyn.2013.08.012
Arias F, Romero R, Joist H, Kraus FT. Thrombophilia: a mechanism of disease in women with adverse pregnancy outcome and thrombotic lesions in the placenta. J Matern Fetal Med 1998;7:277-86. DOI: https://doi.org/10.1002/(SICI)1520-6661(199811/12)7:6<277::AID-MFM5>3.0.CO;2-3
Robertson L, Wu O, Langhorne P, et al. Thrombophilia in pregnancy: a systematic review. Br J Haematol 2006;132:171-96. DOI: https://doi.org/10.1111/j.1365-2141.2005.05847.x
Middeldorp S. Pregnancy failure and heritable thrombophilia. Semin Hematol 2007;44:93-7. DOI: https://doi.org/10.1053/j.seminhematol.2007.01.005
Gao H, Tao FB. Prothrombin G20210A mutation is associated with recurrent pregnancy loss: a systematic review and meta-analysis update. Thromb Res 2015;135:339-46. DOI: https://doi.org/10.1016/j.thromres.2014.12.001
Sergi C, Al Jishi T, Walker M. Factor V Leiden mutation in women with early recurrent pregnancy loss: a meta-analysis and systematic review of the causal association. Arch Gynecol Obstet 2015;291:671-9. DOI: https://doi.org/10.1007/s00404-014-3443-x
Hamedi B, Feulefack J, Khan A, Sergi C. Association between factor V Leiden mutation and recurrent pregnancy loss in the middle east countries: a Newcastle-Ottawa metaanalysis. Arch Gynecol Obstet 2020;302:345-54. DOI: https://doi.org/10.1007/s00404-020-05610-6
Klai S, Fekih-Mrissa N, Rachdi R, Gritli N. The status of thrombophilic defects and non-O blood group as risk factors for gestational vascular complications among Tunisian women. Acta Haematol 2011;125:115-20. DOI: https://doi.org/10.1159/000321934
Akdemir N, Cevrioglu AS, Ozden S, et al. Platelet indices and blood groups in early recurrent miscarriage: a study in pregnant women. J Clin Gynecol Obstet 2013;2:27-30 DOI: https://doi.org/10.4021/jcgo90e
Dentali F, Sironi AP, Ageno W, et al. Non-O blood type is the commonest genetic risk factor for VTE: results from a meta-analysis of the literature. Semin Thromb Hemost 2012;38:535-48. DOI: https://doi.org/10.1055/s-0032-1315758
Spiezia L, Campello E, Bon M, et al. ABO blood groups and the risk of venous thrombosis in patients with inherited thrombophilia. Blood Transfus 2013;11:250-3.
American Diabetes Association. Classification and Diagnosis of Diabetes: Standards of Medical Care in Diabetes- 2021. Diabetes Care 2021;44:S15-S33. DOI: https://doi.org/10.2337/dc21-S002
Campello E, Spiezia L, Adamo A, Simioni P. Thrombophilia, risk factors and prevention. Review Expert Rev Hematol 2019;12:147-58. DOI: https://doi.org/10.1080/17474086.2019.1583555
Blood type. Available at: http//en.wikipedia.org/wiki/Blood_type. Accessed on: 5 April 2021.
Isermann B, Sood R, Pawlinski R, et al. The thrombomodulin-protein C system is essential for the maintenance of pregnancy. Nat Med 2003;9:331-7. DOI: https://doi.org/10.1038/nm825
Wu X, Zhao L, Zhu H et al. Association between the MTHFR C677T polymorphism and recurrent pregnancy loss: a meta-analysis. Genet Test Mol Biomarkers 2012;16:806-11. DOI: https://doi.org/10.1089/gtmb.2011.0318
Deloughery TG, Hunt BJ, Barnes GD, et al. A call to action: MTHFR polymorphisms should not be a part of inherited thrombophilia testing. Res Pract Thromb Haemost 2022;6:e12739. DOI: https://doi.org/10.1002/rth2.12739
Franchini M, Crestani S, Frattini F, et al. ABO blood group and von Willebrand factor: biological implications. Clin Chem Lab Med 2014;52:1273-6. DOI: https://doi.org/10.1515/cclm-2014-0564
Albánez S, Ogiwara K, Michels A, et al. Aging and ABO blood type influence von Willebrand factor and factor VIII levels through interrelated mechanisms. J Thromb Haemost 2016;14:953-63. DOI: https://doi.org/10.1111/jth.13294
Marietta M, Facchinetti F, Sgarbi L, et al. Elevated plasma levels of factor VIII in women with early recurrent miscarriage. J Thromb Haemost 2003;1:2536-9. DOI: https://doi.org/10.1111/j.1538-7836.2003.00496.x
Intzes S, Symeonidou M, Zagoridis K, et al. Hold your needles in women with recurrent pregnancy losses with or without hereditary thrombophilia: Meta-analysis and review of the literature. J Gynecol Obstet Hum Reprod 2021;50: 101935. DOI: https://doi.org/10.1016/j.jogoh.2020.101935
Lauritsen JG, Grunnet N, Jensen OM. Materno-fetal ABO incompatibility as a cause of spontaneous abortion. Clin Genet 1975;7:308-16. DOI: https://doi.org/10.1111/j.1399-0004.1975.tb00334.x
How to Cite
1.
Poretto A, Borella E, Turatti G, Marobin M, Campello E, Tormene D, et al. Association between non-O blood type and early unexplained recurrent spontaneous abortion in women with and without inherited thrombophilia. Bleeding Thromb Vascul Biol [Internet]. 2022 Nov. 14 [cited 2026 Jan. 21];1(3). Available from: https://www.btvb.org/btvb/article/view/47
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