Commentaries
Vol. 5 No. 3 (2026): In memory of Armando D’Angelo
Defending tranexamic acid and sensible scientific clinical trial design
Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Published: 28 August 2026
0
Views
0
Downloads
Authors
Three recent clinical trial reports published in the New England Journal of Medicine (NEJM) appear to undermine reputed effectiveness of tranexamic acid (TXA) as a hemostatic drug. They found no value for TXA over placebo as they used TXA, and as they assessed the outcome [...]
Downloads
Download data is not yet available.
Citations
1.Mannucci PM. Hemostatic drugs. N Engl J Med 1998;339: 245-53.
2. Pacheco LD, Clifton RG, Saade GR et al. Tranexamic acid to prevent obstetrical hemorrhage after cesarean delivery. N Engl J Med 2023;388:1365-75.
3. Devereaux PJ, Marcucci M, Painter TW et al. Tranexamic acid in patients undergoing noncardiac surgery. N Engl J Med 2022;386:1986-97.
4. PATCH-Trauma Investigators and the ANZICS Clinical Trials Group; Gruen RL, Mitra B, Bernard SA, et al. Prehospital tranexamic acid for severe trauma. N Engl J Med 2023;389: 127-16.
5. Shakur-Still H, Roberts I. Tranexamic acid for trauma patients — more lives to save and outcomes to consider. N Engl J Med 2023;389:181-3.
6. HALT-IT Trial Collaborators. Effects of a high-dose 24-h infusion of tranexamic acid on death and thromboembolic events in patients with acute gastrointestinal bleeding (HALT-IT): an international randomised, double-blind, placebo- controlled trial. Lancet 2020;395:1927-36.
How to Cite
1.
Davidson BL. Defending tranexamic acid and sensible scientific clinical trial design. Bleeding Thromb Vasc Biol [Internet]. 2026 Aug. 28 [cited 2026 Aug. 28];5(3). Available from: https://www.btvb.org/btvb/article/view/405
Copyright (c) 2026 The Author(s)
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Most read articles by the same author(s)
- Franco Piovella, Björn Dahlbäck, Raimondo De Cristofaro, Jim Morrissey, Bruce L. Davidson, Stefanie Mahan, Hugo ten Cate, Alex Spyropoulos, Charles Mahan, Charles T. Esmon, Valerio De Stefano, Francesco Bernardi, In memoriam of Prof. Armando D’Angelo (1952-2024) , Bleeding, Thrombosis and Vascular Biology: Vol. 5 No. 3 (2026): In memory of Armando D’Angelo
