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CO108 | MECHANOCHEMICAL REPROGRAMMING OF VWF–GPIB INTERACTIONS UNCOUPLES AFFINITY FROM AVIDITY AND LINKS THROMBOCYTOPENIA TO ANGIODYSPLASIA IN TYPE 2B VON WILLEBRAND DISEASE A. Ferretti1, M. Sacco1, S. Lancellotti1, P. Concolino2, A. Minucci2, R. De Cristofaro1|3 | 1Center for Hemorrhagic and Thrombotic Diseases; 2Molecular and Genomic Diagnostics Unit, Fondazione Policl.nico Univ. Gemelli IRCCS, Roma, Italy; 3Department of Translational Medicine and Surgery, Catholic University of the Sacred Heart, Roma, Italy
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