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• CO-05 | IN SILICO ANALYSIS THROUGH A NEWLY GENERATED FACTOR VIII MODEL SUPPORTS TOLERANCE OF B DOMAIN TO MULTIPLE AMINO ACID SUBSTITUTIONS LIMITING THE LOCAL IMPACT OF MISSENSE VARIANTS A. Branchini¹, M.F. Testa¹, M. Pinotti¹, R. De Cristofaro^2|3 | ¹Department of Life Sciences and Biotechnology, University of Ferrara, Italy; ²Department of Translational Medicine and Surgery, Catholic University of the Sacred Heart, Roma, Italy; ³Center for Hemorrhagic and Thrombotic Diseases, Foundation University Hospital “A. Gemelli” IRCCS, Roma, Italy

  Alessio Branchini

  14-10-2026

  https://doi.org/10.4081/btvb.2026.615

  5

  PDF: 1

• BEST-09 | IMMUNOGENIC IMPLICATIONS OF TRANSLATIONAL READTHROUGH MODULATE THE ASSOCIATION OF F8 NONSENSE MUTATIONS WITH INHIBITORS IN HEMOPHILIA A D. Balestra¹, M.F. Testa¹, M. Pinotti¹, A. Branchini¹, M.E. Mancuso², F. Bernardi¹ | ¹Department of Life Sciences and Biotechnology and LTTA Center, University of Ferrara, Italy; ²IRCCS, Humanitas Research Hospital, Center for Thrombosis and Hemorrhagic diseases, Milano, Italy

  Dario Balestra

  14-10-2026

  https://doi.org/10.4081/btvb.2026.609

  6

  PDF: 0

• CO-55 | DEVELOPMENT OF ENGINEERED LONG-ACTING BYPASSING FX VIA ALBUMIN FUSION FOR HEMOPHILIA WITH INHIBITORS A. Martucci¹, R. Tarantino¹, K.H. Aaen², M. Pinotti¹, J.T. Andersen², A. Branchini¹ | ¹Department of Life Sciences and Biotechnology, University of Ferrara, Ferrara, Italy; ²Institute of Clinical Medicine, Department of Pharmacology, University of Oslo, Norway

  Alessandro Martucci

  14-10-2026

  https://doi.org/10.4081/btvb.2026.665

  1

  PDF: 0

• BEST-01 | IDENTIFICATION OF NOVEL HYPERACTIVE rFVIIa BYPASSING MOLECULES INFERRED BY ANCESTRAL SEQUENCE RECONSTRUCTION APPROACH M.F. Testa, I. Passerini, P. Santos, A. Benazzo, S. Ghirotto, F. Bernardi, A. Branchini, M. Pinotti, D. Balestra | Dep. of LSB, University of Ferrara, Italy

  Maria Francesca Testa

  14-10-2026

  https://doi.org/10.4081/btvb.2026.601

  8

  PDF: 3