Case Reports
Vol. 5 No. 2 (2026)
Beyond the usual workup: severe hypertriglyceridemia as a potential cause of cerebral venous thrombosis
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All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Published: 15 July 2026
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Hypertriglyceridemia and cerebral venous thrombosis are well-recognized complications of asparaginase therapy for B-cell acute lymphoblastic leukemia. Hypertriglyceridemia has also been associated with an increased risk of thrombosis in conditions such as Behçet’s disease and has been implicated in a pediatric case of cerebral venous thrombosis, suggesting a possible link between hypertriglyceridemia and cerebral venous thrombosis. We present the case of a patient with acute delirium and amnesia, revealing a venous infarction caused by cerebral venous thrombosis of the sinus rectus. Classical causes, including hereditary thrombophilia, were excluded. Notably, the patient’s blood appeared lactescent at admission, and laboratory testing revealed severe hypertriglyceridemia. The patient improved significantly with heparin, dietary modifications, and ciprofibrate. This case suggests that severe hypertriglyceridemia should be considered as a potential trigger of cerebral venous thrombosis and that including a lipid panel in cerebral venous thrombosis work-ups could be considered, allowing subsequent specific therapeutic interventions.
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Ethics Approval
The patient described in this manuscript has not been reported elsewhere. Written informed consent for publication was obtained from the patient. In accordance with local regulations, ethics committee approval was not required.CRediT authorship contribution
Conceptualization: A.L ; Investigation: A.L, J.M, A.DL; Writing – original draft: A.L; R.KB ; Writing – review & editing: A.L, R.KB, J.M, A.DL, B.D ; Supervision: B.D.
Supporting Agencies
No supporting agency.Data Availability Statement
The datasets used and/or analyzed during the current study are available upon reasonable request from the corresponding author.
How to Cite
1.
Lapostolle A, Khani-Bittar R, Mazoyer J, De Liege A, Degos B. Beyond the usual workup: severe hypertriglyceridemia as a potential cause of cerebral venous thrombosis. Bleeding Thromb Vasc Biol [Internet]. 2026 Jul. 15 [cited 2026 Jul. 15];5(2). Available from: https://www.btvb.org/btvb/article/view/477
Copyright (c) 2026 The Author(s)
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
