Narrative Reviews
Vol. 4 No. 3 (2025)
https://doi.org/10.4081/btvb.2025.368

The key to fibrinolysis and thrombolysis

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Published: 9 September 2025
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tissue-type plasminogen activator, fibrinolysis, thrombolysis

Authors

Roger Lijnen
roger.lijnen@kuleuven.be
https://orcid.org/0000-0002-2401-1279
Department of Cardiovascular Sciences, Center for Molecular and Vascular Biology (CMVB), KU Leuven, Belgium.
Désiré Collen
Department of Cardiovascular Sciences, Center for Molecular and Vascular Biology (CMVB), KU Leuven, Belgium.
This narrative review was written at the occasion of the "Verstraete Centennial Memorial Lecture" organized on September 15, 2025 at NEUROMED (Pozzilli, Italy) by Giovanni de Gaetano and Maria Benedetta Donati. It represents a historical account of contributions by the Center for Molecular and Vascular Biology (CMVB), KU Leuven, Belgium, founded by Marc Verstraete, to our understanding of the regulation of fibrinolysis and the development of thrombolytic therapy. This review covers the long trajectory of events which, over almost half a century, have led from basic biochemical discoveries to the development of recombinant tissue-type plasminogen activator (rt-PA) and other clinically valuable drugs to treat thrombotic diseases.

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Lijnen R, Collen D. The key to fibrinolysis and thrombolysis. Bleeding Thromb Vascul Biol [Internet]. 2025 Sep. 9 [cited 2025 Nov. 7];4(3). Available from: https://www.btvb.org/btvb/article/view/368
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