Commentaries
Vol. 3 No. 2 (2024)
Commentary on “Preventive percutaneous coronary intervention versus optimal medical therapy alone for the treatment of vulnerable atherosclerotic coronary plaques (PREVENT): a multicenter, open-label, randomized controlled trial”
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All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Published: 26 June 2024
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To address the potential risk of acute coronary syndrome, the current clinical guidelines on coronary artery diseases recommend revascularization in significant and flow-limiting lesions, but emerging data depict vulnerable atherosclerotic coronary plaques as possibly at risk of adverse cardiac events, compared to fibroatheromous or calcific plaques [...].
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Citations
Neumann FJ, Sousa-Uva M, Ahlsson A, et al. 2018 ESC/EACTS guidelines on myocardial revascularization. Eur Heart J 2019;40:87-165. DOI: https://doi.org/10.1093/eurheartj/ehy855
Lawton JS, Tamis-Holland JE, Bangalore S, et al. 2021 ACC/AHA/SCAI guideline for coronary artery revascularization: a report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. Circulation 2022;145:e18-114. DOI: https://doi.org/10.1161/CIR.0000000000001060
Virani SS, Newby LK, Arnold SV, et al. 2023 AHA/ACC/ACCP/ASPC/NLA/PCNA guideline for the management of patients with chronic coronary disease: a report of the American Heart Association/American College of Cardiology Joint Committee on Clinical Practice Guidelines. Circulation 2023;148:e9-119. DOI: https://doi.org/10.1161/CIR.0000000000001195
Stone GW, Maehara A, Lansky AJ, et al. A prospective natural history study of coronary atherosclerosis. N Engl J Med 2011;364:226-35. DOI: https://doi.org/10.1056/NEJMoa1002358
Erlinge D, Maehara A, Ben-Yehuda O, et al. Identification of vulnerable plaques and patients by intracoronary near-infrared spectroscopy and ultrasound (PROSPECT II): a prospective natural history study. Lancet 2021;397:985-95. DOI: https://doi.org/10.1016/S0140-6736(21)00249-X
Gallone G, Bellettini M, Gatti M, et al. Coronary plaque characteristics associated with major adverse cardiovascular events in atherosclerotic patients and lesions: a systematic review and meta-analysis. JACC Cardiovasc Imaging 2023;16:1584-604. DOI: https://doi.org/10.1016/j.jcmg.2023.08.006
Park SJ, Ahn JM, Kang DY, et al. Preventive percutaneous coronary intervention versus optimal medical therapy alone for the treatment of vulnerable atherosclerotic coronary plaques (PREVENT): a multicentre, open-label, randomised controlled trial. Lancet. 2024;403:1753-65. DOI: https://doi.org/10.1016/S0140-6736(24)00413-6
Kubo T, Maehara A, Mintz GS, et al. The dynamic nature of coronary artery lesion morphology assessed by serial virtual histology intravascular ultrasound tissue characterization. J Am Coll Cardiol 2010;55:1590-7. DOI: https://doi.org/10.1016/j.jacc.2009.07.078
Zimmermann FM, Pijls NHJ, Gould KL, Johnson NP. Stenting "vulnerable" but fractional flow reserve-negative lesions: potential statistical limitations of ongoing and future trials. JACC Cardiovasc Interv 2021;14:461-7. DOI: https://doi.org/10.1016/j.jcin.2020.05.036
Stone GW, Maehara A, Ali ZA, et al; PROSPECT ABSORB Investigators. Percutaneous coronary intervention for vulnerable coronary atherosclerotic plaque. J Am Coll Cardiol 2020;76:2289-301. DOI: https://doi.org/10.1016/j.jacc.2020.09.547
Mol JQ, Bom MJ, Damman P, et al. Pre-emptive OCT-guided angioplasty of vulnerable intermediate coronary lesions: results from the prematurely halted PECTUS-Trial. J Interv Cardiol 2020;2020:8821525. DOI: https://doi.org/10.1155/2020/8821525
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Borghese O, Vincenzoni C. Commentary on “Preventive percutaneous coronary intervention versus optimal medical therapy alone for the treatment of vulnerable atherosclerotic coronary plaques (PREVENT): a multicenter, open-label, randomized controlled trial”. Bleeding Thromb Vascul Biol [Internet]. 2024 Jun. 26 [cited 2025 Nov. 10];3(2). Available from: https://www.btvb.org/btvb/article/view/141
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