Thrombophilia work-up and clinical outcomes in Indian patients with unprovoked venous and arterial thrombosis aged 18-50 years | BTVB Bioequivalence of von Willebrand factor-containing concentrates: implications for von Willebrand disease | BTVB Cardiovascular risk in hormone replacement therapy | BTVB Direct oral anticoagulants: does one dose fit all? Why, when and how testing | BTVB Cardiovascular risk profile evolution over 15 years: CV-PREVITAL vs Moli-sani Study | BTVB Launch of National Registry for Congenital Hematological Disorders in Palestine: Haemo-PAL | BTVB
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Bleeding, Thrombosis and Vascular Biology

Editor-in-Chief: Giovanni de Gaetano, Italy | eISSN: 2785-5309

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  • Platelet distribution width is associated with cardiovascular mortality in an adult general population

    Benedetta Izzi, Simona Costanzo, Alessandro Gialluisi, Amalia De Curtis, Sara Magnacca, Teresa Panzera, Augusto Di Castelnuovo, Maria Benedetta Donati, Chiara Cerletti, Marc F. Hoylaerts, Giovanni de Gaetano, Licia Iacoviello, *on behalf of the Moli-sani Study Investigators
    27-09-2023
    https://doi.org/10.4081/btvb.2023.83
    2738
    PDF: 408
    Supplementary Material: 97
  • Plasma fibrinogen levels and all-cause and cause-specific mortality in an Italian adult population: results from the Moli-sani study

    Roberta Parisi, Simona Costanzo, Romy de Laat-Kremers, Augusto Di Castelnuovo, Amalia De Curtis, Teresa Panzera, Mariarosaria Persichillo, Chiara Cerletti, Giovanni de Gaetano, Maria Benedetta Donati, Licia Iacoviello, Bas de Laat , for the Moli-sani Study Investigators
    27-01-2023
    https://doi.org/10.4081/btvb.2023.46
    2099
    PDF: 534
    APPENDIX: 178
  • When a feminist platelet went to the convention of prostaglandins and thromboxanes

    Giovanni de Gaetano
    04-11-2025
    https://doi.org/10.4081/btvb.2025.412
    1070
    PDF: 111
    HTML: 63
    Italian version: 61
  • The night of randomized clinical trials where all patients are black: a need to estimate variability in treatment effects

    Giovanni de Gaetano, Chiara Cerletti, Licia Iacoviello, Maria Benedetta Donati
    22-03-2022
    https://doi.org/10.4081/btvb.2022.24
    2138
    PDF: 336
  • Medicine at the crossroads of science, compassion and ethical responsibility

    Maria Benedetta Donati
    12-12-2025
    https://doi.org/10.4081/btvb.2025.423
    484
    PDF: 46
    HTML: 30
  • It’s definitely time to consider diet in its ultra-processing form as a major risk factor for thrombotic vascular disorders

    Marialaura Bonaccio, Licia Iacoviello, Maria Benedetta Donati
    03-08-2023
    https://doi.org/10.4081/btvb.2023.91
    1508
    PDF: 411
  • Still unmet problems with low molecular weight heparin prophylaxis of venous thromboembolism. An Italian survey

    Stefania Cavazza, Gualtiero Palareti*
    03-10-2025
    https://doi.org/10.4081/btvb.2025.177
    1291
    PDF: 217
    HTML: 86
    Supplementary: 60
  • On the impact of generative artificial intelligence on peer review

    Giovanni de Gaetano, Chiara Cerletti, Augusto Di Castelnuovo
    03-03-2025
    https://doi.org/10.4081/btvb.2025.176
    1091
    PDF: 346
  • Cardiovascular risk profile evolution over 15 years: comparison between CV-PREVITAL Trial and Moli-sani Study participants

    Augusto Di Castelnuovo, Mariarosaria Persichillo
    15-01-2026
    https://doi.org/10.4081/btvb.2026.416
    824
    PDF: 198
  • Cancer-associated ischemic stroke: current knowledge and future directions

    Ronda Lun, Deborah M. Siegal
    16-05-2024
    https://doi.org/10.4081/btvb.2024.117
    2710
    PDF: 772
  • Unveiling the “common soil” of cardiovascular disease and cancer

    Licia Iacoviello, Maria Benedetta Donati
    24-02-2025
    https://doi.org/10.4081/btvb.2025.167
    1306
    PDF: 351
  • Bleeding in cancer: epidemiological aspects

    Kelsey Bria, Amir Mahmoud, Kristen M. Sanfilippo
    16-04-2026
    https://doi.org/10.4081/btvb.2026.453
    0
    PDF: 0
  • Trends and updates on the epidemiology of cancer-associated thrombosis: a systematic review

    Ang Li, Emily Zhou
    16-05-2024
    https://doi.org/10.4081/btvb.2024.108
    1437
    PDF: 563
  • PO16 | EPIDEMIOLOGY, CLINICAL CHARACTERISTICS, AND OUTCOMES OF PROVOKED AND UNPROVOKED PULMONARY EMBOLISM IN A MULTICULTURAL ISRAELI POPULATION R. Farah1, N.L. Bragazzi2|3|4, H.İ. Ceylan5, Ł. Szarpak6|7|8|9, W. Mahajni1, N. Ashqar1, A. M. Fioretti10, R. Khamisy-Farah11 | 1Internal Medicine B Department, Ziv Medical Center, Azrieli Faculty of Medicine, Bar-Ilan University, Galilee, Safed, Israel; 2Laboratory for Industrial and Applied Mathematics, Department of Mathematics and Statistics, York University, Toronto, Canada; 3Postgraduate School of Public Health, Department of Health Sciences, University of Genoa, Italy; 4UNESCO Chair, Health Anthropology, Biosphere and Healing Systems, University of Genoa, Italy; 5Physical Education and Sports Teaching Department, Faculty of Sports Sciences, Atatürk University, Erzurum, Turkey; 6Department of Clinical Research and Development, LUXMED Group, Warsaw, Poland; 7Institute of Medical Science, Collegium Medicum, The John Paul II Catholic University of Lublin, Lublin, Poland; 8The World Academic Council of Emergency Medicine, Sarasota, FL, USA; 9Henry JN Taub Department of Emergency Medicine, Baylor College of Medicine, Houston, TX, USA; 10Cardio-Oncology Unit, IRCCS Istituto Tumori “Giovanni Paolo II”, Bari, Italy; 11Clalit Health Service, Azrieli Faculty of Medicine, Bar-Ilan University, Galilee, Safed, Israel

    Società Italiana di Emostasi e Trombosi
    16-04-2026
    https://doi.org/10.4081/btvb.2026.511
    1
    PDF: 0
  • Risk of recurrent venous thromboembolism in cancer patients after discontinuation of anticoagulant therapy

    Gary E. Raskob
    16-05-2024
    https://doi.org/10.4081/btvb.2024.124
    1321
    PDF: 752
  • In this issue

    Giovanni de Gaetano, Chiara Cerletti
    18-03-2026
    https://doi.org/10.4081/btvb.2026.472
    129
    PDF: 42
  • Anticoagulation in obese patients: challenges and strategies

    Alice Lipari, Esmeralda Capristo, Antonietta Ferretti, Erica De Candia
    18-09-2025
    https://doi.org/10.4081/btvb.2025.174
    1827
    PDF: 261
    HTML: 195
    XML: 77
  • PO68 | RISK OF VENOUS THROMBOEMBOLISM IN PATIENTS WITH CANCER AND MIGRAINE: A COHORT ANALYSIS AMONG DANISH NATIONAL HEALTH SURVEY PARTICIPANTS O. Rosenkrantz1, P. Szentkúti1, L. Amdisen1, E. Horváth-Puhó1, A.L. Pedersen1, H.E. Bøtker2, H. Elser1|3, J.P. Vandenbroucke1|4|5, H.T. Sørensen1 | 1Department of Clinical Epidemiology and Center for Population Medicine, Aarhus University Hospital and Aarhus University, Denmark; 2Department of Cardiology, Aarhus University Hospital, Department of Clinical Medicine, University of Aarhus, Denmark; 3Department of Neurology, Hospital of the University of Pennsylvania, Philadelphia, PA, USA; 4Department of Clinical Epidemiology, Leiden University Medical School Leiden, The Netherlands; 5School of Hygiene and Tropical Medicine, London, UK

    Società Italiana di Emostasi e Trombosi
    16-04-2026
    https://doi.org/10.4081/btvb.2026.557
    2
    PDF: 0
  • SISET50: trajectories of hemostasis and thrombosis in Italy 1970-2020

    Giovanni de Gaetano, Maria Benedetta Donati, Americo Bonanni
    17-01-2025
    https://doi.org/10.4081/btvb.2025.170
    1370
    PDF: 290
  • Preface to the 13th International Conference on Thrombosis and Hemostasis Issues in Cancer, 2026

    Anna Falanga, Benjamin Brenner, Alok A. Khorana
    16-04-2026
    https://doi.org/10.4081/btvb.2026.479
    0
    PDF: 0
  • Executive summary of the SISET position paper on the management of antithrombotic therapy in left ventricular thrombus

    Emanuele Valeriani, Arianna Pannunzio, Danilo Menichelli, Domenico Prisco, Walter Ageno, Daniele Pastori, Pasquale Pignatelli
    16-12-2025
    https://doi.org/10.4081/btvb.2025.401
    261
    PDF: 58
    HTML: 19
  • CO27 | Intracerebral hemorrhage in hemophilia A and B: a 10-year prospective multicenter study in Italy (2012–2022) E. Zanon1, A. Napolitano1, A. Porreca2, F. Demartis3, A. Coppola4, C. Santoro5, I. Cantori6, A. C. Molinari7, C. Biasioli8, M. Luciani9, G. Sottilotta10, B. Pollio11, A. Borchiellini12, A. Tosetto13, P. Flora14, P. Simioni1 | 1Haemophilia Center, First Chair of Internal Medicine, Department of Medicine, University-Hospital of Padua Medical School, Padua; 2Department of Human Sciences and Promotion of the Quality of Life, Unit of Clinical and Molecular Epidemiology IRCCS San Raffaele Roma Open University, Roma; Unit of Clinical and Molecular Epidemiology IRCCS San Raffaele, Roma; 3Centre for Bleeding Disorders, Careggi University Hospital of Firenze; 4Azienda Ospedaliero Universitaria di Parma; 5Hematology Division, Umberto I University Hospital of Roma; 6Haemophilia Center, Department of Transfusion Medicine, Hospital of Macerata; 7IRCCS Istituto Giannina Gaslini, Genova; 8Haemophilia and Transfusion Centre, Bufalini Hospital, Cesena; 9Children’s Hospital Bambino Gesù, Roma; 10Haemophilia Center, Department of Onco-Hematology and Radioterapy, Hospital of Reggio Calabria; 11Haemophilia Pediatric Center, Transfusion Medicine, City of Health and Science of Turin; 12City of Health and Science of Turin; 13Hemorrhagic and Thrombotic Diseases Unit, S. Bortolo Hospital of Vicenza; 14RCCS Foundation Ca’ Granda Maggiore Policlinico Hospital, Milan, Italy

    22-10-2025
    https://doi.org/10.4081/btvb.2025.233
    523
    PDF: 0
  • Safety and efficacy of treatment with vitamin K antagonists in patients managed in a network of anticoagulation services or as routine general care

    Gianfranco De Girolamo, Luca Sarti, Sonia Cecoli, Karin Bonora, Chiara Ajolfi, Francesco Bellelli, Valeria Coluccio, Gualtiero Palareti, Marco Marietta
    15-04-2022
    https://doi.org/10.4081/btvb.2022.9
    992
    PDF: 310
    Supplementary Files: 117
  • Blood platelets, prostaglandins and aspirin: a historical and personal rereading

    Giovanni de Gaetano, Chiara Cerletti
    13-03-2024
    https://doi.org/10.4081/btvb.2024.121
    1827
    PDF: 311
  • Facts and figures in occult cancer screening among patients with unprovoked venous thromboembolism

    Aurélien Delluc
    16-04-2026
    https://doi.org/10.4081/btvb.2026.428
    0
    PDF: 0
  • The evolution of hemostasis genetics: from monogenic disorders to complex traits. A historical perspective

    Augusto Di Castelnuovo
    01-07-2025
    https://doi.org/10.4081/btvb.2025.184
    1319
    PDF: 244
  • PO13 | OUTPATIENT TREATMENT OF VENOUS THROMBOEMBOLISM AND SUBSEQUENT RISK OF CANCER S. Sørensen, D. Farkas, H. Sørensen | Department of Clinical Epidemiology, Aarhus University Hospital and Aarhus University, Aarhus, Denmark

    Società Italiana di Emostasi e Trombosi
    16-04-2026
    https://doi.org/10.4081/btvb.2026.509
    1
    PDF: 0
  • PO09 | CANCER MORTALITY AFTER INCIDENT VENOUS THROMBOEMBOLISM C. Langholm1, N.H. Eide1, K. Hveem2|3|4, N. Van Es5|6, V.M. Morelli1|7, S.K. Braekkan1|7, J.B. Hansen1|7 | 1Thrombosis Research Group, Department of Clinical Medicine, UiT – The Arctic University of Norway, Tromsø, Norway; 2HUNT Research Centre, Department of Public Health and General Practice, Norwegian University of Science and Technology, Levanger, Norway; 3HUNT Center for Molecular and Clinical Epidemiology, Department of Public Health and Nursing, Norwegian University of Science and Technology, Trondheim, Norway; 4Department of Research, St. Olav University Hospital, Trondheim, Norway; 5Department of Vascular Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands; 6Amsterdam Cardiovascular Sciences Pulmonary Hypertension and Thrombosis Amsterdam, the Netherlands; 7Thrombosis Research Center, Department of Internal Medicine, University Hospital of North Norway, Tromsø, Norway

    Società Italiana di Emostasi e Trombosi
    16-04-2026
    https://doi.org/10.4081/btvb.2026.505
    1
    PDF: 0
  • Venous thromboembolism and mortality in patients with hematological malignancies

    Kristen M. Sanfilippo, Tzu-Fei Wang
    16-05-2024
    https://doi.org/10.4081/btvb.2024.119
    1262
    PDF: 628
  • Moving beyond p-value

    Augusto Di Castelnuovo, Licia Iacoviello
    15-04-2022
    https://doi.org/10.4081/btvb.2022.30
    2363
    PDF: 535
  • PO29 | Quality of anticoagulation as a predictor of early left ventricular thrombosis resolution: a retrospective cohort study A. Pannunzio1, I.M. Palumbo1, M.P. Donadini2, D. Santagata2, W. Ageno2, F. Dragoni3, A. Chistolini3, C. Becattini4, K. Satula4, D. Menichelli1, D. Pastori1, P. Pignatelli5, E. Valeriani1 | 1Department of General Surgery and Surgical Specialty Paride Stefanini, Sapienza University of Roma; 2Department of Medicine and Surgery, University of Insubria, Varese; 3Hematology, Department of Translational and Precision Medicine, Sapienza University of Roma; 4Internal Vascular and Emergency Medicine - Stroke Unit, University of Perugia; 5Department of Clinical Internal, Anesthesiological and Cardiovascular Sciences, Sapienza University of Roma, Italy

    22-10-2025
    https://doi.org/10.4081/btvb.2025.290
    450
    PDF: 0
  • PO57 | A NOVEL RISK ASSESSMENT MODEL FOR CANCER DETECTION WITHIN ONE YEAR AFTER INCIDENT VENOUS THROMBOEMBOLISM C. Antoun1, J. Hansen1|3, S. Brækkan1|3, C. Langholm1, N. Eide1, V. Morelli1|3, K. Hveem2 | 1Department of Clinical Medicine, UiT The Arctic University of Norway, Tromsø; 2HUNT Center for Molecular and Clinical Epidemiology, Norwegian University of Science and Technology, Trondheim; 3Thrombosis Research Center, Division of Internal Medicine, University Hospital of North Norway, Tromsø, Norway

    Società Italiana di Emostasi e Trombosi
    16-04-2026
    https://doi.org/10.4081/btvb.2026.549
    1
    PDF: 0
  • PO43 | ELEVATED CIRCULATING TISSUE PLASMINOGEN ACTIVATOR LEVELS PREDICT GASTROINTESTINAL AND BREAST CANCER RISK: A PROSPECTIVE NESTED CASE-COHORT STUDY S. Bolognini1|2, C. Ticozzi1, P. Gomez-Rosas1|3, F. Schieppati1|2, G. Sampietro4, L. Barcella1, M. Marchetti1|2, A. Falanga1|2 | 1Immunohematology and Transfusion Medicine, Hospital Papa Giovanni XXIII, Bergamo, Italy; 2School of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy; 3Maastricht University Medical Center, Cardiovascular Research Institute Maastricht (CARIM), Maastricht, The Netherlands; 4Unit of Epidemiology and Statistics, ATS Bergamo, Italy

    Società Italiana di Emostasi e Trombosi
    16-04-2026
    https://doi.org/10.4081/btvb.2026.537
    1
    PDF: 0
  • Author's Reply. Da la scheggia rotta usciva insieme parole e sangue: an unusual case of bleeding and the metaphor of a clinical trial

    Giovanni de Gaetano
    05-12-2024
    https://doi.org/10.4081/btvb.2024.163
    893
    PDF: 184
  • Thromboprophylaxis in primary brain cancer

    Eva N. Hamulyák, Barbara A. Hutten, Nick van Es
    16-04-2026
    https://doi.org/10.4081/btvb.2026.455
    0
    PDF: 0
  • CO14 | Inflammation and fibrinolysis biomarkers as predictors of cancer risk in healthy subjects: results from the hypercan study C. Ticozzi1, S. Bolognini1,2, P. Gomez-Rosas1,3, L. Russo1,2, Cj. Tartari1,2, F. Schieppati1,2, G. Sampietro4, L. Barcella1, M. Marchetti1,2, A. Falanga1,2 | 1Immunohematology and Transfusion Medicine, Hospital Papa Giovanni XXIII, Bergamo, Italy; 2School of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy; 3Maastricht University Medical Center, Cardiovascular Research Institute Maastricht, Maastricht, The Netherlands; 4Unit of Epidemiology and Statistics, ATS Bergamo, Italy

    22-10-2025
    https://doi.org/10.4081/btvb.2025.218
    492
    PDF: 0
  • PO17 | PREDICTIVE VALUE OF INFLAMMATORY AND ENDOTHELIAL BIOMARKERS FOR CANCER RISK IN HEALTHY INDIVIDUALS: EVIDENCE FROM THE HYPERCAN STUDY C. Ticozzi1, S. Bolognini1|2, P. Gomez-Rosas1|3, F. Schieppati1|2, G. Sampietro4, L. Barcella1, M. Marchetti1|2, A. Falanga1|2 | 1Immunohematology and Transfusion Medicine, Hospital Papa Giovanni XXIII, Bergamo, Italy; 2School of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy; 3Maastricht University Medical Center, Cardiovascular Research Institute Maastricht (CARIM), Maastricht, The Netherlands; 4Unit of Epidemiology and Statistics, ATS Bergamo, Italy

    Società Italiana di Emostasi e Trombosi
    16-04-2026
    https://doi.org/10.4081/btvb.2026.512
    1
    PDF: 0
  • Diagnostic and management practices for inherited fibrinogen disorders: a nationwide survey of Italian Hemophilia Treatment Centers

    Renato Marino, Silvia Linari, Marzia Leotta, Antonio Coppola, Chiara Biasoli, Maria Elisa Mancuso, Flora Peyvandi, Cristina Santoro, Ezio Zanon, Rita Carlotta Santoro
    02-12-2025
    https://doi.org/10.4081/btvb.2025.372
    425
    PDF: 60
    HTML: 40
    Supplementary: 19
    Appendix: 34
  • Da la scheggia rotta usciva insieme parole e sangue: an unusual case of bleeding and the metaphor of a clinical trial

    Giovanni de Gaetano
    29-10-2024
    https://doi.org/10.4081/btvb.2024.156
    1870
    PDF: 357
    Appendix: 261
  • Mortality following major gastrointestinal bleeding among patients receiving direct oral anticoagulants

    Julia Sharobim, Tzu-Fei Wang, Marc Carrier
    16-04-2026
    https://doi.org/10.4081/btvb.2026.432
    0
    PDF: 0
  • CS04 | Association between elevated plasma levels of tissue plasminogen activator and occult cancer risk: a nested case-cohort analysis in 10,294 healthy subjects S. Bolognini1,2, C. Ticozzi1, P. Gomez-Rosas1,3, L. Russo1,2, Cj. Tartari1,2, F. Schieppati1,2, G. Sampietro4, L. Barcella1, M. Marchetti1,2, A. Falanga1,2 | 1Immunohematology and Transfusion Medicine, Hospital Papa Giovanni XXIII, Bergamo, Italy; 2School of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy; 3Maastricht University Medical Center, Cardiovascular Research Institute Maastricht, The Netherlands; 4Unit of Epidemiology and Statistics, ATS Bergamo, Italy

    22-10-2025
    https://doi.org/10.4081/btvb.2025.201
    519
    PDF: 0
  • Distal deep vein thrombosis: is there a way out of this dark forest?

    Matteo Guarascio, Gerardo Nicola Pititto, Alessia Abenante, Marco Paolo Donadini
    04-09-2024
    https://doi.org/10.4081/btvb.2024.129
    1400
    PDF: 379
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Vol. 5 No. 1 (2026)
A lifetime in biomedical research: an interview with Silvio Garattini
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