Milvexian and other drugs targeting Factor XI: a new era of anticoagulation?

Published: 15 April 2022
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Authors

  • Marco P. Donadini marcopaolo.donadini@uninsubria.it Research Center on Thromboembolic Diseases and Antithrombotic Therapies, Department of Medicine and Surgery, University of Insubria, Varese; Thrombosis and Hemostasis Center, Ospedale di Circolo e Fondazione Macchi, Azienda Socio-Sanitaria territoriale dei Sette Laghi, Varese, Italy.
  • Walter Ageno Research Center on Thromboembolic Diseases and Antithrombotic Therapies, Department of Medicine and Surgery, University of Insubria, Varese; Thrombosis and Hemostasis Center, Ospedale di Circolo e Fondazione Macchi, Azienda Socio-Sanitaria territoriale dei Sette Laghi, Varese, Italy.

For almost 90 years, the discovery and development of anticoagulant drugs have focused on maximizing their antithrombotic efficacy while minimizing the risk of bleeding, in addition to providing manageable compounds with predictable and/or monitorable effects [...].

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Sanghai S, Wong C, Wang Z, et al. Rates of potentially inappropriate dosing of direct-acting oral anticoagulants and associations with geriatric conditions among older patients with atrial fibrillation: The SAGE-AF Study. J Am Heart Assoc 2020;9:e014108. DOI: https://doi.org/10.1161/JAHA.119.014108
Trujillo-Santos J, Di Micco P, Dentali F, et al. Real-life treatment of venous thromboembolism with direct oral anticoagulants: The influence of recommended dosing and regimens. Thromb Haemost 2017;117:382-9. DOI: https://doi.org/10.1160/TH16-07-0494
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Weitz JI, Bauersachs R, Becker B, et al. Effect of osocimab in preventing venous thromboembolism among patients undergoing knee arthroplasty: the foxtrot randomized clinical trial. JAMA 2020;323:130-9. DOI: https://doi.org/10.1001/jama.2019.20687
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Weitz JI, Strony J, Ageno W, et al. Milvexian for the Prevention of Venous Thromboembolism. N Engl J Med 2021;385:2161-72. DOI: https://doi.org/10.1056/NEJMoa2113194
Lorentz CU, Tucker EI, Verbout NG, et al. The contact activation inhibitor AB023 in heparin-free hemodialysis: results of a randomized phase 2 clinical trial. Blood 2021;138:2173-84. DOI: https://doi.org/10.1182/blood.2021011725

How to Cite

Donadini, M. P., & Ageno, W. (2022). Milvexian and other drugs targeting Factor XI: a new era of anticoagulation?. Bleeding, Thrombosis and Vascular Biology, 1(1). https://doi.org/10.4081/btvb.2022.22

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