Branchini A. CO-05 | IN SILICO ANALYSIS THROUGH A NEWLY GENERATED FACTOR VIII MODEL SUPPORTS TOLERANCE OF B DOMAIN TO MULTIPLE AMINO ACID SUBSTITUTIONS LIMITING THE LOCAL IMPACT OF MISSENSE VARIANTS: A. Branchini1, M.F. Testa1, M. Pinotti1, R. De Cristofaro2|3 | 1Department of Life Sciences and Biotechnology, University of Ferrara, Italy; 2Department of Translational Medicine and Surgery, Catholic University of the Sacred Heart, Roma, Italy; 3Center for Hemorrhagic and Thrombotic Diseases, Foundation University Hospital “A. Gemelli” IRCCS, Roma, Italy. Bleeding Thromb Vasc Biol [Internet]. 2026 Oct. 14 [cited 2026 Nov. 3];5(s2). Available from: https://www.btvb.org/btvb/article/view/615