Branchini, Alessio. 2026. “CO-05 | IN SILICO ANALYSIS THROUGH A NEWLY GENERATED FACTOR VIII MODEL SUPPORTS TOLERANCE OF B DOMAIN TO MULTIPLE AMINO ACID SUBSTITUTIONS LIMITING THE LOCAL IMPACT OF MISSENSE VARIANTS: A. Branchini1, M.F. Testa1, M. Pinotti1, R. De Cristofaro2|3 | 1Department of Life Sciences and Biotechnology, University of Ferrara, Italy; 2Department of Translational Medicine and Surgery, Catholic University of the Sacred Heart, Roma, Italy; 3Center for Hemorrhagic and Thrombotic Diseases, Foundation University Hospital ‘A. Gemelli’ IRCCS, Roma, Italy”. Bleeding, Thrombosis and Vascular Biology 5 (s2). https://doi.org/10.4081/btvb.2026.615.